Current Search:  ("kbrew@health.fau.edu") (x)

View All Items

  • CSV Spreadsheet
(1 - 18 of 18)
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases
Title
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases.
Creator
Brew, Keith
Date Issued
2019-01-20
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1096_fj.201801262R_1638460567
Format
Document (PDF)
Hypothesis
Title
Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease.
Creator
Lizotte-Waniewski, Michelle, Brew, Keith, Hennekens, Charles H.
Date Issued
2016-07-24
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1177_1074248415615237_1638375551
Format
Document (PDF)
Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14
Title
Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14.
Creator
Zou, Haiyin, Wu, Ying, Brew, Keith
Date Issued
2016-05
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M116.720250_1638376717
Format
Document (PDF)
Structures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis Products
Title
Structures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis Products.
Creator
Pham, Tram T.K., Stinson, Brittany, Thiyagarajan, Nethaji, Lizotte-Waniewski, Michelle, Brew, Keith, Acharya, K. Ravi
Date Issued
2014-03
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M113.545384_1638284195
Format
Document (PDF)
Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen
Title
Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.
Creator
Thiyagarajan, Nethaji, Pham, Tram T. K., Stinson, Brittany, Sundriyal, Amit, Tumbale, Percy, Lizotte-Waniewski, Michelle, Brew, Keith, Acharya, K. Ravi
Date Issued
2012-12-07
PURL
http://purl.flvc.org/fau/fd/FAUIR000113
Format
Citation
Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia
Title
Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia.
Creator
Ashutosh, Chao, C, Borgmann, K, Brew, Keith, Ghorpade, A
Date Issued
2012-06
PURL
http://purl.flvc.org/fau/fd/FAUIR000129
Format
Citation
Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)
Title
Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2).
Creator
Bahudhanapati, Harinath, Zhang, Yingnan, Sidhu, Sachdev S., Brew, Keith
Date Issued
2011-09
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M111.253328_1638375138
Format
Document (PDF)
Entropy Increases from Different Sources Support the High-affinity Binding of the N-terminal Inhibitory Domains of Tissue Inhibitors of Metalloproteinases to the Catalytic Domains of Matrix Metalloproteinases-1 and -3
Title
Entropy Increases from Different Sources Support the High-affinity Binding of the N-terminal Inhibitory Domains of Tissue Inhibitors of Metalloproteinases to the Catalytic Domains of Matrix Metalloproteinases-1 and -3.
Creator
Wu, Ying, Wei, Shuo, Van Doren, Steven R., Brew, Keith
Date Issued
2011-05
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M111.222307_1638299359
Format
Document (PDF)
Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer May Enhance Mutualism between Vertebrates and Bacteria
Title
Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer May Enhance Mutualism between Vertebrates and Bacteria.
Creator
Brew, Keith, Tumbale, Percy, Acharya, K. Ravi
Date Issued
2010-11
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.R110.176248_1638296127
Format
Document (PDF)
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Title
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
Creator
Lim, Ngee H., Kashiwagi, Masahide, Visse, Robert, Jones, Jonathan, Enghild, Jan J., Brew, Keith, Nagase, Hideaki
Date Issued
2010-10-01
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1042_BJ20100725_1638297790
Format
Document (PDF)
A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons
Title
A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons.
Creator
Ould-yahoui, Adlane, Tremblay, Evelyne, Sbai, Oualid, Ferhat, Lotfi, Bernard, Anne, Charrat, Eliane, Gueye, Yatma, Lim, Ngee Han, Brew, Keith, Risso, Jean-Jacques, Dive, Vincent, Khrestchatisky, Michel, Rivera, Santiago, Chédotal, Alain
Date Issued
2009-12-14
PURL
http://purl.flvc.org/fau/fd/FAUIR000096
Format
Citation
Characterization of a Metal-independent CAZy Family 6 Glycosyltransferase from Bacteroides ovatus
Title
Characterization of a Metal-independent CAZy Family 6 Glycosyltransferase from Bacteroides ovatus.
Creator
Tumbale, Percy, Brew, Keith
Date Issued
2009-09
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M109.033878_1638385976
Format
Document (PDF)
Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria
Title
Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria.
Creator
Van Doren, Steven R., Wei, Shuo, Gao, Guanghua, DaGue, Beverly B., Palmier, Mark O., Bahudhanapati, Harinath, Brew, Keith
Date Issued
2008-11
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1002_bip.21043_1638215239
Format
Document (PDF)
Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
Title
Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis.
Creator
Crabtree, Benedict, Thiyagarajan, Nethaji, Prior, Stephen H., Wilson, Peter, Iyer, Shalini, Ferns, Tyrone, Shapiro, Robert, Brew, Keith, Subramanian, Vasanta, Acharya, K. Ravi
Date Issued
2007-10-01
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_bi701333h_1638203835
Format
Document (PDF)
Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors
Title
Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors.
Creator
Lauer-Fields, Janelle L., Cudic, Mare, Wei, Shuo, Mari, Frank, Fields, Gregg B., Brew, Keith
Date Issued
2007-09
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M611612200_1638212835
Format
Document (PDF)
Development of a convenient peptide-based assay for lysyl hydroxylase
Title
Development of a convenient peptide-based assay for lysyl hydroxylase.
Creator
Cudic, Mare, Patel, Deepak A., Lauer-Fields, Janelle L., Brew, Keith, Fields, Gregg B.
Date Issued
2007-07-03
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1002_bip.20799_1638210547
Format
Document (PDF)
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity
Title
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity.
Creator
Minond, Dmitriy, Lauer-Fields, Janelle L., Cudic, Mare, Overall, Christopher M., Pei, Duanqing, Brew, Keith, Visse, Robert, Nagase, Hideaki, Fields, Gregg B.
Date Issued
2006-12
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M606004200_1638203001
Format
Document (PDF)
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
Title
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
Creator
Nagase, Hideaki, Brew, Keith
Abstract/Description
Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition...
Show moreMatrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition mechanism of TIMPs, the biological activities of TIMPs, the unique properties of TIMP-3, and the altered specificity towards MMPs achieved by mutagenesis. A potential therapeutic use of TIMP variants is discussed.
Show less
Date Issued
2002-04-02
PURL
http://purl.flvc.org/fcla/dt/3327266
Subject Headings
Gene Therapy --Methods, Genetic Engineering --methods, Protein Structure, Tertiary, Rheumatic Diseases --therapy, Tissue Inhibitor of Metalloproteinases, Wound Healing --physiology, Metalloproteinases --Inhibitors --Therapeutic use
Format
Document (PDF)