Current Search: ("jdiaka@fau.edu") (x)
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Title
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The Potential Therapeutic Effects of Low-Dose Ionizing Radiation in Alzheimer's Disease.
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Creator
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Joubin Jebelli, Michael C. Hamper, Danielle Van Quelef, Davian Caraballo, James Hartmann, James Kumi-Diaka
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Abstract/Description
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Dementia is an umbrella term used to describe a loss of cognitive function which results in the interference of an individual's daily life and activities. The most common form of dementia is Alzheimer's disease. Alzheimer’s is classified as a progressive, debilitating neurodegenerative disease that results in disturbances to a patient’s higher executive function, memory, language, and visuospatial orientation. Despite extensive research on Alzheimer’s dementia, including both available and...
Show moreDementia is an umbrella term used to describe a loss of cognitive function which results in the interference of an individual's daily life and activities. The most common form of dementia is Alzheimer's disease. Alzheimer’s is classified as a progressive, debilitating neurodegenerative disease that results in disturbances to a patient’s higher executive function, memory, language, and visuospatial orientation. Despite extensive research on Alzheimer’s dementia, including both available and potential therapeutic modalities, this neurodegenerative disease is incurable and will continue to pose a major public health concern. Current treatment options for Alzheimer’s focus on symptom management and/or delaying the progression of the disease. Therefore, new treatment strategies must be developed to combat such a deadly disease. One field of medicine that has garnered significant interest from researchers to potentially treat Alzheimer’s is lowdose ionizing radiation. Various reports suggest that the brain’s exposure to low doses of ionizing radiation may serve as a therapeutic modality for combating neurodegenerative diseases, including Alzheimer’s dementia. This article serves as a review of the current available treatments for Alzheimer’s disease and discusses recent studies that provide evidence for the potential use of low-dose ionizing radiation as a therapeutic in the treatment of Alzheimer’s disease.
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Date Issued
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2022
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000508
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Format
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Document (PDF)
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Title
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Chemopreventive Effects of Magnesium Chloride Supplementation on Hormone Independent Prostate Cancer Cells.
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Creator
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Saheed Oluwasina Oseni, Elsa Quiroz, James Kumi-Diaka
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Abstract/Description
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Lifestyle significantly impacts the risk factors associated with prostate cancer, out of which diet appears to be the most influential. An emerging chemopreventive approach, which involves the adequate intake of dietary constituents, has shown great potential in preventing the occurrence or progression of cancer. Magnesium is known to be an essential cofactor for more than 300 enzymatic processes, and is responsible for the regulation of various cellular reactions in the body. A plethora of...
Show moreLifestyle significantly impacts the risk factors associated with prostate cancer, out of which diet appears to be the most influential. An emerging chemopreventive approach, which involves the adequate intake of dietary constituents, has shown great potential in preventing the occurrence or progression of cancer. Magnesium is known to be an essential cofactor for more than 300 enzymatic processes, and is responsible for the regulation of various cellular reactions in the body. A plethora of studies have shown evidence that changes in the intracellular levels of magnesium could contribute to cell proliferation and apoptosis in some normal and malignant cells. The aim of the study was to investigate the effects of magnesium chloride (MgCl2) in DU-145 prostate cancer cells.
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Date Issued
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2016
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000486
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Format
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Document (PDF)
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Title
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CytoregR inhibits growth and proliferation of human adenocarcinoma cells via induction of apoptosis.
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Creator
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Kumi-Diaka, James, Hassanhi, M., Brown, Jayann Marie, Merchant, Kendra T., Garcia, C., Jimenez, W.
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Date Issued
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2006-01-09
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PURL
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http://purl.flvc.org/fcla/dt/3327155
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Format
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Document (PDF)
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Title
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Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment.
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Creator
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Kumi-Diaka, James, Saddler, Shawnette Simone, Aller, Alex, Brown, Jayann Marie
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Date Issued
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2004-08-17
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PURL
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http://purl.flvc.org/fcla/dt/3327156
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Format
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Document (PDF)
