View All Items
(1 - 8 of 8)
- Scholar's name
- Joseph Velasquez
- Department
- Department of Visual Arts and Art History
- Status
- Current
- jvelasquez@fau.edu
- Format
- Institutional Scholar
- Title
- EFFECT OF G-CSF GENE THERAPY IN A MICROGLIA MODEL OF STROKE.
- Creator
- Velasquez Saldarriaga, Esteban, Wu, Jang-Yen, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
- Abstract/Description
-
Cerebrovascular events (stroke) are a significant cause of morbidity and mortality worldwide. Ischemic stroke accounts for ~85% of all strokes and is caused by the blockade of blood flow to a certain area of the brain, resulting in oxygen and nutrient deprivation and ultimately cell death. Cerebral ischemia induces a strong neuroinflammatory response that contributes to tissue damage and is driven by changes in the gene expression profile and phenotype of brain cells including neurons,...
Show moreCerebrovascular events (stroke) are a significant cause of morbidity and mortality worldwide. Ischemic stroke accounts for ~85% of all strokes and is caused by the blockade of blood flow to a certain area of the brain, resulting in oxygen and nutrient deprivation and ultimately cell death. Cerebral ischemia induces a strong neuroinflammatory response that contributes to tissue damage and is driven by changes in the gene expression profile and phenotype of brain cells including neurons, astrocytes, and microglia. Microglia are the resident immune and phagocytic cells of the central nervous system. They rapidly respond to ischemia by migrating to the site of injury and modulating the inflammatory response there. Although microglia may play a deleterious role in the acute phase of stroke, evidence suggests that they play an important role in the reduction of excitotoxic injury as well as in neurogenesis during the tissue regeneration phase. Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that has shown beneficial effects in models of ischemic stroke. G-CSF exerts its neuroprotective effects through different mechanisms including mobilization of haemopoietic stem cells, angiogenesis, neurogenesis, anti-inflammation, and anti-apoptosis. However, its effect on microglia is not well understood yet. The main objective of this project was to evaluate the protective and anti-inflammatory effect of G-CSF gene therapy against glutamate cytotoxicity in the human microglial clone 3 cell line (HMC3). Our results show that although G-CSF gene therapy did not significantly protect HMC3 cells against glutamate induced cell death, it reduced the expression levels of pro-inflammatory proteins NF-κB p65, IL-1β and IL-6, while increasing the phosphorylation of Akt, a regulator of cell survival and proliferation.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013821
- Subject Headings
- Stroke, Granulocyte Colony-Stimulating Factor, Cerebrovascular disease, Microglia
- Format
- Document (PDF)
- Title
- THE TEAR THAT NEVER REACHES THE GROUND.
- Creator
- Albert, Leslie Deborah, Velasquez, Joseph, Florida Atlantic University, Department of Visual Arts and Art History, Dorothy F. Schmidt College of Arts and Letters
- Abstract/Description
-
My fascination with the human figure remains a prominent part of my work as a familiar and complex path to formalist traditions. But as I have sought to expand my engagement with representational figuration, I look towards themes of universal emotions and conditions - grief, remembrance, anger, affection and resolve. Within this, I often allude to socio-political content, art historical references or personal experiences. In integrating representational figuration with a contemporary approach...
Show moreMy fascination with the human figure remains a prominent part of my work as a familiar and complex path to formalist traditions. But as I have sought to expand my engagement with representational figuration, I look towards themes of universal emotions and conditions - grief, remembrance, anger, affection and resolve. Within this, I often allude to socio-political content, art historical references or personal experiences. In integrating representational figuration with a contemporary approach, I incorporate techniques of drawing, painting and printmaking into narrative formats while preserving the figure as the protagonist. I lean into gestural lines, expressive marks and abstract color fields to breathe life into the work and enhance the emotive context. I embrace the intuitive process as I believe it reflects and retains a certain spiritual spontaneity and response. Recently, I have experienced deep loss. It is the grief associated with this that has informed these pieces. Grief is a process that can be present, historical, anticipatory or prolonged. I have been stricken by a wide range of losses –personal, societal, political and cultural - death of loved ones, risk of severe limitations to civil liberties and bodily autonomy, global wars and violence, xenophobia, brutal attacks on democratic ideals and even the inevitable passage of time have precipitated my personal and visceral grief.
Show less - Date Issued
- 2024
- PURL
- http://purl.flvc.org/fau/fd/FA00014445
- Subject Headings
- Art, Fine arts, Figurative art
- Format
- Document (PDF)
- Title
- Messiah: FAU Chamber Singers and Chamber Alumni - December 2008.
- Creator
- FAU Department of Music, FAU Chamber Singers, Fleitas, Patricia P. (Conductor)
- Date Issued
- 2008-12
- PURL
- http://purl.flvc.org/fau/fd/FADT363391
- Subject Headings
- Choruses with piano
- Format
- Set of related objects
- Title
- FAU Choral Ensembles - November 2007.
- Creator
- FAU Women's Chorus, FAU Men's Chorus, FAU Chamber Singers, FAU Department of Music
- Date Issued
- 2007-11
- PURL
- http://purl.flvc.org/fau/fd/FAU358422
- Subject Headings
- Choruses with piano
- Format
- Set of related objects
- Title
- FAU Spring Music Festival 2008: FAU Choral Organizations - April 2008.
- Creator
- FAU Department of Music, FAU Men's Chorus, Brown, Sally C. (Conductor), FAU Women's Chorus, Rossow, Stacie Lee (Conductor), FAU Chamber Singers, Fleitas, Patricia P. (Conductor), FAU Vocal Troupe Ensemble
- Date Issued
- 2008-04
- PURL
- http://purl.flvc.org/fau/fd/FADT337406
- Subject Headings
- Choruses, Secular, with piano
- Format
- Set of related objects
- Title
- FAU ensembles performing works by composer in residence, Libby Larsen - March 2008.
- Creator
- Larsen, Libby (Composer), FAU Choral Ensembles, FAU Symphony Orchestra, FAU Wind Ensemble, Department of Music
- Date Issued
- 2008-03
- PURL
- http://purl.flvc.org/fau/fd/FADT222894
- Subject Headings
- Wind Ensemble, Symphonies
- Format
- Set of related objects
- Title
- Master's Conducting Recital by Catherine Anne Briggs (Conductor): The Choral Music of Zoltan Kodaly - Spring 2010.
- Creator
- Briggs, Catherine Anne (Conductor), FAU Women's Chorus, FAU Vocal Performance Troupe, FAU Chamber Singers, FAU Department of Music
- Date Issued
- 2010-04-20
- PURL
- http://purl.flvc.org/fau/fd/FADT3171021
- Subject Headings
- Choral conducting, Choruses, Secular, with piano
- Format
- Set of related objects
