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Title
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Effects of anoxia on methionine sulfoxide reductase (Msr) deficient drosophila.
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Creator
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Howard, Danielle, Binninger, David
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Date Issued
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2013-04-05
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PURL
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http://purl.flvc.org/fcla/dt/3361093
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Subject Headings
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Anoxia, Drosophila, Reactive Oxygen Species
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Format
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Document (PDF)
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Title
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Eco-physiology of juvenile snook Centropomus undecimalis (Bloch): life-history implications.
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Creator
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Peterson, Mark S., Gilmore, R. G., Harbor Branch Oceanographic Institute
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Date Issued
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1991
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PURL
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http://purl.flvc.org/FCLA/DT/3171646
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Subject Headings
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Snook, Fishes --Habitat, Hematocrit, Hypoxia (Water), Anoxia
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Format
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Document (PDF)
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Title
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The Effects of MsrA and MsrB in Anoxia Tolerance in Aging Drosophila melanogaster.
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Creator
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Suthakaran, Nirthieca, Binninger, David, Florida Atlantic University, Charles E. Schmidt College of Medicine, Department of Biomedical Sciences
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Abstract/Description
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Drosophila melanogaster tolerates several hours of anoxia (the absence of oxygen) by entering a protective coma. A burst of reactive oxygen species (ROS) is produced when oxygen is reintroduced to the cells. ROS causes oxidative damage to critical cellular molecules, which contribute to aging and development of certain agerelated conditions. The amino acid, methionine, is susceptible to oxidation, although this damage can be reversed by methionine sulfoxide reductases (Msr). This project...
Show moreDrosophila melanogaster tolerates several hours of anoxia (the absence of oxygen) by entering a protective coma. A burst of reactive oxygen species (ROS) is produced when oxygen is reintroduced to the cells. ROS causes oxidative damage to critical cellular molecules, which contribute to aging and development of certain agerelated conditions. The amino acid, methionine, is susceptible to oxidation, although this damage can be reversed by methionine sulfoxide reductases (Msr). This project investigates the effect of Msr-deficiency on anoxia tolerance in Drosophila throughout the lifespan of the animal. The data show that the time for recovery from the protective comma as well as the survival of the animals lacking any Msr activity depends on how quickly the coma is induced by the anoxic conditions. Insight into the roles(s) of Msr genes under anoxic stress can lead us to a path of designing therapeutic drugs around these genes in relation to stroke.
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Date Issued
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2018
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PURL
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http://purl.flvc.org/fau/fd/FA00013046
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Subject Headings
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Drosophila melanogaster, Methionine Sulfoxide Reductases, Anoxia, Aging, Oxidative stress
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Format
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Document (PDF)