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Title: Dynactin is a processivity factor for dynein in vivo.
Creator: Fulton, Edward., Harriet L. Wilkes Honors College
Abstract/Description: Dynein is a motor protein responsible for microtubule-based minus-end directed trafficking in eukaryotic cells. Dynactin is a protein complex involved in mitosis, embryonic development, intracellular trafficking and anchoring microtubules at the centrosome. While dynactin is widely recognized to improve the array of cargo with which dynein can associate, there has been some dispute over whether dynactin, which binds both dynein and microtubules, improves the distance that dynein can travel...
Show moreDynein is a motor protein responsible for microtubule-based minus-end directed trafficking in eukaryotic cells. Dynactin is a protein complex involved in mitosis, embryonic development, intracellular trafficking and anchoring microtubules at the centrosome. While dynactin is widely recognized to improve the array of cargo with which dynein can associate, there has been some dispute over whether dynactin, which binds both dynein and microtubules, improves the distance that dynein can travel processively in the act of cargo trafficking before it dissociates from its microtubule. In this study, we compare movement parameters of wild type dynein-based vesicle movements with movements in cells where expression of dynactin's microtubule binding subunit, p150glued, has been knocked down. We find that dynactin does act as a processivity factor for dynein by increasing the distance that dynein can travel smoothly in a single movement event, but does not increase dynein's velocity.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209990
Subject Headings: Cell organelles, Formation, Microtubules, Cytoskeletal proteins, Molecular biology
Format: Document (PDF)

Title: Jury decision-making: a study of the influence of sentencing information on jurors.
Creator: Hackett, Steven., Harriet L. Wilkes Honors College
Abstract/Description: This thesis is a study of the empirical significance of sentencing information on jury decision-making. A challenge in conducting jury behavior research is that direct observation of jury deliberation is either illegal or impractical. Thus most studies of jury behavior are conducted using archival analysis and mock jury questionnaires. And while we have some information on the issue of jury instruction complexity on jury decision-making, we know very little about the specific role of...
Show moreThis thesis is a study of the empirical significance of sentencing information on jury decision-making. A challenge in conducting jury behavior research is that direct observation of jury deliberation is either illegal or impractical. Thus most studies of jury behavior are conducted using archival analysis and mock jury questionnaires. And while we have some information on the issue of jury instruction complexity on jury decision-making, we know very little about the specific role of sentencing information on jury decision-making. My research combines aspects of the jury decision-making literature with the sentencing literature, and thus fills a crucial gap in the literature. While we know much about jury decision-making and much about the process of sentencing--this research directly tested whether these two phenomena are related. Mock trials of 100 participants were used to collect the data for this thesis study. The results provide clear evidence that there is a significant effect on jury decision-making when the jurors are provided with sentencing information.
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Date Issued: 2008
PURL: http://purl.flvc.org/FAU/209991
Subject Headings: Sentences (Criminal procedure), Justice, Administration of, Decision making, Judicial discretion, Verdicts, Psychological aspects
Format: Document (PDF)

Title: Help or hype?: the role of Internet marketing in rural development strategies.
Creator: Klaas, Kathryn, Harriet L. Wilkes Honors College
Abstract/Description: International development literature suggests that Internet marketing has the potential to play an important role in rural development. Despite the abundant theoretical support for incorporating Internet marketing into development strategies, there is little empirical evidence regarding whether Internet marketing actually generates development. This thesis helps fill this gap in the literature by investigating whether one Internet marketing application associated with development, competitive...
Show moreInternational development literature suggests that Internet marketing has the potential to play an important role in rural development. Despite the abundant theoretical support for incorporating Internet marketing into development strategies, there is little empirical evidence regarding whether Internet marketing actually generates development. This thesis helps fill this gap in the literature by investigating whether one Internet marketing application associated with development, competitive-online auctions (COAs), contributes to growth and poverty reduction. An analysis of price premiums earned in Latin American specialty coffee auctions and interviews with participating coffee farmers suggest that this application's strength lies in its ability to catalyze development; it provides the foundation from which farmers can pursue above-market prices, access new markets, and improve local living conditions. However, evidence also emphasizes that COAs do not inevitably advance development goals because their ability to do so is contingent on external factors, including the actions taken by individual farmers.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209992
Subject Headings: Internet marketing, Small business, Computer network resources, Developmental economics, Rural development, Information technology, Economic aspects
Format: Document (PDF)

Title: The activism of the Catholic Church on immigrants' rights in the United States: testing the religious economy model.
Creator: Lazo de la Vega, Sandra, Harriet L. Wilkes Honors College
Abstract/Description: This paper tests the religious economy model for predicting Church behavior which predicts that religious firms will become more politically active on behalf of potential members in areas where competition for those members is most fierce. An analysis of data from a survey of 106 U.S. Catholic dioceses and archdioceses on outreach to Hispanic immigrants does not support this hypothesis. Religious competition and Church activism on immigration issues did not correlate. Rather, demand for...
Show moreThis paper tests the religious economy model for predicting Church behavior which predicts that religious firms will become more politically active on behalf of potential members in areas where competition for those members is most fierce. An analysis of data from a survey of 106 U.S. Catholic dioceses and archdioceses on outreach to Hispanic immigrants does not support this hypothesis. Religious competition and Church activism on immigration issues did not correlate. Rather, demand for services (measured as Hispanic presence within each diocese) was a better predictor of Church activism on immigration issues. This finding suggests that the "inelastic demand" assumption of the religious economy model must be dropped, re-opening demand side explanations for Church behavior across national and local contexts.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209993, http://purl.flvc.org/fau/fd/FADT209993
Subject Headings: Church work with immigrants, Progressivism (United States politics), Immigrants, Religious life, Immigrants, Social conditions, Emigration and immigration, Religious aspects
Format: Document (PDF)

Title: Construction of mitochondrion-targeted telomerase for analysis in Saccharomyces cerevisiae.
Creator: Martin, Ricardo., Harriet L. Wilkes Honors College
Abstract/Description: Telomerase is associated with telomere production and nDNA protection. However, studies by Santos et al. have demonstrated that human telomerase has a mitochondrial entry sequence and in the presence of hydrogen peroxide it has been found inside the mitochondrion and may cause mitochondrial DNA mutations. Saccharomyces cerevisiae contains telomerase, but it does not have the mitochondrial entry sequence. To determine if the presence of telomerase in the mitochondria can induce mutations an...
Show moreTelomerase is associated with telomere production and nDNA protection. However, studies by Santos et al. have demonstrated that human telomerase has a mitochondrial entry sequence and in the presence of hydrogen peroxide it has been found inside the mitochondrion and may cause mitochondrial DNA mutations. Saccharomyces cerevisiae contains telomerase, but it does not have the mitochondrial entry sequence. To determine if the presence of telomerase in the mitochondria can induce mutations an experiment was developed in which a mitochondrion entry sequence would be fused to the S. cerevisiae telomerase enzyme. This fusion could then be screened in S. cerevisiae with an ade2 mutation for a simple color assay of mitochondrial activity. To date, no successful transformant has been identified. The frequency of incorrect ligations has been recognized and may indicate that the desired fusion is lethal to E. coli cells.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209994
Subject Headings: Cell membranes, Formation, Mitochondrial DNA, Mutation (Biology), Cell metabolism
Format: Document (PDF)

Title: Caught red-handed, but not guilty: the entrapment defense and culpability.
Creator: Mockler, Katherine L., Harriet L. Wilkes Honors College
Abstract/Description: There is a debate among scholars regarding how courts should judge defendants caught in government decoy and sting operations. As a retributivist, I believe we should only punish those who are culpable. Following this assumption, I argue that courts should punish entrapped people if they are culpable and that the subjective test, which holds that a defendant is culpable if he was predisposed to commit the crime, should be the standard by which courts judge defendants who claim entrapment. The...
Show moreThere is a debate among scholars regarding how courts should judge defendants caught in government decoy and sting operations. As a retributivist, I believe we should only punish those who are culpable. Following this assumption, I argue that courts should punish entrapped people if they are culpable and that the subjective test, which holds that a defendant is culpable if he was predisposed to commit the crime, should be the standard by which courts judge defendants who claim entrapment. The objective test, which focuses on the propriety of the government conduct, fails to accurately assess culpability because, under this test, the guilt of the defendant depends largely on what the average person would have done under the same circumstances. I also propose that if government conduct reached the level of outrageous, defendants found to be predisposed may claim that the government violated their right to due process.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209995
Subject Headings: Undercover operations, Government investigations, Criminal justice, Administration of, Entrapment (Criminal law)
Format: Document (PDF)

Title: Alternate applications of anticancer drugs on COS-7 normal cells.
Creator: Morris, Deborah., Harriet L. Wilkes Honors College
Abstract/Description: Anticancer drugs, including nocodazole and vinblastine, work by disrupting the dynamics of microtubules. Unfortunately, these drugs often produce numerous side effects, including nausea, vomiting, loss of appetite, loss of hair, increased chance of infection, and fatigue. My thesis research evaluated the efficacy of using repeated low doses of microtubule drugs instead of a single high dose, in an attempt to minimize side effects. Using nocodazole and vinblastine, I first established the...
Show moreAnticancer drugs, including nocodazole and vinblastine, work by disrupting the dynamics of microtubules. Unfortunately, these drugs often produce numerous side effects, including nausea, vomiting, loss of appetite, loss of hair, increased chance of infection, and fatigue. My thesis research evaluated the efficacy of using repeated low doses of microtubule drugs instead of a single high dose, in an attempt to minimize side effects. Using nocodazole and vinblastine, I first established the minimum effective concentration that disrupts the microtubules in normal human cells grown in vitro and treated cells with those concentrations over a period of several days. I found that microtubules were increasingly depolymerized as the days progressed. Next, I tested a combination of nocodazole and vinblastine at low concentrations.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209996
Subject Headings: Cancer cells, Growth, Regulation, Antineoplastic agents, Physiological effect, Cell cycle, Effect of drugs on, Cancer, Chemotherapy
Format: Document (PDF)

Title: Before and after NAGPRA: the effect of the Native American Graves Protection and Repatriation Act on archaeological practices in the United States.
Creator: Ray, Laura., Harriet L. Wilkes Honors College
Abstract/Description: The Native American Graves Protection and Repatriation Act (NAGPRA) was approved by Congress on November 16, 1990 after years of American Indian lobbying due to the unfair treatment of American Indian remains. Since the enactment of NAGPRA there have been multiple complaints from the archaeological community that the way in which they conduct their jobs has been severely limited by the implementation of NAGPRA. In this study I compare data from the Secretary's Report to Congress questionnaire...
Show moreThe Native American Graves Protection and Repatriation Act (NAGPRA) was approved by Congress on November 16, 1990 after years of American Indian lobbying due to the unfair treatment of American Indian remains. Since the enactment of NAGPRA there have been multiple complaints from the archaeological community that the way in which they conduct their jobs has been severely limited by the implementation of NAGPRA. In this study I compare data from the Secretary's Report to Congress questionnaire, conducted by the National Park Service's Federal Archaeology Program, to determine whether NAGPRA has caused an increase or decrease in the amount of archaeological administrative, laboratory, and fieldwork completed between 1985 and 2005. The comparison shows that there was a significant increase in specific archaeological practices in the years following the implementation of NAGPRA. Looking at the changes in work patterns of archaeologists allows us to assess the success of NAGPRA and it provides empirical evidence to evaluate the claims made by parties affected by the act.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209997
Subject Headings: Archaeology, Moral and ethical aspects, Indians of North America, Antiquities, Law and legislation, Cultural property, Repatriation, Philosophy, Cultural property, Government policy, Anthropological ethics
Format: Document (PDF)

Title: Knockdown of dynactin's p150[Glued] subunit abrogates microtubule organization.
Creator: Roeckner, Jared Todd., Harriet L. Wilkes Honors College
Abstract/Description: Dynactin is a multifunctional protein complex composed of at least 11 different subunits. Dynactin functions as a cofactor for cytoplasmic dynein facilitating long-range vesicle movements, microtubule anchoring, endomembrane localization, and mitotic progression. Previous studies have shown that dynactin binds to microtubules at the centrosome maintaining a radial array in interphase. The p150Glued subunit contains two distinct microtubule-binding sequences named CAP-Gly and Basic. While both...
Show moreDynactin is a multifunctional protein complex composed of at least 11 different subunits. Dynactin functions as a cofactor for cytoplasmic dynein facilitating long-range vesicle movements, microtubule anchoring, endomembrane localization, and mitotic progression. Previous studies have shown that dynactin binds to microtubules at the centrosome maintaining a radial array in interphase. The p150Glued subunit contains two distinct microtubule-binding sequences named CAP-Gly and Basic. While both domains can interact with microtubule, CAP-Gly has a much greater affinity for binding to microtubules, suggesting that the two domains may be active for different dynactin-based functions within the cell. Using siRNA, we found that knockdown of p150Glued was sufficient to alter the maintenance of radial microtubule arrays, cause an increase in centrosome number and mitotic index. In the future we will replace the endogenous protein with versions lacking the CAP-Gly or Basic domains to investigate the contribution of each to microtubule anchoring and cytoskeletal architecture.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209998
Subject Headings: Cytoskeletal proteins, Cell organelles, Formation, Microtubules, Molecular biology
Format: Document (PDF)

Title: Satan's imprisoning words: examining the value of language in John Milton's Paradise Lost.
Creator: Ryan, Victoria., Harriet L. Wilkes Honors College
Abstract/Description: Through a critique of Satan's misuse of language, John Milton's Paradise Lost makes the greater argument that language should coincide with God's creation narrative. The poem proposes a theory of how language should be used: to connect the mutable world of humans to the immutable world of God. I propose that Milton uses Satan to portray both a fear and a faith in the power of language. Satan makes language the accomplice to his sin, attempting to use language, which has the power of creating...
Show moreThrough a critique of Satan's misuse of language, John Milton's Paradise Lost makes the greater argument that language should coincide with God's creation narrative. The poem proposes a theory of how language should be used: to connect the mutable world of humans to the immutable world of God. I propose that Milton uses Satan to portray both a fear and a faith in the power of language. Satan makes language the accomplice to his sin, attempting to use language, which has the power of creating a world that seems true, to replace God's Truth. Milton's poem neither solely endorses the theory that language points directly to absolute Truth, nor does it endorse the theory that language is an arbitrary system of signs which impose meaning the world. Milton blends these two theories of language, connecting the Idealist system to what will be Friedrich Nietzsche's.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/209999
Subject Headings: Criticism and interpretation, Language, Devil in literature, Narration (Rhetoric)
Format: Document (PDF)

Title: The Tolan Committee and the internment of Japanese Americans.
Creator: Saccento, Matthew., Harriet L. Wilkes Honors College
Abstract/Description: Within three months of the Japanese attack on Pearl Harbor, President Franklin Roosevelt issued Executive Order 9066, which allowed military commanders to establish zones of military importance within which they could remove any person considered dangerous, specifically those of Japanese descent. The Tolan Committee, a House committee examining the logistics of the new wartime economy, was immediately sent to the West Coast in order to evaluate the merit of the President's policy. They were...
Show moreWithin three months of the Japanese attack on Pearl Harbor, President Franklin Roosevelt issued Executive Order 9066, which allowed military commanders to establish zones of military importance within which they could remove any person considered dangerous, specifically those of Japanese descent. The Tolan Committee, a House committee examining the logistics of the new wartime economy, was immediately sent to the West Coast in order to evaluate the merit of the President's policy. They were presented with the most complete set of arguments both supporting and opposing internment, and were therefore in a unique position to make a well-informed decision regarding the internment of over 100,000 persons. Despite the strength of the arguments of the opposition, the Committee abdicated their power and submitted to the will of the President and the military. In succumbing to fear, the Committee legitimized the policy of internment without making a truly objective decision.
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Date Issued: 2008
PURL: http://purl.flvc.org/FAU/210001
Subject Headings: Japanese Americans, Evacuation and relocation, 1942-1945, Japanese Americans, Civil rights, World War, 1939-1945, Evacuation of civilians, World War, 1939-1945, Concentration camps, Tolan, John H. (John Harvey)
Format: Document (PDF)

Title: Delivery failure close-out: an event study on the effects of newly adopted regulation SHO amendments.
Creator: Scherle, Richard., Harriet L. Wilkes Honors College
Abstract/Description: A generally illegal form of short selling in United States equity markets, called "naked shorting," occurs when a seller of stock sells shares that do not exist. This type of short selling has negative consequences that result from the tactic's ability to be used as a tool to artificially inflate an issuer's stock supply, which introduces significant harm to the integrity of the market's natural forces of supply and demand. Newly adopted amendments to the Securities and Exchange Commission's...
Show moreA generally illegal form of short selling in United States equity markets, called "naked shorting," occurs when a seller of stock sells shares that do not exist. This type of short selling has negative consequences that result from the tactic's ability to be used as a tool to artificially inflate an issuer's stock supply, which introduces significant harm to the integrity of the market's natural forces of supply and demand. Newly adopted amendments to the Securities and Exchange Commission's short sale governance regulation, called Regulation SHO, required the mandatory purchasing of shares by certain market participants in order for those participants to close-out previously excused delivery failures, called "grandfathered" failures. This study examines the consequences of this new regulation, in terms of share price and volume, for those few securities that had the most persistent delivery failure problems. Because the regulation mandates the purchase of shares by certain influential market participants, I examine if the stock markets of these securities exhibited unusual volatility which may be indicative of the market maker trying to cover at low cost. Using technical analysis techniques, such as volume surge detection (using moving volume averages), the performance of the target securities will be compared with appropriate benchmark indices for the purpose of detecting unusual activity. Unusual activity may be consistent with my hypothesis that market makers may encourage additional volatility to cause liquidity problems for marginal investors which forces them to sell part or all of their position. As discussed in great detail, the extra marginal shares injected into the market by the action of forced selling by these marginal investors may be used by the market makers to lower their cost of regulation compliance.
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Date Issued: 2008
PURL: http://purl.flvc.org/FAU/210002
Subject Headings: Securities industry, Investment analysis, Short selling, Capitalism, Moral and ethical aspects
Format: Document (PDF)

Title: Municipal privatization: a case study of Sandy Springs, Georgia.
Creator: Stubbs, Tyler., Harriet L. Wilkes Honors College
Abstract/Description: Governments across the country have been outsourcing traditional government services at an ever-increasing rate. Researchers debate the efficiency of privatization, and evidence exists both for and against increased private production of public goods. At the local level of government, a growing trend is privatization in the form of public-private partnerships. To determine the efficiency of these partnerships between municipal governments and private companies, this study examines the "most"...
Show moreGovernments across the country have been outsourcing traditional government services at an ever-increasing rate. Researchers debate the efficiency of privatization, and evidence exists both for and against increased private production of public goods. At the local level of government, a growing trend is privatization in the form of public-private partnerships. To determine the efficiency of these partnerships between municipal governments and private companies, this study examines the "most" privatized city in the United States, Sandy Springs, Georgia. I compared spending in Sandy Springs to five similar nearby cities and derived cost estimates of government services. I found that the "Sandy Springs Model" of local government lowered costs and increased efficiency when compared to traditional municipalities.
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Date Issued: 2008
PURL: http://purl.flvc.org/FAU/210003
Subject Headings: Municipal government, Municipal services, Contracting out, Privatization, Government business enterprises, Management
Format: Document (PDF)

Title: The " living presence" and the "ideal character": sex, fantasy, and photographs in Thomas Hardy's Jude the Obscure.
Creator: Taylor, Margaret, Harriet L. Wilkes Honors College
Abstract/Description: In my thesis I will argue that the source of the major conflict in Jude the Obscure - the traumatic relationship between Sue and Jude - is Jude's viewing of his cousin's photograph early in the novel. Because of his tendency to idealize the individuals around him, Jude projects a desired image onto a photograph of Sue before meeting her in real life. This projection takes on an aspect of reality for Jude which he can not escape, despite Sue's efforts to disillusion him and introduce him to...
Show moreIn my thesis I will argue that the source of the major conflict in Jude the Obscure - the traumatic relationship between Sue and Jude - is Jude's viewing of his cousin's photograph early in the novel. Because of his tendency to idealize the individuals around him, Jude projects a desired image onto a photograph of Sue before meeting her in real life. This projection takes on an aspect of reality for Jude which he can not escape, despite Sue's efforts to disillusion him and introduce him to her actual self. Since his projection starkly contrasts to Sue's actual being, not only does Jude believe that the two are compatible when they are not, but he believes that Sue's attempts to disillusion him are in fact deceitful. Thus the initial impetus of the photograph eventually leads to their conflicted relationship and the tragedy of the novel overall.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/210004
Subject Headings: Criticism and interpretation, Symbolism in literature, Imagination in literature, Despair in literature
Format: Document (PDF)

Title: The consequences of conditioned democracy promotion by the United States in Latin America.
Creator: Walsh, Kelly., Harriet L. Wilkes Honors College
Abstract/Description: Democracy promotion is an important tenet of United States foreign policy. However, U.S. democracy promotion efforts are conditioned by geopolitical concerns, economic goals, and security interests. This thesis analyzes the impact of U.S. foreign policy in Chile, Colombia, El Salvador and Nicaragua. Evidence from these cases suggests that United States foreign policy has contributed to the growth of unhealthy or pseudo-democracies in Latin America because frequently the policy reinforces the...
Show moreDemocracy promotion is an important tenet of United States foreign policy. However, U.S. democracy promotion efforts are conditioned by geopolitical concerns, economic goals, and security interests. This thesis analyzes the impact of U.S. foreign policy in Chile, Colombia, El Salvador and Nicaragua. Evidence from these cases suggests that United States foreign policy has contributed to the growth of unhealthy or pseudo-democracies in Latin America because frequently the policy reinforces the political and economic power of entrenched elites or the military. These groups, whose interests more closely align with U.S interests, are often uncommitted to supporting policy that promotes human rights and equitable distribution of wealth and power or that demands universal political liberties. Democracy is promoted rhetorically rather than in practice, and consequently is unresponsive and illegitimate. Future democracy promotion efforts by the United States, if they are to be successful, must overcome this illegitimacy by compensating for the conflicts that conditioned democracy produces.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/210005
Subject Headings: Democracy, Democratization, Government policy, Politics and government, Foreign relations, Foreign relations
Format: Document (PDF)

Title: Sentinels of liberty: Captain America, his doubles, and the dilemma of American identity.
Creator: Wicks, Robert, Harriet L. Wilkes Honors College
Abstract/Description: The Marvel character Captain America was created in 1941 as an unabashed, patriotic icon who was meant to inspire Americans in the face of war. At the end of World War II, however, American identity underwent a split between diplomatic "prophetic realism" and aggressive "zealous nationalism." The inherent dilemma for Captain America quickly became which side of the American psyche he was to represent. Marvel has dealt with the problem of representation by allowing the original Captain America...
Show moreThe Marvel character Captain America was created in 1941 as an unabashed, patriotic icon who was meant to inspire Americans in the face of war. At the end of World War II, however, American identity underwent a split between diplomatic "prophetic realism" and aggressive "zealous nationalism." The inherent dilemma for Captain America quickly became which side of the American psyche he was to represent. Marvel has dealt with the problem of representation by allowing the original Captain America to be a prophetic realist, while introducing "doubles" of Captain America who act as zealous nationalists. In each era of Captain America's publication, the conflict between the real Captain and his zealous doubles has provided a dialogue on the American spirit, while allowing for meaningful speculation on what the future holds for this country.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/210006
Subject Headings: America, Captain (Fictitious character), Comic books, strips, etc, Political aspects, Metaphor
Format: Document (PDF)

Title: Correlation between specific carcinogenic chemicals and specific mitotic defects and the restorative role of antioxidants.
Creator: Yates, Travis., Harriet L. Wilkes Honors College
Abstract/Description: The progression of cancerous cells towards a more aggressive tumor can be linked to external elements called carcinogens. The goal of this project is to examine the correlation between exposure to specific carcinogens and an increase of mitotic defects. These defects can manifest as lagging chromosomes, multipolar spindles, and anaphase bridges. Some of these instabilities are associated with the formation of reactive oxygen species (ROS), which are known to damage DNA. The potential for...
Show moreThe progression of cancerous cells towards a more aggressive tumor can be linked to external elements called carcinogens. The goal of this project is to examine the correlation between exposure to specific carcinogens and an increase of mitotic defects. These defects can manifest as lagging chromosomes, multipolar spindles, and anaphase bridges. Some of these instabilities are associated with the formation of reactive oxygen species (ROS), which are known to damage DNA. The potential for damage to the genome can be averted via antioxidants. Using the oral cancer cell line UPCI:SCC103, we established a baseline for the mitotic defects in the absence and presence of various ROS-inducing carcinogens using DAPI-stained fixed cells examined by immunofluorescent microscopy, The cells were treated with varying concentrations of the antioxidants, Vitamin C, (Sb(B-Carotene, and Vitamin E. The reactive oxygen scavengers significantly reduced the number of mitotic defects. A possible link between the carcinogens and lagging chromosomes was established.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/210007
Subject Headings: Cellular signal transduction, Genetic regulation, Antioxidants, Therapeutic use, Apoptosis, Molecular aspects, Cancer, Chemoprevention
Format: Document (PDF)

Title: Analyzing the growth of Protestantism: a case study of Mexico.
Creator: Hoogkamp, Amanda., Harriet L. Wilkes Honors College
Abstract/Description: There are several competing theoretical explanations for why Pentecostal Protestantism is growing rapidly in Latin America including affinities with the indigenous religions of the region, a recent increase in the supply of Pentecostalism due to missionary movements, a reduction in government regulation of religion, social anomie theory, and the pull of economic upward mobility through conversion. This study analyses the growth of Pentecostal Protestantism in the case of Mexico, utilizing...
Show moreThere are several competing theoretical explanations for why Pentecostal Protestantism is growing rapidly in Latin America including affinities with the indigenous religions of the region, a recent increase in the supply of Pentecostalism due to missionary movements, a reduction in government regulation of religion, social anomie theory, and the pull of economic upward mobility through conversion. This study analyses the growth of Pentecostal Protestantism in the case of Mexico, utilizing state by state comparative data measuring these variables. While higher percentages of indigenous residents are correlated significantly with Pentecostal growth, government regulation and supply are less so. Social anomie and economic upward mobility are not conducive to studying in minute detail but on a larger scale seem to serve as broad explanations for Pentecostal growth. Theories explaining Pentecostal growth should be revised to reflect these convergent factors and focus on the reasons for the divergent growth patterns.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/3325075
Subject Headings: Pentacostalism, Protestant churches, Church and state, Evangelicalism, Church history
Format: Document (PDF)

Title: Manipulation of normal cells to produce a cancer-like mitotic phenotype.
Creator: Luffman, Christina., Harriet L. Wilkes Honors College
Abstract/Description: Most tumors contain multiple karyotypes due to genomic instability gained through chromosomal segregational defects. The variability of genomic changes within a population makes it difficult to study specific processes without the existence of confounding mutations. My project is to create a model system for observation of mitotic defects, specifically multipolar spindles, in a normal cell line, where the genome is intact. Induction of centrosome amplification is required for formation of...
Show moreMost tumors contain multiple karyotypes due to genomic instability gained through chromosomal segregational defects. The variability of genomic changes within a population makes it difficult to study specific processes without the existence of confounding mutations. My project is to create a model system for observation of mitotic defects, specifically multipolar spindles, in a normal cell line, where the genome is intact. Induction of centrosome amplification is required for formation of multipolar spindles. Treatments with colcemid showed a 10% increase in abnormal centrosome numbers over control. However, treatment with hydroxyurea and transfection of hMPSl showed little increase. Extra centrosomes are insufficient to drive multipolarity, therefore, I am using siRNA-mediated knockdown of Nek2 or HSET to decluster the extra centrosomes. Successful declustering will preferably show an increase in multipolar frequency, allowing us to study the formation and resolution of these structres to better understand how they contribute to aneuploidy and tumor progression.
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Date Issued: 2009
PURL: http://purl.flvc.org/FAU/3325079
Subject Headings: Cell division, Karyokinesis, Cancer, Genetic aspects, Genomics, Cellular signal transduction, Centrosomes
Format: Document (PDF)

Title: Gun control in Florida: an analysis of the Right to Carry Law of 1987.
Creator: Mathews, Sunil., Harriet L. Wilkes Honors College
Abstract/Description: In 1987, Florida passed a Right to Carry Law, allowing citizens to purchase a concealed weapons license. Bill proponents believe that an armed citizenry will deter crime. This study examines the relationship between gun control legislation and violent crime in Florida. By using multiple regression analysis, I conclude that gun control legislation has a significant effect on homicide rates, and the presence of national economic conditions is associated with violent crime in Florida.
Date Issued: 2009
PURL: http://purl.flvc.org/FAU/3325083
Subject Headings: Firearms ownership, Law and legislation, Violence, Prevention, Firearms, Law and legislation, Gun control
Format: Document (PDF)

FAU Theses and Dissertations (8193)	+ -
Campus Photographs (4402)	+ -
HBOI Faculty Contributions (1751)	+ -
Political & Rights Issues & Social Movements Collection (1547)	+ -
FAU College Collections (1451)	+ -

Collection to hold Scholars (1121)	+ -
Honors Student Theses (796)	+ -
Speeches (686)	+ -
FAU Graduate Student Research (546)	+ -
Foreign Pamphlets (522)	+ -
Sheet Music (508)	+ -
Clarke Family Papers (458)	+ -
FAU Undergraduate Student Research (374)	+ -
FAU Founding Documents (360)	+ -
Elliott Cross and James A. Cross Civil War Collection (312)	+ -
University Archives (273)	+ -
Theodore Pratt Collection (223)	+ -
Dances We Dance (210)	+ -
Updates, Florida Atlantic University Newsletter 1970-1979 (199)	+ -
FAU Commencements (141)	+ -
Arlyn Austin Katims Civil War Collection (140)	+ -
Yiddish Children's Books (138)	+ -
Christine E. Lynn College of Nursing Doctor of Nursing Practice (133)	+ -
Al-Mutanabbi Street Starts Here (132)	+ -
Sweat Broadside Collection (132)	+ -
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