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Pages
- Title
- Antitumor activity and biochemical effects of topsentin.
- Creator
- Burres, N. S., Barber, D. A., Gunasekera, Sarath P., Clement, J. J., Shen, L. L.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3355144
- Subject Headings
- Marine natural products, Antitumor agents
- Format
- Document (PDF)
- Title
- Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
- Creator
- Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/fau/fd/FA00007199
- Subject Headings
- Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
- Format
- Document (PDF)
- Title
- Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide.
- Creator
- Burres, N. S., Clement, J. J., Harbor Branch Oceanographic Institute
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/fau/fd/FA00007377
- Subject Headings
- Marine natural products, Pyrans, Marine Toxins, Antineoplastic agents
- Format
- Document (PDF)
- Title
- CULTIVATION OF MICROBES ASSOCIATED WITH INDIAN RIVER LAGOON SPONGES.
- Creator
- Burton, Miranda Nicole, McCarthy, Peter, Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
-
Cultivation of microbial populations is a necessity for the use of microbes within the biotechnological and pharmaceutical industries, however, approximately only 1% of bacteria have been successfully cultivated in the lab. Dilution to Extinction (DTE) is a technique which involves serially diluting a microbial suspension to single cell inoculum prior to inoculation in a liquid medium designed to replicate natural aquatic environments. This technique was used here for the cultivation of...
Show moreCultivation of microbial populations is a necessity for the use of microbes within the biotechnological and pharmaceutical industries, however, approximately only 1% of bacteria have been successfully cultivated in the lab. Dilution to Extinction (DTE) is a technique which involves serially diluting a microbial suspension to single cell inoculum prior to inoculation in a liquid medium designed to replicate natural aquatic environments. This technique was used here for the cultivation of diverse, potentially novel microbes from the marine sponge, Mycale microsigmatosa. One hundred thirty-six samples were successfully sequenced and identified with the majority belonging to the classes Alphaproteobacteria and Gammaproteobacteria. Furthermore, when combined with miniaturized fermentation, DTE allowed for the isolation and identification of marine natural products (3-Heptyl-3-hydroxy-2,4 (1H, 3H)-quinolinedione and 2-Heptyl-4-hydroxyquinoline) active against Methicillin-resistant Staphylococcus aureus. These metabolites originated from Pseudomonas aeruginosa, an isolate obtained from Mycale microsigmatosa using this technique.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013858
- Subject Headings
- Indian River (Fla. : Lagoon), Sponges--Microbiology, Marine natural products
- Format
- Document (PDF)
- Title
- A new bastadin from the sponge Psammaplysilla purpurea.
- Creator
- Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/FCLA/DT/3318955
- Subject Headings
- Sponges --Research, Marine metabolites, Marine natural products
- Format
- Document (PDF)
- Title
- Three new peroxides from the sponge Plakinastrella species.
- Creator
- Chen, Ying, Killday, K. B., McCarthy, Peter J., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/FCLA/DT/3319103
- Subject Headings
- Sponges --Research, Spectral analysis, Marine natural products, Peroxides, Antifungal agents
- Format
- Document (PDF)
- Title
- Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri.
- Creator
- Coval, S. J., Conover, M. A., Mierzwa, Ronald, King, Arthur, Puar, M. S., Phife, D. W., Pai, J.-K., Burrier, R. E., Ahn, H.-S., Boykow, G. C., Patel, Mahesh, Pomponi, Shirley A.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3331891
- Subject Headings
- Sponges, Sesquiterpenes, Cholesterol Ester Transfer Proteins, Marine natural products
- Format
- Document (PDF)
- Title
- Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name).
- Creator
- Davis, A. R., Wright, Amy E.
- Date Issued
- 1990
- PURL
- http://purl.flvc.org/FCLA/DT/3333148
- Subject Headings
- Ascidians, Carbolines, Marine natural products, Alkaloids, Fouling
- Format
- Document (PDF)
- Title
- ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT.
- Creator
- Dougan, Cassady, Pomponi, Shirley A., Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
-
Marine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that...
Show moreMarine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that produces the compound of interest. In this study, hybridomas have been produced with cells of two marine sponges, Axinella corrugata, which produces the antitumor compound stevensine, and Geodia neptuni, which divides rapidly in a nutrient medium optimized for sponge cell culture. Successful hybridization and subsequent cell division and in vitro stevensine production may unlock the potential for sustainable mass production of other sponge-derived compounds.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FA00014024
- Subject Headings
- Marine natural products, Sponges, Hybridomas, In vitro
- Format
- Document (PDF)
- Title
- Discovery and investigation of survivin-targeting marine natural products from Ellisella paraplexauroides and Eudistoma olivaceum.
- Creator
- Francis, Kirstie Tandberg, Wright, Amy E., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
In 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target...
Show moreIn 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target for new drug therapies. At only 16.5 kDa, it consists of a single Baculovirus IAP Repeat (BIR) domain and an α-helical coiled coil. Survivin plays a multitude of roles in the growth and survival of cancer cells—which can be attributed to the variable cellular localizations and posttranslational modifications of the protein—including inhibition of apoptosis, mitosis and cell cycle progression, DNA damage repair, drug resistance, metastasis, angiogenesis, and cell senescence, among others. A drug that is able to target surviving transcription or posttranslational modification or disrupt one of these critical pathways may serve as an attractive new cancer therapy. Despite decades of research on surviving and its intracellular functions, researchers have yet to find an FDA approved drug. Using a high throughput approach, Harbor Branch Oceanographic Institute’s chemical library of marine natural products was screened by the Guzmán lab to identify compounds capable of downregulating survivin expression in A549 non-small cell lung carcinoma and DLD-1 colorectal adenocarcinoma cell lines. From the screening assay, pure compounds were identified which reduce levels of survivin protein in cancer cells. Chapter 2 describes the isolation and structure elucidation of five polyhydroxylated sterol analogs from Ellisella paraplexauroides, four of them novel. Chapter 3 describes the isolation and structure elucidation of two compounds from Eudistoma olivaceum, eudistomin H and I. Chapter 4 describes the secondary biological testing employed to determine if the reduction of survivin expression was driven by reducing de novo production or increasing the degradation of existing protein by evaluating differential gene expression of survivin mRNA using reverse transcriptase quantitative polymerase chain reaction and measuring degradation rates of survivin protein, respectively.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013828
- Subject Headings
- Survivin, Marine natural products, Antineoplastic agents--Development
- Format
- Document (PDF)
- Title
- Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
- Creator
- Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/FCLA/DT/3333007
- Subject Headings
- Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
- Format
- Document (PDF)
- Title
- Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva.
- Creator
- Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Garay, M., Sills, Matthew A.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3319084
- Subject Headings
- Sponges --Research, Marine natural products, Receptors, Thrombin, Aplysillin A, Antagonists, Enzyme, Marine pharmacology
- Format
- Document (PDF)
- Title
- Hamacanthins A and B. New antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.
- Creator
- Gunasekera, Sarath P., McCarthy, Peter J., Kelly-Borges, M.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3319078
- Subject Headings
- Sponges --Research, Indole alkaloids, Marine natural products, Antifungal agents
- Format
- Document (PDF)
- Title
- Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels.
- Creator
- Gunasekera, Sarath P., McCarthy, Peter J., Kelly-Borges, M., Lobkovsky, E., Clardy, J.
- Date Issued
- 1996
- PURL
- http://purl.flvc.org/FCLA/DT/3319096
- Subject Headings
- Sponges --Research, Dysidiolide, Marine metabolites, Marine natural products, Protein phosphatases
- Format
- Document (PDF)
- Title
- Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
- Creator
- Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3319079
- Subject Headings
- Sponges --Research, Marine natural products, NMR spectroscopy
- Format
- Document (PDF)
- Title
- Five new Discodermolide analogues from the marine sponge Discodermia species.
- Creator
- Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/3319106
- Subject Headings
- Sponges --Research, Cytotoxin, Marine natural products, Polyketides
- Format
- Document (PDF)
- Title
- Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta.
- Creator
- Gunasekera, Sarath P., Gunasekera, M., McCarthy, Peter J.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332985
- Subject Headings
- Sponges, Lactams, Macrocyclic, Marine natural products
- Format
- Document (PDF)
- Title
- New sterol ester from a deep water marine sponge, Xestospongia sp.
- Creator
- Gunasekera, Sarath P., Cranick, S., Pomponi, Shirley A.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332980
- Subject Headings
- Sponges, Sterols, Marine natural products
- Format
- Document (PDF)
- Title
- Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp.
- Creator
- Gunasekera, Sarath P., Pomponi, Shirley A., McCarthy, Peter J.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3333010
- Subject Headings
- Sponges, Peptides, Marine natural products, Chemical structure
- Format
- Document (PDF)
- Title
- Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity.
- Creator
- Gunasekera, Sarath P., Longley, Ross E., Isbrucker, Richard A., Harbor Branch Oceanographic Institute
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/FCLA/DT/3319101
- Subject Headings
- Sponges --Research, Marine natural products, Cytotoxin, Acetylation
- Format
- Document (PDF)