Current Search: Honors Student Theses (x) » Aging (x) » Molecular aspects (x)
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Title
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Caloric restriction in Drosophila melanogaster.
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Creator
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Hoxha, Sany., Harriet L. Wilkes Honors College
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Abstract/Description
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Caloric restriction (CR), the reduction of nutrient intake short of malnutrition, extends the lifespan of various organisms and can improve measures of human health. Whether mechanisms of lifespan extension are conserved between humans and model organisms is unknown. In mammals, implementing CR is easily achieved by providing a restricted group with a fraction of the food consumed by an "ad libitum" fed group, which has unlimited food access. Due to the difficulty in directly controlling...
Show moreCaloric restriction (CR), the reduction of nutrient intake short of malnutrition, extends the lifespan of various organisms and can improve measures of human health. Whether mechanisms of lifespan extension are conserved between humans and model organisms is unknown. In mammals, implementing CR is easily achieved by providing a restricted group with a fraction of the food consumed by an "ad libitum" fed group, which has unlimited food access. Due to the difficulty in directly controlling Drosophila food intake, caloric restriction, performed similarly to the mammalian paradigm, has never been tested in flies. Here, we demonstrate a system that allows measurement of food intake throughout life. This system will be used to measure fly lifespan under caloric restriction analogous to current mammalian studies. Our work will help tease apart the differences between the various caloric and dietary restriction paradigms in Drosophila, strengthening our understanding of how fly models relate to mammalian systems.
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Date Issued
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2012
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PURL
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http://purl.flvc.org/FAU/3359316
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Subject Headings
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Aging, Physiological aspects, Nutrition disorders in old age, Oxidative stress, Pathophysiology
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Format
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Document (PDF)
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Title
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Is age really just a number?: neuropsychological predictors of eyewitness memory errors.
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Creator
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Tsikis, Tina, Harriet L. Wilkes Honors College
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Abstract/Description
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Two separate groups of young and middle-aged adults watched videos of events being performed by a number of different college-aged females. Both the young goup of adults and the middle-aged group of adults were later tested on their memory for both the individual features of these events (i.e., actors and actions), and for conjunctions of features (i.e., which actor performed which action) in order to determine how likely they were to remember which actors performed which actions. Our results...
Show moreTwo separate groups of young and middle-aged adults watched videos of events being performed by a number of different college-aged females. Both the young goup of adults and the middle-aged group of adults were later tested on their memory for both the individual features of these events (i.e., actors and actions), and for conjunctions of features (i.e., which actor performed which action) in order to determine how likely they were to remember which actors performed which actions. Our results showed that frontal lobe functioning is not affected with age. However, there is a slight decrease in medial temporal functioning that continues on throughout life. There was a main effect of Question, Item Type, and Age Group explained through a three-way ANOVA. Binding errors increase with age because specific areas of the brain, such as the hippocampus and prefrontal cortex, deteriorate with age.
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Date Issued
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2012
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PURL
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http://purl.flvc.org/FAU/3359329, http://purl.flvc.org/fau/fd/FADT3359329
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Subject Headings
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Aging, Psychological aspects, Memory, Age factors, Eyewitness identification, Age factors, Recollection (Psychology), Cognition, Age factors, Transference (Psychology)
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Format
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Document (PDF)
