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- Title
- Reducing Unnecessary Hospitalizations of Nursing Home Residents.
- Creator
- Ouslander, Joseph G., Berenson, Robert A.
- Date Issued
- 2011-09-29
- PURL
- http://purl.flvc.org/fau/fd/fauir00002
- Format
- Citation
- Title
- Infectious Disease and Hospital Surge Capacity Impacts on Urban Transportation.
- Creator
- Kaisar, Evangelos I., Coolahan, James E., Koomullil, Roy P., Averkiou, Peter A.
- Date Issued
- 2016-08-31
- PURL
- http://purl.flvc.org/fau/fd/fauir00003
- Format
- Citation
- Title
- Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.
- Creator
- Cerofolini, Linda, Amar, Sabrina, Lauer, Janelle L., Martelli, Tommaso, Fragai, Marco, Luchinat, Claudio, Fields, Gregg B.
- Abstract/Description
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Cell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in substrate binding and processing. NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells through distinct residues in blades III and IV of its hemopexin-like domain, while binding of collagen-like triple...
Show moreCell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in substrate binding and processing. NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells through distinct residues in blades III and IV of its hemopexin-like domain, while binding of collagen-like triple-helices occurs within blades I and II of this domain. Examination of simultaneous membrane interaction and triple-helix binding revealed a possible regulation of proteolysis due to steric effects of the membrane. At bicelle concentrations of 1%, enzymatic activity towards triple-helices was increased 1.5-fold. A single mutation in the putative membrane interaction region of MT1-MMP (Ser466Pro) resulted in lower enzyme activation by bicelles. An initial structural framework has thus been developed to define the role(s) of cell membranes in modulating proteolysis.
Show less - Date Issued
- 2016-09-13
- PURL
- http://purl.flvc.org/fau/fd/FAUIR0000004
- Format
- Citation
- Title
- Perceptions of Competence, Strength, and Age Influence Voters to Select Leaders with Lower-Pitched Voices.
- Creator
- Klofstad, Casey A., Anderson, Rindy C., Nowicki, Stephen, Snyder, Joel
- Abstract/Description
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Voters prefer leaders with lower-pitched voices because they are perceived as stronger, having greater physical prowess, more competent, and having greater integrity. An alternative hypothesis that has yet to be tested is that lower-pitched voices are perceived as older and thus wiser and more experienced. Here the relationships between candidate voice pitch, candidate age, and electoral success are examined with two experiments. Study 1 tests whether voters discriminate on candidate age. The...
Show moreVoters prefer leaders with lower-pitched voices because they are perceived as stronger, having greater physical prowess, more competent, and having greater integrity. An alternative hypothesis that has yet to be tested is that lower-pitched voices are perceived as older and thus wiser and more experienced. Here the relationships between candidate voice pitch, candidate age, and electoral success are examined with two experiments. Study 1 tests whether voters discriminate on candidate age. The results show that male and female candidates in their 40s and 50s, the time in the lifecycle when voice pitch is at its lowest, are preferred over candidates in their 30s, 60s, and 70s. Study 2 shows that the preference for leaders with lower-pitched voices correlates with the perception that speakers with lower voices are stronger, more competent, and older, but the influence of perception of age on vote choice is the weakest of the three.
Show less - Date Issued
- 2015-08-07
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000005
- Format
- Citation
- Title
- Measurement of the Doppler shift in forward-scattered waves caused by moderate sea surface motion in shallow waters.
- Creator
- Beaujean, Pierre-Philippe, Strutt, Guenael T.
- Abstract/Description
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A study of the impulse response of the acoustic channel in shallow waters is presented with respect to space, time, and frequency shift over a time window of two hours. A broadband chirp (42–54 kHz) and a narrow band sine wave (58 kHz) are transmitted from a static source located at 51 and 166 m from a vertical line receiver array. In 20 m of water with 0.4 m of wave height, an average Doppler shift of 20 Hz is measured at 51 m range, and 10 Hz at 166 m range, due to the sea-surface motion.
- Date Issued
- 2005-10
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000001
- Format
- Citation
- Title
- Experimental drying intensifies burning and carbon losses in a northern peatland.
- Creator
- Turetsky, Merritt R., Donahue, W.F., Benscoter, Brian
- Abstract/Description
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For millennia, peatlands have served as an important sink for atmospheric CO2 and today represent a large soil carbon reservoir. While recent land use and wildfires have reduced carbon sequestration in tropical peatlands, the influence of disturbance on boreal peatlands is uncertain, yet it is important for predicting the fate of northern high-latitude carbon reserves. Here we quantify rates of organic matter storage and combustion losses in a boreal peatland subjected to long-term...
Show moreFor millennia, peatlands have served as an important sink for atmospheric CO2 and today represent a large soil carbon reservoir. While recent land use and wildfires have reduced carbon sequestration in tropical peatlands, the influence of disturbance on boreal peatlands is uncertain, yet it is important for predicting the fate of northern high-latitude carbon reserves. Here we quantify rates of organic matter storage and combustion losses in a boreal peatland subjected to long-term experimental drainage, a portion of which subsequently burned during a wildfire. We show that drainage doubled rates of organic matter accumulation in the soils of unburned plots. However, drainage also increased carbon losses during wildfire ninefold to 16.8 ± 0.2 kg C m^-2, equivalent to a loss of more than 450 years of peat accumulation. Interactions between peatland drainage and fire are likely to cause long-term carbon emissions to far exceed rates of carbon uptake, diminishing the northern peatland carbon sink.
Show less - Date Issued
- 2011-11-01
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000002
- Format
- Citation
- Title
- Moderate drop in water table increases peatland vulnerability to post-fire regime shift.
- Creator
- Kettridge, N., Turetsky, Merritt R., Sherwood, J. H., Thompson, D. K., Miller, C. A., Benscoter, Brian, Flannigan, Michael D., Wotton, B. M., Waddington, J. M.
- Abstract/Description
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Northern and tropical peatlands represent a globally significant carbon reserve accumulated over thousands of years of waterlogged conditions. It is unclear whether moderate drying predicted for northern peatlands will stimulate burning and carbon losses as has occurred in their smaller tropical counterparts where the carbon legacy has been destabilized due to severe drainage and deep peat fires. Capitalizing on a unique long-term experiment, we quantify the post-wildfire recovery of a...
Show moreNorthern and tropical peatlands represent a globally significant carbon reserve accumulated over thousands of years of waterlogged conditions. It is unclear whether moderate drying predicted for northern peatlands will stimulate burning and carbon losses as has occurred in their smaller tropical counterparts where the carbon legacy has been destabilized due to severe drainage and deep peat fires. Capitalizing on a unique long-term experiment, we quantify the post-wildfire recovery of a northern peatland subjected to decadal drainage. We show that the moderate drop in water table position predicted for most northern regions triggers a shift in vegetation composition previously observed within only severely disturbed tropical peatlands. The combined impact of moderate drainage followed by wildfire converted the low productivity, moss-dominated peatland to a non-carbon accumulating shrub-grass ecosystem. This new ecosystem is likely to experience a low intensity, high frequency wildfire regime, which will further deplete the legacy of stored peat carbon.
Show less - Date Issued
- 2015-07-27
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000003
- Format
- Citation
- Title
- Protecting People, Infrastructure, Economies, and Ecosystem Assets: Water Management in the Face of Climate Change.
- Creator
- Bloetscher, Frederick
- Abstract/Description
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Recent literature outlines significant impacts from climate change on many areas of the world, with much focus on causes and impacts. However the long-term trends demand adaptation strategies. While a variety of solutions have been suggested, some politically viable, others not, perhaps the most significant barrier to a cohesive approach to climate adaptation is the failure from the public and policy-makers to realize that different areas will be affected differently and that “one-size-fits...
Show moreRecent literature outlines significant impacts from climate change on many areas of the world, with much focus on causes and impacts. However the long-term trends demand adaptation strategies. While a variety of solutions have been suggested, some politically viable, others not, perhaps the most significant barrier to a cohesive approach to climate adaptation is the failure from the public and policy-makers to realize that different areas will be affected differently and that “one-size-fits-all” policy solutions will not be successful. In addition, as one area may identify and respond to challenges in their location, others should be supportive of those efforts, realizing that while such actions may be neither desirable nor appropriate for them, they may need support for solutions in the future in their areas. This project was designed as a framework to identify solutions and demonstrate differences between small regions and locales based on field conditions. The State of Florida was used as a case example to outline these differences because Florida is faced with significant challenges in the coming years related to water resources, the use of funds and political capital, and the potential for economic disruption. The intent is that the results of this project will lead to a series of recommendations and action steps for policy makers to conserve the state’s assets. A similar approach can be used in other states and countries to assess the likely policy and infrastructure needs for different locales.
Show less - Date Issued
- 2012-04-11
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000006
- Format
- Citation
- Title
- Reduced Variability of Ongoing and Evoked Cortical Activity Leads to Improved Behavioral Performance.
- Creator
- Ledberg, Anders, Montagnini, Anna, Coppola, Richard, Bressler, Steven L., Sporns, Olaf
- Abstract/Description
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Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predicts mean response time. We used cortical local field potentials, simultaneously recorded from...
Show moreSensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predicts mean response time. We used cortical local field potentials, simultaneously recorded from widespread cortical areas, to gauge both ongoing and visually evoked activity. Trial-to-trial variability of sensory evoked responses was strongly modulated by foreperiod duration and correlated both with the cortical variability before stimulus onset as well as with response times. In a separate set of experiments we probed the relation between small saccadic eye movements, foreperiod duration and manual response times. The rate of eye movements was modulated by foreperiod duration and eye position variability was positively correlated with response times. Our results indicate that when the time of a sensory stimulus is predictable, reduction in cortical variability before the stimulus can improve normal behavioral function that depends on the stimulus.
Show less - Date Issued
- 2012-08-24
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000007
- Format
- Citation
- Title
- Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers.
- Creator
- Roner, Michael R., Carraher, Charles E., Shahi, Kimberly, Barot, Girish
- Abstract/Description
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Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will...
Show morePolymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.
Show less - Date Issued
- 2011-05-27
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000008
- Format
- Citation
- Title
- Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro.
- Creator
- Carraher, Charles E., Roner, Michael R., Shahi, Kimberly, Barot, Girish
- Abstract/Description
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The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much...
Show moreThe ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
Show less - Date Issued
- 2011-04-15
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000009
- Format
- Citation
- Title
- Organotin Polyethers as Biomaterials.
- Creator
- Carraher, Charles E., Roner, Michael R.
- Abstract/Description
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Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of...
Show moreOrganotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synthetic diols. Included in these materials are the first water soluble organotin polymers. The organotin polyethers exhibit a wide range of biological activities. Some selectively inhibit a number of unwanted bacteria, including Staph. MRSA, and unwanted yeasts such as Candida albicans. Some also inhibit a variety of viruses including those responsible for herpes infections and smallpox. Others show good inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer. The synthesis, structural characterization, and biological characterization of these materials is described in this review.
Show less - Date Issued
- 2009-10-21
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000010
- Format
- Citation
- Title
- Eastern Caribbean Circulation and Island Mass Effect on St. Croix, US Virgin Islands: A Mechanism for Relatively Consistent Recruitment Patterns.
- Creator
- Chérubin, Laurent Marcel, Garavelli, Lysel, Han, Guoqi, Harbor Branch Oceanographic Institute
- Abstract/Description
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The northeastern Caribbean Sea is under the seasonal influence of the Trade Winds but also of the Orinoco/Amazon freshwater plume. The latter is responsible for intensification of the Caribbean Current in general and of its eddy activity in the northern part of the Caribbean Sea. More importantly, we show in this study that the front of the freshwater plume drives a northward flow that impinges directly on the island of St. Croix in the United States Virgin Islands. The angle of incidence of...
Show moreThe northeastern Caribbean Sea is under the seasonal influence of the Trade Winds but also of the Orinoco/Amazon freshwater plume. The latter is responsible for intensification of the Caribbean Current in general and of its eddy activity in the northern part of the Caribbean Sea. More importantly, we show in this study that the front of the freshwater plume drives a northward flow that impinges directly on the island of St. Croix in the United States Virgin Islands. The angle of incidence of the incoming flow controls the nature of the wake on both sides and ends of the island, which changes from cyclonic to anticylonic wake flow, with either attached or shed eddies. Using an off-line bio-physical model, we simulated the dispersal and recruitment of an abundant Caribbean coral reef fish, the bluehead wrasse (Thalassoma bifasciatum) in the context of the wake flow variability around St. Croix. Our results revealed the role played by the consistent seasonal forcing of the wake flow on the recruitment patterns around the island at the interannual scale. The interannual variability of the timing of arrival and northward penetration of the plume instead controls the nature of the wake, hence the regional spatial recruitment patterns.
Show less - Date Issued
- 2016-03-04
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000011
- Format
- Citation
- Title
- Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential.
- Creator
- Lohmueller, Jason J., Sato, Shuji, Popova, Lana, Chu, Isabel M., Tucker, Meghan A., Barberena, Roberto, Innocenti, Gregory M., Cudic, Mare, Ham, James D., Cheung, Wan Cheung, Polakiewicz, Roberto D., Finn, Olivera J.
- Abstract/Description
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MUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon cancer. This trial provided a unique source of potentially effective and safe immunotherapeutic drugs, fully-human antibodies affinity-matured in a healthy host to a tumor antigen. We purified, cloned, and characterized 13 IgGs specific for several tumor-associated MUC1 epitopes with a...
Show moreMUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon cancer. This trial provided a unique source of potentially effective and safe immunotherapeutic drugs, fully-human antibodies affinity-matured in a healthy host to a tumor antigen. We purified, cloned, and characterized 13 IgGs specific for several tumor-associated MUC1 epitopes with a wide range of binding affinities. These antibodies bind hypoglycosylated MUC1 on human cancer cell lines and tumor tissues but show no reactivity against fully-glycosylated MUC1 on normal cells and tissues. We found that several antibodies activate complement-mediated cytotoxicity and that T cells carrying chimeric antigen receptors with the antibody variable regions kill MUC1+ target cells, express activation markers, and produce interferon gamma. Fully-human and tumor-specific, these antibodies are candidates for further testing and development as immunotherapeutic drugs.
Show less - Date Issued
- 2016-10-22
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000012
- Format
- Citation
- Title
- Lesula: A New Species of Cercopithecus Monkey Endemic to the Democratic Republic of Congo and Implications for Conservation of Congo’s Central Basin.
- Creator
- Hart, John A., Detwiler, Kate M., Gilbert, Christopher C., Burrell, Andrew S., Fuller, James L., Emetshu, Maurice, Hart, Terese B., Vosper, Ashley, Sargis, Eric J., Tosi, Anthony J., Turvey, Samuel T.
- Abstract/Description
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In June 2007, a previously undescribed monkey known locally as ‘‘lesula’’ was found in the forests of the middle Lomami Basin in central Democratic Republic of Congo (DRC). We describe this new species as Cercopithecus lomamiensis sp. nov., and provide data on its distribution, morphology, genetics, ecology and behavior. C. lomamiensis is restricted to the lowland rain forests of central DRC between the middle Lomami and the upper Tshuapa Rivers. Morphological and molecular data confirm that...
Show moreIn June 2007, a previously undescribed monkey known locally as ‘‘lesula’’ was found in the forests of the middle Lomami Basin in central Democratic Republic of Congo (DRC). We describe this new species as Cercopithecus lomamiensis sp. nov., and provide data on its distribution, morphology, genetics, ecology and behavior. C. lomamiensis is restricted to the lowland rain forests of central DRC between the middle Lomami and the upper Tshuapa Rivers. Morphological and molecular data confirm that C. lomamiensis is distinct from its nearest congener, C. hamlyni, from which it is separated geographically by both the Congo (Lualaba) and the Lomami Rivers. C. lomamiensis, like C. hamlyni, is semi-terrestrial with a diet containing terrestrial herbaceous vegetation. The discovery of C. lomamiensis highlights the biogeographic significance and importance for conservation of central Congo’s interfluvial TL2 region, defined from the upper Tshuapa River through the Lomami Basin to the Congo (Lualaba) River. The TL2 region has been found to contain a high diversity of anthropoid primates including three forms, in addition to C. lomamiensis, that are endemic to the area. We recommend the common name, lesula, for this new species, as it is the vernacular name used over most of its known range.
Show less - Date Issued
- 2012-09-12
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000013
- Format
- Citation
- Title
- Antioptimization of earthquake exitation and response.
- Creator
- Zuccaro, G., Elishakoff, Isaac, Baratta, A.
- Abstract/Description
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The paper presents a novel approach to predict the response of earthquake-excited structures. The earthquake excitation is expanded in terms of series of deterministic functions. The coefficients of the series are represented as a point in N-dimensional space. Each available accelerogram at a certain site is then represented as a point in the above space, modeling the available fragmentary historical data. The minimum volume ellipsoid, containing all points, is constructed. The ellipsoidal...
Show moreThe paper presents a novel approach to predict the response of earthquake-excited structures. The earthquake excitation is expanded in terms of series of deterministic functions. The coefficients of the series are represented as a point in N-dimensional space. Each available accelerogram at a certain site is then represented as a point in the above space, modeling the available fragmentary historical data. The minimum volume ellipsoid, containing all points, is constructed. The ellipsoidal models of uncertainty, pertinent to earthquake excitation, are developed. The maximum response of a structure, subjected to the earthquake excitation, within ellipsoidal modeling of the latter, is determined. This procedure of determining least favorable response was termed in the literature (Elishakoff, 1991) as an antioptimization. It appears that under inherent uncertainty of earthquake excitation, antioptimization analysis is a viable alternative to stochastic approach.
Show less - Date Issued
- 1998
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000014
- Format
- Citation
- Title
- Co-Cultures of Pseudomonas aeruginosa and Roseobacter denitrificans Reveal Shifts in Gene Expression Levels Compared to Solo Cultures.
- Creator
- Conway, Crystal A., Esiobu, Nwadiuto, Lopez, Jose V.
- Abstract/Description
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Consistent biosynthesis of desired secondary metabolites (SMs) from pure microbial cultures is often unreliable. In a proof-ofprinciple study to induce SM gene expression and production, we describe mixed “co-culturing” conditions and monitoring of messages via quantitative real-time PCR (qPCR). Gene expression of model bacterial strains (Pseudomonas aeruginosa PAO1 and Roseobacter denitrificans Och114) was analyzed in pure solo and mixed cocultures to infer the effects of interspecies...
Show moreConsistent biosynthesis of desired secondary metabolites (SMs) from pure microbial cultures is often unreliable. In a proof-ofprinciple study to induce SM gene expression and production, we describe mixed “co-culturing” conditions and monitoring of messages via quantitative real-time PCR (qPCR). Gene expression of model bacterial strains (Pseudomonas aeruginosa PAO1 and Roseobacter denitrificans Och114) was analyzed in pure solo and mixed cocultures to infer the effects of interspecies interactions on gene expression in vitro, Two P. aeruginosa genes (PhzH coding for portions of the phenazine antibiotic pathway leading to pyocyanin (PCN) and the RhdA gene for thiosulfate: cyanide sulfurtransferase (Rhodanese)) and two R. denitrificans genes (BetaLact formetallo-beta-lactamase and the DMSP gene for dimethylpropiothetin dethiomethylase) were assessed for differential expression. Results showed that R. denitrificans DMSP and BetaLact gene expression became elevated in a mixed culture. In contrast, P. aeruginosa co-cultures with R. denitrificans or a third species did not increase target gene expression above control levels. This paper provides insight for better control of target SM gene expression in vitro and bypass complex genetic engineering manipulations.
Show less - Date Issued
- 2012
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000016
- Format
- Citation
- Title
- Introduction to the Special Issue on Evaluating the Security of Complex Systems.
- Creator
- Fernandez, Eduardo B.
- Abstract/Description
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Recent security breaches show the need to secure large, distributed, complex systems. A fundamental, but little discussed aspect of security is how to evaluate when a complete system is secure. Purely formal methods cannot handle this level of complexity. Code checking does not consider the interaction of separate modules working together and is hard to scale. Model-based approaches, such as patterns and problem frames, can be effective for handling large systems. Their use in evaluating...
Show moreRecent security breaches show the need to secure large, distributed, complex systems. A fundamental, but little discussed aspect of security is how to evaluate when a complete system is secure. Purely formal methods cannot handle this level of complexity. Code checking does not consider the interaction of separate modules working together and is hard to scale. Model-based approaches, such as patterns and problem frames, can be effective for handling large systems. Their use in evaluating security appears promising. A few works in this direction exist, but there is a need for more ideas. This Special Issue focuses on global, model-based, architectural, and systems-oriented evaluation methods.
Show less - Date Issued
- 2016-07-18
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000017
- Format
- Citation
- Title
- Noiseonomics: The relationship between ambient noise levels in the sea and global economic trends.
- Creator
- Frisk, George V.
- Abstract/Description
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In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their acoustic environment may have an impact on their behavior. Specifically, a growing body of literature suggests that low-frequency, ambient noise levels in the open ocean...
Show moreIn recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their acoustic environment may have an impact on their behavior. Specifically, a growing body of literature suggests that low-frequency, ambient noise levels in the open ocean increased approximately 3.3 dB per decade during the period 1950–2007. Here we show that this increase can be attributed primarily to commercial shipping activity, which in turn, can be linked to global economic growth. As a corollary, we conclude that ambient noise levels can be directly related to global economic conditions. We provide experimental evidence supporting this theory and discuss its implications for predicting future noise levels based on global economic trends.
Show less - Date Issued
- 2012-12-01
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000018
- Format
- Citation
- Title
- Antonio Ruiz de Montoya, Apostle of the Guaraní.
- Creator
- Ganson, Barbara
- Abstract/Description
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This essay highlights the accomplishments of one of the foremost Jesuit missionaries in seventeenth-century Paraguay, Antonio Ruiz de Montoya. Born in Lima, Montoya distinguished himself as a chronicler of the first encounters between the Jesuits and the Guaraní Indians of South America. He defended Indian rights by speaking out against Indian slavery. Montoya spent approximately twenty-five years among the Guaraní indigenous peoples who influenced his worldview and sense of spirituality,...
Show moreThis essay highlights the accomplishments of one of the foremost Jesuit missionaries in seventeenth-century Paraguay, Antonio Ruiz de Montoya. Born in Lima, Montoya distinguished himself as a chronicler of the first encounters between the Jesuits and the Guaraní Indians of South America. He defended Indian rights by speaking out against Indian slavery. Montoya spent approximately twenty-five years among the Guaraní indigenous peoples who influenced his worldview and sense of spirituality, which are reflected in his 1636 first account of the Jesuit reducciones in Paraguay, Conquista espiritual hecha por los religiosos de la Compañía de Jesús en las provincias del Paraguay, Paraná, Uruguay, y Tapé.
Show less - Date Issued
- 2016-03-01
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000019
- Format
- Citation