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Synthesis of Podophyllotoxin Derivatives
Title
Synthesis of Podophyllotoxin Derivatives.
Creator
Flint, Madison, Roche, Stéphane P.
Abstract/Description
Podophyllotoxin is a natural aryltetralin lignan compound isolated from plants within the genus Podophyllum. Podophyllotoxin has been under extensive biochemical investigation since the discovery of its biological activity as a strong microtubule destabilizing mitotic agent. Although these antineoplastic compounds have shown significant activity as cancerous cell growth inhibitors, they lack selectivity and are thus extremely toxic to healthy cells. This has led to a recent interest in the...
Show morePodophyllotoxin is a natural aryltetralin lignan compound isolated from plants within the genus Podophyllum. Podophyllotoxin has been under extensive biochemical investigation since the discovery of its biological activity as a strong microtubule destabilizing mitotic agent. Although these antineoplastic compounds have shown significant activity as cancerous cell growth inhibitors, they lack selectivity and are thus extremely toxic to healthy cells. This has led to a recent interest in the synthesis of Podophyllotoxin analogues in hopes of optimizing the biological selectivity and potency of these semi-synthetic derivatives. The objective of my research in the Roche group is to generate a library of these derivatives for subsequent biological assays to determine their potential as chemotherapeutic agents. In total I have synthesized 22 Podophyllotoxin analogues. Of these 22 derivatives, 14 have been biologically evaluated and 4 were observed to possess promising anti-cancer activity and are currently undergoing further evaluation.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA0005014
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Synthesis of Complex Polycyclic Scaffolds Incorporating α-Amino Esters
Title
Synthesis of Complex Polycyclic Scaffolds Incorporating α-Amino Esters.
Creator
Zorc, Stephen A., Samanta, Shyam S., Roche, Stéphane P., Charles E. Schmidt College of Science
Abstract/Description
In order to keep up with the high demand for biologically active molecules, chemists devised several synthetic strategies to access novel chemical spaces. The two main strategies to construct new scaffolds are to revisit underexploited or forgotten reactions or to devise new transformations. We are exploring a unique and underexploited reaction, the Himbert–Henn cycloaddition, to produce complex molecular scaffolds in a single step (strategy 1). In a second novel approach, we are modifying...
Show moreIn order to keep up with the high demand for biologically active molecules, chemists devised several synthetic strategies to access novel chemical spaces. The two main strategies to construct new scaffolds are to revisit underexploited or forgotten reactions or to devise new transformations. We are exploring a unique and underexploited reaction, the Himbert–Henn cycloaddition, to produce complex molecular scaffolds in a single step (strategy 1). In a second novel approach, we are modifying the Hantzsch 4-component reaction (4CR) by incorporating an α-amino ester residue to construct new molecules (strategy 2). Both of these reactions have great potential to synthesize novel and chiral molecules from proteinogenic α-amino esters. These unprecedented and complex polycyclic molecules have potential application in medicinal chemistry and natural product synthesis. 4-aza-podophyllotoxins obtained by the Hantzsch-4CR have been proven to be potent as anti-leukemia, anti-colon cancer, and vascular disrupting agents (with nanomolar activity).
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00005218
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Symbiosis between bacteria and oceanic clonal sea star larvae in the western North Atlantic Ocean
Title
Symbiosis between bacteria and oceanic clonal sea star larvae in the western North Atlantic Ocean.
Creator
Bosch, Isidro, Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333204
Subject Headings
Symbiosis, Sea stars, Starfishes, Larvae, Bacteria
Format
Document (PDF)
Impacts of algal toxins on marine mammals
Title
Impacts of algal toxins on marine mammals.
Creator
Van Dolah, F. M., Doucette, G. J., Gulland, F. M. D., Rowles, T. L., Bossart, Gregory D., Harbor Branch Oceanographic Institute
Date Issued
2003
PURL
http://purl.flvc.org/fcla/dt/3352937
Subject Headings
Algal toxins, Marine mammals, Neurotoxins
Format
Document (PDF)
Women’s Representation in Contemporary Hollywood Film Culture
Title
Women’s Representation in Contemporary Hollywood Film Culture.
Creator
Trujillo, Michelle, Sim, Gerald, Dorothy F. Schmidt College of Arts and Letters
Abstract/Description
See Her is a found footage montage that identifies the issue of women’s representation in contemporary Hollywood film culture. It analyzes different ways that spectatorship develops through the division of the film into four sections of which three analyze film from the perspective of Laura Mulvey, Mary Ann Doane, and Linda Williams. These three sections also approach the representation of women as a sociological issue of oppression as discussed by sociologist Patricia Hill Collins. The last...
Show moreSee Her is a found footage montage that identifies the issue of women’s representation in contemporary Hollywood film culture. It analyzes different ways that spectatorship develops through the division of the film into four sections of which three analyze film from the perspective of Laura Mulvey, Mary Ann Doane, and Linda Williams. These three sections also approach the representation of women as a sociological issue of oppression as discussed by sociologist Patricia Hill Collins. The last section serves as a speculative vision of the future of female representation in Hollywood Film Culture. While this film is critical on the current state of representation, it presents hope for a more equal future.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00005215
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Oogenesis and female gametes
Title
Oogenesis and female gametes.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/fau/fd/FA00007371
Subject Headings
Polychaeta, Gametes, Oogenesis, Oocytes
Format
Document (PDF)
Metamorphosis and post-settling development of Sabellaria vulgaris (Verrill, 1873) (Polychaeta: Sabellariidae)
Title
Metamorphosis and post-settling development of Sabellaria vulgaris (Verrill, 1873) (Polychaeta: Sabellariidae).
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1974
PURL
http://purl.flvc.org/FCLA/DT/3179296
Subject Headings
Sabellariidae, Metamorphosis, Polychaeta
Format
Document (PDF)
Metamorphosis and settlement in the Sabellariidae
Title
Metamorphosis and settlement in the Sabellariidae.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1978
PURL
http://purl.flvc.org/FCLA/DT/3331802
Subject Headings
Sabellariidae, Polychaeta, Larvae
Format
Document (PDF)
Ultrastructural evidence for both autosynthetic andheterosynthetic yolk formation in the oocytes of an annelid (Phragmatopoma Lapidosa: Polychaeta)
Title
Ultrastructural evidence for both autosynthetic andheterosynthetic yolk formation in the oocytes of an annelid (Phragmatopoma Lapidosa: Polychaeta).
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1979
PURL
http://purl.flvc.org/fau/fd/FA00007136
Subject Headings
Oocytes, Ultrastructure (Biology), Polychaeta, Egg yolk, Oogenesis, Vitellogenesis
Format
Document (PDF)
Ultrastructure of spermatogenesis in the reef-building polychaete Phragmatopoma lapidosa (Sabellariidae) with special reference to acrosome morphogenesis
Title
Ultrastructure of spermatogenesis in the reef-building polychaete Phragmatopoma lapidosa (Sabellariidae) with special reference to acrosome morphogenesis.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1984
PURL
http://purl.flvc.org/FCLA/DT/3353742
Subject Headings
Spermatogenesis, Polychaeta, Sabellariidae, Spermatozoa--Ultrastructure, Acrosome
Format
Document (PDF)
Ultrastructure of the ovary andoogenesis in the polychaete Capitella jonesi (Hartman, 1959)
Title
Ultrastructure of the ovary andoogenesis in the polychaete Capitella jonesi (Hartman, 1959).
Creator
Eckelbarger, Kevin J., Grassle, J. P., Harbor Branch Oceanographic Institute
Date Issued
1982
PURL
http://purl.flvc.org/fau/fd/FA00007086
Subject Headings
Ultrastructure (Biology), Ovary, Oogenesis, Polychaeta, Capitellida
Format
Document (PDF)
The outer retina and tapetum lucidum of the snook Centropomus undecimalis (Teleostei)
Title
The outer retina and tapetum lucidum of the snook Centropomus undecimalis (Teleostei).
Creator
Eckelbarger, Kevin J., Scalan, R., Nicol, J. A. C., Harbor Branch Oceanographic Institute
Date Issued
1980
PURL
http://purl.flvc.org/FCLA/DT/3342217
Subject Headings
Centropomus undecimalis, Tapetum lucidum, Retina, Snook
Format
Document (PDF)
Origin and development of the amoebocytes of Nicolea zostericola (Polychaeta: Terebellidae) with a discussion of their possible role in oogenesis
Title
Origin and development of the amoebocytes of Nicolea zostericola (Polychaeta: Terebellidae) with a discussion of their possible role in oogenesis.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1976
PURL
http://purl.flvc.org/FCLA/DT/3333066
Subject Headings
Terebellidae, Oogenesis, Polychaeta
Format
Document (PDF)
Evolutionary radiation in polychaete ovaries and vitellogenic mechanisms: their possible role in life history patterns
Title
Evolutionary radiation in polychaete ovaries and vitellogenic mechanisms: their possible role in life history patterns.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1983
PURL
http://purl.flvc.org/FCLA/DT/3342221
Subject Headings
Polychaeta, Polychaeta--Evolution, Vitellogenesis, Oogenesis
Format
Document (PDF)
Polychaeta: oogenesis
Title
Polychaeta: oogenesis.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3342310
Subject Headings
Polychaeta, Oogenesis
Format
Document (PDF)
Comparative aspects of oogenesis in polychaetes
Title
Comparative aspects of oogenesis in polychaetes.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1984
PURL
http://purl.flvc.org/fau/fd/FA00007209
Format
Document (PDF)
Stochastic events and dynamics of a mangrove root epifaunal community
Title
Stochastic events and dynamics of a mangrove root epifaunal community.
Creator
Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/fau/fd/FA00007233
Subject Headings
Mangroves, Ascidians, Sponges, Stability
Format
Document (PDF)
Chemical defense and aposematic coloration in larvae of the ascidian Ecteinascidia turbinata
Title
Chemical defense and aposematic coloration in larvae of the ascidian Ecteinascidia turbinata.
Creator
Young, Craig M., Bingham, Brian L., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3333096
Subject Headings
Ascidians, Sea squirts, Larvae--Defenses, Aposematic coloration, Chemical defenses, Animal
Format
Document (PDF)
A light and electron microscope investigation of gametogenesis in Nicolea zostericola (Polychaeta: Terebellidae)
Title
A light and electron microscope investigation of gametogenesis in Nicolea zostericola (Polychaeta: Terebellidae).
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1975
PURL
http://purl.flvc.org/FCLA/DT/3176685
Subject Headings
Gametogenesis, Polychaeta
Format
Document (PDF)
An ultrastructural study of oogenesis in Streblospio benedicti (Spionidae), with remarks on diversity of vitellogenic mechanisms in Polychaeta
Title
An ultrastructural study of oogenesis in Streblospio benedicti (Spionidae), with remarks on diversity of vitellogenic mechanisms in Polychaeta.
Creator
Eckelbarger, Kevin J., Harbor Branch Oceanographic Institute
Date Issued
1980
PURL
http://purl.flvc.org/FCLA/DT/3333070
Subject Headings
Spionidae, Oogenesis, Polychaeta, Vitellogenesis
Format
Document (PDF)

Pages