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Title: Comparison of non-traditional intersection designs using microscopic simulation.
Creator: Chery, Steve, Graduate College
Date Issued: 2010-04-09
PURL: http://purl.flvc.org/fcla/dt/3176731
Format: Document (PDF)

Title: Comparison of Treatment Plans Calculated using Ray Tracing (RT) and Monte Carlo (MC) Algorithms for Lung Cancer Patients Having Undergone Radiotherapy with Cyberknife.
Creator: Pennington, Andreea, Selvaraj, Raj, Graduate College, Leventouri, Theodora, Kirkpatrick, Steven, Oliveira, Silvana
Abstract/Description: Purpose/ Objectives: The latest publications indicate that the Ray Tracing algorithm significantly overestimates the dose delivered as compared to the Monte Carlo MC algorithm. The purpose of this study is to quantify this overestimation and to identify significant correlations between the RT and MC calculated dose distributions.
Materials/Methods: Preliminary results are based on 50 preexisting RT algorithm dose optimization and calculation treatment plans prepared on the Multiplan treatment...
Show morePurpose/ Objectives: The latest publications indicate that the Ray Tracing algorithm significantly overestimates the dose delivered as compared to the Monte Carlo MC algorithm. The purpose of this study is to quantify this overestimation and to identify significant correlations between the RT and MC calculated dose distributions.
Materials/Methods: Preliminary results are based on 50 preexisting RT algorithm dose optimization and calculation treatment plans prepared on the Multiplan treatment planning system Accuray Inc., Sunnyvale, CA. The analysis will be expanded to include 100 plans. These plans are recalculated using the MC algorithm, with high resolution and 1 uncertainty. The geometry and number of beams for a given plan, as well as the number of monitor units, is constant for the calculations for both algorithms and normalized differences are compared.

Results: MC calculated doses were significantly smaller than RT doses. The D95 of the PTV was 27 lower for the MC calculation. The GTV and PTV mean coverage were 13 and 39 less for MC calculation. The first parameter of conformality, as defined as the ratio of the Prescription Isodose Volume to the PTV Volume was on average 1.18 for RT and 0.62 for MC. Maximum doses delivered to OARs was reduced in the MC plans. The correlation of the ratio of air in PTV to the PTV with the difference in PTV coverage had a coefficient of -0.54.

Conclusions: The preliminary results confirm that the RT algorithm significantly overestimates the dosages delivered confirming previous analyses.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005162
Format: Document (PDF)

Title: Comparison study between BrainLab and Eclipse for small cancer lesions.
Creator: Doozan, Brian, Leventouri, Theodora, Pella, Silvia, Graduate College
Abstract/Description: There are many available options today for treating small lesion cancer cells. Two of the most used options are the planning systems BrainLab and Eclipse. The main difference between the two is the algorithms that are used to calculate the dose distribution of external beam radiation therapy. BrainLab offers a Monte Carlo based algorithm while Eclipse utilizes the Anisotropic Analytical Algorithm. An investigative study on the quality of the planning system is done for cases in lung, head and...
Show moreThere are many available options today for treating small lesion cancer cells. Two of the most used options are the planning systems BrainLab and Eclipse. The main difference between the two is the algorithms that are used to calculate the dose distribution of external beam radiation therapy. BrainLab offers a Monte Carlo based algorithm while Eclipse utilizes the Anisotropic Analytical Algorithm. An investigative study on the quality of the planning system is done for cases in lung, head and neck and prostate. In particular, lung cases are highly heterogeneous which can lead to problems in the calculation. The ability to be able to plan on the best system for individual cases can lead to better and more consistent treatments for cancer patients.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005812
Format: Document (PDF)

Title: Computer based testing vs. paper and pencil testing.
Creator: Davis, Heather Arp, Graduate College
Date Issued: 2010-04-09
PURL: http://purl.flvc.org/fcla/dt/3176745
Format: Document (PDF)

Title: Computer-based interaction system for children with Asperger's Syndrome.
Creator: Amador, Francisco Javier, Graduate College
Date Issued: 2010-04-09
PURL: http://purl.flvc.org/fcla/dt/3176182
Format: Document (PDF)

Title: Connectivity and Plasticity of Mesophotic Corals in the Gulf of Mexico and Caribbean.
Creator: Studivan, Michael, Voss, Joshua, Graduate College
Abstract/Description: Coral reef ecosystems worldwide are threatened by disease, anthropogenic damage, and climate change. Recently mesophotic coral ecosystems MCEs have been discovered and characterized as continuations of shallow reefs below traditional SCUBA depths. Because MCEs appear to be sheltered from many of the stressors known to affect shallow reefs, Glynn 1996 originally proposed that deeper reefs may act as a refuge for coral species by providing larvae to nearby shallow reefs. My dissertation...
Show moreCoral reef ecosystems worldwide are threatened by disease, anthropogenic damage, and climate change. Recently mesophotic coral ecosystems MCEs have been discovered and characterized as continuations of shallow reefs below traditional SCUBA depths. Because MCEs appear to be sheltered from many of the stressors known to affect shallow reefs, Glynn 1996 originally proposed that deeper reefs may act as a refuge for coral species by providing larvae to nearby shallow reefs. My dissertation research will address key questions that underlie this theory and advance our knowledge of coral ecology and physiology at mesophotic depths. including: 1 How well are MCEs connected to shallow reefs, and 2 Can corals adapt their morphology and gene expression to match changing environmental stimuli? Microsatellite based analysis of genetic connectivity will be complemented by morphometric analyses of corallite phenotypic plasticity and gene expression profiling in the dominant coral species, Montastraea cavernosa. MCEs in the Flower Garden Banks and Pulley Ridge have been surveyed and sampled using both ROVs and technical diving in 2011-2013, with additional expeditions planned for 2014-2015. A reciprocal transplant experiment on Carrie Bow Cay, Belize will assess the physiological and morphological plasticity of M. cavernosa in shallow and mesophotic environments. This project will address the influences of both environment and genotype control on coral’s potentially plastic responses. Additionally, this research is designed to provide data for improved regional management of mesophotic coral reef ecosystems and to strengthen collaborative marine research through NOAA’s Cooperative Institute for Ocean Exploration, Research, and Technology CIOERT.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005168
Format: Document (PDF)

Title: Conserved toxin framework between cone snail and violet plant.
Creator: Hoggard, Mickelene F., Mari, Frank, Graduate College
Date Issued: 2013-04-12
PURL: http://purl.flvc.org/fcla/dt/3361932
Subject Headings: Conotoxins, Snails, Conus, Cyclotides, Viola tricolor
Format: Document (PDF)

Title: Control of RNA oxidation as a novel mechanism for preventing mitochondrial dysfunction.
Creator: Malla, Sulochan, Walker, Merritt, Graduate College, Li, Zhongwei
Abstract/Description: Mitochondria generate energy through oxidative phosphorylation in eukaryotic cell and produce large amount of reactive oxygen species ROS as byproducts during this process. In particular in mitochondria, oxidative modifications of biomolecules by ROS can cause their inactivation. The situation is exacerbated during oxidative stress when excessive amounts of ROS are produced. Oxidative damage of macromolecules causes mitochondrial dysfunction and eventually leads to numerous diseases such as...
Show moreMitochondria generate energy through oxidative phosphorylation in eukaryotic cell and produce large amount of reactive oxygen species ROS as byproducts during this process. In particular in mitochondria, oxidative modifications of biomolecules by ROS can cause their inactivation. The situation is exacerbated during oxidative stress when excessive amounts of ROS are produced. Oxidative damage of macromolecules causes mitochondrial dysfunction and eventually leads to numerous diseases such as cardiovascular and neural disorders. Although the deleterious effects of oxidized DNA, proteins and lipids have been extensively characterized, little is known about the potential causative effects of oxidized RNA. Here, we assessed RNA oxidation levels in the mitochondria and cytosol of cultured human cells, which was analyzed by using 8-hydroxyguanosine 8-oxo-G on the RNA as a marker for oxidative stress. Interestingly, our result revealed that 8-oxo-G levels of mitochondrial mt-RNA was relatively higher than that of cytosolic RNA suggesting that RNA is one of the contributing factors leading to mitochondrial dysfunction. To further evaluate the consequence of RNA oxidation, we will examine mitochondrial functionality, permeability, and cell viability to determine a correlation with the levels of 8-oxo-G in mt-RNA. We previously showed that human polynucleotide phosphorylase hPNPase, which mainly localizes to mitochondria and binds oxidized RNA with high affinity, reduces RNA oxidation and protects HeLa cell during oxidative stress. We intend to elucidate the potential role of hPNPase and its associated RNA helicase, hSUV3, in reducing mt-RNA oxidation which is of relevance to diseases associated with mitochondrial dysfunction.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005156
Format: Document (PDF)

Title: Cooperation in the midst of chaos: an examination of Colombia's civil-military relations and its effort in combating socio-political destabilization.
Creator: Schoonover, Harvey A., Graduate College
Date Issued: 2010-04-09
PURL: http://purl.flvc.org/fcla/dt/3176883
Format: Document (PDF)

Title: Core clock genes modulate the sleep-feeding axis.
Creator: Murphy, Keith Richard, Bruce, Kimberly, Dawson-Scully, Ken, Graduate College, Ja, William W.
Abstract/Description: Sleep and feeding are processes essential to nearly all complex organisms, impacting the behavioral output of an animal through homeostatic drive. In Drosophila melanogaster it has been shown that starvation leads to sleep suppression through the signaling of core clock proteins that regulate the animal circadian rhythm. Furthermore overexpression of short neuropeptide, a sleep-promoting inhibitory modulator, increases sleep in animals and alters feeding behavior. While these findings provide...
Show moreSleep and feeding are processes essential to nearly all complex organisms, impacting the behavioral output of an animal through homeostatic drive. In Drosophila melanogaster it has been shown that starvation leads to sleep suppression through the signaling of core clock proteins that regulate the animal circadian rhythm. Furthermore overexpression of short neuropeptide, a sleep-promoting inhibitory modulator, increases sleep in animals and alters feeding behavior. While these findings provide a framework of the interaction between the pressures to feed and sleep, they are bi-modal shifts, limiting the understanding of this relationship between to its extreme states. Using the Activity Recording CAFÉ ARC, a tool for measuring the sleep and feeding of individual flies, we tuned either behavior and observed corresponding effects. By shifting food concentrations we are able to control hunger state of an animal while recording its sleep and activity patterns. By coupling this system with a gentle air puff we were also able to control sleep while measuring feeding. We found that the hunger state of an animal had a direct effect on sleep and sleep consolidation. Conversely, we show that increasing sleep pressure led to increased feeding and reduced satiety as calculated through the animal’s prandial behavior. In addition, we show that the direct relationship of the sleep/feeding is disrupted by core clock gene mutations but not by secondary clock genes such as period. By use of the ARC and bi-directional perturbation, we provide a higher resolution understanding of the sleep-feeding axis.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005843
Format: Document (PDF)

Title: Cornoside A, a new monoterpenoid glucoside with an unusual skeleton from cornus controversa.
Creator: He, Yangqing, Peng, Jiangnan, Ma, Guoyi, Ma, Zhanying, West, Lyndon, Hamann, Mark T., Graduate College
Date Issued: 2012-03-30
PURL: http://purl.flvc.org/fcla/dt/3342376
Format: Document (PDF)

Title: Correcting diastolic dysfunction by Ca2+ desensitizing Troponin in restrictive cardiomyopathy mice.
Creator: Li, Yuejin, Graduate College
Date Issued: 2010-04-09
PURL: http://purl.flvc.org/fcla/dt/3176815
Format: Document (PDF)

Title: Corrosion initiation on corrosion resistant alloys via acceleration chloride transport.
Creator: Gutierrez, Francisco, Graduate College
Date Issued: 2013-04-12
PURL: http://purl.flvc.org/fcla/dt/3361305
Subject Headings: Corrosion resistant alloys, Corrosion, Corrosion and anti-corrosives--Testing
Format: Document (PDF)

Title: Corrosion Propagation in Dry-Cast Reinforced Concrete Pipes.
Creator: Weber, Brian W., Presuel-Moreno, Francisco, Graduate College
Abstract/Description: Dry-cast reinforced concrete pipes (D-C-RCP) have been used as drainage pipes by the Florida Department of Transportation and other DOTs in the United States. Corrosion of the steel reinforcement embedded in concrete is a major economic burden for bridges and other structures subjected to de-icing salts, or harsh marine environments. This study investigates the corrosion propagation of instrumented specimens obtained from segments of two types of D-CRCPs (Types F and C). The objectives of...
Show moreDry-cast reinforced concrete pipes (D-C-RCP) have been used as drainage pipes by the Florida Department of Transportation and other DOTs in the United States. Corrosion of the steel reinforcement embedded in concrete is a major economic burden for bridges and other structures subjected to de-icing salts, or harsh marine environments. This study investigates the corrosion propagation of instrumented specimens obtained from segments of two types of D-CRCPs (Types F and C). The objectives of this study are to better understand the mechanism of corrosion propagation in D-C-RCPs and to identify the factors that affect the corrosion propagation. Potential, depolarization, linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) measurements were carried out to monitor the corrosion condition and the mechanistic properties of the reinforcement. A galvanostatic approach was used to accelerate the chloride transport to the steel surface until corrosion initiated. Once the specimen was declared active, the electric field was suspended. For ~250 days, the corrosion was monitored in the laboratory environment. The specimens were then transferred to a high humidity chamber and anodically polarized with a galvanostat to accelerate the corrosion propagation. The specimens were disconnected every two weeks to perform depolarization, LPR and EIS measurements. In the high humidity environment, type F specimens are exhibiting a higher corrosion rate most likely due to the smaller concrete cover allowing the chlorides to reach the steel rebar surface quicker and reach a higher chloride concentration. Results will be compared with conventional gravimetric weight loss measurements.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA00005863
Format: Document (PDF)

Title: Corrosion propagation of dry-cast reinforced concrete pipes after initiation.
Creator: Balasubramanian, Hariharan, Graduate College
Date Issued: 2013-04-12
PURL: http://purl.flvc.org/fcla/dt/3361269
Subject Headings: Reinforced concrete, Corrosion, Drainage pipes
Format: Document (PDF)

Title: Covering Small Alternating Groups with Proper Subgroups.
Creator: Epstein, Michael, Kappe, Luise-Charlotte, Magliveras, Spyros S., Graduate College, Popova, Daniela
Abstract/Description: Any group with a finite noncyclic homomorphic image is a finite union of proper subgroups. Given such a group G, we define the covering number of G to be the least positive integer m such that G is the union of m proper subgroups. We present recent results on the determination of the covering numbers of the alternating groups on nine and eleven letters.
Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00005874
Format: Document (PDF)

Title: Crayfish (Procambarus spp.) sorting and density effects across a predator gradient.
Creator: Kellogg, Christopher M., Dorn, Nathan, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3165803
Subject Headings: Crayfish culture, Predation (Biology), Sunfishes
Format: Document (PDF)

Title: Critical pedagogy: an approach to professional development for holocaust education.
Creator: Shah, Rachayita, Wachtel, Julie, Gatens, Rose, Schoorman, Dilys, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3164691
Subject Headings: Critical pedagogy, Holocaust, Jewish (1939-1945) --Study and teaching, Teachers --Training of
Format: Document (PDF)

Title: Cross-modality correspondences are not an innate aspect of perception: synaesthesia emerges late in infancy.
Creator: Minar, Nicholas J., Graduate College
Date Issued: 2013-04-12
PURL: http://purl.flvc.org/fcla/dt/3361331
Subject Headings: Synesthesia, Lewkowicz, David J., Perception, Perception in infants
Format: Document (PDF)

$Crystal structure studies of cone snail shells by powder x-ray diffraction$

Title: Crystal structure studies of cone snail shells by powder x-ray diffraction.
Creator: Khanal, Suraj P., Kathriarachchi, Vindu, Kyriacou, Andreas, Leventouri, Theodora, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3165805
Subject Headings: Snails, Shells, X-rays --Diffraction
Format: Document (PDF)

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