Current Search:  ("carraher@fau.edu") (x)

View All Items

  • CSV Spreadsheet
(1 - 6 of 6)
Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers
Title
Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers.
Creator
Roner, Michael R., Carraher, Charles E., Shahi, Kimberly, Barot, Girish
Abstract/Description
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will...
Show morePolymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This article examines the use of metal-containing polymers as a novel class of antivirals.
Show less
Date Issued
2011-05-27
PURL
http://purl.flvc.org/fau/fd/FAUIR000008
Format
Citation
Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro
Title
Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro.
Creator
Carraher, Charles E., Roner, Michael R., Shahi, Kimberly, Barot, Girish
Abstract/Description
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much...
Show moreThe ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
Show less
Date Issued
2011-04-15
PURL
http://purl.flvc.org/fau/fd/FAUIR000009
Format
Citation
Organotin Polyethers as Biomaterials
Title
Organotin Polyethers as Biomaterials.
Creator
Carraher, Charles E., Roner, Michael R.
Abstract/Description
Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of...
Show moreOrganotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synthetic diols. Included in these materials are the first water soluble organotin polymers. The organotin polyethers exhibit a wide range of biological activities. Some selectively inhibit a number of unwanted bacteria, including Staph. MRSA, and unwanted yeasts such as Candida albicans. Some also inhibit a variety of viruses including those responsible for herpes infections and smallpox. Others show good inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer. The synthesis, structural characterization, and biological characterization of these materials is described in this review.
Show less
Date Issued
2009-10-21
PURL
http://purl.flvc.org/fau/fd/FAUIR000010
Format
Citation
Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines
Title
Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines.
Creator
Roner, Michael R., Carraher, Charles E., Shahi, Kimberly, Ashida, Yuki, Barot, Girish
Date Issued
2009-10-07
PURL
http://purl.flvc.org/fcla/dt/3325102
Format
Document (PDF)
Materials and methods for controlling methicillin-resistant Staphylococcus aureus microbes
Title
Materials and methods for controlling methicillin-resistant Staphylococcus aureus microbes.
Creator
Carraher, Charles E., Butler, Cynthia, Florida Atlantic University
Date Issued
1998-11
PURL
http://purl.flvc.org/fcla/dt/15842
Format
Document (PDF)
Novel compunds for the control of microorganisms.
Title
Novel compunds for the control of microorganisms.
Creator
Carraher, Charles E., Butler, Cynthia, Florida Atlantic University
Date Issued
1991-08
PURL
http://purl.flvc.org/fcla/dt/15859
Format
Document (PDF)