Current Search: FAU Graduate Student Research (x) » Stackman, Robert W. (x) » Lora, Joan C. (x)
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Title
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Effects of hippocampal impairment on rodent spatial and non-spatial memory.
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Creator
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Rios, Lisa, Lora, Joan C., Zhang, Gongliang, Stackman, Robert W., Graduate College
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Date Issued
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2011-04-08
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PURL
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http://purl.flvc.org/fcla/dt/3164769
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Subject Headings
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Nerve Degeneration, Rodents, Space perception
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Format
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Document (PDF)
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Title
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Evidence for the emergence of relative navigational responding in male C57BL/6J mice in a land-based task.
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Creator
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Lora, Joan C., Stackman, Robert W., Graduate College
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Abstract/Description
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We recently reported that male C57BL/6J mice navigate in spatial tasks, such as the Morris water maze MWM, by swimming in a particular direction to a location relative to poolbased cues, rather than to an absolute location defined by room-based cues. Neural mechanisms supporting this bias in rodents for relative responding rather than absolute responding in spatial tasks are not yet understood. Anterior thalamic neurons discharge according to the current directional heading of the animal. The...
Show moreWe recently reported that male C57BL/6J mice navigate in spatial tasks, such as the Morris water maze MWM, by swimming in a particular direction to a location relative to poolbased cues, rather than to an absolute location defined by room-based cues. Neural mechanisms supporting this bias in rodents for relative responding rather than absolute responding in spatial tasks are not yet understood. Anterior thalamic neurons discharge according to the current directional heading of the animal. The contribution of head direction HD cell activity to navigation has been difficult to elucidate. Selective inactivation of anterior thalamic nuclei ATN by microinfusion of muscimol or fluorophore-conjugated muscimol caused a near complete shift in preference from relative to absolute responding. Interestingly, inactivation of the dorsal CA1 region of the hippocampus did not affect relative responding. A land based version of the MWM has been developed to permit the recording of anterior thalamic HD cells during spatial search behavior. These experiments have been conducted to further examine the contribution of the HD cell activity to relative responding during spatial navigation.
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Date Issued
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2014
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PURL
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http://purl.flvc.org/fau/fd/FA00005834
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Format
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Document (PDF)