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A mammalian cell agar-diffusion assay for the detection of toxic compounds
Title
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Creator
Burres, N. S., Hunter, J. E., Wright, Amy E.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332955
Subject Headings
Antineoplastic agents, Toxins, Chromatographic analysis, Thin layer chromatography
Format
Document (PDF)
Chemistry and biology of the discodermolides, potent mitotic spindle poisons
Title
Chemistry and biology of the discodermolides, potent mitotic spindle poisons.
Creator
Gunasekera, Sarath P., Wright, Amy E.
Date Issued
2005
PURL
http://purl.flvc.org/FCLA/DT/3352941
Subject Headings
Polyketides, Sponges, Immunosuppressive agents, Antimitotic agents, Chemistry, Biology
Format
Document (PDF)
Antimicrobial constituent of the brown alga Sporochnus pedunculatus
Title
Antimicrobial constituent of the brown alga Sporochnus pedunculatus.
Creator
Gunasekera, L. S., Wright, Amy E., Gunasekera, Sarath P., McCarthy, Peter J., Reed, John K.
Date Issued
1995
PURL
http://purl.flvc.org/fau/fd/FA00007231
Subject Headings
Brown algae, Antimicrobial agents, Nuclear magnetic resonance, Candida albicans, Bacillus subtilis
Format
Document (PDF)
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
Title
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
Creator
Guzman, Esther A., Johnson, J. D., Linley, P. A., Wright, Amy E., Gunasekera, Sarath P.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3318907
Subject Headings
Pancreas--Cancer, Apoptosis, Sponges--Research, Marine natural products, Drug Discovery
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
Final cruise report: Submersible and scuba collections around little Bahama Bank, Bahama Islands
Title
Final cruise report: Submersible and scuba collections around little Bahama Bank, Bahama Islands.
Creator
Reed, John K., Wright, Amy E., Willoughby, Robin, Janda, Kathleen E., Pitts, Tara P., Robertson, Lynn, Scarpa, Sandra, McElroy, Melanie
Date Issued
1997-01-23
PURL
http://purl.flvc.org/fcla/dt/3359256
Subject Headings
Biomedical research, Biodiversity--Research, Porifera, Gorgonacea, Bahamas
Format
Document (PDF)
Cytotoxin production by a marine Lyngbya strain (cyanobacterium) in a large-scale laboratory bioreactor
Title
Cytotoxin production by a marine Lyngbya strain (cyanobacterium) in a large-scale laboratory bioreactor.
Creator
Armstrong, J. E., Janda, Kathleen E., Alvarado, B., Wright, Amy E.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3333194
Subject Headings
Lyngbya, Cyanobacteria, Cytotoxin, Bioreactors
Format
Document (PDF)
Diversity and bathymetric distribution of lithistid sponges in the tropical western Atlantic region
Title
Diversity and bathymetric distribution of lithistid sponges in the tropical western Atlantic region.
Creator
Pomponi, Shirley A., Kelly-Borges, M., Reed, John K., Wright, Amy E.
Date Issued
2001
PURL
http://purl.flvc.org/FCLA/DT/3321239
Subject Headings
Sponges, Demospongiae, Porifera
Format
Document (PDF)
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix
Title
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
Creator
Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2009
PURL
http://purl.flvc.org/FCLA/DT/3319109
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
Format
Document (PDF)
A systematic revision of the Central Atlantic Halichondrida (Demospongiae, Porifera). Part II. Patterns of distribution of secondary metabolites
Title
A systematic revision of the Central Atlantic Halichondrida (Demospongiae, Porifera). Part II. Patterns of distribution of secondary metabolites.
Creator
Pomponi, Shirley A., Wright, Amy E., Diaz, Maria Cristina, Van Soest, Rob W. M.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3333131
Subject Headings
Halichondrida, Secondary metabolites, Demospongiae--Classification
Format
Document (PDF)
Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp
Title
Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.
Creator
Cassler, M., Peterson, C. L., Ledger, Angela, Pomponi, Shirley A., Wright, Amy E., Winegar, R., McCarthy, Peter J., Lopez, Jose V.
Date Issued
2008
PURL
http://purl.flvc.org/FCLA/DT/2708323
Subject Headings
Microbiology --Research, Sponges --Microbiology, Marine biology --Caribbean Area
Format
Document (PDF)
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Title
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3351980
Subject Headings
Sponges, Sesterterpenes, Marine natural products
Format
Document (PDF)
A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer
Title
A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Chen, Guodong, Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/fau/fd/FA00007361
Subject Headings
Sponges, Alkaloids, Guanidines, Antibacterial agents, Molecular structure
Format
Document (PDF)
Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
Title
Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
Creator
Paterson, Ian, Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzman, Esther A., Isbrucker, Richard A., Pitts, Tara P., Linley, P. A., Divlianska, D. B., Reed, John K., Wright, Amy E.
Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00007465
Subject Headings
Antimitotic Agents, Macrolides, Sponges, Molecular structure, Nuclear Magnetic Resonance, Biomolecular, Cell lines
Format
Document (PDF)
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
Title
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
Creator
Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
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Date Issued
2013-09-17
PURL
http://purl.flvc.org/fau/fd/FAUIR000075
Format
Citation
Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516
Title
Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
Creator
Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description
We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
Date Issued
2014-04-21
PURL
http://purl.flvc.org/fau/fd/FAUIR000076
Format
Citation
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells
Title
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
Creator
Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
Date Issued
2013-04-02
PURL
http://purl.flvc.org/fau/fd/FAUIR000178
Format
Citation
Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani
Title
Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani.
Creator
Kohmoto, S., McConnell, O. J., Wright, Amy E., Koehn, F. E., Thompson, W., Lui, M. S., Snader, K. M.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3332938
Subject Headings
Sponges, Sesquiterpenes, Cytotoxin, Antineoplastic agents, Marine natural products
Format
Document (PDF)
Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity
Title
Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity.
Creator
Gunasekera, Sarath P., Mickel, Stuart J., Daeffler, Robert, Niederer, Daniel, Wright, Amy E., Linley, P. A., Pitts, Tara P.
Date Issued
2004
PURL
http://purl.flvc.org/FCLA/DT/3164107
Subject Headings
Microtubules, Cancer --Research, Biopharmaceutics, Molecular biology, Stereochemistry
Format
Document (PDF)
Microxine, a New cdc2 Kinase Inhibitor from the Australian MarinE Sponge Microxina Species
Title
Microxine, a New cdc2 Kinase Inhibitor from the Australian MarinE Sponge Microxina Species.
Creator
Killday, K. B., Yarwood, Donna, Sills, Matthew A., Murphy, Peter T., Hooper, J. N. A., Wright, Amy E.
Date Issued
2001
PURL
http://purl.flvc.org/FCLA/DT/3164092
Subject Headings
Sponges, Chromatographic analysis, Spectrum analysis, Phosphoprotein Phosphatase --analysis, Nucleosides
Format
Document (PDF)

Pages