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Impact of Glutamate In Amyotrophic Lateral Sclerosis (ALS)
Title
Impact of Glutamate In Amyotrophic Lateral Sclerosis (ALS).
Creator
Maldonado, Dianabell, Jaiprashad, Rajesh, Snyder, Patricia Ann, Office of Undergraduate Research and Inquiry
Abstract/Description
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease afflicting the global population. This disease affects motor neuron nerve cells located in the brain, brainstem, and spinal cord that serve as controlling units and communication points between the nervous system and the muscles of the body. In ALS, both the upper motor neurons, in the brain, and the lower motor neurons, in the spinal cord, degenerate or die; thus ceasing transmission. The cause of this disease is still under...
Show moreAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease afflicting the global population. This disease affects motor neuron nerve cells located in the brain, brainstem, and spinal cord that serve as controlling units and communication points between the nervous system and the muscles of the body. In ALS, both the upper motor neurons, in the brain, and the lower motor neurons, in the spinal cord, degenerate or die; thus ceasing transmission. The cause of this disease is still under investigation. Here in, it is hypothesized that ALS engenders from the over excitation of motor nerve cells due to an excess of the amino acid, glutamate, the principal neurotransmitter in the brain. Therefore, an investigation into the properties of the neurotransmitter glutamate, which could be the potential cause of this neurodegenerative disease, will help elucidate the role of this amino acid in ALS.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00005577
Subject Headings
College students --Research --United States.
Format
Document (PDF)
An Experimental and Theoretical Investigation of the Excited States of Isobutene
Title
An Experimental and Theoretical Investigation of the Excited States of Isobutene.
Creator
McLachlan, Jeffrey, Snyder, Patricia Ann, Office of Undergraduate Research and Inquiry
Abstract/Description
Vacuum ultraviolet magnetic circular dichroism (MCD) and absorption spectra of isobutene were obtained experimentally and compared to theoretical data (DFT calculation with Gaussian software) with the goal of better understanding the electronic structure of simple olefins. MCD is the differential absorption of left and right circular polarized light in the presence of an external magnetic field. This means that a MCD spectrum contains both positive and negative peaks while an absorbance...
Show moreVacuum ultraviolet magnetic circular dichroism (MCD) and absorption spectra of isobutene were obtained experimentally and compared to theoretical data (DFT calculation with Gaussian software) with the goal of better understanding the electronic structure of simple olefins. MCD is the differential absorption of left and right circular polarized light in the presence of an external magnetic field. This means that a MCD spectrum contains both positive and negative peaks while an absorbance spectrum contains only positive peaks. MCD is useful when used in conjunction with a corresponding absorbance spectrum to assign spectral bands that may have been hidden by overlap in the absorbance spectrum. The experimental and theoretical results coincide with the two lowest energy transitions of isobutene being assigned as [...]. This is also consistent with what has been observed in ethylene and propylene, π→π^* is not the lowest transition in mono-olefins.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00005589
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Conformational Masking in HIV-1
Title
Conformational Masking in HIV-1.
Creator
Goordeen, Ashley, Snyder, Patricia Ann
Abstract/Description
Molecular modeling enables an individual to explore the nature of various molecules and the interaction between molecules using only a computer and their fingertips. This computer technology is an expanding field and has a plethora of applications ranging from teaching to the design of new drugs. Molecular modeling allows studying through calculation and visualization of molecular systems varying in size from minute chemical systems to hefty biological ones. The system analyzed in this study...
Show moreMolecular modeling enables an individual to explore the nature of various molecules and the interaction between molecules using only a computer and their fingertips. This computer technology is an expanding field and has a plethora of applications ranging from teaching to the design of new drugs. Molecular modeling allows studying through calculation and visualization of molecular systems varying in size from minute chemical systems to hefty biological ones. The system analyzed in this study is that of gp120, the envelope glycoprotein on HIV-1 essential for viral entry into cells. HIV-1’s invasive success can be attributed to its ability to conformationally mask itself from the immune system. It achieves this because of the highly glycosylated surface of gp120. Using HyperChem Release 7, Visual Molecular Dynamics (VMD) 1.9.1, and NAMD 2.9, the glycosylated surface of gp120 and its molecular dynamics were examined to confirm its effectiveness.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA0005020
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Molecular modeling and dynamics of sphinogomyelin phosphodiesterase D LISicTox-alphalll1i
Title
Molecular modeling and dynamics of sphinogomyelin phosphodiesterase D LISicTox-alphalll1i.
Creator
Jordan, Autumn, Snyder, Patricia Ann
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361099
Subject Headings
Molecular models, Molecules--Models--Computer simulation, Computational chemistry
Format
Document (PDF)
Atom distance and interaction between DNA and acetylated histone tails
Title
Atom distance and interaction between DNA and acetylated histone tails.
Creator
Goordeen, Victoria, Snyder, Patricia Ann
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361087
Subject Headings
Transcription, Genetic, Histones, DNA
Format
Document (PDF)