Current Search: ("rzoeller@fau.edu") (x)
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Title
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Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.
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Creator
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Ash, Garrett I., Kostek, Matthew A., Lee, Harold, Angelopoulos, Theodore J., Clarkson, Priscilla M., Gordon, Paul M., Moyna, Niall M., Visich, Paul S., Zoeller, Robert F., Price, Thomas B., Devaney, Joseph M., Gordish-Dressman, Heather, Thompson, Paul D., Hoffman, Eric P., Pescatello, Linda S., Fine, Michael L
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Abstract/Description
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Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm^2) preand post-resistance training. Subjects were genotyped for NR3C1 -2722G>A,...
Show moreGlucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n = 602, 23.8±0.4yr) completed a 12 week unilateral arm RT program. Maximum voluntary contraction (MVC) assessed isometric strength (kg) and MRI assessed biceps size (cm^2) preand post-resistance training. Subjects were genotyped for NR3C1 -2722G>A, -1887G>A, -1017T>C, and +363A>G. Men carrying the -2722G allele gained less relative MVC (17.3 ±1.2vs33.5±6.1%) (p = 0.010) than AA homozygotes; men with -1887GG gained greater relative MVC than A allele carriers (19.6±1.4vs13.2±2.3%) (p = 0.016). Women carrying the -1017T allele gained greater relative size (18.7±0.5vs16.1±0.9%) (p = 0.016) than CC homozygotes.We found sex-specific NR3C1 associations with the muscle strength and size response to RT. Future studies should investigate whether these associations are partially explained by cortisol’s actions in muscle tissue as they interact with sex differences in cortisol production.
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Date Issued
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2016-01-28
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000062
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Format
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Citation
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Title
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INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men.
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Creator
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Orkunoglu-Suer, Funda E., Gordish-Dressman, Heather, Clarkson, Priscilla M., Thompson, Paul D., Angelopoulos, Theodore J., Gordon, Paul M., Moyna, Niall M., Pescatello, Linda S., Visich, Paul S., Zoeller, Robert F., Harmon, Brennan, Seip, Richard L., Hoffman, Eric P., Devaney, Joseph M.
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Date Issued
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2008-12-23
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PURL
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http://purl.flvc.org/fcla/dt/3327172
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Subject Headings
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Adiposity --genetics, Alleles, Gene Frequency, Intracellular Signaling Peptides and Proteins, Resistance Training, Subcutaneous Fat, INSIG2 protein, Obesity, Genotype, Membrane Proteins, Membrane Proteins --Genetics
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Format
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Document (PDF)
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Title
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PPARᾳ L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males.
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Creator
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Uthurralt, Julieta, Gordish-Dressman, Heather, Bradbury, Meg, Tesi-Rocha, Carolina, Devaney, Joseph M., Harmon, Brennan, Reeves, Erica K., Brandoli, Cinzia, Hansen, Barbara C., Seip, Richard L., Thompson, Paul D., Price, Thomas B., Angelopoulos, Theodore J., Clarkson, Priscilla M., Moyna, Niall M., Pescatello, Linda S., Visich, Paul S., Zoeller, Robert F., Gordon, Paul M., Hoffman, Eric P.
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Date Issued
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2007-08-16
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PURL
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http://purl.flvc.org/fcla/dt/3327177
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Subject Headings
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Alleles, Exercise, Insulin Resistance --genetics, PPAR alpha --genetics, Polymorphism, Single Nucleotide, Triglycerides, Subcutaneous Fat, PPAR alpha
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Format
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Document (PDF)
