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Title: You’ve got to keep ‘em separated: characterizing lagging chromosome prevention in oral cancer cells.
Creator: Beltran, Rosa Nathalie, Quintyne, Nicholas, Harriet L. Wilkes Honors College
Abstract/Description: Mitosis is the separation of duplicated chromosomes into two daughter cells in order to create viable offspring. There are many checks in mitosis to ensure the inherited chromosome number is correct. Sometimes, these checkpoints are overcome and daughter cells inherit defects which can lead to cancer. One defect is the appearance of lagging chromosomes, the result of inaccurate chromosomal separation which leads to incorrect chromosome number termed aneuploidy. Aneuploidy is one of the...
Show moreMitosis is the separation of duplicated chromosomes into two daughter cells in order to create viable offspring. There are many checks in mitosis to ensure the inherited chromosome number is correct. Sometimes, these checkpoints are overcome and daughter cells inherit defects which can lead to cancer. One defect is the appearance of lagging chromosomes, the result of inaccurate chromosomal separation which leads to incorrect chromosome number termed aneuploidy. Aneuploidy is one of the defining traits of cancerous cells. The potential mechanism of lagging chromosomes in the cancerous cell line UPCI:OSCC070 is investigated in this study. siRNA-induced knockdown of KIFC1, a protein that is involved in the centrosomal clustering to prevent multipolar spindles, was used in the cells. Examining both levels of knockdown and time of exposure, we saw that the loss of KIFC1 led to a significant increase in lagging chromosomes, indicating this protein is critical to proper mitotic progression.
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Date Issued: 2013
PURL: http://purl.flvc.org/fau/fd/FA00003505
Format: Document (PDF)

Title: You should be ashamed of yourself: a study of moral development and moral emotion.
Creator: Bright, Justin., Harriet L. Wilkes Honors College
Abstract/Description: Research on Kohlberg's theory of moral development has examined moral development by examining individuals' justice operations. However, how the moral emotions are related to moral development has been neglected. In a sample of mostly undergraduates (N=53), moral development (measured using an index of higher-level moral reasoning and one of reasoning consistency from the Defining Issues Test) and the moral emotions of guilt, shame, empathy, and self-esteem were measured. Shame was positively...
Show moreResearch on Kohlberg's theory of moral development has examined moral development by examining individuals' justice operations. However, how the moral emotions are related to moral development has been neglected. In a sample of mostly undergraduates (N=53), moral development (measured using an index of higher-level moral reasoning and one of reasoning consistency from the Defining Issues Test) and the moral emotions of guilt, shame, empathy, and self-esteem were measured. Shame was positively related to higher moral reasoning (r=.26, p<.10); guilt was not (r=-.02, ns). Empathy was also positively correlated with higher moral reasoning (r=.19). Moral consistency was positively related to shame (r=.31, p<.05) and guilt (r=.32, p<.05). Existential theory was used to explain the differentiation between shame and guilt in their correlations with higher moral reasoning. The correlations between moral consistency and guilt and between moral consistency and shame are discussed with respect to the inhibitive nature of shame and guilt.
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Date Issued: 2008
PURL: http://purl.flvc.org/FAU/77659
Subject Headings: Moral development, Social ethics, Emotions, Moral and ethical aspects, Emotions and cognition
Format: Document (PDF)

Title: You keep me hangin' on: dynactin's p24 is essential for microtube anchoring.
Creator: Le, Ariel., Harriet L. Wilkes Honors College
Abstract/Description: Dynactin is a multisubunit protein complex that functions as a processivity cofactor to cytoplasmic dynein, assisting in vesicle transport and cell division. Independent of dynein,dynactin also serves to anchor microtubules to the centrosome. The functions of the majority of dynactin's subunits have been described to a certain degree ; however, the p24 subunit remains largely uncharacterized. Among the few things that are known about p24 are that it has a predicted molecular weight of about...
Show moreDynactin is a multisubunit protein complex that functions as a processivity cofactor to cytoplasmic dynein, assisting in vesicle transport and cell division. Independent of dynein,dynactin also serves to anchor microtubules to the centrosome. The functions of the majority of dynactin's subunits have been described to a certain degree ; however, the p24 subunit remains largely uncharacterized. Among the few things that are known about p24 are that it has a predicted molecular weight of about 20,822 Da, forms an a-helix, and binds directly to the p150[Glued] subunit. In order to explore its function further, we have performed shRNA-mediated knockdown, and fluorescent microscopy. We observe that microtubule disorganization is amplified due to the loss of p24. Our findings support the model that p24 serves as reinforcement to stabilize p150[Glued] at the centrosome.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3355592
Subject Headings: Cytoskeletal proteins, Cell organellles, Formation, Microtubules, Molecular biology
Format: Document (PDF)

Title: Wolf perception and policy in the United States: an analysis of two red wolf reintroduction programs.
Creator: Rouse, Sarah., Harriet L. Wilkes Honors College
Abstract/Description: Throughout the course of North American history, wolves have been persecuted with a vengeance. Negative wolf perceptions have in the past created and continue to create controversial policies and views towards wolves. While most of these attitudes are geared towards gray wolves, as gray wolves are the most common and prominent, unfavorable perceptions have also extended to the less well-known red wolf. This study compares two red wolf reintroduction programs, one in the Tennessee-Kentucky...
Show moreThroughout the course of North American history, wolves have been persecuted with a vengeance. Negative wolf perceptions have in the past created and continue to create controversial policies and views towards wolves. While most of these attitudes are geared towards gray wolves, as gray wolves are the most common and prominent, unfavorable perceptions have also extended to the less well-known red wolf. This study compares two red wolf reintroduction programs, one in the Tennessee-Kentucky area and the other in North Carolina, as well as the Yellowstone Gray Wolf Reintroduction program. After analyzing these three programs, it can be concluded that the perceptions towards wolves regardless of the type of wolf or location remain largely negative and that wolves continue to face persecution.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3359331
Subject Headings: Wildlife reintroduction, Gray wolf, Reintroduction, Red wolf, Reintroduction, Wolves, Reintroduction, Social aspects, Endangered species, Wildlife management
Format: Document (PDF)

Title: William Shakespeare and Herman Melville: emotional manipulation through verbal performance.
Creator: Murphy, Nicole E., Harriet L. Wilkes Honors College
Abstract/Description: This thesis considers the role of two rhetoricians, Petruchio from William Shakespeare's The Taming of the Shrew and Captain Ahab from Herman Melville's Moby-DIck, and analyzes their use of verbal performances. BOth Petruchio and Captain Ahab use pathologically manipulative rhetoric to manipulate others emotionally. Through this manipulation, they attempt to gain control, power, and authority. While both Petrucio and Ahab appear to succeed in manipulating others, they actually fail. Petruchio...
Show moreThis thesis considers the role of two rhetoricians, Petruchio from William Shakespeare's The Taming of the Shrew and Captain Ahab from Herman Melville's Moby-DIck, and analyzes their use of verbal performances. BOth Petruchio and Captain Ahab use pathologically manipulative rhetoric to manipulate others emotionally. Through this manipulation, they attempt to gain control, power, and authority. While both Petrucio and Ahab appear to succeed in manipulating others, they actually fail. Petruchio attempts to manipulate Katherine, but fails to attain mental submission from her, and Captain Ahab attempts to manipulate the crew to pursue hunting the whale, but as the narrative progresses, the crew becomes too disillusioned with the hunt to be persuaded by Ahab's rhetoric. In conclusion, both Petruchio and Captain Ahab are unable to sustain rhetorical control, and they both fall into demagoguery, therby suggesting that while they are alike as rhetoricians, they both fail similarly as rhetoricians.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3359309
Subject Headings: Criticism and interpretation, Criticism and interpretation, Rhetoric, Oral communication
Format: Document (PDF)

Title: Why security is but a symptom: understanding the persistence of state failure.
Creator: Jones, Stephen, Jakee, Keith, Harriet L. Wilkes Honors College
Abstract/Description: Most international relations scholars focus on internal insecurity as the primary problem in a failed state. I disagree with that view, and instead I seek to show that insecurity is created by rampant rule-breaking. Specifically, I argue that what I term “alegality” is the primary institutional structure of failed states. An alegal system is one where rules are written but seldom followed. An alegal system contains a government, so it cannot be considered anarchic. Under such systems, rule...
Show moreMost international relations scholars focus on internal insecurity as the primary problem in a failed state. I disagree with that view, and instead I seek to show that insecurity is created by rampant rule-breaking. Specifically, I argue that what I term “alegality” is the primary institutional structure of failed states. An alegal system is one where rules are written but seldom followed. An alegal system contains a government, so it cannot be considered anarchic. Under such systems, rule-breaking eroded reciprocal rule-following relationships, and this erosion removes constraints on behavior present in other societies. Without these constraints, states are characterized by internal insecurity, few publiclyprovided goods, a large and inefficient bureaucracy, and an autocratic leadership. Under the assumption that leaders, bureaucrats, and individual citizens all seek to maximize self-interest, I will show that their interactions within an alegal system result cause state failure to persist indefinitely.
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Date Issued: 2013
PURL: http://purl.flvc.org/fau/fd/FA00003520
Format: Document (PDF)

Title: What was "Behind the Green Door?": reclaiming femininity and sexual pleasure within pornography.
Creator: Williams, Faith Abigail., Harriet L. Wilkes Honors College
Abstract/Description: This project focuses on, Behind the Green Door, a film that inaugurated and in many ways defined the genre of hard-core pornography. I will examine the subversive modes of sexual behavior created and promoted by society and will argue that pornographic films actively attempt to redefine socially created notions of sexual comportment. I will then examine the notion of sexual fantasy and behavior as represented in two pornographic films, The Masseuse and The Fashionistas, in relation to the...
Show moreThis project focuses on, Behind the Green Door, a film that inaugurated and in many ways defined the genre of hard-core pornography. I will examine the subversive modes of sexual behavior created and promoted by society and will argue that pornographic films actively attempt to redefine socially created notions of sexual comportment. I will then examine the notion of sexual fantasy and behavior as represented in two pornographic films, The Masseuse and The Fashionistas, in relation to the models of sexual comportment present in Behind the Green Door. Specifically, I will study the work of two female pornographic stars, Jenna Jameson and Belladonna, and discuss the manner in which their work has reclaimed the notion of femininity and the necessity for female sexual pleasure by presenting women as sexually empowered beings able controlling and creating sexual scenarios specifically designed to garner physical pleasure.
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Date Issued: 2007
PURL: http://purl.flvc.org/FAU/40974
Subject Headings: Sex differences (Psychology), Pornography, Social aspects, Feminism, Sex role
Format: Document (PDF)

Title: What remittances can't buy: the social costs of migration and transnational gossip on women in Jacaltenango, Guatemala.
Creator: Sabbagh, Jocelyn., Harriet L. Wilkes Honors College
Abstract/Description: The academic debate on gender and migration has missed some of the key factors that impact women's lives and communities of origin. Interviews conducted in Jacaltenango, a Mayan sending community in Guatemala, suggest that while the migration of a spouse does bring substantial financial benefits there are significant individual and social costs that result from migration. More importantly, the interviews uncovered the crucial impact of transnational gossip on women's lives, a feature that has...
Show moreThe academic debate on gender and migration has missed some of the key factors that impact women's lives and communities of origin. Interviews conducted in Jacaltenango, a Mayan sending community in Guatemala, suggest that while the migration of a spouse does bring substantial financial benefits there are significant individual and social costs that result from migration. More importantly, the interviews uncovered the crucial impact of transnational gossip on women's lives, a feature that has been absent in previous academic treatments of gender and migration. Transnational gossip has exacerbated the negative effects of migration for women in migrant-sending locations, pushing women to stay in the "private sphere" and serving as a form of social control that keeps women from actively participating in their communities. For many women, long periods of time living apart from their spouses combined with fears about transnational gossip have brought severe loneliness, anxiety, health problems and even seclusion. This phenomenon is helping define the contemporary social structures of Jacaltenango, and represents one of the most important effects of migration in terms of the lived reality of spouses and families of the predominantly male immigrants who leave Mayan communities in Guatemala to seek work in the United States.
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Date Issued: 2007
PURL: http://purl.flvc.org/FAU/11603
Subject Headings: Women heads of households, Guatemalans, Family, Emigration and immigration, Social life and customs
Format: Document (PDF)

Title: What are words worth?: Thomas Malthus and political economy in William Wordsworth's poetry and prose.
Creator: Kirchner, Christina R., Harriet L. Wilkes Honors College
Abstract/Description: The works of Romantic poet William Wordsworth are generally regarded as idealistic nature poems. However, Wordsworth was writing in a turbulent era, between the French Revolution and the Industrial Revolution. Contrary to conventional labels, Wordsworth's prose and poetry of the late eighteenth and early nineteenth centuries strongly critiques social and economic affairs, similar to the ways Thomas Malthus comments on the same subjects. In 1798, political and economic theorist Thomas Robert...
Show moreThe works of Romantic poet William Wordsworth are generally regarded as idealistic nature poems. However, Wordsworth was writing in a turbulent era, between the French Revolution and the Industrial Revolution. Contrary to conventional labels, Wordsworth's prose and poetry of the late eighteenth and early nineteenth centuries strongly critiques social and economic affairs, similar to the ways Thomas Malthus comments on the same subjects. In 1798, political and economic theorist Thomas Robert Malthus published his infamous Essay on the Principle of Population, in which he devotes considerable thought to the subjects of poverty and England's Old Poor Law system. This thesis explores the connections between Wordsworth and Malthus, establishing Wordsworth as an amateur political economic theorist, who was concerned with the contemporary treatment of poverty and the morals of the legislators of the Poor Laws. I further claim that Wordsworth was a parable-poet, who sought to provide moral guidance regarding poor relief through affective poetry.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3359307
Subject Headings: Criticism and interpretation, Criticism and interpretation, Poetry, Psychological aspects, Economics
Format: Document (PDF)

Title: Wealth Determines Health: Socioeconomic Status and Life Expectancy in Washington, DC.
Creator: Garafola, Jessica Rose, McGovern, Warren W., Harriet L. Wilkes Honors College
Abstract/Description: Socioeconomic status has profound impact on one’s health. A person is able to spend more on health and wellness when that person has more disposable income. Socioeconomic status therefore affects people’s biology over their lifetime, making them more or less susceptible to chronic illness. This rate of chronic illness within a population will obviously be related to the life expectancy of the community. Firstly, this thesis examines socioeconomic status in Washington, D.C., where there is...
Show moreSocioeconomic status has profound impact on one’s health. A person is able to spend more on health and wellness when that person has more disposable income. Socioeconomic status therefore affects people’s biology over their lifetime, making them more or less susceptible to chronic illness. This rate of chronic illness within a population will obviously be related to the life expectancy of the community. Firstly, this thesis examines socioeconomic status in Washington, D.C., where there is wide inequality between people living only miles away. Secondly, this thesis correlates, among the eight wards in Washington, D.C., the different aspects of socioeconomic status to life expectancy. In an interdisciplinary manner, this thesis aims to analyze the disparity in life expectancy in Washington, D.C. and the significant factor that socioeconomic status plays in one’s biological destiny.
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Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00003643
Format: Document (PDF)

Title: We are Limestone Creek: an oral history of Limestone Creek community Jupiter, Florida.
Creator: Stout, Sara M., Harriet L. Wilkes Honors College
Abstract/Description: Limestone Creek is an unincorporated community existing within the planning and zoning boundary lines of Jupiter, Florida. Contrasting the economically flush and rapidly developing surrounding municipality of Jupiter, Limestone Creek is a predominantly African American community with an apparent economic gap that leaves the community untouched by development. This thesis project attempts to capture the voices of Limestone Creek and Jupiter residents pertaining to their accounts with an...
Show moreLimestone Creek is an unincorporated community existing within the planning and zoning boundary lines of Jupiter, Florida. Contrasting the economically flush and rapidly developing surrounding municipality of Jupiter, Limestone Creek is a predominantly African American community with an apparent economic gap that leaves the community untouched by development. This thesis project attempts to capture the voices of Limestone Creek and Jupiter residents pertaining to their accounts with an unincorporated area surrounded by a much wealthier municipality. Interviews were conducted with the residents of the community, Palm Beach County and the Town of Jupiter residents and officials, in an effort to explore the existence of an isolated African American community. The research resulted in varied responses to the idea of incorporation because of lack of funds. Conclusions to this research reveal that, to the members of the community, while race underlies all discussions of incorporation the more immediate issue is about securing basic services and infrastructure.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/3325089
Subject Headings: Municipal government, Suburban African Americans, Social conditions, Social aspects, Political aspects
Format: Document (PDF)

Title: Watching a life over time: the effects of viewing a videotaped longitudinal portrayal on cultural worldviews.
Creator: Franz, Stephanie., Harriet L. Wilkes Honors College
Abstract/Description: Terror management theory focuses on defenses used to buffer the anxiety caused by the awareness of death. This study attempted to induce an effect opposite to anxiety interpersonal connectedness-using a video clip. This feeling of connectedness was anticipated to decrease the need for the defenses described by terror management theory, and more specifically to lower the need for cultural worldview defense. Participants were assigned to one of two video conditions: the control video condition ...
Show moreTerror management theory focuses on defenses used to buffer the anxiety caused by the awareness of death. This study attempted to induce an effect opposite to anxiety interpersonal connectedness-using a video clip. This feeling of connectedness was anticipated to decrease the need for the defenses described by terror management theory, and more specifically to lower the need for cultural worldview defense. Participants were assigned to one of two video conditions: the control video condition (K-Web) or the experimental video condition (42-Up). After the video clip was shown, participants judged a list of social transgressions and rated the amount of punishment they felt the transgressor deserved. Individuals with high levels of self-esteem and positive affect were found to be more punitive than their counterparts, but the amount of punishment doled out to the transgressors was lower in the experimental video groups than in the control video groups.
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Date Issued: 2007
PURL: http://purl.flvc.org/FAU/11617
Subject Headings: Interpersonal relations, Terrorism, Psychological aspects, Attitude (Psychology), Testing
Format: Document (PDF)

Title: "The Voice of society": Dickens' surprising lesson in diplomacy spoken by the "innocent" table in Our Mutual Friend.
Creator: Hernandez, Patricia., Harriet L. Wilkes Honors College
Abstract/Description: In Our Mutual Friend Dickens plays with the idea of people becoming things and things becoming people. One such person, who is initially introduced as a table, is Melvin Twemlow. This member of the aristocracy plays an almost comical, minor role within one sub-plot of the novel, but over the course of the novel progresses from a "feeble" character into a strong, morally authoritative voice. Dickens concludes his novel with a debate concerning who is, or should be, "the voice of society" and...
Show moreIn Our Mutual Friend Dickens plays with the idea of people becoming things and things becoming people. One such person, who is initially introduced as a table, is Melvin Twemlow. This member of the aristocracy plays an almost comical, minor role within one sub-plot of the novel, but over the course of the novel progresses from a "feeble" character into a strong, morally authoritative voice. Dickens concludes his novel with a debate concerning who is, or should be, "the voice of society" and the last word of the debate is given to the mysterious table-man character. Rather than allowing a central protagonist to champion his thoughts, Dickens surprises his readers by making an exemplary moral figure of a mild, minor character from among the ranks of the pompous aristocracy. Twemlow's speech makes a familiar Dickensian point about the need for social reform in a strange, politically incorrect way.
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Date Issued: 2007
PURL: http://purl.flvc.org/FAU/40950
Subject Headings: Criticism and interpretation, English fiction, Criticism and interpretation, Literature and society, History, Class consciousness in literature
Format: Document (PDF)

Title: VERDAD Y FICCIÓN EN EN EL TIEMPO DE LAS MARIPOSAS (1994) DE JULIA ÁLVAREZ Y VIVAS EN SU JARDÍN (2009) DE DEDÉ MIRABAL.
Creator: Coletti, Erin Melissa, Cañete-Quesada, Carmen, Vázquez, Miguel Ángel, Harriet L. Wilkes Honors College
Abstract/Description: This thesis investigates the case of the legendary Mirabal sisters, or the so called “Mariposas” [the “Butterflies”]: three young Dominican women who sacrificed their lives to end the tyranny of General Rafael L. Trujillo. The purpose of this thesis is to compare the portrayal of the Mirabal sisters in two different books, In the Time of the Butterflies (1994) by Dominican-American writer Julia Álvarez and Vivas en su jardín [Alive in their Garden] (2009) by Dedé Mirabal, the only sister to...
Show moreThis thesis investigates the case of the legendary Mirabal sisters, or the so called “Mariposas” [the “Butterflies”]: three young Dominican women who sacrificed their lives to end the tyranny of General Rafael L. Trujillo. The purpose of this thesis is to compare the portrayal of the Mirabal sisters in two different books, In the Time of the Butterflies (1994) by Dominican-American writer Julia Álvarez and Vivas en su jardín [Alive in their Garden] (2009) by Dedé Mirabal, the only sister to survive. Mirabal implements an important biographical component in her testimony while Álvarez utilizes the genre of historical fiction to describe the events leading to the sisters’ assassination in 1960. This thesis explores the concepts of “truth” and “fiction” in Mirabal’s memoir and Álvarez’s historical novel, arguing that the range of objectivity and subjectivity in these two genres are interchangeable in the representation of this tragic episode in the history of the Dominican Republic.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00003612
Format: Document (PDF)

Title: Verb acquisition and generalization strategies of preschool children.
Creator: Pruzansky, Rita, Harriet L. Wilkes Honors College
Abstract/Description: This experiment tested 3 to 5-year-old children's (n=18) abilities to learn a novel verb in the context of one or two novel objects. We showed the children claymation videos of novel creatures performing two novel actions. They were then tested on whether they could correctly identify the action that a creature was performing in the form of a 'yes' or 'no' response. Children in the blocked condition, who learned the verbs in the context of one creature, responded correctly more often (p=.01)...
Show moreThis experiment tested 3 to 5-year-old children's (n=18) abilities to learn a novel verb in the context of one or two novel objects. We showed the children claymation videos of novel creatures performing two novel actions. They were then tested on whether they could correctly identify the action that a creature was performing in the form of a 'yes' or 'no' response. Children in the blocked condition, who learned the verbs in the context of one creature, responded correctly more often (p=.01) than children in the grouped condition, who learned the verbs in the context of two creatures. Results were similar when tested again one week later. These findings suggest that when teaching young children verbs, it may be more effective to first teach in the context of one object so that the children have a more confident understanding of the verb meaning.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3359311, http://purl.flvc.org/fau/fd/FADT3359311
Subject Headings: Language acquisition, Age factors, Child development, Language awareness in children, Psycholinguistics, Language arts (Early childhood), Cognitive grammar
Format: Document (PDF)

Title: Using oral cancer cell line UPCI: SCC078 to purify NuMA protein.
Creator: Rodrigues, Ana, Quintyne, Nicholas, Harriet L. Wilkes Honors College
Abstract/Description: Formation of multipolar spindles is closely linked to increased genomic instability and tumor progression. Centrosome hyperamplification is insufficient to initiate this mitotic defect, centrosome coalescence must be interrupted. Studies have indicated that cytoplasmic dynein is a key factor in preventing multipolarity, and overexpression of the NuMA protein is sufficient to mislocalize dynein from the spindle and abrogate the coalescence machinery. Because the mechanism by which NuMA can...
Show moreFormation of multipolar spindles is closely linked to increased genomic instability and tumor progression. Centrosome hyperamplification is insufficient to initiate this mitotic defect, centrosome coalescence must be interrupted. Studies have indicated that cytoplasmic dynein is a key factor in preventing multipolarity, and overexpression of the NuMA protein is sufficient to mislocalize dynein from the spindle and abrogate the coalescence machinery. Because the mechanism by which NuMA can inhibit dynein is unclear, we are purifying NuMA to use in in vitro studies, to better understand how NuMA blocks dynein activity. Purifying NuMA from recombinant sources has not been successful; therefore we are utilizing a native source. We are using the oral cancer cell line UPCI:SCC078 as the source because it has nine copies of the NUMA1 gene. With modifications to the protocols used previously, our goal is to yield sufficient quantities of NuMA for biochemical analysis with purified NuMA.
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Date Issued: 2013
PURL: http://purl.flvc.org/fau/fd/FA00003532
Format: Document (PDF)

Title: Using C. elegans as a Model System to Discover Antiepileptic Drugs.
Creator: Merritt, Mckenzie D., Wetterer, James K., Harriet L. Wilkes Honors College
Abstract/Description: Novel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans...
Show moreNovel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans to test FDA approved AEDs. My tests support the contention that C. elegans can be a useful model system for AED discovery.
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Date Issued: 2016
PURL: http://purl.flvc.org/fau/fd/FA00003682
Format: Document (PDF)

Title: The use of novel HDACi's for treatment of memory impairment in a mouse model of Alzheimer's disease.
Creator: Moyes, Jonathan., Harriet L. Wilkes Honors College
Abstract/Description: Alzheimer's disease (AD) is an increasingly common neurological disorder that mainly affects memory formation and retention. It is characterized by unique intercellular neurofibrillary tangles and extracellular beta-amyloid plaques. Histone deacetylase inhibitors (HDACi's) are competitive antagonists against histone deacetylases, causing histone acetyltransferases to acetylate the genome unregulated. This thesis investigates the use of new histone deacetylase inhibitors on recovering memory...
Show moreAlzheimer's disease (AD) is an increasingly common neurological disorder that mainly affects memory formation and retention. It is characterized by unique intercellular neurofibrillary tangles and extracellular beta-amyloid plaques. Histone deacetylase inhibitors (HDACi's) are competitive antagonists against histone deacetylases, causing histone acetyltransferases to acetylate the genome unregulated. This thesis investigates the use of new histone deacetylase inhibitors on recovering memory in a mouse model of Alzheimer's disease. By use of a fear conditioning paradigm, we have shown that these HDACI's increase memory in AD mice, but show either no effect or a positive effect in wild-type mice. Future experiments will investigate the efficacy of compound 966 and the spine density of hippocampal brain slices after fear conditioning trials.
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Date Issued: 2012
PURL: http://purl.flvc.org/FAU/3359315
Subject Headings: Alzheimer's disease, Chemotherapy, Pharmacogenetics, Histone deacetylase, Inhibitors, Nervous system, Degeneration, Molecular aspects
Format: Document (PDF)

Title: Use of multisensory therapy by adolescents with co-occurring autism and profound intellectual disability.
Creator: Leichner, Jared., Harriet L. Wilkes Honors College
Abstract/Description: The education of profoundly intellectually disabled individuals requires identifying motivators to help them learn basic tasks and skills. When these individuals also suffer from Autism Spectrum Disorder, one promising method of therapy, multisensory therapy, has been shown to relax patients, facilitating the educational process. Relaxation drastically minimizes maladaptive behaviors such as repetitive movement (stereotypy) and self-injury, allowing the participant to learn efficiently. In...
Show moreThe education of profoundly intellectually disabled individuals requires identifying motivators to help them learn basic tasks and skills. When these individuals also suffer from Autism Spectrum Disorder, one promising method of therapy, multisensory therapy, has been shown to relax patients, facilitating the educational process. Relaxation drastically minimizes maladaptive behaviors such as repetitive movement (stereotypy) and self-injury, allowing the participant to learn efficiently. In this study, a multi-axis measure was developed to determine behavioral differences between an experimental group that underwent the therapy and a control group that performed a functional task in their classroom. Stereotypic behaviors were significantly reduced and gaze focus was enhanced within the therapy. The significance of these effects carried over when participants were returned to their classroom.
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Date Issued: 2010
PURL: http://purl.flvc.org/FAU/3335109
Subject Headings: Autism in adolescents, Therapy, Children with disabilities, Development, Autistic children, Behavior modification, Social skills in children, Behavior therapy for children, Children with disabilities, Education, Language arts, Relaxation (Methodology), Behaviorism (Psychology)
Format: Document (PDF)

Title: Urban space and the birth of punk.
Creator: Fletcher, Paul., Harriet L. Wilkes Honors College
Abstract/Description: While the general public agrees that the Sex Pistols were punk--they were dirty, vile, low-class, and they sang crass lyrics--their aesthetics were originally brought into punk by the New York Dolls, by bringing the street into their performance. The New York Dolls were from the New York City streets; they were mediocre musicians, unglamorous, and not at all phantasmagorical. They removed the hierarchy and the bourgeois elements from their performances that had been established by previous...
Show moreWhile the general public agrees that the Sex Pistols were punk--they were dirty, vile, low-class, and they sang crass lyrics--their aesthetics were originally brought into punk by the New York Dolls, by bringing the street into their performance. The New York Dolls were from the New York City streets; they were mediocre musicians, unglamorous, and not at all phantasmagorical. They removed the hierarchy and the bourgeois elements from their performances that had been established by previous New York City bands like the Velvet Underground--who performed as high-class, elitist artists. The New York Dolls destroyed this hierarchy, allowing the audience to join them. So, all the aesthetics that are associated with punk are the physical, visual, and auditory manifestations of the original scene and unity that began with the New York Dolls.
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Date Issued: 2006
PURL: http://purl.flvc.org/FAU/11586
Subject Headings: Rock musicians, Music, Philosophy and aesthestics, Counterculture, History, Punk rock music, History and criticism, Punk culture, History
Format: Document (PDF)

Honors Student Theses (338)	+ -
FAU Undergraduate Student Research (1)	+ -

Criticism and interpretation (30)	+ -
History (25)	+ -
Social aspects (12)	+ -
Wildlife conservation (12)	+ -
Politics and government (11)	+ -

Psychological aspects (11)	+ -
Ecology (10)	+ -
Cellular signal transduction (9)	+ -
Formation (9)	+ -
Cell organelles (8)	+ -
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