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Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri
Title
Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri.
Creator
Coval, S. J., Conover, M. A., Mierzwa, Ronald, King, Arthur, Puar, M. S., Phife, D. W., Pai, J.-K., Burrier, R. E., Ahn, H.-S., Boykow, G. C., Patel, Mahesh, Pomponi, Shirley A.
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3331891
Subject Headings
Sponges, Sesquiterpenes, Cholesterol Ester Transfer Proteins, Marine natural products
Format
Document (PDF)
Verongamine, a novel bromotyrosine derived histamine H3-antagonist from the marine sponge Verongula gigantea
Title
Verongamine, a novel bromotyrosine derived histamine H3-antagonist from the marine sponge Verongula gigantea.
Creator
Mierzwa, Ronald, King, Arthur, Conover, M. A., Tozzi, S., Puar, M. S., Patel, Mahesh, Coval, S. J., Pomponi, Shirley A.
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3318974
Subject Headings
Sponges --Research, Marine natural products, Drug Discovery
Format
Document (PDF)
Three new peroxides from the sponge Plakinastrella species
Title
Three new peroxides from the sponge Plakinastrella species.
Creator
Chen, Ying, Killday, K. B., McCarthy, Peter J., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
Date Issued
2001
PURL
http://purl.flvc.org/FCLA/DT/3319103
Subject Headings
Sponges --Research, Spectral analysis, Marine natural products, Peroxides, Antifungal agents
Format
Document (PDF)
The oceans and human health: the discovery and development of marine-derived drugs
Title
The oceans and human health: the discovery and development of marine-derived drugs.
Creator
Pomponi, Shirley A.
Date Issued
2001
PURL
http://purl.flvc.org/fau/fd/FA00007240
Subject Headings
Marine natural products, Marine pharmacology, Drug development
Format
Document (PDF)
The chemistry and biological activity of five marine sponges of the genus Aplysina
Title
The chemistry and biological activity of five marine sponges of the genus Aplysina.
Creator
Gunasekera, Sarath P., Cross, S. S., Longley, Ross E., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/fau/fd/FA00007303
Subject Headings
Sponges, Antiviral agents, Immunosuppressive agents, Bioactive compounds, Marine natural products
Format
Document (PDF)
Sustainable use of deep-sea organisms collected for biomedical research
Title
Sustainable use of deep-sea organisms collected for biomedical research.
Creator
Reed, John K., Pomponi, Shirley A.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007394
Subject Headings
Biomedical Research, Bioactive compounds, Marine natural products
Format
Document (PDF)
Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi
Title
Sesquiterpene-derived metabolites from the deep water marine sponge Poecillastra sollasi.
Creator
Killday, K. B., Longley, Ross E., McCarthy, Peter J., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318952
Subject Headings
Sponges --Research, Sesquiterpenes, Marine natural products, Marine metabolites
Format
Document (PDF)
Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella
Title
Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3172682
Subject Headings
Sponges --Caribbean Sea, Marine natural products, Toxicity testing --In vitro, Phosphatases, Peptidase
Format
Document (PDF)
New sterol ester from a deep water marine sponge, Xestospongia sp.
Title
New sterol ester from a deep water marine sponge, Xestospongia sp.
Creator
Gunasekera, Sarath P., Cranick, S., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332980
Subject Headings
Sponges, Sterols, Marine natural products
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
Maximizing the potential of marine organism collections for both pharmacological and systematic studies
Title
Maximizing the potential of marine organism collections for both pharmacological and systematic studies.
Creator
Pomponi, Shirley A.
Date Issued
1989
PURL
http://purl.flvc.org/fau/fd/FA00007194
Subject Headings
Marine organisms, Marine natural products, Pharmacology, Johnson-Sea-Link II (Submarine), Submersibles
Format
Document (PDF)
Marine natural products
Title
Marine natural products.
Creator
Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
Date Issued
1999
PURL
http://purl.flvc.org/fau/fd/FA00007503
Subject Headings
Marine natural products
Format
Document (PDF)
Marine biotechnology: realizing the potential
Title
Marine biotechnology: realizing the potential.
Creator
Pomponi, Shirley A., Baden, Daniel G., Zohar, Y.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3338530
Subject Headings
Marine biotechnology, Marine pharmacology, Marine natural products
Format
Document (PDF)
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix
Title
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
Creator
Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2009
PURL
http://purl.flvc.org/FCLA/DT/3319109
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
Format
Document (PDF)
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella
Title
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
Creator
Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3333007
Subject Headings
Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
Format
Document (PDF)
In vitro production of marine-derived antitumor compounds
Title
In vitro production of marine-derived antitumor compounds.
Creator
Pomponi, Shirley A., Willoughby, Robin, Wright, Amy E., Pecorella, C., Sennett, Susan H., Lopez, Jose V., Samples, Gail A.
Date Issued
1998
PURL
http://purl.flvc.org/fau/fd/FA00007238
Subject Headings
Antineoplastic agents, Bioactive compounds, Marine natural products, In vitro, Antitumor agents
Format
Document (PDF)
Five new Discodermolide analogues from the marine sponge Discodermia species
Title
Five new Discodermolide analogues from the marine sponge Discodermia species.
Creator
Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3319106
Subject Headings
Sponges --Research, Cytotoxin, Marine natural products, Polyketides
Format
Document (PDF)
ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT
Title
ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT.
Creator
Dougan, Cassady, Pomponi, Shirley A., Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
Abstract/Description
Marine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that...
Show moreMarine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that produces the compound of interest. In this study, hybridomas have been produced with cells of two marine sponges, Axinella corrugata, which produces the antitumor compound stevensine, and Geodia neptuni, which divides rapidly in a nutrient medium optimized for sponge cell culture. Successful hybridization and subsequent cell division and in vitro stevensine production may unlock the potential for sustainable mass production of other sponge-derived compounds.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FA00014024
Subject Headings
Marine natural products, Sponges, Hybridomas, In vitro
Format
Document (PDF)
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands
Title
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands.
Creator
Pomponi, Shirley A., Reed, John K., Wright, Amy E., McCarthy, Peter J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3351966
Subject Headings
Sponges--Turks and Caicos Islands, Bioactive compounds, Marine natural products, Sponges, Demospongiae
Format
Document (PDF)
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella
Title
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E., Lobkovsky, E., Clardy, J.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3319100
Subject Headings
Sponges --Research, Marine natural products, discorhabdin P, Enzyme inhibitors
Format
Document (PDF)

Pages