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- Title
- Spectral decomposition of grid data.
- Creator
- Donovan, Andrew., Harriet L. Wilkes Honors College
- Abstract/Description
-
Spectral decomposition is a method of expressing functions as a harmonic series, and can be used for the simplification of complicated physical problems. This type of analysis requires knowledge of the function at all points on a circle or sphere. In problems where the function is known only at discreet points, regular intervals in a rectangular grid, for example, numerical methods must be employed to compute approximate coefficients for the harmonic expansion. In this paper, we investigate...
Show moreSpectral decomposition is a method of expressing functions as a harmonic series, and can be used for the simplification of complicated physical problems. This type of analysis requires knowledge of the function at all points on a circle or sphere. In problems where the function is known only at discreet points, regular intervals in a rectangular grid, for example, numerical methods must be employed to compute approximate coefficients for the harmonic expansion. In this paper, we investigate numerical methods for computing Fourier coefficients of a two dimensional function at a fixed radius, and spherical harmonic coefficients in three dimensions on a sphere of fixed radius.
Show less - Date Issued
- 2005
- PURL
- http://purl.flvc.org/FAU/11572
- Subject Headings
- Inverse problems (Differential equations), Boundary value problems, Differential equations, Partial, Mathematical physics, Harmonic analysis
- Format
- Document (PDF)
- Title
- SPREAD OF AN EXOTIC TRAPJAW ANT ANOCHETUS MAYRI IN SOUTH FLORIDA.
- Creator
- Bryant, Andrew M., Wetterer, James, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
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Anochetus mayri is a widespread New World species, ranging from South and Central America and the West Indies, north to Florida and the Bahamas. Published records of A. mayri outside of the tropics come from six sites in Florida and two in the Bahamas . The northernmost published record of A. mayri came from the Pine Jog Environmental Learning Center in West Palm Beach, Florida, collected in 2002 in pine and oak litter samples. I examined whether A. mayri was also present in surrounding areas...
Show moreAnochetus mayri is a widespread New World species, ranging from South and Central America and the West Indies, north to Florida and the Bahamas. Published records of A. mayri outside of the tropics come from six sites in Florida and two in the Bahamas . The northernmost published record of A. mayri came from the Pine Jog Environmental Learning Center in West Palm Beach, Florida, collected in 2002 in pine and oak litter samples. I examined whether A. mayri was also present in surrounding areas with similar environmental conditions. I found A. mayri in pine litter at other sites in Palm Beach County, but I did not find this species in similar habitats in Lee County. Additional unpublished records indicate that A. mayri is widespread in deep pine litter in Florida north to Indian River County and West to Highlands County.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00008
- Format
- Document (PDF)
- Title
- Spread of the Invasive Brown Basilisk, Basiliscus vittatus, in Florida.
- Creator
- Wallington, John, Wetterer, James, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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The brown basilisk, Basiliscus vittatus, is large lizard native to coastal lowlands from central Mexico to Ecuador. In 1976, this species was first discovered in southern Florida, and it has been spreading since. My thesis documents the spread of B. vittatus through southern Florida using published and unpublished records. I mapped a total of 545 records of B. vittatus in Florida: 73 from published records, 15 from my own observations, and 457 from photographs uploaded to iNaturalist....
Show moreThe brown basilisk, Basiliscus vittatus, is large lizard native to coastal lowlands from central Mexico to Ecuador. In 1976, this species was first discovered in southern Florida, and it has been spreading since. My thesis documents the spread of B. vittatus through southern Florida using published and unpublished records. I mapped a total of 545 records of B. vittatus in Florida: 73 from published records, 15 from my own observations, and 457 from photographs uploaded to iNaturalist. Published reports of B. vittatus have been reported from 11 Florida counties (Miami-Dade, Broward, Palm Beach, Martin, St. Lucie, Indian River, Monroe, Collier, Lee, Hendry, and Manatee). In addition, there have been additional unpublished photographic records uploaded to iNaturalist from two more counties (Pinellas and Brevard). These additions expand the known northern range of B. vittatus on both the East and West coasts of Florida.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00131
- Format
- Document (PDF)
- Title
- State-Level COVID-19 Vaccine Mandates: A Constitutional Analysis.
- Creator
- Moran, Hillary, Tunick, Mark, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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The coronavirus pandemic has upended our daily lives, especially regarding our civil liberties. With the development of a vaccine, many Americans are concerned about the possibility of vaccine mandates. Regardless of whether states should implement these mandates, the first question that needs to be answered is whether they can. Although the Supreme Court’s recent National Federation of Independent Business v. Department of Labor, Occupational Safety and Health Administration decision put an...
Show moreThe coronavirus pandemic has upended our daily lives, especially regarding our civil liberties. With the development of a vaccine, many Americans are concerned about the possibility of vaccine mandates. Regardless of whether states should implement these mandates, the first question that needs to be answered is whether they can. Although the Supreme Court’s recent National Federation of Independent Business v. Department of Labor, Occupational Safety and Health Administration decision put an end to a vaccine mandate implemented through OSHA’s workplace safety standards, the possibility of state level mandates remains. Although there have been legal challenges to localized mandates, it is clear from Jacobson v Massachusetts that state vaccine mandates are constitutional.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00209
- Format
- Document (PDF)
- Title
- Statistical Model for College Enrollment: Exaninatino of a Selective Liberal Arts College.
- Creator
- Howard, Tamara, Jakee, Keith, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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In this study, I use a logistic regression to model the probability of an admitted applicant either enrolling into the Harriet L. Wilkes Honors College of Florida Atlantic University or declining admission. This institution is a small, selective liberal arts college and the case study spans an eleven year period (from 1999 to 2009). To construct my model, I examine variables such as level of academic performance, personal characteristics, geographic proximity to the institution, amount of...
Show moreIn this study, I use a logistic regression to model the probability of an admitted applicant either enrolling into the Harriet L. Wilkes Honors College of Florida Atlantic University or declining admission. This institution is a small, selective liberal arts college and the case study spans an eleven year period (from 1999 to 2009). To construct my model, I examine variables such as level of academic performance, personal characteristics, geographic proximity to the institution, amount of financial aid offered, timing of admission decision, and contact with the college. I expect that students with the highest levels of academic performance, furthest distance from the college, and least amount of financial aid offered have a higher probability of declining admissions.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00003585
- Format
- Document (PDF)
- Title
- Status of the imperiled Gull-billed Tern in Florida.
- Creator
- Lucas, Stephanie N., Harriet L. Wilkes Honors College
- Abstract/Description
-
The Gull-billed Tern is a globally distributed species. Distribution in the United States is limited, however, with the majority of breeding birds being found in Texas. The remainder can be found scattered throughout the southeastern states. Florida has a mere 1.6% of the breeding birds in the U.S. This study has accumulated all breeding records of the Gull-billed Tern in Florida since 1973, and distribution trends were analyzed. Since 1973 the population of these birds has fluctuated widely...
Show moreThe Gull-billed Tern is a globally distributed species. Distribution in the United States is limited, however, with the majority of breeding birds being found in Texas. The remainder can be found scattered throughout the southeastern states. Florida has a mere 1.6% of the breeding birds in the U.S. This study has accumulated all breeding records of the Gull-billed Tern in Florida since 1973, and distribution trends were analyzed. Since 1973 the population of these birds has fluctuated widely and experienced an alarming decline of about "95% between 1975 and 1999" (Smith, in press.). I determined that the current status of this bird in Florida mandates that further conservation efforts occur rapidly in order to protect its diminishing population. This study examines those conservation measures already in place, and those pending, such as my petition to list this species as "threatened" under the endangered species provisions of the Florida Wildlife Code (Chap. 39 F.A.C.).
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/FAU/77675
- Subject Headings
- Gull-billed Tern, Reproduction, Birds, Wildlife conservation, Endangered species
- Format
- Document (PDF)
- Title
- STEPS TOWARD A MARXIST HUMANISM.
- Creator
- Locop, John, Baima, Nicholas, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
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The historical connections between Marxism and humanism are diverse and at times, contradictory. Contemporary debates within the Marxist tradition continue to revolve around questions regarding the proper attitude toward humanism and its universalizing implications. To state the problem as a question, “If a Marxist Humanism is possible, with what problems, convictions, concepts etc. should one be concerned in order to create a Marxist Humanist project?” This thesis draws out problems and...
Show moreThe historical connections between Marxism and humanism are diverse and at times, contradictory. Contemporary debates within the Marxist tradition continue to revolve around questions regarding the proper attitude toward humanism and its universalizing implications. To state the problem as a question, “If a Marxist Humanism is possible, with what problems, convictions, concepts etc. should one be concerned in order to create a Marxist Humanist project?” This thesis draws out problems and solutions raised by different trends in the history of Marxist thought which attempt to deal with humanism in order to propose a few steps forward for Marxist Humanism.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00085
- Format
- Document (PDF)
- Title
- Stinging Ants at Gopher Tortoise Burrows.
- Creator
- Viluan, Valerie, Wetterer, James, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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Several predatory ant species are known to attack, injure, and even kill vertebrates. Perhaps the most notorious of these are the red imported fire ant, Solenopsis invicta and the little fire ant, Wasmannia auropunctata. In areas where they invade, both are most common in disturbed habitats. Solenopsis invicta often dominates open, grassy areas, while Wasmannia auropunctata more often dominates in forested areas. This study compares the distribution of ant species, including Solenopsis...
Show moreSeveral predatory ant species are known to attack, injure, and even kill vertebrates. Perhaps the most notorious of these are the red imported fire ant, Solenopsis invicta and the little fire ant, Wasmannia auropunctata. In areas where they invade, both are most common in disturbed habitats. Solenopsis invicta often dominates open, grassy areas, while Wasmannia auropunctata more often dominates in forested areas. This study compares the distribution of ant species, including Solenopsis invicta and Wasmannia auropunctata at the burrows of Gopher Tortoises at the Abacoa Greenway located in Jupiter, Florida. Wasmannia auropunctata replaced Solenopsis invicta as the dominating species at our study site in 2021, compared to the results gathered by Rich Jones in 2013. Although both species are not selective with their targets, this shift in pattern could result in a difference of injuries to the Greenway’s inhabitants and should be considered a potential threat in future wildlife schemes.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00163
- Format
- Document (PDF)
- Title
- STRANGE FREQUENCIES: DEVELOPMENT OF A POST-HUMAN SEQUENTIAL NARRATIVE.
- Creator
- Young, Jessica E., Luria, Rachel, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Posthumanism embodies a wide-ranging scope of philosophies, including works of transhumanism dealing with cybernetics or androids. Few works treat advanced technological developments like A.I. and androids as equal to, or companions to humanity. Despite the potential for future technology to be equally as intelligent as humans, there remains a limited number of stories treating android or A.I. characters as main characters and narrative lenses. This project grapples with questions of humanity...
Show morePosthumanism embodies a wide-ranging scope of philosophies, including works of transhumanism dealing with cybernetics or androids. Few works treat advanced technological developments like A.I. and androids as equal to, or companions to humanity. Despite the potential for future technology to be equally as intelligent as humans, there remains a limited number of stories treating android or A.I. characters as main characters and narrative lenses. This project grapples with questions of humanity, spirituality, and environment through sequential storytelling using an android protagonist. This adds critical reflection to the body of posthumanist works by serving as one of a few stories where the main character is not human, and the world is after the time of humankind. Instead of encapsulating a purely entertaining story of science fiction, this work delves into ideas of rapid environmental degradation and ever-evolving levels and functions of technology in our world and our near future.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00237
- Format
- Document (PDF)
- Title
- STRESS-REGULATING PATHWAYS INTERACT WITH SLEEP-REGULATING PATHWAYS UNDER SLEEP DEPRIVED CONDITIONS.
- Creator
- Almeida, Ghabrielle Zepeda Almeida, Duboué, Erik R., Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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Sleep deprivation (SD) is an extremely common problem worldwide. SD is correlated with various psychological and physiological consequences, such as mood instability or somatic pain, and it has also been linked to increased stress. While the relationship between stress and SD is well-studied, little is known about the neuronal mechanism underlying this relationship. Sleep-regulating (SL) pathways and stress-regulating (ST) pathways are both modulated by the circadian rhythm, and there are...
Show moreSleep deprivation (SD) is an extremely common problem worldwide. SD is correlated with various psychological and physiological consequences, such as mood instability or somatic pain, and it has also been linked to increased stress. While the relationship between stress and SD is well-studied, little is known about the neuronal mechanism underlying this relationship. Sleep-regulating (SL) pathways and stress-regulating (ST) pathways are both modulated by the circadian rhythm, and there are interactions between the two—some regions that contribute to sleep regulation also contribute to stress regulation. Sleep inhibits the activation of the HPA-axis, an ST system. SD results in a disruption in the SL systems, which subsequently disrupts ST systems. Three mechanisms underlying how SD leads to increased stress includes: 1. decreased inhibition of the HPA-axis, 2. ultradian rhythm dysregulation resulting in dysregulated stress response and 3. activation of other stress-responding regions.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00185
- Format
- Document (PDF)
- Title
- Studies towards synthesis of paraconic acids.
- Creator
- Soto, Karenia, Dragojlovic, Veljko, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
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Paraconic acids are naturally occurring compounds synthesized by bacteria and fungi. They are known for having antitumor and antibiotic properties. By use of a phasevanishing (PV) halolactonization with PTFE (Teflon) as a phase screen, we were able to synthesize precursors to these compounds. The PV-PTFE halolactonization of alkenoic acids with iodine monochloride gave the corresponding iodolactones, while halolactonization with bromine gave the corresponding bromolactone. Halolactonization...
Show moreParaconic acids are naturally occurring compounds synthesized by bacteria and fungi. They are known for having antitumor and antibiotic properties. By use of a phasevanishing (PV) halolactonization with PTFE (Teflon) as a phase screen, we were able to synthesize precursors to these compounds. The PV-PTFE halolactonization of alkenoic acids with iodine monochloride gave the corresponding iodolactones, while halolactonization with bromine gave the corresponding bromolactone. Halolactonization of 4-pentenoic acid with water as a solvent also gave good results. Future experiments will explore the synthesis of further precursors by means of a photolytic carbonylation of iodolactone and a phenylation-ruthenium tetroxide oxidation sequence.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00003607
- Format
- Document (PDF)
- Title
- Study of controlled burn effects on Avian population and diversity in Jonathan Dickinson State Park.
- Creator
- Shattow, Katherine, Moore, Jon, Harriet L. Wilkes Honors College
- Abstract/Description
-
This study examines the effects of controlled burning on avian population and diversity in various habitats at Jonathan Dickinson State Park. My hypothesis was that areas more recently burned would have both greater avian population and diversity than areas burned longer ago.
- Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003534
- Format
- Document (PDF)
- Title
- Summary of SARS-CoV-2 Variants and Omicron’s Evolution.
- Creator
- Freedman, Brandon, Mincer, Tracy, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
SARS-CoV-2, commonly referred to by the disease it causes, COVID-19, took the world by surprise in late 2019 and triggered a multi-year-long pandemic. Helped by its initial airborne infectivity, the virus accumulated mutations causing the disease to become even more infectious and lethal. This led to variants that struck the globe in waves, outcompeting their predecessors and leading to yet more mutations. However, this trend ended with the emergence of Omicron, the present dominant variant,...
Show moreSARS-CoV-2, commonly referred to by the disease it causes, COVID-19, took the world by surprise in late 2019 and triggered a multi-year-long pandemic. Helped by its initial airborne infectivity, the virus accumulated mutations causing the disease to become even more infectious and lethal. This led to variants that struck the globe in waves, outcompeting their predecessors and leading to yet more mutations. However, this trend ended with the emergence of Omicron, the present dominant variant, which exhibits greater infectivity but lessened lethality. Notably, the same mutations have repeatedly emerged, evolving from independent lineages all around the planet. This paper aims to identify and compare these mutations, and evaluate their influence on the variants that they inhabit. Using this information, this paper predicts characteristics of future SARS-CoV-2 variants by speculating what changes Omicron may undergo.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00231
- Format
- Document (PDF)
- Title
- SUPERMODEL OF THE WORLD: HOW RUPAUL AND RUPAUL’S DRAG RACE FORGED A QUEER PERFORMANCE EMPIRE.
- Creator
- McNeill, Michael, Nur-tegin, Kanybek, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
The art of drag, once looked down upon in society and criminalized for many years, has seen a recent surge in popularity and become celebrated and welcomed internationally. RuPaul and their Emmy-award-winning television franchise RuPaul’s Drag Race have created a whole new industry and career path for what was once seen as a menace to society and unwanted for its challenges against cis-gendered and heterosexual norms. Changing the media industry and political landscape for LGBTQ+ people,...
Show moreThe art of drag, once looked down upon in society and criminalized for many years, has seen a recent surge in popularity and become celebrated and welcomed internationally. RuPaul and their Emmy-award-winning television franchise RuPaul’s Drag Race have created a whole new industry and career path for what was once seen as a menace to society and unwanted for its challenges against cis-gendered and heterosexual norms. Changing the media industry and political landscape for LGBTQ+ people, RuPaul and their show have positively uplifted queer performers by providing a platform to show off their talents and opportunities to make money they otherwise wouldn’t have been able to. Despite the backlash from non-supporters, queens have been able to turn their television fame into large fanbases, international spin-offs, and financially successful cosmetic, media, and hospitality industries.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00264
- Format
- Document (PDF)
- Title
- SUPRESSING IGF-R1 SIGNALING PATHWAY RESCUES NEURONAL OVERGROWTH OF PTEN +/- MICE.
- Creator
- Laffita, Dalina, Earles, Julie L., Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
-
Macrocephaly is a well-replicated phenotype in a subset of individuals with autism spectrum disorder (ASD). Heterozygous mutation in PTEN, which encode a negative regulator of the PI3K-mTR signaling pathway, causes the macrocephaly/autism syndrome. Mice with germline heterozygous Pten deletion (Pten+/-) exhibit both brain overgrowth and social behavioral deficits. Here, we showed that reduction of Igf-1 receptor (Igf-1r), which is an upstream receptor of PI3K-mTOR pathway, in Pten+/- mice...
Show moreMacrocephaly is a well-replicated phenotype in a subset of individuals with autism spectrum disorder (ASD). Heterozygous mutation in PTEN, which encode a negative regulator of the PI3K-mTR signaling pathway, causes the macrocephaly/autism syndrome. Mice with germline heterozygous Pten deletion (Pten+/-) exhibit both brain overgrowth and social behavioral deficits. Here, we showed that reduction of Igf-1 receptor (Igf-1r), which is an upstream receptor of PI3K-mTOR pathway, in Pten+/- mice rescues the neuronal overgrowth of cortical layer V neurons, which is associated with social behavior deficits shown in the Pten+/- mice. These are promising results shows that a pharmacological agent, one that blocks Igf1r, could recover the damage done by the Pten mutation. However, the pathway being targeted is a cellular pathway within the brain and any potential pharmacological agent must be able to cross the blood brain barrier, and must alter the pathway within the brain and not influence other pathways within the system.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00026
- Format
- Document (PDF)
- Title
- SYNESTHESIA AND THIN BOUNDARIES OF THE MIND.
- Creator
- Mayernik, Samantha M., Lanning, Kevin, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
-
Synesthesia is a phenomenon in which the lines between senses are blurred, suggesting permeable boundaries in the mind. This notion of boundary permeability is inherently linked with Openness to Experience, one of the Big Five personality traits. Conversely, some people are characterized by heavy boundaries and thus a lack of Openness. Since the 1930s, the relationship between Openness and boundaries has been important in political psychology, as previous research has established that...
Show moreSynesthesia is a phenomenon in which the lines between senses are blurred, suggesting permeable boundaries in the mind. This notion of boundary permeability is inherently linked with Openness to Experience, one of the Big Five personality traits. Conversely, some people are characterized by heavy boundaries and thus a lack of Openness. Since the 1930s, the relationship between Openness and boundaries has been important in political psychology, as previous research has established that conservatives tend to be low in Openness, while the opposite is true for liberals. Authoritarianism can be seen as the embodiment of a mind with thick boundaries, while the most pure example of a thin-bounded mind would be synesthesia. I perform a text analysis of Reddit comments made by 117 self-reported synesthetes and compare their responses to the Openness category of the Linguistic Inquiry and Word Count (LIWC), to examine whether synesthesia correlates with Openness.
Show less - Date Issued
- 2020
- PURL
- http://purl.flvc.org/fau/fd/FA00013662
- Format
- Document (PDF)
- Title
- SynGAP1 Haploinsufficiency affects neuronal structure and development in mouse models.
- Creator
- McGuire, Megan, Dragojlovic, Veljko, Harriet L. Wilkes Honors College
- Abstract/Description
-
Intellectual Disability (ID) is an increasingly common neurological disorder that causes intellectual deficients in cognition and behavior and is scientifically diagnosed by an intelligence score (IQ) under 70 along with the presence of two or more associated behaviors. A recent study showed that sporadic ID in humans was correlated with autosomal dominant de novo mutations in SynGap1.
- Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003525
- Format
- Document (PDF)
- Title
- Synthesis and reactivity of organometallic complexes of iridium and iron in aqueous and basic media.
- Creator
- Webster-Gardiner, Michael, Smith, Eugene, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
The catalytic activation of C-H bonds and the subsequent functionalization of hydrocarbons into heteroatom containing products is an area of fundamental importance in chemistry. Three different iridium pincer complexes for C-H activation were synthesized, IrCl3NNN, IrCl3NNN methyl, IrCl3NNNN (NNN= bis-((benzoimidazol))amine), (NNNmethyl = bis-(benzoimidazol)methyl)amine), and (NNNN = tris-((benzoimidazol))amine). These complexes were analyzed for C-H activation between benzoic acid and KOD...
Show moreThe catalytic activation of C-H bonds and the subsequent functionalization of hydrocarbons into heteroatom containing products is an area of fundamental importance in chemistry. Three different iridium pincer complexes for C-H activation were synthesized, IrCl3NNN, IrCl3NNN methyl, IrCl3NNNN (NNN= bis-((benzoimidazol))amine), (NNNmethyl = bis-(benzoimidazol)methyl)amine), and (NNNN = tris-((benzoimidazol))amine). These complexes were analyzed for C-H activation between benzoic acid and KOD/D2O solutions. We found that the C-H activation did not proceed catalytically. Also iron containing derivatives containing similar ligand motifs were synthesized , FeCl3NNNN, FeCl3IPI, FeCl3BPB, FeCl3BPB-OH (IPI = 2,6-diimidizoylpyridine, BPB = 2,6-dibenzoimidizoylpyridine, BPB-OH = 4-hydoxy-2,6,dibenzoimidizoylpyridine) and studied for their reactivity towards C-H bonds, O2 and N2 in aqueous basic media. The iron complexes were analyzed for the possibility of using them as O-atom or N-atom transfer reagents for hydrocarbon oxidation. Preliminary results suggest that upon reduction the iron complexes are capable of direct reaction with O2 and N2.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00003609_0
- Format
- Document (PDF)
- Title
- Synthesis of Flosal.
- Creator
- Brettler, Steven, Dragojlovic, Veljko, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
-
Flosal (Jasmonal, Jasmine Aldehyde, (E)-2-benzylideneheptanal) is an important commercial fragrance compound. The principal method for its preparation involves a crossed aldol condensation reaction of heptanal and benzaldehyde. The method has a serious drawback as the synthesis of jasmine aldehyde is accompanied by self-condensation of heptanal to produce foul-smelling 2-pentyl-2-nonenal. We optimized the reaction conditions to maximize yield of jasmine aldehyde while preventing formation of...
Show moreFlosal (Jasmonal, Jasmine Aldehyde, (E)-2-benzylideneheptanal) is an important commercial fragrance compound. The principal method for its preparation involves a crossed aldol condensation reaction of heptanal and benzaldehyde. The method has a serious drawback as the synthesis of jasmine aldehyde is accompanied by self-condensation of heptanal to produce foul-smelling 2-pentyl-2-nonenal. We optimized the reaction conditions to maximize yield of jasmine aldehyde while preventing formation of 2-pentyl-2-nonenal. The desired product was obtained in ~60% yield, with a room for future improvement.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00013638
- Format
- Document (PDF)
- Title
- SYNTHESIS OF FMOC-GLY-VAL PHOSPHINIC PSEUDODIPEPTIDE BUILDING BLOCK FOR PRODUCTION OF TRIPLE-HELICAL PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASE-2 AND -9.
- Creator
- Deutsch, Michael H., Fields, Gregg B., Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Capable of reshaping the extracellular matrix, matrix metalloproteinases (MMPs) are of enormous consequence to human health. The pathologies of cancers and diseases of the skeletal, central nervous, and cardiovascular systems often owe to the overactivity of MMPs. While efforts to produce therapeutic inhibitors have been largely unsuccessful, triple-helical peptide inhibitors (THPIs) of MMPs show tremendous potential. The synthesis of phosphinic pseudodipeptide building blocks needed for...
Show moreCapable of reshaping the extracellular matrix, matrix metalloproteinases (MMPs) are of enormous consequence to human health. The pathologies of cancers and diseases of the skeletal, central nervous, and cardiovascular systems often owe to the overactivity of MMPs. While efforts to produce therapeutic inhibitors have been largely unsuccessful, triple-helical peptide inhibitors (THPIs) of MMPs show tremendous potential. The synthesis of phosphinic pseudodipeptide building blocks needed for THPIs is entirely replicable and convenient. Here we replicate a crucial step in the synthesis, the cascade bis-deprotection, and formation of Fmoc-amine. The procedure’s feasibility is demonstrated through a 77% yield of the Fmoc-Gly-Val phosphinic pseudodipeptide building block to be incorporated into THPIs of the gelatinases. In the future, it is hoped that such procedures will culminate in large-scale production of refined THPIs, enabling in-depth biochemical studies, further optimization, clinical trials, and novel therapeutics.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00194
- Format
- Document (PDF)