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- Title
- The Drosophila Mitochondrial Translation Elongation Factor G1 Contains a Nuclear Localization Signal and Inhibits Growth and DPP Signaling.
- Creator
- Trivigno, Catherine F., Haerry, Theodor E., Treisman, Jessica
- Abstract/Description
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Mutations in the human mitochondrial elongation factor G1 (EF-G1) are recessive lethal and cause death shortly after birth. We have isolated mutations in iconoclast (ico), which encodes the highly conserved Drosophila orthologue of EF-G1. We find that EF-G1 is essential during fly development, but its function is not required in every tissue. In contrast to null mutations, missense mutations exhibit stronger, possibly neomorphic phenotypes that lead to premature death during embryogenesis....
Show moreMutations in the human mitochondrial elongation factor G1 (EF-G1) are recessive lethal and cause death shortly after birth. We have isolated mutations in iconoclast (ico), which encodes the highly conserved Drosophila orthologue of EF-G1. We find that EF-G1 is essential during fly development, but its function is not required in every tissue. In contrast to null mutations, missense mutations exhibit stronger, possibly neomorphic phenotypes that lead to premature death during embryogenesis. Our experiments show that EF-G1 contains a secondary C-terminal nuclear localization signal. Expression of missense mutant forms of EF-G1 can accumulate in the nucleus and cause growth and patterning defects and animal lethality. We find that transgenes that encode mutant human EF-G1 proteins can rescue ico mutants, indicating that the underlying problem of the human disease is not just the loss of enzymatic activity. Our results are consistent with a model where EF-G1 acts as a retrograde signal from mitochondria to the nucleus to slow down cell proliferation if mitochondrial energy output is low.
Show less - Date Issued
- 2011-02-25
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000088
- Format
- Citation
- Title
- The coordination dynamics of social neuromarkers.
- Creator
- Tognoli, Emmanuelle, Kelso, J. A. Scott
- Date Issued
- 2015-10-20
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000164
- Format
- Citation
- Title
- The coelacanth rostral organ is a unique low-resolution electro-detector that facilitates the feeding strike.
- Creator
- Berquist, Rachel M., Galinsky, Vitaly L., Kajiura, Stephen M., Frank, Lawrence R.
- Abstract/Description
-
The cartilaginous and non-neopterygian bony fishes have an electric sense typically comprised of hundreds or thousands of sensory canals distributed in broad clusters over the head. This morphology facilitates neural encoding of local electric field intensity, orientation, and polarity, used for determining the position of nearby prey. The coelacanth rostral organ electric sense, however, is unique in having only three paired sensory canals with distribution restricted to the dorsal snout,...
Show moreThe cartilaginous and non-neopterygian bony fishes have an electric sense typically comprised of hundreds or thousands of sensory canals distributed in broad clusters over the head. This morphology facilitates neural encoding of local electric field intensity, orientation, and polarity, used for determining the position of nearby prey. The coelacanth rostral organ electric sense, however, is unique in having only three paired sensory canals with distribution restricted to the dorsal snout, raising questions about its function. To address this, we employed magnetic resonance imaging methods to map electrosensory canal morphology in the extant coelacanth, Latimeria chalumnae, and a simple dipole ‘rabbit ears’ antennae model with toroidal gain function to approximate their directional sensitivity. This identified a unique focal region of electrosensitivity directly in front of the mouth, and is the first evidence of a low-resolution electro-detector that solely facilitates prey ingestion.
Show less - Date Issued
- 2015-08-11
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000024
- Format
- Citation
- Title
- The brain decade in debate: VII. Neurobiology of sleep and dreams.
- Creator
- Aloe, F., Amzica, F., Hening, W., Menna-Barreto, L., Pinto Jr., L.R., Velluti, R., Vertes, Robert P., Timo-Iaria, C.
- Date Issued
- 2001-12
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000196
- Format
- Citation
- Title
- Technomyrmex difficilis (Hymenoptera: Formicidae) in the West Indies.
- Creator
- Wetterer, James K.
- Date Issued
- 2008-09
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000215
- Format
- Citation
- Title
- Task Allocation and Path Planning for Collaborative Autonomous Underwater Vehicles Operating through an Underwater Acoustic Network.
- Creator
- Deng, Yueyue, Beaujean, Pierre-Philippe J., An, Edgar, Carlson, Edward
- Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1155_2013_483095_1629813605
- Format
- Citation
- Title
- Sulindac Enhances the Killing of Cancer Cells Exposed to Oxidative Stress.
- Creator
- Marchetti, Maria, Resnick, Lionel, Gamliel, Edna, Kesaraju, Shailaja, Weissbach, Herbert, Binninger, David, Bauer, Joseph Alan
- Date Issued
- 2009-06-05
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000108
- Format
- Citation
- Title
- Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.
- Creator
- Thiyagarajan, Nethaji, Pham, Tram T. K., Stinson, Brittany, Sundriyal, Amit, Tumbale, Percy, Lizotte-Waniewski, Michelle, Brew, Keith, Acharya, K. Ravi
- Date Issued
- 2012-12-07
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000113
- Format
- Citation
- Title
- Structural, optical, photoluminescence and photocatalytic investigations on Fe doped Tio2 thin films.
- Creator
- Nair, Prabitha B., Justinvictor, V.B., Daniel, Georgi P., Joy, K., Ramakrishnan, V., Kumar, David D., Thomas, P.V.
- Abstract/Description
-
Pure and Fe doped TiO2 thin films were deposited onto quartz substrates maintained at room temperature by radio frequency magnetron sputtering. The films were annealed at 873 K in air for 2 h and characterized using X-ray diffraction (XRD), micro Raman spectroscopy, Scanning electron microscopy (SEM), Energy dispersive spectroscopy, ultraviolet-visible and photoluminescence (PL) spectroscopy. Pure TiO2 thin films were XRDamorphous, but micro Raman spectra revealed the presence of anatase...
Show morePure and Fe doped TiO2 thin films were deposited onto quartz substrates maintained at room temperature by radio frequency magnetron sputtering. The films were annealed at 873 K in air for 2 h and characterized using X-ray diffraction (XRD), micro Raman spectroscopy, Scanning electron microscopy (SEM), Energy dispersive spectroscopy, ultraviolet-visible and photoluminescence (PL) spectroscopy. Pure TiO2 thin films were XRDamorphous, but micro Raman spectra revealed the presence of anatase phase. Doping with Fe has influenced the transformation of films to anatase phase. Improved crystallinity was observed in the 0.1 at% Fe doped films, where the lattice constants approached the values for bulk anatase TiO2, and the films showed minimum strain. At higher Fe concentrations, micro Raman spectra revealed the presence of rutile phase also. SEM images revealed crack free surface and surface roughness was found to increase with increase in Fe concentration. Dopingwith Fe has resulted in a red shift of absorption edge. PL emission intensitywas found to increase with Fe concentration, but at higher concentrations quenching of PL emission was observed. Fe doping resulted in enhancement of photocatalytic activity, evaluated by monitoring the degradation of methylene blue solution. 0.8 at% Fe doped TiO2 films exhibited the highest photocatalytic activity.
Show less - Date Issued
- 2014-01
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000031
- Format
- Citation
- Title
- Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro.
- Creator
- Carraher, Charles E., Roner, Michael R., Shahi, Kimberly, Barot, Girish
- Abstract/Description
-
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much...
Show moreThe ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth.
Show less - Date Issued
- 2011-04-15
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000009
- Format
- Citation
- Title
- Stress Experienced by Guatemalan–Mayan Immigrants.
- Creator
- Millender, Eugenia I.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000237
- Format
- Citation
- Title
- Stochastic analysis of an ecosystem of two competing species.
- Creator
- Cai, Guo-Qiang, Lin, Y. K.
- Date Issued
- 2006-08
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000098
- Format
- Citation
- Title
- Stem cell harvesting protocol research in autologous transplantation setting: Large volume vs. conventional cytapheresis.
- Creator
- Balint, Bela, Ljubenov, Marika, Stamatovic, Dragana, Todorovic, Milena, Pavlovic, Mirjana, Ostojic, Gordana, Jocic, Miodrag, Trkuljic, Miroljub
- Abstract/Description
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Background/Aim. The use of peripheral blood as a source of hematopoietic stem cells (SCs) is progressively increasing and has nearly supplanted bone marrow transplantation. Interpatient variability in the degree and kinetics of SC mobilization into peripheral blood is an expected event after conventional chemotherapy–based treatment, followed by sequential administration of recombinant granulocyte–colony– stimulating factor (rHu–CSF). In this study, specific factors associated with the...
Show moreBackground/Aim. The use of peripheral blood as a source of hematopoietic stem cells (SCs) is progressively increasing and has nearly supplanted bone marrow transplantation. Interpatient variability in the degree and kinetics of SC mobilization into peripheral blood is an expected event after conventional chemotherapy–based treatment, followed by sequential administration of recombinant granulocyte–colony– stimulating factor (rHu–CSF). In this study, specific factors associated with the application of two different SC–harvesting approaches, including the use of large volume leukapheresis (LVL) vs. repetitive conventional apheresis (RCA), were analyzed. The basic goal of the study was to evaluate the influence of apheresis protocol (collection timing, processed blood volume and cell yield) upon the clinical outcome of transplantation. Methods. Results obtained by LVL (76 pts) and RCA (20 pts – control group) were compared. The SC mobilizing regimen used was cyclophosphamide (4–7 g/m^2) or polychemotherapy and rHuG–CSF 10–16 μg/kg of body mess (bm) per day. Cell harvesting was performed using COBE-Spectra (Caridian–BCT, USA). The volume of processed blood in LVL setting was ≥ 3.5 – fold of the patient's circulating blood quantity (ranged from 12.7 to 37.8 l). All patients tolerated well the use of intensive treatment, without any side or adverse effects. Our original controlled–rate cryopreservation was carried out with 10% dimethyl sulfoxide (DMSO) using Planer R203/200R or Planer 560–16 equipments (Planer Products Ltd, UK). Total nucleated cell (NC) and mononuclear cell (MNC) counts were examined by flow cytometry (Advia–2120 Bayer, Germany; Technicon H–3 System, USA). The CD34+ cell surface antigen was investigated by the EPICS XL–MCL device (Coulter, Germany). Results. Performing LVL–apheresis, high–level MNC and CD34+ cell yields (7.6±4.6 × 10^8/kg bm and 11.8±6.5 × 10^6/kg bm, respectively) were obtained. As a result, rapid hematopoietic reconstitution ("graft–healing") – on the 9.4th and 12.4th day for granulocytes and platelets, respectively was achieved. Using repetitive conventional apheresis (2–3 procedures), the total MNC count was high (8.2±7.0 × 10^8/kg bm), but the total CD34+ yield was lower 10.8±9.9 due to inferior CD34+ vs. MNC ratio. Conclusion. The results obtained suggest that well–timed LVL–apheresis increased SC–yield in cell harvest, resulting in faster bone marrow repopulation and hematological reconstitution, as well as better overall clinical outcome of transplantation. These results necessitate additional examinations of CD34+ subsets ratio in cell harvest.
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000042
- Format
- Citation
- Title
- SQER.
- Creator
- Chamely-Wiik, Donna M., Haky, Jerome E., Louda, Deborah W., Romance, Nancy
- Date Issued
- 2014-03-11
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_ed300689n_1521555360
- Format
- Citation
- Title
- Spread in Trinidad of the South American Fire Ant Solenopsis invicta (Hymenoptera, Formicidae).
- Creator
- Wetterer, James K., Davis, Lloyd R., White, Graham L.
- Date Issued
- 2014-03
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000213
- Format
- Citation
- Title
- Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
- Creator
- Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
- Date Issued
- 2013-04-02
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000178
- Format
- Citation
- Title
- Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.
- Creator
- Chen, Guozhen, Zhu, Jing, Lv, Tiewei, Wu, Gang, Sun, Hui-Chao, Huang, Xupei, Tian, Jie
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000153
- Format
- Citation
- Title
- South Atlantic MPAs and Oculina HAPC: Characterization of Fish Communities, Benthic Habitat, and Benthic Macrobiota: Final Report for 2015-2017 NOAA Ship Pisces Cruises (15-02, 16-20, 17-02).
- Creator
- Reed, John K., Harter, Stacey, Farrington, Stephanie, David, Andrew
- Date Issued
- 2018-06-27
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000240
- Format
- Citation
- Title
- Solvent-free phase-vanishing reactions with PTFE (Teflon®) as a phase screen.
- Creator
- Pels, Kevin C, Dragojlovic, Veljko
- Date Issued
- 2009-12-09
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000135
- Format
- Citation
- Title
- Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase.
- Creator
- Wu, Gang, Nan, Changlong, Rollo, Johnathon C, Huang, Xupei, Tian, Jie
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000219
- Format
- Citation