Current Search: FAU (x) » Electronic Thesis or Dissertation (x) » Wright, Amy E. (x)
View All Items
Pages
- Title
- Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
- Date Issued
- 2014-04-21
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000076
- Format
- Citation
- Title
- The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
Show less - Date Issued
- 2013-09-17
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000075
- Format
- Citation
- Title
- Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
- Creator
- Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
- Date Issued
- 2013-04-02
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000178
- Format
- Citation
- Title
- Natural Products from the Lithistida: A Review of the Literature since 2000.
- Creator
- Winder, Priscilla L., Pomponi, Shirley A., Wright, Amy E.
- Abstract/Description
-
Lithistid sponges are known to produce a diverse array of compounds ranging from polyketides, cyclic and linear peptides, alkaloids, pigments, lipids, and sterols. A majority of these structurally complex compounds have very potent and interesting biological activities. It has been a decade since a thorough review has been published that summarizes the literature on the natural products reported from this amazing sponge order. This review provides an update on the current taxonomic...
Show moreLithistid sponges are known to produce a diverse array of compounds ranging from polyketides, cyclic and linear peptides, alkaloids, pigments, lipids, and sterols. A majority of these structurally complex compounds have very potent and interesting biological activities. It has been a decade since a thorough review has been published that summarizes the literature on the natural products reported from this amazing sponge order. This review provides an update on the current taxonomic classification of the Lithistida, describes structures and biological activities of 131 new natural products, and discusses highlights from the total syntheses of 16 compounds from marine sponges of the Order Lithistida providing a compilation of the literature since the last review published in 2002.
Show less - Date Issued
- 2011-12-15
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000059
- Format
- Citation
- Title
- Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
- Creator
- Paterson, Ian, Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzman, Esther A., Isbrucker, Richard A., Pitts, Tara P., Linley, P. A., Divlianska, D. B., Reed, John K., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007465
- Subject Headings
- Antimitotic Agents, Macrolides, Sponges, Molecular structure, Nuclear Magnetic Resonance, Biomolecular, Cell lines
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
- Creator
- Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007463
- Subject Headings
- Macrolides, Antimitotic Agents, Natural products, Tubulin
- Format
- Document (PDF)
- Title
- A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
- Creator
- Guzman, Esther A., Johnson, J. D., Linley, P. A., Wright, Amy E., Gunasekera, Sarath P.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3318907
- Subject Headings
- Pancreas--Cancer, Apoptosis, Sponges--Research, Marine natural products, Drug Discovery
- Format
- Document (PDF)
- Title
- Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
- Creator
- Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FA00007065
- Subject Headings
- Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
- Format
- Document (PDF)
- Title
- Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii.
- Creator
- Wangun, H. V. K., Wood, A., Fiorilla, C., Reed, John K., McCarthy, Peter J., Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3319112
- Subject Headings
- Crinoidea, Marine natural products, Cytotoxin, Marine metabolites, Anthraquinones
- Format
- Document (PDF)
- Title
- The Lithistida: important sources of compounds useful in biomedical research.
- Creator
- Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3331940
- Subject Headings
- Sponges, Biomedical research, Marine natural products, Bioactive compounds
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin.
- Creator
- Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2009-03-15
- PURL
- http://purl.flvc.org/FCLA/DT/1745595
- Subject Headings
- Bioorganic chemistry, Cancer--Research
- Format
- Document (PDF)
- Title
- Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
- Creator
- Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/FCLA/DT/3319109
- Subject Headings
- Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
- Format
- Document (PDF)
- Title
- Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
- Creator
- Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/fau/fd/FA00007114
- Subject Headings
- Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
- Creator
- Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2008-12-01
- PURL
- http://purl.flvc.org/FCLA/DT/1591053
- Subject Headings
- Bioorganic chemistry, Cancer--Research
- Format
- Document (PDF)
- Title
- Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.
- Creator
- Cassler, M., Peterson, C. L., Ledger, Angela, Pomponi, Shirley A., Wright, Amy E., Winegar, R., McCarthy, Peter J., Lopez, Jose V.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/FCLA/DT/2708323
- Subject Headings
- Microbiology --Research, Sponges --Microbiology, Marine biology --Caribbean Area
- Format
- Document (PDF)
- Title
- Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
- Creator
- Paterson, Ian, Naylor, G. J., Wright, Amy E.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/fau/fd/FA00007062
- Subject Headings
- Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
- Format
- Document (PDF)
- Title
- Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
- Creator
- Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/FCLA/DT/3333013
- Subject Headings
- Macrolides, Antineoplastic agents, Biological evaluation, Synthesis, Antimitotic agents
- Format
- Document (PDF)
- Title
- Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
- Creator
- Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/3333011
- Subject Headings
- Sponges, Macrolides, Marine natural products
- Format
- Document (PDF)
- Title
- Synthesis and biological evaluation of novel analogues of dictyostatin.
- Creator
- Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/2763290
- Subject Headings
- Microtubules --Research--Methodology, Microtubules
- Format
- Document (PDF)
- Title
- Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.
- Creator
- Yang, Shu-Wei, Chan, Tze-Ming, Buevich, Alexei, Priestley, T., Crona, J., Reed, John K., Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Chen, Guodong, Pramanik, B., Chu, Min
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/3343845
- Subject Headings
- Steroid saponins, Starfishes
- Format
- Document (PDF)