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Pages
- Title
- Indications ofrelationships between poriferan classes using full-length 18S rRNA gene sequences.
- Creator
- Adams, Christi L., McInerney, James O., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/fau/fd/FA00007272
- Subject Headings
- Sponges, RNA, Ribosomal, 18S, Demospongiae, Phylogeny--Molecular aspects, Calcarea, Hexactinellida
- Format
- Document (PDF)
- Title
- The comparative structure of two western Atlantic reef-fish assemblages.
- Creator
- Alevizon, W. S., Brooks, M. G., Harbor Branch Oceanographic Institute
- Date Issued
- 1975
- PURL
- http://purl.flvc.org/FCLA/DT/3174428
- Subject Headings
- Coral reef fishes, Fish populations, Species diversity, Coral reef ecology, Sponges
- Format
- Document (PDF)
- Title
- Biosynthetic Studies of the Alkaloid, Stevensine, in a Cell Culture of the Marine Sponge Teichaxinella morchella.
- Creator
- Andrade, Paul, Willoughby, Robin, Pomponi, Shirley A., Kerr, Russell G.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/FCLA/DT/3158768
- Subject Headings
- Alkaloids, Sponges, Marine invertebrates, Amino acids, Biosynthetic Pathways
- Format
- Document (PDF)
- Title
- In vitro biosynthetic studies of stevensine, a natural product from the sponge Teichaxinella morchella.
- Creator
- Andrade, Paul., Florida Atlantic University, Kerr, Russell G.
- Abstract/Description
-
Stevensine is a biologically active secondary metabolite produced by several marine sponges, including Teichaxinella morchella. Two in vitro methods were used to investigate the biosynthetic origin of stevensine in the sponge T. morchella. A cell-free enzyme extract was developed to test for the incorporation of the potential radiolabeled metabolic precursors histidine, arginine, ornithine, and proline. Secondly, cell cultures of T. morchella were used to determine the biosynthetic origin of...
Show moreStevensine is a biologically active secondary metabolite produced by several marine sponges, including Teichaxinella morchella. Two in vitro methods were used to investigate the biosynthetic origin of stevensine in the sponge T. morchella. A cell-free enzyme extract was developed to test for the incorporation of the potential radiolabeled metabolic precursors histidine, arginine, ornithine, and proline. Secondly, cell cultures of T. morchella were used to determine the biosynthetic origin of stevensine from the radiolabeled amino acids histidine, arginine, ornithine, and proline. Histidine and ornithine/proline were converted to stevensine in the cell culture system. This represents the first study involving the use of cell cultures of a marine invertebrate to investigate the biosynthesis of a biologically active natural product. An understanding of the biosynthetic process leading to the production of this compound in the source organism could lead to the development of more efficient and environmentally safer production methods.
Show less - Date Issued
- 1999
- PURL
- http://purl.flvc.org/fcla/dt/15620
- Subject Headings
- Sponges, Marine biotechnology, Marine pharmacology
- Format
- Document (PDF)
- Title
- Influence of sponges on invertebrate recruitment: a field test of allelopathy.
- Creator
- Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3333176
- Subject Headings
- Allelopathy, Sponges, Invertebrates
- Format
- Document (PDF)
- Title
- Stochastic events and dynamics of a mangrove root epifaunal community.
- Creator
- Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/fau/fd/FA00007233
- Subject Headings
- Mangroves, Ascidians, Sponges, Stability
- Format
- Document (PDF)
- Title
- Identification of the bacterial symbiont Entotheonella sp. in the mesohyl of the marine sponge Discodermia sp.
- Creator
- Bruck, W. M., Sennett, Susan H., Pomponi, Shirley A., Willenz, P., McCarthy, Peter J.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/FCLA/DT/3183806
- Subject Headings
- Bacteria Ecology, Symbiosis, Sponges
- Format
- Document (PDF)
- Title
- Comparison of the anaerobic microbiota of deep-water Geodia spp. and sandy sediments in the Straits of Florida.
- Creator
- Bruck, W. M., Bruck, T. B., Self, W. T., Reed, John K., Nitecki, S. S., McCarthy, Peter J.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3351982
- Subject Headings
- Microbial ecology, Marine sediments, Florida, Straits of, Fluorescence in situ hybridization, Sponges
- Format
- Document (PDF)
- Title
- Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
- Creator
- Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/fau/fd/FA00007199
- Subject Headings
- Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
- Format
- Document (PDF)
- Title
- Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
- Creator
- Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/FCLA/DT/3331874
- Subject Headings
- Sponges, Cytotoxin, Tryptamine--Derivatives--Synthesis, Tyramine, Antineoplastic agents
- Format
- Document (PDF)
- Title
- New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae.
- Creator
- Chen, Ying, McCarthy, Peter J., Harmody, Dedra K., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/3164099
- Subject Headings
- Sponges, Peroxides, Pathogenic fungi, Candida albicans, Aspergillus fumigatus
- Format
- Document (PDF)
- Title
- Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri.
- Creator
- Coval, S. J., Conover, M. A., Mierzwa, Ronald, King, Arthur, Puar, M. S., Phife, D. W., Pai, J.-K., Burrier, R. E., Ahn, H.-S., Boykow, G. C., Patel, Mahesh, Pomponi, Shirley A.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3331891
- Subject Headings
- Sponges, Sesquiterpenes, Cholesterol Ester Transfer Proteins, Marine natural products
- Format
- Document (PDF)
- Title
- ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT.
- Creator
- Dougan, Cassady, Pomponi, Shirley A., Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
- Abstract/Description
-
Marine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that...
Show moreMarine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that produces the compound of interest. In this study, hybridomas have been produced with cells of two marine sponges, Axinella corrugata, which produces the antitumor compound stevensine, and Geodia neptuni, which divides rapidly in a nutrient medium optimized for sponge cell culture. Successful hybridization and subsequent cell division and in vitro stevensine production may unlock the potential for sustainable mass production of other sponge-derived compounds.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FA00014024
- Subject Headings
- Marine natural products, Sponges, Hybridomas, In vitro
- Format
- Document (PDF)
- Title
- Farming sponges for chemicals with pharmaceutical potential.
- Creator
- Duckworth, Alan R., Harbor Branch Oceanographic Institute
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/FCLA/DT/3352965
- Subject Headings
- Sponges, Metabolites, Sponges--Biotechnology, Marine metabolites, Marine pharmacology
- Format
- Document (PDF)
- Title
- Relative importance of bacteria, microalgae and yeast for growth of the sponge Halichondria melanadocia (De Laubenfels, 1936): A laboratory study.
- Creator
- Duckworth, Alan R., Pomponi, Shirley A.
- PURL
- http://purl.flvc.org/FCLA/DT/2827821
- Subject Headings
- Sponges, Microalgae, Bacteria, Plankton, Yeast
- Format
- Document (PDF)
- Title
- Reproduction, growth and trophic interactions of Doriopsilla pharpa Marcus in South Carolina.
- Creator
- Eyster, Linda S., Stancyk, Stephen E., Harbor Branch Oceanographic Institute
- Date Issued
- 1981
- PURL
- http://purl.flvc.org/FCLA/DT/3174442
- Subject Headings
- Nudibranchia, Reproduction, Sponges, Predation (Biology), Food chains (Ecology)
- Format
- Document (PDF)
- Title
- Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols.
- Creator
- Giner, José-Luis, Gunasekera, Sarath P., Pomponi, Shirley A.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/FCLA/DT/3158771
- Subject Headings
- Sponges, Sterols --Analysis, Steroids, Biosynthesis, Marine metabolites
- Format
- Document (PDF)
- Title
- Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata.
- Creator
- Grima, Jennifer., Charles E. Schmidt College of Science, Department of Biological Sciences
- Abstract/Description
-
Sponges are an important source of bioactive marine natural products, or secondary metabolites. The common Caribbean reef sponge, Axinella corrugata, produces an antitumor and antibacterial chemical, stevensine. This study determined whether environmental stressors, such as elevated temperature and exposure to Amphibalanus amphitrite larvae, affect the production of stevensine by A.corrugata and if the stressors caused A.corrugata to exhibit differential gene expression. Temperature stress...
Show moreSponges are an important source of bioactive marine natural products, or secondary metabolites. The common Caribbean reef sponge, Axinella corrugata, produces an antitumor and antibacterial chemical, stevensine. This study determined whether environmental stressors, such as elevated temperature and exposure to Amphibalanus amphitrite larvae, affect the production of stevensine by A.corrugata and if the stressors caused A.corrugata to exhibit differential gene expression. Temperature stress resulted in no significant change in the production of stevensine; only two genes were significantly differentially expressed, including hsp70. Larval stressed resulted in increased production of stevensine and significant differential gene expression (more than seventy genes). This study suggests that A.corrugata may be resilient to elevations in temperature and that one of stevensine's roles in nature is as an antifoulant.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fcla/dt/3360781
- Subject Headings
- Axinellida, Sponges, Marine pharmacology, Adaptation (Biology), Gene expression, Genetic regulation, Stress (Physiology), Ecophysiology
- Format
- Document (PDF)
- Title
- Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp.
- Creator
- Gulavita, N. K., Gunasekera, Sarath P., Pomponi, Shirley A., Robinson, E. V.
- Date Issued
- 1992
- PURL
- http://purl.flvc.org/FCLA/DT/3332992
- Subject Headings
- Sponges, Depsipeptides, Peptides, Cyclic
- Format
- Document (PDF)
- Title
- Isolation of Latrunculin A, 6,7-Epoxylatrunculin A, Fijianolide A, and Euryfuran from a new genus of the family Thorectidae.
- Creator
- Gulavita, N. K., Gunasekera, Sarath P., Pomponi, Shirley A.
- Date Issued
- 1992
- PURL
- http://purl.flvc.org/FCLA/DT/3332996
- Subject Headings
- Sponges, Marine toxins, Marine metabolites
- Format
- Document (PDF)