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Pages
- Title
- Cytotoxin production by a marine Lyngbya strain (cyanobacterium) in a large-scale laboratory bioreactor.
- Creator
- Armstrong, J. E., Janda, Kathleen E., Alvarado, B., Wright, Amy E.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3333194
- Subject Headings
- Lyngbya, Cyanobacteria, Cytotoxin, Bioreactors
- Format
- Document (PDF)
- Title
- Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata.
- Creator
- Biabani, Misbah F., Gunasekera, Sarath P., Longley, Ross E., Wright, Amy E., Pomponi, Shirley A.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/2795916
- Subject Headings
- Demospongiae, Nucleosides --chemistry, Cytotoxins --biosynthesis --congresses, Streptomyces, Antitumor antibiotics
- Format
- Document (PDF)
- Title
- A mammalian cell agar-diffusion assay for the detection of toxic compounds.
- Creator
- Burres, N. S., Hunter, J. E., Wright, Amy E.
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/FCLA/DT/3332955
- Subject Headings
- Antineoplastic agents, Toxins, Chromatographic analysis, Thin layer chromatography
- Format
- Document (PDF)
- Title
- Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.
- Creator
- Cassler, M., Peterson, C. L., Ledger, Angela, Pomponi, Shirley A., Wright, Amy E., Winegar, R., McCarthy, Peter J., Lopez, Jose V.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/FCLA/DT/2708323
- Subject Headings
- Microbiology --Research, Sponges --Microbiology, Marine biology --Caribbean Area
- Format
- Document (PDF)
- Title
- Three new peroxides from the sponge Plakinastrella species.
- Creator
- Chen, Ying, Killday, K. B., McCarthy, Peter J., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/FCLA/DT/3319103
- Subject Headings
- Sponges --Research, Spectral analysis, Marine natural products, Peroxides, Antifungal agents
- Format
- Document (PDF)
- Title
- New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae.
- Creator
- Chen, Ying, McCarthy, Peter J., Harmody, Dedra K., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/3164099
- Subject Headings
- Sponges, Peroxides, Pathogenic fungi, Candida albicans, Aspergillus fumigatus
- Format
- Document (PDF)
- Title
- Interspecific differences in fouling of two congeneric ascidians (Eudistoma olivaceum and E. capsulatum): is surface acidity an effective defense?.
- Creator
- Davis, A. R., Wright, Amy E.
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/FCLA/DT/3333136
- Subject Headings
- Ascidians, Epibiosis, Fouling
- Format
- Document (PDF)
- Title
- Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name).
- Creator
- Davis, A. R., Wright, Amy E.
- Date Issued
- 1990
- PURL
- http://purl.flvc.org/FCLA/DT/3333148
- Subject Headings
- Ascidians, Carbolines, Marine natural products, Alkaloids, Fouling
- Format
- Document (PDF)
- Title
- In vitro culture of the ascidian Ecteinascidia turbinata to supply the antitumor compounds ecteinascidins.
- Creator
- Duckworth, Alan R., Samples, Gail A., Wright, Amy E., Pomponi, Shirley A.
- Date Issued
- 2004
- PURL
- http://purl.flvc.org/FCLA/DT/2827818
- Subject Headings
- Ascidians, Microalgae --Congresses, Marine ecology, Marine ecosystem management, Antineoplastic agents
- Format
- Document (PDF)
- Title
- In vitro culture of the tropical sponge Axinella Corrugata (Demospongiae): effect of food cell concentration on growth, clearance rate, and biosynthesis of stevensine.
- Creator
- Duckworth, Alan R., Samples, Gail A., Wright, Amy E., Pomponi, Shirley A.
- Date Issued
- 2003
- PURL
- http://purl.flvc.org/FCLA/DT/2709450
- Subject Headings
- Sponges --Microbiology
- Format
- Document (PDF)
- Title
- Discovery and investigation of survivin-targeting marine natural products from Ellisella paraplexauroides and Eudistoma olivaceum.
- Creator
- Francis, Kirstie Tandberg, Wright, Amy E., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
In 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target...
Show moreIn 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target for new drug therapies. At only 16.5 kDa, it consists of a single Baculovirus IAP Repeat (BIR) domain and an α-helical coiled coil. Survivin plays a multitude of roles in the growth and survival of cancer cells—which can be attributed to the variable cellular localizations and posttranslational modifications of the protein—including inhibition of apoptosis, mitosis and cell cycle progression, DNA damage repair, drug resistance, metastasis, angiogenesis, and cell senescence, among others. A drug that is able to target surviving transcription or posttranslational modification or disrupt one of these critical pathways may serve as an attractive new cancer therapy. Despite decades of research on surviving and its intracellular functions, researchers have yet to find an FDA approved drug. Using a high throughput approach, Harbor Branch Oceanographic Institute’s chemical library of marine natural products was screened by the Guzmán lab to identify compounds capable of downregulating survivin expression in A549 non-small cell lung carcinoma and DLD-1 colorectal adenocarcinoma cell lines. From the screening assay, pure compounds were identified which reduce levels of survivin protein in cancer cells. Chapter 2 describes the isolation and structure elucidation of five polyhydroxylated sterol analogs from Ellisella paraplexauroides, four of them novel. Chapter 3 describes the isolation and structure elucidation of two compounds from Eudistoma olivaceum, eudistomin H and I. Chapter 4 describes the secondary biological testing employed to determine if the reduction of survivin expression was driven by reducing de novo production or increasing the degradation of existing protein by evaluating differential gene expression of survivin mRNA using reverse transcriptase quantitative polymerase chain reaction and measuring degradation rates of survivin protein, respectively.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013828
- Subject Headings
- Survivin, Marine natural products, Antineoplastic agents--Development
- Format
- Document (PDF)
- Title
- Cytotoxic peptides from marine sponges.
- Creator
- Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Longley, Ross E.
- Date Issued
- 1996
- PURL
- http://purl.flvc.org/fau/fd/FA00007341
- Subject Headings
- Sponges, Peptides, Cytotoxins, Stereochemistry
- Format
- Document (PDF)
- Title
- Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
- Creator
- Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/FCLA/DT/3333007
- Subject Headings
- Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
- Format
- Document (PDF)
- Title
- Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva.
- Creator
- Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Garay, M., Sills, Matthew A.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3319084
- Subject Headings
- Sponges --Research, Marine natural products, Receptors, Thrombin, Aplysillin A, Antagonists, Enzyme, Marine pharmacology
- Format
- Document (PDF)
- Title
- Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
- Creator
- Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Yarwood, Donna, Sills, Matthew A.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3331880
- Subject Headings
- Sponges, Cyclic peptides, Peptides--Structure, Spectroscopic techniques
- Format
- Document (PDF)
- Title
- Eryloside E from an Atlantic sponge Erylus goffrilleri.
- Creator
- Gulavita, N. K., Wright, Amy E., Kelly-Borges, M., Longley, Ross E., Yarwood, Donna, Sills, Matthew A.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/fau/fd/FA00007261
- Subject Headings
- Sponges, Terpenes, Glycosides, Chemical structure
- Format
- Document (PDF)
- Title
- Antimicrobial constituent of the brown alga Sporochnus pedunculatus.
- Creator
- Gunasekera, L. S., Wright, Amy E., Gunasekera, Sarath P., McCarthy, Peter J., Reed, John K.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/fau/fd/FA00007231
- Subject Headings
- Brown algae, Antimicrobial agents, Nuclear magnetic resonance, Candida albicans, Bacillus subtilis
- Format
- Document (PDF)
- Title
- Chemistry and biology of the discodermolides, potent mitotic spindle poisons.
- Creator
- Gunasekera, Sarath P., Wright, Amy E.
- Date Issued
- 2005
- PURL
- http://purl.flvc.org/FCLA/DT/3352941
- Subject Headings
- Polyketides, Sponges, Immunosuppressive agents, Antimitotic agents, Chemistry, Biology
- Format
- Document (PDF)
- Title
- Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity.
- Creator
- Gunasekera, Sarath P., Mickel, Stuart J., Daeffler, Robert, Niederer, Daniel, Wright, Amy E., Linley, P. A., Pitts, Tara P.
- Date Issued
- 2004
- PURL
- http://purl.flvc.org/FCLA/DT/3164107
- Subject Headings
- Microtubules, Cancer --Research, Biopharmaceutics, Molecular biology, Stereochemistry
- Format
- Document (PDF)
- Title
- Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
- Creator
- Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E., Lobkovsky, E., Clardy, J.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/FCLA/DT/3319100
- Subject Headings
- Sponges --Research, Marine natural products, discorhabdin P, Enzyme inhibitors
- Format
- Document (PDF)