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Title: The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Creator: Kowalski, R. J., Giannakakou, P., Gunasekera, Sarath P., Longley, Ross E., Day, B. W., Hamel, E., Harbor Branch Oceanographic Institute
Date Issued: 1997
PURL: http://purl.flvc.org/fau/fd/FA00007052
Subject Headings: Marine natural products, Cytotoxins, Tubulin Modulators, Paclitaxel, Lactones, Sponges
Format: Document (PDF)

Title: Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
Creator: Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued: 1989
PURL: http://purl.flvc.org/fau/fd/FA00007199
Subject Headings: Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
Format: Document (PDF)

Title: Discodermolide- a new, marine-derived immunosuppressive compound. I.In vitro studies.
Creator: Longley, Ross E., Caddigan, D., Harmody, Dedra K., Gunasekera, M., Gunasekera, Sarath P., Harbor Branch Oceanographic Institute
Date Issued: 1991
PURL: http://purl.flvc.org/fau/fd/FA00007255
Subject Headings: Polyketides, Immunosuppressive agents, Marine natural products, discodermolide
Format: Document (PDF)

Title: Discodermolide-a new, marine-derived immunosuppressive compound. II.In vivo studies.
Creator: Longley, Ross E., Caddigan, D., Harmody, Dedra K., Gunasekera, M., Gunasekera, Sarath P., Harbor Branch Oceanographic Institute
Date Issued: 1991
PURL: http://purl.flvc.org/fau/fd/FA00007256
Subject Headings: Polyketides, Immunosuppressive agents, Marine natural products, discodermolide
Format: Document (PDF)

Title: Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide.
Creator: Burres, N. S., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued: 1989
PURL: http://purl.flvc.org/fau/fd/FA00007377
Subject Headings: Marine natural products, Pyrans, Marine Toxins, Antineoplastic agents
Format: Document (PDF)

Title: The discovery of marine natural products with therapeutic potential.
Creator: McConnell, O. J., Longley, Ross E., Koehn, F. E., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/fau/fd/FA00007447
Subject Headings: Marine natural products, Drug Discovery, Pharmacognosy
Format: Document (PDF)

Title: Structure-activity relationship studies of Discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.
Creator: Isbrucker, Richard A., Harbor Branch Oceanographic Institute
Date Issued: 2001
PURL: http://purl.flvc.org/FCLA/DT/2783239
Subject Headings: Paclitaxel, Sponges --Research, Marine natural products, Tubulins, Cytotoxicity tests, Immunologic
Format: Document (PDF)

Title: A new bastadin from the sponge Psammaplysilla purpurea.
Creator: Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3318955
Subject Headings: Sponges --Research, Marine metabolites, Marine natural products
Format: Document (PDF)

Title: Three new bromotyrosine derived metabolites of the sponge Psammaplysilla purpurea.
Creator: Jurek, J., Yoshida, W. Y., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3318965
Subject Headings: Marine natural products, Sponges --Research, Marine metabolites
Format: Document (PDF)

Title: Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites.
Creator: Hamann, Mark T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3318968
Subject Headings: Sponges --Research, Marine metabolites, Sesquiterpenes, Marine natural products
Format: Document (PDF)

Title: Three bromotyrosine derivatives, one terminating in an unprecedented diketocyclopentenylidene enamine.
Creator: Ichiba, T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3318969
Subject Headings: Sponges --Research, Marine natural products, Cytotoxin, Antimicrobial agents
Format: Document (PDF)

Title: 8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp.
Creator: Ichiba, T., Corgiat, J. M., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3318972
Subject Headings: Sponges --Research, Marine natural products
Format: Document (PDF)

Title: Two steroidal alkaloids from a sponge, Corticium sp.
Creator: Jurek, J., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3319071
Subject Headings: Sponges --Research, Marine natural products
Format: Document (PDF)

Title: New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes.
Creator: Horton, P. A., Longley, Ross E., Kelly-Borges, M., McConnell, O. J., Ballas, L. M., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3319074
Subject Headings: Sponges --Research, Marine natural products, Cytotoxin
Format: Document (PDF)

Title: Lasonolide A, a new cytotoxic macrolide from the marine sponge Forcepia sp.
Creator: Horton, P. A., Koehn, F. E., Longley, Ross E., McConnell, O. J., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3319075
Subject Headings: Sponges --Research, Antineoplastic agents, Marine natural products, Macrolides
Format: Document (PDF)

Title: Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
Creator: Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3319079
Subject Headings: Sponges --Research, Marine natural products, NMR spectroscopy
Format: Document (PDF)

Title: Puupehenone-related metabolites from two Hawaiian sponges, Hyrtios spp.
Creator: Nasu, S. S., Yeung, Bryan K. S., Hamann, Mark T., Scheuer, P. J., Kelly-Borges, M., Goins, K., Harbor Branch Oceanographic Institute
Date Issued: 1995
PURL: http://purl.flvc.org/FCLA/DT/3319088
Subject Headings: Sponges --Research, Marine metabolites, Marine natural products, Sesquiterpenes
Format: Document (PDF)

Title: A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi.
Creator: Gunasekera, Sarath P., Kelly-Borges, M., Longley, Ross E., Harbor Branch Oceanographic Institute
Date Issued: 1996
PURL: http://purl.flvc.org/FCLA/DT/3319090
Subject Headings: Sponges --Research, Sterols, Marine natural products, NMR spectroscopy
Format: Document (PDF)

Title: Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
Creator: Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, Ross E., Gunasekera, Sarath P., Rosenkranz, H. S., Day, B. W., Harbor Branch Oceanographic Institute
Date Issued: 1996
PURL: http://purl.flvc.org/FCLA/DT/3319092
Subject Headings: Marine natural products, Antimitotic agents, Taxol, Cytotoxin, Marine toxins
Format: Document (PDF)

Title: Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp.
Creator: Ohtani, I. I., Ichiba, T., Isobe, M., Kelly-Borges, M., Scheuer, P. J., Harbor Branch Oceanographic Institute
Date Issued: 1995
PURL: http://purl.flvc.org/FCLA/DT/3319093
Subject Headings: Sponges, Sponges --Research, Marine natural products, Alkaloids
Format: Document (PDF)

Sponges --Research (15)	+ -
Sponges (9)	+ -
Cytotoxin (5)	+ -
Antineoplastic agents (4)	+ -
Marine metabolites (4)	+ -

Alkaloids (2)	+ -
Cytotoxins (2)	+ -
Immunosuppressive agents (2)	+ -
Macrolides (2)	+ -
NMR spectroscopy (2)	+ -
Paclitaxel (2)	+ -
Polyketides (2)	+ -
Sesquiterpenes (2)	+ -
Sterols (2)	+ -
discodermolide (2)	+ -
Acetylation (1)	+ -
Acridines (1)	+ -
Antimicrobial agents (1)	+ -
Antimitotic agents (1)	+ -
Antiviral agents (1)	+ -
Chemical structure (1)	+ -
Cyclic peptides (1)	+ -
Cytotoxicity tests, Immunologic (1)	+ -
Drug Discovery (1)	+ -
Fatty acids (1)	+ -
Indole Alkaloids (1)	+ -
Indoles (1)	+ -
Lactones (1)	+ -
Marine Toxins (1)	+ -

Kelly-Borges, M. (13)	+ -
Scheuer, P. J. (11)	+ -
Longley, Ross E. (9)	+ -
Gunasekera, Sarath P. (7)	+ -
Ichiba, T. (4)	+ -

Gunasekera, M. (3)	+ -
Koehn, F. E. (3)	+ -
McConnell, O. J. (3)	+ -
Burres, N. S. (2)	+ -
Caddigan, D. (2)	+ -
Carney, J. R. (2)	+ -
Clement, J. J. (2)	+ -
Day, B. W. (2)	+ -
Hamann, Mark T. (2)	+ -
Hamel, E. (2)	+ -
Harmody, Dedra K. (2)	+ -
Horton, P. A. (2)	+ -
Isbrucker, Richard A. (2)	+ -
Jurek, J. (2)	+ -
Kowalski, R. J. (2)	+ -
Sakemi, S. (2)	+ -
Sun, H. H. (2)	+ -
Yeung, Bryan K. S. (2)	+ -
Yoshida, W. Y. (2)	+ -
Ballas, L. M. (1)	+ -
Bryant, R. W. (1)	+ -
Corgiat, J. M. (1)	+ -
Cross, S. S. (1)	+ -
Fusetani, N. (1)	+ -

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