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FSTL-1 secreted by mesenchymal stem cells increases cell viability of human aortic endothelial cells under hypoxic stress
Title
FSTL-1 secreted by mesenchymal stem cells increases cell viability of human aortic endothelial cells under hypoxic stress.
Creator
Eid, Nibal., Harriet L. Wilkes Honors College
Abstract/Description
Human mesenchymal stem cells (MSCs) are being evaluated for the treatment of a broad array of diseases due to their ability to secrete a variety of therapeutically beneficial paracrine-acting factors. For example, MSC conditioned media (MSC-CM) has been shown to inhibit hypoxia-induced apoptosis in human aortic endothelial cells (HAECs) via activation of the P13-AKT pathway. However, the factors secreted by MSCs responsible for this effect have yet to be identified. Recent studies have shown...
Show moreHuman mesenchymal stem cells (MSCs) are being evaluated for the treatment of a broad array of diseases due to their ability to secrete a variety of therapeutically beneficial paracrine-acting factors. For example, MSC conditioned media (MSC-CM) has been shown to inhibit hypoxia-induced apoptosis in human aortic endothelial cells (HAECs) via activation of the P13-AKT pathway. However, the factors secreted by MSCs responsible for this effect have yet to be identified. Recent studies have shown that the glycoprotein Follistatin-like 1 (FSTL1) activates the P13-AKT pathway by binding to the receptor disco-interacting protein (DIP2A) expressed on the surface of cells. Based on our data indicating that MSCs constitutively secrete high quantities of FSTL1, we hypothesize that this protein principally mediates the anti-apoptopic effect of MSC-CM on HAECs. Loss-of-function studies employing siRNA-mediated knockdown of the protein and neutralizing antibodies will be used to assess the role of FSTL1 in growth and survival of HAECs following exposure to hypoxic stress.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3359296
Subject Headings
Stem cells, Transplantation, Molecular biology, Gene therapy, Coronary heart disease, Prevention, Stress (Physiology)
Format
Document (PDF)
Investigating child sexual abuse
Title
Investigating child sexual abuse: a feminist's perspective.
Creator
Herman-Davis, Lisa., Harriet L. Wilkes Honors College
Abstract/Description
The issue of sexual exploitation of children occurs in various forms and across socio-economic, racial, and cultural classes. Children experience abuse at the hands of authority figures who are family members, friends, and sometimes strangers. The discussions on this social issue tell the stories of children who have experienced abuse along with the processes and outcomes that arise in providing assistance to help them cope with these unwanted experiences. Discourses in the fields of...
Show moreThe issue of sexual exploitation of children occurs in various forms and across socio-economic, racial, and cultural classes. Children experience abuse at the hands of authority figures who are family members, friends, and sometimes strangers. The discussions on this social issue tell the stories of children who have experienced abuse along with the processes and outcomes that arise in providing assistance to help them cope with these unwanted experiences. Discourses in the fields of psychology, social work, medical sciences, and law have in their own unique style, taken different measures to highlight and address this social problem. However,there is remarkably little discussion held on the institutional changes that are required to stop this practice of child sexual abuse and public discourse and response is not reflective of the urgency required to address the issue. I argue that to address the issue of child sexual abuse requires addressing all the elements entrenched in the institutions of patriarchy and compulsory heterosexuality that fosters and promotes the subjugation of women and children, which is a topic best addressed through feminist theory.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3359297
Subject Headings
Child sexual abuse, Prevention, Sexually abused children, Feminist theory, Internet and children
Format
Document (PDF)
Just grin and bear it?
Title
Just grin and bear it?: proactive coping and PTSD in nursing students.
Creator
Borges-Garcia, Raquel., Harriet L. Wilkes Honors College
Abstract/Description
Past research has found that among traumatized undergraduate women, proactive coping style was independently negatively associated with posttraumatic stress disorder symptom severity. It also shows that nurses experience many work-related traumas. The present study tests the PTSD symptom level in nursing students and measured whether proactive coping and other personality variables could successfully buffer the effects of trauma. This study found a surprisingly low PTSD symptom level among...
Show morePast research has found that among traumatized undergraduate women, proactive coping style was independently negatively associated with posttraumatic stress disorder symptom severity. It also shows that nurses experience many work-related traumas. The present study tests the PTSD symptom level in nursing students and measured whether proactive coping and other personality variables could successfully buffer the effects of trauma. This study found a surprisingly low PTSD symptom level among the nursing students though they reported several distressing traumas. Also surprising, participants reported more distress from traumas relating to verbal abuse than to traumas relating to death and/or severe injury. Proactive coping, optimism, and self-esteem were negatively related to PTSD, anxiety, and depression. Further research will be needed to support these findings.
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Date Issued
2010
PURL
http://purl.flvc.org/FAU/3334254
Subject Headings
Post-traumatic stress disorder, Nursing students, Mental health, Nurses, Job stress, Nurses, Conduct of life, Resilience (Personality trait), Stress management, Burn out (Psychology), Prevention
Format
Document (PDF)
Proteomic identification of N86-hnRNPU-interacting proteins involved in HIV-1 inhibition
Title
Proteomic identification of N86-hnRNPU-interacting proteins involved in HIV-1 inhibition.
Creator
Hoxha, Sarah., Harriet L. Wilkes Honors College
Abstract/Description
HIV-1 is the human immunodeficiency virus that can lead to acquired immune deficiency syndrome, or AIDS. Multiple cellular proteins have been identified as playing a critical role in all steps of HIV-1 replication. The heterogeneous nuclear ribonuclear protein U, or hnRNPU is a RNA and DNA binding protein known to influence pre-mRNA processsing, transport to the cytoplasm, intracellular localization, translation and turnover of mRNAs. Recently, the expression of N86-hnRNPU, an N-terminal...
Show moreHIV-1 is the human immunodeficiency virus that can lead to acquired immune deficiency syndrome, or AIDS. Multiple cellular proteins have been identified as playing a critical role in all steps of HIV-1 replication. The heterogeneous nuclear ribonuclear protein U, or hnRNPU is a RNA and DNA binding protein known to influence pre-mRNA processsing, transport to the cytoplasm, intracellular localization, translation and turnover of mRNAs. Recently, the expression of N86-hnRNPU, an N-terminal fragment of hnRNPU, was found to inhibit HIV-1 mRNA export (6). This study primarily aims at identifying proteins that associate with the fragment (N86-hnRNPU) also called H1, and secondarily aims to exclude the possibility that N86-hnRNPU transcripts act as microRNAs.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3359314
Subject Headings
Enzyme inhibitors, Proteinase, Inhibitors, HIV infections, Prevention, HIV infections, Pathogenesis, Antiviral agents
Format
Document (PDF)
security of America's Fourth Amendment rights
Title
The security of America's Fourth Amendment rights: a study on National Security Letters.
Creator
Thompson, Maria., Harriet L. Wilkes Honors College
Abstract/Description
National Security Letters allow the Federal Bureau of Investigation to obtain records on individuals from corporations without prior judicial intervention or approval. Statutory changes, most significantly those resulting from the passage of the United States Patriot Act in 2001, have substantially altered the four different federal statutes from which National Security Letters originate. In creating these National Security Letters the government intended to protect its citizens from national...
Show moreNational Security Letters allow the Federal Bureau of Investigation to obtain records on individuals from corporations without prior judicial intervention or approval. Statutory changes, most significantly those resulting from the passage of the United States Patriot Act in 2001, have substantially altered the four different federal statutes from which National Security Letters originate. In creating these National Security Letters the government intended to protect its citizens from national security threats. This goal has been regarded historically as legitimate, but the legislation potentially limits rights, which raises the question of whether these letters are acceptable. Drawing on relevant case law and scholarly opinion, I argue that use of these letters is unacceptable and may render the Fourth Amendment's protection of person and property from unreasonable searches meaningless in certain federal investigations.
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Date Issued
2008
PURL
http://purl.flvc.org/FAU/77696
Subject Headings
Privacy, Right of, National security, Law and legislation, Terrorism, Prevention, Civil rights
Format
Document (PDF)