Current Search: info:fedora/islandora:entityCModel (x) » Harriet L. Wilkes Honors College (x)
View All Items
(1 - 20 of 685)
Pages
- Title
- Evaluating the DRY motif and its effects on ligand binding at the µ-Opioid Receptor.
- Creator
- Zimmerman, Frank, Bohn, Laura, Schmid, Cullen, Harriet L. Wilkes Honors College
- Abstract/Description
-
Opioids are considered the most efficacious drugs for management of moderate to severe pain, yet their use clinically is often restricted due to the onset of adverse side-effects. Drugs in this class produce most of their physiological effects (analgesia, nausea, vomiting) through activation of the μ-opioid receptor; however, an increasing number of studies have demonstrated that opioids can activate distinct downstream responses, a phenomenon termed functional selectivity. This project...
Show moreOpioids are considered the most efficacious drugs for management of moderate to severe pain, yet their use clinically is often restricted due to the onset of adverse side-effects. Drugs in this class produce most of their physiological effects (analgesia, nausea, vomiting) through activation of the μ-opioid receptor; however, an increasing number of studies have demonstrated that opioids can activate distinct downstream responses, a phenomenon termed functional selectivity. This project attempts to determine the amino acid residues involved in the activation of the μ-opioid receptor and the role they play in the binding of ligands to the receptor. The highly conserved DRY motif (aspartic acid-arginine-tyrosine) found commonly in GPCRs was mutated via site directed mutagenesis, aspartic acid-164 to alanine (A), glutamic acid (E), and arginine (R) and G-protein coupling and competition binding assays were performed to test whether ligand affinity and activity differed in the mutant receptors compared to the wild-type.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00003698
- Format
- Document (PDF)
- Title
- Disrupting methamphetamine associated memory by targeting synaptic dynamics.
- Creator
- Zigmond, Zachary, Miller, Courtney, Young, Erica, Quintyne, Nicholas, Harriet L. Wilkes Honors College
- Abstract/Description
-
Methamphetamine (METH) is addictive and associated with a high rate of relapse. One relapse trigger is re-experiencing drug-associated contextual associations. Therefore it is possible that, by targeting METH-associated contextual memories, drug seeking behavior can be inhibited. Recent evidence has suggested that memory formation relies on actin polymerization, which allows dendritic spines to undergo structural and functional plasticity, key components of memory. To see if actin...
Show moreMethamphetamine (METH) is addictive and associated with a high rate of relapse. One relapse trigger is re-experiencing drug-associated contextual associations. Therefore it is possible that, by targeting METH-associated contextual memories, drug seeking behavior can be inhibited. Recent evidence has suggested that memory formation relies on actin polymerization, which allows dendritic spines to undergo structural and functional plasticity, key components of memory. To see if actin polymerization could be a target for the extinction of METH seeking memories we inhibited actin polymerization in animals that had been trained in either METH or food associated conditioned place preference. Pretest inhibition of actin cycling in the basolateral amygdala complex produced immediate and persistent extinction of METH seeking behavior. Additionally, inhibiting actin polymerization 24hrs before testing disrupted seeking behavior for METH but not food. These results indicate that METH-associated memories are selectively vulnerable to disruption through inhibition of actin dynamics.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003542
- Format
- Document (PDF)
- Title
- ON HUMILITY IN MEDICINE.
- Creator
- Zavala, Frida, Baima, Nicholas, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
The importance of medical virtues has allowed physicians to flourish within their fields as they interact and form relationships with their co-workers, themselves, and, most importantly, their patients. Though much attention has been paid to virtues like compassion and integrity, the virtue of humility has been overlooked. This is unfortunate because humility, I will argue, is deeply important to being a virtuous physician. The humble physician collaboratively works with their patients to...
Show moreThe importance of medical virtues has allowed physicians to flourish within their fields as they interact and form relationships with their co-workers, themselves, and, most importantly, their patients. Though much attention has been paid to virtues like compassion and integrity, the virtue of humility has been overlooked. This is unfortunate because humility, I will argue, is deeply important to being a virtuous physician. The humble physician collaboratively works with their patients to understand their concerns and find a solution in the patient’s best interest. In addition, I will argue that humility can indeed be taught and offer how it can be implemented in the medical school curriculum.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00226
- Format
- Document (PDF)
- Title
- THE EVOLUTIONARY BASIS OF SENSORY-MOTOR INTEGRATION THROUGH CRISPR/CAS9.
- Creator
- Zaninelli, Samantha, Duboué, Erik R., Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Startle responses are evolutionarily conserved behaviors that play key roles in the daily necessities of an animal, including foraging and predator avoidance. While the neuronal mechanisms underlying startle responses are well understood, less is known about the evolutionary mechanisms that modify this behavior. This study places a focus on uncovering the evolutionary and genetic basis of sensory-motor integration through the analysis of startle response behavior. We address this question...
Show moreStartle responses are evolutionarily conserved behaviors that play key roles in the daily necessities of an animal, including foraging and predator avoidance. While the neuronal mechanisms underlying startle responses are well understood, less is known about the evolutionary mechanisms that modify this behavior. This study places a focus on uncovering the evolutionary and genetic basis of sensory-motor integration through the analysis of startle response behavior. We address this question using the emerging evolutionary model, Astyanax mexicanus, which consists of 2 different populations: a river-dwelling surface fish and a cave-dwelling fish. These populations drastically evolved differential traits due to their environment. This study focused on the extracellular leucine-rich repeat and fibronectin type III domain containing 1 (elfn1) gene, and its impact on sensory-motor behaviors utilizing the CRISPR/Cas 9 gene- editing technique. It was found that there is no statistically significant involvement of startle response with this gene. Together, this study helps reveal genetic mechanisms underlying the evolution of conserved sensory-motor behavior. Startle response behaviors are evolutionarily fundamental assets to life, and understanding the role genetics play in this will assist us with identifying a continuous circuit of genes with significant roles in sensory overload.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00281
- Format
- Document (PDF)
- Title
- Characterization of the spinster gene ortholog C13C4.5 in Caenorhabditis elegans.
- Creator
- Zahornacky, Darrin., Harriet L. Wilkes Honors College
- Abstract/Description
-
The dauer larva is an alternate larval stage which allows the nematode C. elegans to survive environmestress during development. Dauer formation requires autophagy, a cellular process responsible for degrading and recycling cytoplasmic components. I investigated the role of a spinster orthiolog, C13C4.5, by examining the effects of C13C4.5 loss-of-function and by generating a transgenic strain which expressed a C13C4.5::GFP fusion protein. Under normal conditions C13C4.5::GFP is expressed...
Show moreThe dauer larva is an alternate larval stage which allows the nematode C. elegans to survive environmestress during development. Dauer formation requires autophagy, a cellular process responsible for degrading and recycling cytoplasmic components. I investigated the role of a spinster orthiolog, C13C4.5, by examining the effects of C13C4.5 loss-of-function and by generating a transgenic strain which expressed a C13C4.5::GFP fusion protein. Under normal conditions C13C4.5::GFP is expressed diffusely in the intestine, but under autophagy-promoting conditions the expression pattern becomes more punctate. This is consistent with localization of C13C4.5 to autophagolysomoes during autophagy, as has been shown for spinster in D. melanogaster. Loss of C13C4.5 function in a dauer-constitutive mutant resulted in a reduction in the proportion of animals entering into the dauer stage. Together these data suggest that C13C4.5 is involved in dauer formation and the autophagy pathway.
Show less - Date Issued
- 2012
- PURL
- http://purl.flvc.org/FAU/3359320
- Subject Headings
- Gene expression, Apoptosis, Caenorhabditis elegans, Proteins, Analysis
- Format
- Document (PDF)
- Title
- An analysis of Froehde’s and Duquenois-Levine colorimetric tests.
- Creator
- Zaglul, Javier, Smith, Eugene, Harriet L. Wilkes Honors College
- Abstract/Description
-
Colorimetric testing is frequently used to identify unknown substances in the field. These tests are composed of a solution which changes colors in the presence of certain drugs. Each solution can yield a variety of colors to test compounds, but the tests are nonspecific. The speed of colorimetric analysis has made it ideal for onsite preliminary drug tests. In particular, the Froehde’s solution can identify various opiates and hallucinogens; and the Duquenois-Levine test can identify...
Show moreColorimetric testing is frequently used to identify unknown substances in the field. These tests are composed of a solution which changes colors in the presence of certain drugs. Each solution can yield a variety of colors to test compounds, but the tests are nonspecific. The speed of colorimetric analysis has made it ideal for onsite preliminary drug tests. In particular, the Froehde’s solution can identify various opiates and hallucinogens; and the Duquenois-Levine test can identify cannabinoids. Our analysis revealed that the Froehde’s test yields results beyond what is stated in the literature, but that these results are not very specific. The Duquenois-Levine test yields a number of different results, but its criteria for a positive result keep it a more specific test.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003541
- Format
- Document (PDF)
- Title
- ASEXUAL REPRODUCTION OF NATIVE AND NON-NATIVE SPECIES OF MILKWEED IN VARIANT SOIL CONDITIONS.
- Creator
- Young, Jessica Elizabeth, O’Brien, William, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Milkweeds (genus Asclepias) are the host plants for caterpillar stages of milkweed butterflies (subfamily Danianae), notably the monarch butterfly, Danaius plexippus (Linnaeus). Loss of suitable habitat and host plants threaten monarch populations. For my thesis research, I examined artificial propagation of milkweed plants, specifically the effects of three different soil substrates and exposure to hormone powder on the survival rates of cuttings from two milkweed species, A. tuberosa...
Show moreMilkweeds (genus Asclepias) are the host plants for caterpillar stages of milkweed butterflies (subfamily Danianae), notably the monarch butterfly, Danaius plexippus (Linnaeus). Loss of suitable habitat and host plants threaten monarch populations. For my thesis research, I examined artificial propagation of milkweed plants, specifically the effects of three different soil substrates and exposure to hormone powder on the survival rates of cuttings from two milkweed species, A. tuberosa rolfsii and A. curassavica. Fifty-four cuttings of each species were transplanted to substrates of a mixture of peat moss and perlite, only peat moss, and potting soil. Half of each of the groups of cuttings were exposed to rooting hormone powder. A binomial logistic regression model was developed to determine the significance of each of the independent variables in the likelihood of survival of any individual cutting. The model specified had an 84.3% accuracy in correctly predicting the survival of the cuttings. This experiment may offer insights on the best environment for the propagation of native species of milkweed, which could be beneficial in the development of more native habitats for monarch butterflies in Florida.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00238
- Format
- Document (PDF)
- Title
- STRANGE FREQUENCIES: DEVELOPMENT OF A POST-HUMAN SEQUENTIAL NARRATIVE.
- Creator
- Young, Jessica E., Luria, Rachel, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Posthumanism embodies a wide-ranging scope of philosophies, including works of transhumanism dealing with cybernetics or androids. Few works treat advanced technological developments like A.I. and androids as equal to, or companions to humanity. Despite the potential for future technology to be equally as intelligent as humans, there remains a limited number of stories treating android or A.I. characters as main characters and narrative lenses. This project grapples with questions of humanity...
Show morePosthumanism embodies a wide-ranging scope of philosophies, including works of transhumanism dealing with cybernetics or androids. Few works treat advanced technological developments like A.I. and androids as equal to, or companions to humanity. Despite the potential for future technology to be equally as intelligent as humans, there remains a limited number of stories treating android or A.I. characters as main characters and narrative lenses. This project grapples with questions of humanity, spirituality, and environment through sequential storytelling using an android protagonist. This adds critical reflection to the body of posthumanist works by serving as one of a few stories where the main character is not human, and the world is after the time of humankind. Instead of encapsulating a purely entertaining story of science fiction, this work delves into ideas of rapid environmental degradation and ever-evolving levels and functions of technology in our world and our near future.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00237
- Format
- Document (PDF)
- Title
- COMPUTER VISION: A PAIR OF FRESH EYES TO STUDY ANIMAL BEHAVIOR.
- Creator
- Yee, Warren, Fily, Yaouen, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Computer vision has completely changed the way we study animal behavior. Over the past 15 years, researchers have developed several computer vision-based tools to automatically track an animal’s position and pose through time. This data can then be used to uncover the reasons behind the animal’s behavior. In this talk, I will compare two tracking tools, one based on contrast detection (Trilab-Tracker), and one based on machine learning (DeepLabCut), to determine which performs better on an...
Show moreComputer vision has completely changed the way we study animal behavior. Over the past 15 years, researchers have developed several computer vision-based tools to automatically track an animal’s position and pose through time. This data can then be used to uncover the reasons behind the animal’s behavior. In this talk, I will compare two tracking tools, one based on contrast detection (Trilab-Tracker), and one based on machine learning (DeepLabCut), to determine which performs better on an existing set of videos of Mexican cavefish (Astyanax mexicanus) collected in Johanna Kowalko’s lab.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00280
- Format
- Document (PDF)
- Title
- International Peacekeeping: A Critique of the United Nations’ Operational Procedures.
- Creator
- Ybarra, Angelo, Steigenga, Timothy, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
International Peacekeeping has been a polarizing topic since becoming established as a mainstay in United Nations policy. Although international involvement of this sort is bound to be vulnerable to situational complications, the consistency of the UN’s failures makes it impossible to ignore the fundamental issues engrained in its standard operating procedures. This thesis analyses a number of key UN peacekeeping operations that resulted in varying degrees of success as well as the general...
Show moreInternational Peacekeeping has been a polarizing topic since becoming established as a mainstay in United Nations policy. Although international involvement of this sort is bound to be vulnerable to situational complications, the consistency of the UN’s failures makes it impossible to ignore the fundamental issues engrained in its standard operating procedures. This thesis analyses a number of key UN peacekeeping operations that resulted in varying degrees of success as well as the general assessments that have been developed in response to these operations. Based upon an analysis of these cases as well as the literature on the issue of UN Peacekeeping, the thesis identifies the common problems in Peacekeeping operations and traces their evolution to the foundational elements of the UN Peacekeeping program combined with the evolving types of Peacekeeping missions undertaken.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00164
- Format
- Document (PDF)
- Title
- Correlation between specific carcinogenic chemicals and specific mitotic defects and the restorative role of antioxidants.
- Creator
- Yates, Travis., Harriet L. Wilkes Honors College
- Abstract/Description
-
The progression of cancerous cells towards a more aggressive tumor can be linked to external elements called carcinogens. The goal of this project is to examine the correlation between exposure to specific carcinogens and an increase of mitotic defects. These defects can manifest as lagging chromosomes, multipolar spindles, and anaphase bridges. Some of these instabilities are associated with the formation of reactive oxygen species (ROS), which are known to damage DNA. The potential for...
Show moreThe progression of cancerous cells towards a more aggressive tumor can be linked to external elements called carcinogens. The goal of this project is to examine the correlation between exposure to specific carcinogens and an increase of mitotic defects. These defects can manifest as lagging chromosomes, multipolar spindles, and anaphase bridges. Some of these instabilities are associated with the formation of reactive oxygen species (ROS), which are known to damage DNA. The potential for damage to the genome can be averted via antioxidants. Using the oral cancer cell line UPCI:SCC103, we established a baseline for the mitotic defects in the absence and presence of various ROS-inducing carcinogens using DAPI-stained fixed cells examined by immunofluorescent microscopy, The cells were treated with varying concentrations of the antioxidants, Vitamin C, (Sb(B-Carotene, and Vitamin E. The reactive oxygen scavengers significantly reduced the number of mitotic defects. A possible link between the carcinogens and lagging chromosomes was established.
Show less - Date Issued
- 2009
- PURL
- http://purl.flvc.org/FAU/210007
- Subject Headings
- Cellular signal transduction, Genetic regulation, Antioxidants, Therapeutic use, Apoptosis, Molecular aspects, Cancer, Chemoprevention
- Format
- Document (PDF)
- Title
- The Ethics of Non-Medical Gender Selection.
- Creator
- Yagudaev, Eva, Kennedy, Ashley, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
-
Due to the rate at which technological advancement is occurring, it has become increasingly difficult for the medical field to address the new ethical dilemmas that arise. Many new techniques and methods call into question ethical standards that have been the norm for many years. Further, these advancements tread into new territory that can be perplexing to many. One such field that has grown by leaps and bounds is the field of reproductive endocrinology. On one hand it has allowed women who...
Show moreDue to the rate at which technological advancement is occurring, it has become increasingly difficult for the medical field to address the new ethical dilemmas that arise. Many new techniques and methods call into question ethical standards that have been the norm for many years. Further, these advancements tread into new territory that can be perplexing to many. One such field that has grown by leaps and bounds is the field of reproductive endocrinology. On one hand it has allowed women who have trouble conceiving to become pregnant and has created families where there was little hope before. However, it also has created a minefield of ethical dilemmas. Due to the nature of the field there are a lot of ethical questions regarding the procedures that reproductive endocrinologists perform. Since we are now able to manipulate embryos and potentially change their genetics, people have become worried of the potential repercussions.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00064
- Format
- Document (PDF)
- Title
- ANALYSIS OF MENTHOL EXTRACTED FROM MINT LEAVES USING VCD AND COMPUTATION GENERATED SPECTRA.
- Creator
- Xu, Ethan, Chandrasekhar, Chitra, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Recently, the terpene class of molecules have been under much interest due to their potential medicinal properties. Terpenes such as cannabidiol and tetrahydrocannabinol have been studied for their psychological effects, while others like myrcene are of interest due to their antifungal and antibacterial properties. However, some of these terpenes possess different properties dependent on their stereochemistry, potentially with one enantiomer having the desired the effect and the other having...
Show moreRecently, the terpene class of molecules have been under much interest due to their potential medicinal properties. Terpenes such as cannabidiol and tetrahydrocannabinol have been studied for their psychological effects, while others like myrcene are of interest due to their antifungal and antibacterial properties. However, some of these terpenes possess different properties dependent on their stereochemistry, potentially with one enantiomer having the desired the effect and the other having a reduced or even harmful effect in some cases. Despite the importance of stereochemistry in medicine, techniques that are sensitive to it are still uncommon, but one technique in the form of VCD/IR spectroscopy has been under interest due to its ability to effectively analyze small molecules with limited flexibility, such as many terpenes. This thesis will cover the use of VCD/IR spectroscopy in the analysis of menthol from Mentha piperita, specifically the stereochemistry based on a known pure sample, and through calculated spectra.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00225
- Format
- Document (PDF)
- Title
- Dinner conversation: eating sustainably without dietary elitism.
- Creator
- Wood, Alyssa A., Harriet L. Wilkes Honors College
- Abstract/Description
-
This study explores the perceived elitism within both the environmentalist community and general public in regards to "environmental diets" such as : vegetarianism, veganism, locavore-ism, and ethical omnivory. I explore these diets and potential expressions of elitism within the framework developed by Morrison and Dunlap in their discussion of environmental elitism. Examples come from published sources as well as personal anecdotes. Through this study, I suggest that this perceived elitism...
Show moreThis study explores the perceived elitism within both the environmentalist community and general public in regards to "environmental diets" such as : vegetarianism, veganism, locavore-ism, and ethical omnivory. I explore these diets and potential expressions of elitism within the framework developed by Morrison and Dunlap in their discussion of environmental elitism. Examples come from published sources as well as personal anecdotes. Through this study, I suggest that this perceived elitism is actually not elitism per se, but a very thin line of tension between describing the ideal food systems aside the current state of food inequity and industrial agriculture. Simply, I am trying to grapple with how to be educated in the fields of Food Studies and systems of oppression without perpetuating elitism alongside the system which desperately needs reform.
Show less - Date Issued
- 2012
- PURL
- http://purl.flvc.org/FAU/3359330
- Subject Headings
- Food industry and trade, Food habits, Nutrition policy, Food, Marketing, Eating (Philosophy), Food, Social aspects
- Format
- Document (PDF)
- Title
- TWO PARMOTREMA LICHEN SPECIES AS POLLUTION BIOINDICATORS IN FLORIDA.
- Creator
- Womble, Hunter, Wetterer, James K., Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Lichens are commonly used as bioindicators of air pollution. For my thesis, I tested the utility of two easily identified lichen species as bioindicators. Parmotrema perforatum is considered to be pollution intolerant, while Parmotrema subrigidium is considered to be somewhat pollution tolerant. I surveyed P. perforatum and P. subrigidum growing on the trunks of southern live oak trees (Quercus virginiana) at two sites on the John D. MacArthur campus of Florida Atlantic University in Jupiter,...
Show moreLichens are commonly used as bioindicators of air pollution. For my thesis, I tested the utility of two easily identified lichen species as bioindicators. Parmotrema perforatum is considered to be pollution intolerant, while Parmotrema subrigidium is considered to be somewhat pollution tolerant. I surveyed P. perforatum and P. subrigidum growing on the trunks of southern live oak trees (Quercus virginiana) at two sites on the John D. MacArthur campus of Florida Atlantic University in Jupiter, Florida that differed in exposure to road traffic. One site on the interior of campus (AOS1) was distant from any road, while the other site (AOS2) was along a busy road. I identified lichen samples from using keys and chemical spot tests. I found AOS1 had a higher density of P. perforatum, and whereas AOS2 had a higher density of P. subrigidum, confirming the utility of these two lichens as bioindicators of pollution.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00279
- Format
- Document (PDF)
- Title
- 45 YEARS OF BURNOUT RESEARCH: EXAMINING RISKS, TREATMENTS, AND PREVALENCE IN MENTAL HEALTH PROFESSIONALS.
- Creator
- Wojcik, Schuyler, Vernon, Laura, Harriet L. Wilkes Honors College, Florida Atlantic University
- Abstract/Description
-
Professional burnout is the state or process of mental exhaustion typically associated with factors such as chronic job stress and work overload. Several models of burnout have been proposed, but Christina Maslach’s (1976) model continues to be the most prominent, with her Maslach Burnout Inventory (MBI) remaining the most commonly used burnout assessment tool. According to her model, burnout is made up of three dimensions: exhaustion, cynicism, and inefficacy. Multiple studies have found...
Show moreProfessional burnout is the state or process of mental exhaustion typically associated with factors such as chronic job stress and work overload. Several models of burnout have been proposed, but Christina Maslach’s (1976) model continues to be the most prominent, with her Maslach Burnout Inventory (MBI) remaining the most commonly used burnout assessment tool. According to her model, burnout is made up of three dimensions: exhaustion, cynicism, and inefficacy. Multiple studies have found that burnout is most highly associated with factors involving an excess of job demands and a lack of personal and professional support. Prolonged burnout is associated with decreased effectiveness on the job, multiple health problems, and an increased risk of substance abuse. Burnout researchers have found evidence which points to increased burnout levels among mental health workers, though a few studies contain evidence that mental health workers may not be at a higher risk of burnout than employees in other fields.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00132
- Format
- Document (PDF)
- Title
- The bizarreness effect and memory: implications for eyewitness testimony.
- Creator
- Wiseman, Jennifer., Harriet L. Wilkes Honors College
- Abstract/Description
-
Mistakes in combining components of stimuli are called binding or memory conjunction errors. They occur when people mistakenly associate two previously seen stimulus features that were not previously seen together. It is hypothesized that bizarre items will be better remembered than common items. Participants saw 18 continuous events, each containing four actions performed by four different actors. One week later they returned for a recognition test and were shown more video clips. There were...
Show moreMistakes in combining components of stimuli are called binding or memory conjunction errors. They occur when people mistakenly associate two previously seen stimulus features that were not previously seen together. It is hypothesized that bizarre items will be better remembered than common items. Participants saw 18 continuous events, each containing four actions performed by four different actors. One week later they returned for a recognition test and were shown more video clips. There were old, new action, and conjunction items. A conjunction item was composed of a familiar actor performing a familiar action that had previously been performed by someone else. For each clip, participants were asked if they saw this person perform this action before. Participants responded "yes" to conjunction same context items more often than they did to conjunction different context items.
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/FAU/77698
- Subject Headings
- Eyewitness identification, Context effects (Psychology), Memory
- Format
- Document (PDF)
- Title
- DOES CAENORHABDITIS ELEGANS HAVE THE CAPACITY TO BUILD UP TOLERANCE TO AMPHETAMINE.
- Creator
- Wilson, Ian, Carvelli, Lucia, Florida Atlantic University, Harriet L. Wilkes Honors College
- Abstract/Description
-
Drug tolerance can be defined as a progressive reduction in the effect of a drug following a previous exposure. Amphetamine (AMPH) is a psychostimulant which produces its behavioral effects primarily by an increase extracellular dopamine (DA) level. In C. elegans, this surplus of extracellular DA causes the loss of the ability to swim, also called swimming induced paralysis (SWIP). Here we tested if C. elegans could build up a tolerance for AMPH. Two separate groups of L4 animals were tested...
Show moreDrug tolerance can be defined as a progressive reduction in the effect of a drug following a previous exposure. Amphetamine (AMPH) is a psychostimulant which produces its behavioral effects primarily by an increase extracellular dopamine (DA) level. In C. elegans, this surplus of extracellular DA causes the loss of the ability to swim, also called swimming induced paralysis (SWIP). Here we tested if C. elegans could build up a tolerance for AMPH. Two separate groups of L4 animals were tested for an initial SWIP trial: a control 1st-treated group and an AMPH 1st-treated group. Both groups had 3 recovery periods and reassessed for a 2nd SWIP trial with control or AMPH solutions. Our results show that the first exposure to AMPH reduces the number of animals exhibiting SWIP when treated for the second time with AMPH 30 minutes after the first exposure.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FAUHT00111
- Format
- Document (PDF)
- Title
- Reparations and reconciliation: negotiating claims of historical injustice in the case of the herero genocide.
- Creator
- Williams, Leslie, O’Brien, William, Harriet L. Wilkes Honors College
- Abstract/Description
-
To date, Germany has denied any obligation to financial compensation for the Herero genocide of 1904-1907. The Herero began petitioning in 1995 and haven’t yet seen results. The reconciliation process has been slowed by German denial and Namibian politics alike. Germany maintains that genocide was not technically illegal until the Convention on the Prevention and Punishment of the Crime of Genocide in 1948, an argument that contradicts the hundreds of millions of dollars they continue to pay...
Show moreTo date, Germany has denied any obligation to financial compensation for the Herero genocide of 1904-1907. The Herero began petitioning in 1995 and haven’t yet seen results. The reconciliation process has been slowed by German denial and Namibian politics alike. Germany maintains that genocide was not technically illegal until the Convention on the Prevention and Punishment of the Crime of Genocide in 1948, an argument that contradicts the hundreds of millions of dollars they continue to pay to Jewish victims as restitution for WWII. Historians argue that there are extensive links between German colonialism and the Jewish Holocaust. German concentration camps in Namibia developed extermination techniques that later enabled Jewish Holocaust, and both used the victims’ bodies for scientific research. In 2012, a delegation of Namibians retrieved 20 skulls of Herero and Nama victims from Germany. The repatriation of the skulls stimulated a resurgence of debate about reparations, motivating the Left Party to make a motion in German parliament that outlines an apology, repatriation, reparations, and continued partnership between the two nations.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003540
- Format
- Document (PDF)
- Title
- Tracking mitotic defects via time-lapse photography.
- Creator
- Williams, Joseph, Quintyne, Nicholas, Harriet L. Wilkes Honors College
- Abstract/Description
-
As tumors generate, there is a progression in genomic instability derived from chromosomal rearrangement and instability. Often, these manifest themselves as defects in mitosis, frequently as lagging chromosomes, multipolar spindles, and anaphase bridges. Lagging chromosomes are the result of inaccurate chromosomal division in mitosis, thus jeopardizing the genome of an organism’s offspring; they derive from several errors, such as failure of a chromosome to attach to the mitotic spindle. The...
Show moreAs tumors generate, there is a progression in genomic instability derived from chromosomal rearrangement and instability. Often, these manifest themselves as defects in mitosis, frequently as lagging chromosomes, multipolar spindles, and anaphase bridges. Lagging chromosomes are the result of inaccurate chromosomal division in mitosis, thus jeopardizing the genome of an organism’s offspring; they derive from several errors, such as failure of a chromosome to attach to the mitotic spindle. The goal of this project has been to characterize the mechanisms of lagging chromosomes in the cancer cell line UPCI:SCC103. Our laboratory’s work has shown that treatment with certain carcinogens increase the rate of mitotic defect. To further our understanding these defects, we are monitoring the progression of lagging chromosomes in UPCI:SCC103 cells with live cell analysis, using GFP-tagged histone H2B to track their appearance and fate, so to distinguish between the possible causes and resolutions of this mitotic defect.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA00003539
- Format
- Document (PDF)
