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Cytotoxin production by a marine Lyngbya strain (cyanobacterium) in a large-scale laboratory bioreactor
Title
Cytotoxin production by a marine Lyngbya strain (cyanobacterium) in a large-scale laboratory bioreactor.
Creator
Armstrong, J. E., Janda, Kathleen E., Alvarado, B., Wright, Amy E.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3333194
Subject Headings
Lyngbya, Cyanobacteria, Cytotoxin, Bioreactors
Format
Document (PDF)
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata
Title
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata.
Creator
Biabani, Misbah F., Gunasekera, Sarath P., Longley, Ross E., Wright, Amy E., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/2795916
Subject Headings
Demospongiae, Nucleosides --chemistry, Cytotoxins --biosynthesis --congresses, Streptomyces, Antitumor antibiotics
Format
Document (PDF)
A mammalian cell agar-diffusion assay for the detection of toxic compounds
Title
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Creator
Burres, N. S., Hunter, J. E., Wright, Amy E.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332955
Subject Headings
Antineoplastic agents, Toxins, Chromatographic analysis, Thin layer chromatography
Format
Document (PDF)
Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp
Title
Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.
Creator
Cassler, M., Peterson, C. L., Ledger, Angela, Pomponi, Shirley A., Wright, Amy E., Winegar, R., McCarthy, Peter J., Lopez, Jose V.
Date Issued
2008
PURL
http://purl.flvc.org/FCLA/DT/2708323
Subject Headings
Microbiology --Research, Sponges --Microbiology, Marine biology --Caribbean Area
Format
Document (PDF)
Three new peroxides from the sponge Plakinastrella species
Title
Three new peroxides from the sponge Plakinastrella species.
Creator
Chen, Ying, Killday, K. B., McCarthy, Peter J., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
Date Issued
2001
PURL
http://purl.flvc.org/FCLA/DT/3319103
Subject Headings
Sponges --Research, Spectral analysis, Marine natural products, Peroxides, Antifungal agents
Format
Document (PDF)
New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae
Title
New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae.
Creator
Chen, Ying, McCarthy, Peter J., Harmody, Dedra K., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3164099
Subject Headings
Sponges, Peroxides, Pathogenic fungi, Candida albicans, Aspergillus fumigatus
Format
Document (PDF)
Interspecific differences in fouling of two congeneric ascidians (Eudistoma olivaceum and E. capsulatum): is surface acidity an effective defense?
Title
Interspecific differences in fouling of two congeneric ascidians (Eudistoma olivaceum and E. capsulatum): is surface acidity an effective defense?.
Creator
Davis, A. R., Wright, Amy E.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3333136
Subject Headings
Ascidians, Epibiosis, Fouling
Format
Document (PDF)
Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name)
Title
Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name).
Creator
Davis, A. R., Wright, Amy E.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3333148
Subject Headings
Ascidians, Carbolines, Marine natural products, Alkaloids, Fouling
Format
Document (PDF)
In vitro culture of the ascidian Ecteinascidia turbinata to supply the antitumor compounds ecteinascidins
Title
In vitro culture of the ascidian Ecteinascidia turbinata to supply the antitumor compounds ecteinascidins.
Creator
Duckworth, Alan R., Samples, Gail A., Wright, Amy E., Pomponi, Shirley A.
Date Issued
2004
PURL
http://purl.flvc.org/FCLA/DT/2827818
Subject Headings
Ascidians, Microalgae --Congresses, Marine ecology, Marine ecosystem management, Antineoplastic agents
Format
Document (PDF)
In vitro culture of the tropical sponge Axinella Corrugata (Demospongiae): effect of food cell concentration on growth, clearance rate, and biosynthesis of stevensine
Title
In vitro culture of the tropical sponge Axinella Corrugata (Demospongiae): effect of food cell concentration on growth, clearance rate, and biosynthesis of stevensine.
Creator
Duckworth, Alan R., Samples, Gail A., Wright, Amy E., Pomponi, Shirley A.
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/2709450
Subject Headings
Sponges --Microbiology
Format
Document (PDF)
Discovery and investigation of survivin-targeting marine natural products from Ellisella paraplexauroides and Eudistoma olivaceum
Title
Discovery and investigation of survivin-targeting marine natural products from Ellisella paraplexauroides and Eudistoma olivaceum.
Creator
Francis, Kirstie Tandberg, Wright, Amy E., Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
Abstract/Description
In 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target...
Show moreIn 2020, the National Institute of Health reported that more than 1.8 million people in the U.S. were diagnosed with cancer and over half a million died from those diseases. There is an urgent need for innovative and effective new treatments which stem from novel cancer drug targets. Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family, is highly expressed during development and in cancer cells but not in differentiated tissues, making it a tumor-selective target for new drug therapies. At only 16.5 kDa, it consists of a single Baculovirus IAP Repeat (BIR) domain and an α-helical coiled coil. Survivin plays a multitude of roles in the growth and survival of cancer cells—which can be attributed to the variable cellular localizations and posttranslational modifications of the protein—including inhibition of apoptosis, mitosis and cell cycle progression, DNA damage repair, drug resistance, metastasis, angiogenesis, and cell senescence, among others. A drug that is able to target surviving transcription or posttranslational modification or disrupt one of these critical pathways may serve as an attractive new cancer therapy. Despite decades of research on surviving and its intracellular functions, researchers have yet to find an FDA approved drug. Using a high throughput approach, Harbor Branch Oceanographic Institute’s chemical library of marine natural products was screened by the Guzmán lab to identify compounds capable of downregulating survivin expression in A549 non-small cell lung carcinoma and DLD-1 colorectal adenocarcinoma cell lines. From the screening assay, pure compounds were identified which reduce levels of survivin protein in cancer cells. Chapter 2 describes the isolation and structure elucidation of five polyhydroxylated sterol analogs from Ellisella paraplexauroides, four of them novel. Chapter 3 describes the isolation and structure elucidation of two compounds from Eudistoma olivaceum, eudistomin H and I. Chapter 4 describes the secondary biological testing employed to determine if the reduction of survivin expression was driven by reducing de novo production or increasing the degradation of existing protein by evaluating differential gene expression of survivin mRNA using reverse transcriptase quantitative polymerase chain reaction and measuring degradation rates of survivin protein, respectively.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FA00013828
Subject Headings
Survivin, Marine natural products, Antineoplastic agents--Development
Format
Document (PDF)
Cytotoxic peptides from marine sponges
Title
Cytotoxic peptides from marine sponges.
Creator
Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Longley, Ross E.
Date Issued
1996
PURL
http://purl.flvc.org/fau/fd/FA00007341
Subject Headings
Sponges, Peptides, Cytotoxins, Stereochemistry
Format
Document (PDF)
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella
Title
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
Creator
Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3333007
Subject Headings
Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
Format
Document (PDF)
Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva
Title
Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva.
Creator
Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Garay, M., Sills, Matthew A.
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3319084
Subject Headings
Sponges --Research, Marine natural products, Receptors, Thrombin, Aplysillin A, Antagonists, Enzyme, Marine pharmacology
Format
Document (PDF)
Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
Title
Isolation and structure elucidation of Perthamide B, a novel peptide from the sponge Theonella sp.
Creator
Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Yarwood, Donna, Sills, Matthew A.
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3331880
Subject Headings
Sponges, Cyclic peptides, Peptides--Structure, Spectroscopic techniques
Format
Document (PDF)
Eryloside E from an Atlantic sponge Erylus goffrilleri
Title
Eryloside E from an Atlantic sponge Erylus goffrilleri.
Creator
Gulavita, N. K., Wright, Amy E., Kelly-Borges, M., Longley, Ross E., Yarwood, Donna, Sills, Matthew A.
Date Issued
1994
PURL
http://purl.flvc.org/fau/fd/FA00007261
Subject Headings
Sponges, Terpenes, Glycosides, Chemical structure
Format
Document (PDF)
Antimicrobial constituent of the brown alga Sporochnus pedunculatus
Title
Antimicrobial constituent of the brown alga Sporochnus pedunculatus.
Creator
Gunasekera, L. S., Wright, Amy E., Gunasekera, Sarath P., McCarthy, Peter J., Reed, John K.
Date Issued
1995
PURL
http://purl.flvc.org/fau/fd/FA00007231
Subject Headings
Brown algae, Antimicrobial agents, Nuclear magnetic resonance, Candida albicans, Bacillus subtilis
Format
Document (PDF)
Chemistry and biology of the discodermolides, potent mitotic spindle poisons
Title
Chemistry and biology of the discodermolides, potent mitotic spindle poisons.
Creator
Gunasekera, Sarath P., Wright, Amy E.
Date Issued
2005
PURL
http://purl.flvc.org/FCLA/DT/3352941
Subject Headings
Polyketides, Sponges, Immunosuppressive agents, Antimitotic agents, Chemistry, Biology
Format
Document (PDF)
Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity
Title
Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity.
Creator
Gunasekera, Sarath P., Mickel, Stuart J., Daeffler, Robert, Niederer, Daniel, Wright, Amy E., Linley, P. A., Pitts, Tara P.
Date Issued
2004
PURL
http://purl.flvc.org/FCLA/DT/3164107
Subject Headings
Microtubules, Cancer --Research, Biopharmaceutics, Molecular biology, Stereochemistry
Format
Document (PDF)
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella
Title
Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Longley, Ross E., Pomponi, Shirley A., Wright, Amy E., Lobkovsky, E., Clardy, J.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3319100
Subject Headings
Sponges --Research, Marine natural products, discorhabdin P, Enzyme inhibitors
Format
Document (PDF)

Pages