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Enhanced stress response in zebrafish results in increase expression of the glucocorticoid receptor
Title
Enhanced stress response in zebrafish results in increase expression of the glucocorticoid receptor.
Creator
Phan, Tram-Anh Ngoc, Duboué, Erik, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Humans subjected to childhood trauma are more likely to develop anxiety disorders such as post-traumatic stress disorder, yet how Early-Life-Stress (ELS) impacts the function, or the development of the nervous system remains poorly understood. We developed a zebrafish model of ELS. Because of the powerful genetics and accessibility to the brain, the zebrafish is an excellent system to explore how ELS alters brain development and function. The neuroendocrine stress system in zebrafish is...
Show moreHumans subjected to childhood trauma are more likely to develop anxiety disorders such as post-traumatic stress disorder, yet how Early-Life-Stress (ELS) impacts the function, or the development of the nervous system remains poorly understood. We developed a zebrafish model of ELS. Because of the powerful genetics and accessibility to the brain, the zebrafish is an excellent system to explore how ELS alters brain development and function. The neuroendocrine stress system in zebrafish is mediated in part by the hypothalamic–pituitary–interrenal (HPI) axis, which is analogous to mammalian hypothalamic—pituitary—adrenal (HPA) axis. When perceiving stress, the zebrafish hypothalamus releases corticotropin-releasing hormone, which signals to the pituitary gland to release adrenocorticotropic releasing hormone (acth). Acth then signals down to the interrenal gland, which in-turn secretes cortisol. Cortisol then binds to glucocorticoid and mineralocorticoid receptors in the brain, to mediate stress responses and inhibit the HPA/HPI. We hypothesize that in zebrafish larvae that the ELS may alter the relative expression of genes in the HPI pathway. We generated ELS zebrafish larvae and measured the relative expression levels of corticotropic releasing hormone (crh), glucocorticoid receptor (gr), and mineralocorticoid receptor (mr). We find that the level of expression of crh is modestly higher in ELS zebrafish, which is consistent with higher levels of stress. Moreover, the expression level of gr is higher in ELS zebrafish, while no significant differences in the expression level of mr were found. This data suggests that ELS may disrupt the normal gr:mr ratio in zebrafish subjected to ELS. We are following up on these studies by localizing which neuronal regions are most affected via in situ hybridization.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00156
Format
Document (PDF)
Examining the US-Japan Alliance in a New Security Environment: Japan’s Perception of the Alliance from 2000-2010
Title
Examining the US-Japan Alliance in a New Security Environment: Japan’s Perception of the Alliance from 2000-2010.
Creator
Helber, Caitlyn Rose, Fewkes, Jacqueline H., Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
After the Cold War, many political changes, such as the fall of the Soviet Union, radically changed the global security environment. In response to this new environment, the Japanese government and the United States relationship also changed. The focus of my research is to identify how the Japanese government’s perception of the US-Japan Alliance contributed to changes of Japan’s security policy from 2000 to 2010, particularly how the Japanese government perceives the strength of the US-Japan...
Show moreAfter the Cold War, many political changes, such as the fall of the Soviet Union, radically changed the global security environment. In response to this new environment, the Japanese government and the United States relationship also changed. The focus of my research is to identify how the Japanese government’s perception of the US-Japan Alliance contributed to changes of Japan’s security policy from 2000 to 2010, particularly how the Japanese government perceives the strength of the US-Japan Alliance and increased security threats such as the rise of China, terrorism, and a nuclear armed North Korea. To this end, I analyze primary source documents published by the Ministry of Foreign Affairs of Japan and recorded mentions of security issues and the US-Japan Alliance from 2000-2010. By examining the relationship between perception and policy, I hope to better understand how it affects the US-Japan alliance and Japanese security policy in the future.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00143
Format
Document (PDF)
From Treatment to Trauma: First-Line Cancer Treatment and Cancer-Related Post-Traumatic Stress Disorder
Title
From Treatment to Trauma: First-Line Cancer Treatment and Cancer-Related Post-Traumatic Stress Disorder.
Creator
Ly, An, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University, Earles, Julie
Abstract/Description
The epidemiology of cancer-related PTSD is well-documented, but the effect of first-line cancer treatments on the prevalence and severity of PTSD has yet to be consolidated. Unlike many other traumatic events preceding the onset of post-traumatic stress disorder (PTSD), the cancer experience has ongoing stages of diagnosis, treatment, and survivorship that each present their own stressors. Due to the multifaceted nature of cancer-related trauma, it is important to understand how each...
Show moreThe epidemiology of cancer-related PTSD is well-documented, but the effect of first-line cancer treatments on the prevalence and severity of PTSD has yet to be consolidated. Unlike many other traumatic events preceding the onset of post-traumatic stress disorder (PTSD), the cancer experience has ongoing stages of diagnosis, treatment, and survivorship that each present their own stressors. Due to the multifaceted nature of cancer-related trauma, it is important to understand how each component of the experience plays a role in the onset of mental illness. Thus, I review the existing literature to elucidate how the biochemical changes induced by chemotherapy, radiation, and surgery influence the onset and prevalence of cancer-related PTSD. In being informed of the physiological processes underlying treatment and their implications for mental health, patients and clinicians alike can better predict the psychological changes that occur alongside cancer treatment.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00148
Format
Document (PDF)
Folkway to National Religion: The Metamorphosis of Shinto during the Meiji Era
Title
Folkway to National Religion: The Metamorphosis of Shinto during the Meiji Era.
Creator
Hernanez, Jorge Rafael, Ely, Christopher, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
During the Meiji era (1869-1912) a group of academics known as the National learning school helped create and then institute a civic religion known as State Shinto. This belief system took aspects of the folkway known as Shinto and modified it into a form of nationalism which centered on the figure of the Japanese Emperor. This Thesis examines the applications of State Shinto, how affected the lives of those living in Imperial Japan, and how State Shinto differs from its namesake.
Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00145
Format
Document (PDF)
Preventative Treatments of Diabetes and Non-Alcoholic Fatty Liver Disease
Title
Preventative Treatments of Diabetes and Non-Alcoholic Fatty Liver Disease.
Creator
Bansal, Nikita, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Diabetes mellitus type 2 is a long-term metabolic disease that is currently ranked as the seventh leading cause of mortality in the United States and ninth leading cause worldwide. Recognized as a global health problem, diabetes mellitus is a chronic condition that involves multiple organ systems and can often lead to irreversible damage. Long term complications include neuropathy, retinopathy, nephropathy, cardiovascular disease, and hepatopathy. Diabetes is associated with a wide spectrum...
Show moreDiabetes mellitus type 2 is a long-term metabolic disease that is currently ranked as the seventh leading cause of mortality in the United States and ninth leading cause worldwide. Recognized as a global health problem, diabetes mellitus is a chronic condition that involves multiple organ systems and can often lead to irreversible damage. Long term complications include neuropathy, retinopathy, nephropathy, cardiovascular disease, and hepatopathy. Diabetes is associated with a wide spectrum of liver diseases; the most common is non-alcoholic fatty liver disease, which can lead to liver failure. Sedentary lifestyles in industrialized countries are often seen as the inadvertent cause of increasing obesity and diabetes despite the thoroughly researched treatment plans available. In this study, I will examine the role of lifestyle and dietary modifications (including plant-based diet) in controlling diabetes and diabetes related complications, specifically non-alcoholic fatty liver disease.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00135
Format
Document (PDF)
Online Presence in Real Estate: Case Study Abacoa
Title
Online Presence in Real Estate: Case Study Abacoa.
Creator
Samedy, Christelle M., Nur-tegin, Kanybek, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Most homebuyers are currently using social media and other online platforms to search for the best deals and real estate agents. In 2013, the National Association of Realtors reported that ninety percent of homebuyers use online tools during the purchasing process. This report prompts us to focus our research on the impact of social media marketing on listing agent's success. In this study, we collect data of 20 Abacoa agents to determine whether their number of social media platforms and...
Show moreMost homebuyers are currently using social media and other online platforms to search for the best deals and real estate agents. In 2013, the National Association of Realtors reported that ninety percent of homebuyers use online tools during the purchasing process. This report prompts us to focus our research on the impact of social media marketing on listing agent's success. In this study, we collect data of 20 Abacoa agents to determine whether their number of social media platforms and their online presence contribute to their success. We use data from the agents’ Facebook and Twitter accounts and the total of listings they had during the month of April to November 9, 2020. After testing these data, we discover that agents with two social media platforms are as successful as agents with only one. Furthermore, we also find that there is a positive relationship between their number of Facebook followers and their number of listings. For future research, we recommend using a large sample size.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00159
Format
Document (PDF)
Batman Can Be Anybody: Self-Transcendence And Christopher Nolan's The Dark Knight Trilogy
Title
Batman Can Be Anybody: Self-Transcendence And Christopher Nolan's The Dark Knight Trilogy.
Creator
Borislow, Alec, Luria, Rachel, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Directed and co-written by Christopher Nolan, The Dark Knight Trilogy examines the origin and evolution of Bruce Wayne, and his hero vigilante alter ego, Batman. The trilogy consists of Batman Begins (2005), The Dark Knight (2008), and The Dark Knight Rises (2012). Bruce's post-traumatic journey for physical and mental excellence results in transformative and personal discovery, leading to self-transcendence. The personality trait of self-transcendence is the apex of psychologist Abraham...
Show moreDirected and co-written by Christopher Nolan, The Dark Knight Trilogy examines the origin and evolution of Bruce Wayne, and his hero vigilante alter ego, Batman. The trilogy consists of Batman Begins (2005), The Dark Knight (2008), and The Dark Knight Rises (2012). Bruce's post-traumatic journey for physical and mental excellence results in transformative and personal discovery, leading to self-transcendence. The personality trait of self-transcendence is the apex of psychologist Abraham Maslow's lesser-known and amended hierarchy of needs. It is the highest level of human consciousness and development. Bruce's unwavering morality, intrinsic motivation, and spirituality are characteristic of both humanistic and transpersonal psychology and further illustrate how the motion picture series exemplifies a road map to self-transcendence.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00137
Format
Document (PDF)
Eating Elephants
Title
Eating Elephants.
Creator
George, Hailey, Lanning, Kevin, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
The following novella is a fictional case study of Jethro Jones, a young male who suffers from three pathologies including Binge Eating Disorder, Major Depressive Disorder, and Panic Disorder. It traces the development of his suffering from infancy through childhood trauma into adolescent manifestations such as severe panic attacks, a suicide attempt, and weekly episodes of binge eating. The creative nature of the piece was inspired by works such as The Bell Jar (Plath) and Wasted: A Memoir...
Show moreThe following novella is a fictional case study of Jethro Jones, a young male who suffers from three pathologies including Binge Eating Disorder, Major Depressive Disorder, and Panic Disorder. It traces the development of his suffering from infancy through childhood trauma into adolescent manifestations such as severe panic attacks, a suicide attempt, and weekly episodes of binge eating. The creative nature of the piece was inspired by works such as The Bell Jar (Plath) and Wasted: A Memoir of Anorexia and Bulimia (Hornbacher). The character and story were informed by peer-reviewed studies about the aforementioned pathologies including risk factors, manifestation and course, subtypes, and treatments. While research exists on all three of these topics separately, little of the literature exists on the comorbid presentation of these disorders, despite its common occurrence. Thus, this is what the novella attempts to tackle.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00141
Format
Document (PDF)
Economics in Literature: An Analysis of Economic Theory in John Milton’s Paradise Lost
Title
Economics in Literature: An Analysis of Economic Theory in John Milton’s Paradise Lost.
Creator
Saide, Thalita, Harrawood, Michael, Harriet L. Wilkes Honors College, Florida Atlantic University, Nur-tegin, Kanybek
Abstract/Description
John Milton’s Paradise Lost is a poetry text rife with economic thought that precedes the publications of the most prominent thinkers in modern economics. Centered mostly around ideas of Christianity, Milton’s work uses allegory and imagery to emphasize the economic dynamics that are embedded in religious thought. I will analyze Paradise Lost as a theoretical economic framework that consolidates the never-ending struggle between free-market capitalism and communism—represented by the Devil...
Show moreJohn Milton’s Paradise Lost is a poetry text rife with economic thought that precedes the publications of the most prominent thinkers in modern economics. Centered mostly around ideas of Christianity, Milton’s work uses allegory and imagery to emphasize the economic dynamics that are embedded in religious thought. I will analyze Paradise Lost as a theoretical economic framework that consolidates the never-ending struggle between free-market capitalism and communism—represented by the Devil and God. Looking closely at key features of Christian theology and analyzing it through the lens of Milton’s work, I will relate key events in Genesis to modern economic theory.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00158
Format
Document (PDF)
Assessing the Impacts of Amphetamine Exposure Following Selective Ablation of Dopaminergic Neurons Via the Fluorescent Protein, KillerRed
Title
Assessing the Impacts of Amphetamine Exposure Following Selective Ablation of Dopaminergic Neurons Via the Fluorescent Protein, KillerRed.
Creator
Byrd, Gabrielle Dakota, Carvelli, Lucia, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Killer Red (KRed) is a fluorescent protein which is capable of the selective ablation of targeted cells via the production of reactive oxygen species (ROS) when exposed to the appropriate wavelengths of visible light. By expressing KRed in the dopaminergic neurons via the dopamine transporter (dat-1) promoter, these neurons may then be ablated with minimal to no damage to other limitrophe cells. Utilizing this cell-targeted ablation in the model organism C. elegans, this study aims to...
Show moreKiller Red (KRed) is a fluorescent protein which is capable of the selective ablation of targeted cells via the production of reactive oxygen species (ROS) when exposed to the appropriate wavelengths of visible light. By expressing KRed in the dopaminergic neurons via the dopamine transporter (dat-1) promoter, these neurons may then be ablated with minimal to no damage to other limitrophe cells. Utilizing this cell-targeted ablation in the model organism C. elegans, this study aims to ascertain the impacts of amphetamine exposure in the absence of proteins exclusively expressed in dopaminergic neurons. These impacts will be investigated via the comparison of amphetamine-induced behaviors in control animals and animals which have undergone the selective ablation of dopaminergic neurons. This study adds to a body of literature assessing the neurobiological mechanisms of addiction, raising further research questions and possibilities in the realm of treatment, mechanistic action, and impacts of drug abuse.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00138
Format
Document (PDF)
A Literature Review of the Impacts of College Major on Student Moral Development
Title
A Literature Review of the Impacts of College Major on Student Moral Development.
Creator
Elm, Jack, Lanning, Kevin, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Researchers in moral psychology have established relatively strong evidence of moral development during students’ time in undergraduate university education. Intuition would suggest that one’s major of choice has an impact on this development, but the existing research appears mixed. Conducting a review of the existing literature pertaining to the subject, I establish a firm understanding of broad trends in the data. Correlative effects of major choice do exist in some specific areas, but it...
Show moreResearchers in moral psychology have established relatively strong evidence of moral development during students’ time in undergraduate university education. Intuition would suggest that one’s major of choice has an impact on this development, but the existing research appears mixed. Conducting a review of the existing literature pertaining to the subject, I establish a firm understanding of broad trends in the data. Correlative effects of major choice do exist in some specific areas, but it is currently unclear whether such effects exist as a product of student self-selection or from direct impacts of the curricula.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00139
Format
Document (PDF)
Balancing speed and safety as the rush to find effective and prolonged treatments for COVID-19 continue
Title
Balancing speed and safety as the rush to find effective and prolonged treatments for COVID-19 continue.
Creator
Garcia, Alberto, Wetterer, James, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
The ongoing COVID-19 pandemic has severely impacted life around the world. As of early December 2020, more than 69 million people have tested positive for the virus, and more than 1.6 million people have died from the disease. Researchers are now rushing to find effective means of treating and preventing this disease. The urgency of this problem requires speed, but this must be balanced with caution to avoid possible negative impacts of deploying treatments that have been insufficiently...
Show moreThe ongoing COVID-19 pandemic has severely impacted life around the world. As of early December 2020, more than 69 million people have tested positive for the virus, and more than 1.6 million people have died from the disease. Researchers are now rushing to find effective means of treating and preventing this disease. The urgency of this problem requires speed, but this must be balanced with caution to avoid possible negative impacts of deploying treatments that have been insufficiently tested for effectiveness and safety. For my thesis, I consider challenges of the US Federal Drug Administration (FDA) to balance the urgency of finding quick treatment with the long-term safety of the treatments they approve. I first examine three historical examples where past treatments have been prematurely approved and discuss the lessons that were learned from these mistakes. Finally, I examine two examples from the current COVID-19 pandemic: the emergency use authorization to use hydroxychloroquine to treat severe COVID-19 patients and the new vaccines developed to prevent COVID-19 infection. It is pertinent to ensure that the benefits of any treatment outweigh the risks for the long-term benefit of society, which is of critical importance today as we face the current COVID-19 pandemic.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00140
Format
Document (PDF)
Automatic Fish Tracking: Keeping Track of Who's Who
Title
Automatic Fish Tracking: Keeping Track of Who's Who.
Creator
Spraggins, Ari, Fily, Yaouen, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Automatic video tracking has had a major impact on animal behavior studies. One of the challenges of this technique is keeping track of the identities of the sh, especially when they swim together and exchange positions. In this project we use the python programming language to address this problem for groups of sh. The video data comes from schooling assays performed at FAU's Cave sh Trilab (Dr. Keene, Dr. Duboue, and Dr. Kowalko). The method is inspired by the idTracker animal tracking...
Show moreAutomatic video tracking has had a major impact on animal behavior studies. One of the challenges of this technique is keeping track of the identities of the sh, especially when they swim together and exchange positions. In this project we use the python programming language to address this problem for groups of sh. The video data comes from schooling assays performed at FAU's Cave sh Trilab (Dr. Keene, Dr. Duboue, and Dr. Kowalko). The method is inspired by the idTracker animal tracking software: we track patterns of brightness as a visual identi er of each sh which we then use to detect when the sh swap places.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00162
Format
Document (PDF)
International Peacekeeping: A Critique of the United Nations’ Operational Procedures
Title
International Peacekeeping: A Critique of the United Nations’ Operational Procedures.
Creator
Ybarra, Angelo, Steigenga, Timothy, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
International Peacekeeping has been a polarizing topic since becoming established as a mainstay in United Nations policy. Although international involvement of this sort is bound to be vulnerable to situational complications, the consistency of the UN’s failures makes it impossible to ignore the fundamental issues engrained in its standard operating procedures. This thesis analyses a number of key UN peacekeeping operations that resulted in varying degrees of success as well as the general...
Show moreInternational Peacekeeping has been a polarizing topic since becoming established as a mainstay in United Nations policy. Although international involvement of this sort is bound to be vulnerable to situational complications, the consistency of the UN’s failures makes it impossible to ignore the fundamental issues engrained in its standard operating procedures. This thesis analyses a number of key UN peacekeeping operations that resulted in varying degrees of success as well as the general assessments that have been developed in response to these operations. Based upon an analysis of these cases as well as the literature on the issue of UN Peacekeeping, the thesis identifies the common problems in Peacekeeping operations and traces their evolution to the foundational elements of the UN Peacekeeping program combined with the evolving types of Peacekeeping missions undertaken.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00164
Format
Document (PDF)
Funding the Fundamental Right to a Legal Defense
Title
Funding the Fundamental Right to a Legal Defense.
Creator
Mello, Raven, Tunick, Mark, Harriet L. Wilkes Honors College, Florida Atlantic University, Vernon, Laura
Abstract/Description
The Sixth Amendment of the Constitution guarantees all United States citizens the right to a fair trial. However, that right has not been made equally accessible to all defendants in the criminal justice system due to the underfunding of Public Defender’s offices nationwide. This thesis examines the impact of this underfunding on indigent criminal defendants and analyzes social psychology research to understand the psychological biases that help explain this underfunding, and how they might...
Show moreThe Sixth Amendment of the Constitution guarantees all United States citizens the right to a fair trial. However, that right has not been made equally accessible to all defendants in the criminal justice system due to the underfunding of Public Defender’s offices nationwide. This thesis examines the impact of this underfunding on indigent criminal defendants and analyzes social psychology research to understand the psychological biases that help explain this underfunding, and how they might be overcome. Evidence suggests that the disproportionate government expenditure on the State Attorney and underfunding of the Public Defender has led to a skewed legal system that favors not only the prosecutor, but also the white, abled, and wealthy. I argue that to support a criminal justice system that aligns with the values of equality and justice, the Public Defender must be properly funded to fulfill its adversarial role.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00151
Format
Document (PDF)
Modeling Symmetries: An analysis on the interdisciplinary applications of Lie groups
Title
Modeling Symmetries: An analysis on the interdisciplinary applications of Lie groups.
Creator
Humphreys, Reece, McGovern, Warren, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Symmetries are a driving force in the universe and continue to reveal themselves the deeper we look. While many undergraduate mathematics students are introduced to symmetries with group theory, many practical applications are often overlooked. The application of symmetries provides deep insights into various problems and can frequently simplify complex mathematics. Applying symmetries typically requires high-level mathematics that can be prohibitive for people within other disciplines. As...
Show moreSymmetries are a driving force in the universe and continue to reveal themselves the deeper we look. While many undergraduate mathematics students are introduced to symmetries with group theory, many practical applications are often overlooked. The application of symmetries provides deep insights into various problems and can frequently simplify complex mathematics. Applying symmetries typically requires high-level mathematics that can be prohibitive for people within other disciplines. As such, this paper explores how Lie groups, a mathematical structure for representing symmetries, can be utilized in computing, physics, and control theory to solve practical problems from within these elds. It also serves as an introduction to the mathematics necessary to utilize Lie groups.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00146
Format
Document (PDF)
Identity, Exile, and bacillus emigraticus in the Literature of Spanish Republican Mariano Viñuales (1900-1955)
Title
Identity, Exile, and bacillus emigraticus in the Literature of Spanish Republican Mariano Viñuales (1900-1955).
Creator
Payne, Alyssa Maria, Quesada, Carmen Cañete, Harriet L. Wilkes Honors College, Florida Atlantic University, Vázquez, Miguel Ángel
Abstract/Description
This investigation seeks to recover the memory of Mariano Viñuales (1900-1955), who was a Spanish writer forced into exile first to the Dominican Republic (1939-1942) and later to Mexico (1942-1959) due to his involvement in the Spanish Civil War (1936-1939). Never able to return to his family in Spain, Viñuales experienced what Paul Tabori calls bacillus emigraticus, a shared experience by exiles of an intense longing to return to their home country. Delving into the personal history and...
Show moreThis investigation seeks to recover the memory of Mariano Viñuales (1900-1955), who was a Spanish writer forced into exile first to the Dominican Republic (1939-1942) and later to Mexico (1942-1959) due to his involvement in the Spanish Civil War (1936-1939). Never able to return to his family in Spain, Viñuales experienced what Paul Tabori calls bacillus emigraticus, a shared experience by exiles of an intense longing to return to their home country. Delving into the personal history and literary legacy of Viñuales alongside chronological analysis of his works “¡Siembra!” (1940), “El león y la libertad” (1950), and “Mi tía Dominga” (1952) reveals how his literature represents the identity of Spanish Republican exiles, with special attention to familial themes. In doing so, this project contributes towards Spain’s Historical Memory Law (2007) which reverses the Pact of Forgetting (1977) to recover the memory of victims of the Spanish Civil War.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00155
Format
Document (PDF)
Interleukin-1 Receptor Type 1 contributes to synapse formation in the dentate gyrus: possible mechanism for seizure sensitivity
Title
Interleukin-1 Receptor Type 1 contributes to synapse formation in the dentate gyrus: possible mechanism for seizure sensitivity.
Creator
Smirnova, Maria I., Quan, Ning, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Epilepsy is a chronic neurological disorder that affects 2.3 million adults and 450,000 children within the US. The etiology of epilepsy is unknown; however, increased severity and neuropathology of epilepsy is associated with inflammatory pathways. Specifically, pro-inflammatory cytokine Interleukin-1 signaling via Interleukin 1 receptor type 1 (IL-1R1) has been shown to decrease sensitivity to kainic acid induced status epilepticus. Our lab hypothesizes that IL-1R1 signaling alters synaptic...
Show moreEpilepsy is a chronic neurological disorder that affects 2.3 million adults and 450,000 children within the US. The etiology of epilepsy is unknown; however, increased severity and neuropathology of epilepsy is associated with inflammatory pathways. Specifically, pro-inflammatory cytokine Interleukin-1 signaling via Interleukin 1 receptor type 1 (IL-1R1) has been shown to decrease sensitivity to kainic acid induced status epilepticus. Our lab hypothesizes that IL-1R1 signaling alters synaptic connectivity in the hippocampus thus conferring increased neuronal excitability. Using WT and IL-1R1 null (Il1r1r/r) mice, colocalization of immunolabeled pre- and post-synaptic markers (VGLUT-1/HOMER1) was analyzed, indicating synapses. Additionally, using the Golgi-Cox method we visualized synaptic spines and analyzed dendritic spine morphology in WT and Il1r1r/r mice. Our results indicate that IL-1R1 does alter synaptic structure suggesting a possible role in the induction of epilepsy. However, these results require further investigation.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00161
Format
Document (PDF)
Orbital Debris Cloud Evolution: An analysis of fragmentation events in low Earth orbit
Title
Orbital Debris Cloud Evolution: An analysis of fragmentation events in low Earth orbit.
Creator
Humphreys, Reece, Fily, Yaouen, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
The amount of orbital debris has rapidly grown due to humanity's de- sire to work in, explore, and utilize space. However, compared to most types of pollution that people experience daily, it is unlikely that the aver- age person will ever encounter space pollution. Yet, it poses a signi cant threat to many technologies we depend on daily such as GPS and weather prediction satellites. Orbital debris are the remnants of orbital collisions, weapons tests, decommissioned satellites, and spent...
Show moreThe amount of orbital debris has rapidly grown due to humanity's de- sire to work in, explore, and utilize space. However, compared to most types of pollution that people experience daily, it is unlikely that the aver- age person will ever encounter space pollution. Yet, it poses a signi cant threat to many technologies we depend on daily such as GPS and weather prediction satellites. Orbital debris are the remnants of orbital collisions, weapons tests, decommissioned satellites, and spent rocket stages that are passing over our heads faster than bullets and containing similar energy to hand grenades. This paper explores the existing models of orbital de- bris generation, how clouds of debris evolve with respect to time, and their rami cations.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00147
Format
Document (PDF)
Recent Advances and the Ethical Implications of Anti-Aging Research
Title
Recent Advances and the Ethical Implications of Anti-Aging Research.
Creator
Phelan, Christine, Trivigno, Catherine, Harriet L. Wilkes Honors College, Florida Atlantic University
Abstract/Description
Throughout recorded history there have been accounts of trying to slow and reverse the natural aging process. From the quest for the Fountain of Youth, to the discovery of telomeric degradation, aging has been a hot research topic for centuries. Due to an aging population, anti-aging research has become a magnet for geneticists and researchers. There is great hope in the strive towards anti-aging therapies, and a variation of methods have been developed that have experimentally slowed aging....
Show moreThroughout recorded history there have been accounts of trying to slow and reverse the natural aging process. From the quest for the Fountain of Youth, to the discovery of telomeric degradation, aging has been a hot research topic for centuries. Due to an aging population, anti-aging research has become a magnet for geneticists and researchers. There is great hope in the strive towards anti-aging therapies, and a variation of methods have been developed that have experimentally slowed aging. Yet the biggest hurdle for anti-aging researchers is to try and balance improving lifespan without compromising, or even ignoring, healthspan. Quality of health, or one’s healthspan, is necessary to consider when developing ethical anti-aging therapies. In this review, research behind aging processes and anti-aging therapies will be presented, and the benefits and/or ethical dilemmas that arise will be discussed.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FAUHT00157
Format
Document (PDF)

Pages