Current Search: "Department of Biological Sciences" (x)
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Pages
- Title
- Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage.
- Creator
- Ayyanathan, Kasirajan, Kesaraju, Shailaja, Dawson-Scully, Ken, Weissbach, Herbert, Bauer, Joseph Alan
- Date Issued
- 2012-07-17
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000091
- Format
- Citation
- Title
- In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster.
- Creator
- Bruce, Lindsay, Singkornrat, Diana, Wilson, Kelsey, Hausman, William, Robbins, Kelli, Huang, Lingxi, Foss, Katie, Binninger, David
- Date Issued
- 2018-11-01
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.3390_antiox7110155_1634240527
- Format
- Citation
- Title
- Reproductive success of male Atlantic spotted dolphins (Stenella frontalis) revealed by noninvasive genetic analysis of paternity.
- Creator
- Green, Michelle L., Herzing, Denise L., Baldwin, John D.
- Date Issued
- 2011-03
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1139_Z10-111_1631733445
- Format
- Citation
- Title
- Biomass offsets little or none of permafrost carbon release from soils, streams, and wildfire: an expert assessment.
- Creator
- Abbott, Benjamin W, Jones, Jeremy B, Schuur, Edward A G, Chapin III, F Stuart, Bowden, William B, Bret-Harte, M Syndonia, Epstein, Howard E, Flannigan, Michael D, Harms, Tamara K, Hollingsworth, Teresa N, Mack, Michelle C, McGuire, A David, Natali, Susan M, Rocha, Adrian V, Tank, Suzanne E, Turetsky, Merritt R, Vonk, Jorien E, Wickland, Kimberly P, Aiken, George R, Alexander, Heather D, Amon, Rainer M W, Benscoter, Brian W, Bergeron, Yves, Bishop, Kevin, Blarquez, Olivier, Ben Bond-Lamberty, Breen, Amy L, Buffam, Ishi, Cai, Yihua, Carcaillet, Christopher, Carey, Sean K, Chen, Jing M, Chen, Han Y H, Christensen, Torben R, Cooper, Lee W, Cornelissen, J Hans C, de Groot, William J, DeLuca, Thomas H, Dorrepaal, Ellen, Fetcher, Ned, Finlay, Jacques C, Forbes, Bruce C, French, Nancy H F, Gauthier, Sylvie, Girardin, Martin P, Goetz, Scott J, Goldammer, Johann G, Gough, Laura, Grogan, Paul, Guo, Laodong, Higuera, Philip E, Hinzman, Larry, Hu, Feng Sheng, Hugelius, Gustaf, Jafarov, Elchin E, Jandt, Randi, Johnstone, Jill F, Jan Karlsson, Kasischke, Eric S, Kattner, Gerhard, Kelly, Ryan, Keuper, Frida, Kling, George W, Kortelainen, Pirkko, Kouki, Jari, Kuhry, Peter, Laudon, Hjalmar, Laurion, Isabelle, Macdonald, Robie W, Mann, Paul J, Martikainen, Pertti J, McClelland, James W, Molau, Ulf, Oberbauer, Steven F, Olefeldt, David, Paré, David, Parisien, Marc-André, Payette, Serge, Peng, Changhui, Pokrovsky, Oleg S, Rastetter, Edward B, Raymond, Peter A, Raynolds, Martha K, Rein, Guillermo, Reynolds, James F, Robards, Martin, Rogers, Brendan M, Schädel, Christina, Schaefer, Kevin, Schmidt, Inger K, Shvidenko, Anatoly, Sky, Jasper, Spencer, Robert G M, Starr, Gregory, Striegl, Robert G, Teisserenc, Roman, Tranvik, Lars J, Virtanen, Tarmo, Welker, Jeffrey M, Zimov, Sergei
- Date Issued
- 2016-03-07
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1088_1748-9326_11_3_034014_1632246943
- Format
- Citation
- Title
- Association of postfire peat accumulation and microtopography in boreal bogs.
- Creator
- Benscoter, Brian W, Vitt, Dale H, Wieder, R Kelman
- Date Issued
- 2005-09-01
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1139_x05-115_1632245551
- Format
- Citation
- Title
- Estimating Belowground Carbon Stocks in Isolated Wetlands of the Northern Everglades Watershed, Central Florida, Using Ground Penetrating Radar and Aerial Imagery.
- Creator
- McClellan, Matthew, Comas, Xavier, Benscoter, Brian, Hinkle, Ross, Sumner, David
- Date Issued
- 2017-11-06
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1002_2016JG003573_1632253498
- Format
- Citation
- Title
- Shifts in pore connectivity from precipitation versus groundwater rewetting increases soil carbon loss after drought.
- Creator
- Smith, A. Peyton, Bond-Lamberty, Ben, Benscoter, Brian W., Tfaily, Malak M., Hinkle, C. Ross, Liu, Chongxuan, Bailey, Vanessa L.
- Date Issued
- 2017-12-06
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1038_s41467-017-01320-x_1632338662
- Format
- Citation
- Title
- Postprandial sleep mechanics in Drosophila.
- Creator
- Murphy, Keith R, Deshpande, Sonali A, Yurgel, Maria E, Quinn, James P, Weissbach, Jennifer L, Keene, Alex C, Dawson-Scully, Ken, Huber, Robert, Tomchik, Seth M, Ja, William W
- Date Issued
- 2016-11-22
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.7554_eLife.19334_1644866459
- Format
- Document (PDF)
- Title
- RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease.
- Creator
- Wang, Ruizhi, Palavicini, Juan Pablo, Wang, Hongjie, Maiti, Panchanan, Bianchi, Elisabetta, Xu, Shaohua, Lloyd, B.N., Dawson-Scully, Ken, Kang, David E., Lakshmana, Madepalli K.
- Date Issued
- 2014-09
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1016_j.nbd.2014.05.029_1644863302
- Format
- Document (PDF)
- Title
- The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
- Creator
- Opperman, Karla J., Mulcahy, Ben, Giles, Andrew C., Risley, Monica G., Birnbaum, Rayna L., Tulgren, Erik D., Dawson-Scully, Ken, Zhen, Mei, Grill, Brock
- Date Issued
- 2017-04
- PURL
- http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1016_j.celrep.2017.04.003_1644939781
- Format
- Document (PDF)
- Title
- A content analysis of 32 years of Shark Week documentaries.
- Creator
- Lisa B. Whitenack, Brady L. Mickley, Julia Saltzman, Stephen M. Kajiura, Catherine C. Macdonald, David S. Shiffman
- Abstract/Description
-
Despite evidence of their importance to marine ecosystems, at least 32% of all chondrichthyan species are estimated or assessed as threatened with extinction. In addition to the logistical difficulties of effectively conserving wide-ranging marine species, shark conservation is believed to have been hindered in the past by public perceptions of sharks as dangerous to humans. Shark Week is a high-profile, international programming event that has potentially enormous influence on public...
Show moreDespite evidence of their importance to marine ecosystems, at least 32% of all chondrichthyan species are estimated or assessed as threatened with extinction. In addition to the logistical difficulties of effectively conserving wide-ranging marine species, shark conservation is believed to have been hindered in the past by public perceptions of sharks as dangerous to humans. Shark Week is a high-profile, international programming event that has potentially enormous influence on public perceptions of sharks, shark research, shark researchers, and shark conservation. However, Shark Week has received regular criticism for poor factual accuracy, fearmongering, bias, and inaccurate representations of science and scientists. This research analyzes the content and titles of Shark Week episodes across its entire 32 years of programming to determine if there are trends in species covered, research techniques featured, expert identity, conservation messaging, type of programming, and portrayal of sharks. We analyzed titles from 272 episodes (100%) of Shark Week programming and the content of all available (201; 73.9%) episodes. Our data demonstrate that the majority of episodes are not focused on shark bites, although such shows are common and many Shark Week programs frame sharks around fear, risk, and adrenaline. While criticisms of disproportionate attention to particular charismatic species (e.g. great whites, bull sharks, and tiger sharks) are accurate and supported by data, 79 shark species have been featured briefly at least once. Shark Week’s depictions of research and of experts are biased towards a small set of (typically visual and expensive) research methodologies and (mostly white, mostly male) experts, including presentation of many white male non-scientists as scientific experts. While sharks are more often portrayed negatively than positively, limited conservation messaging does appear in 53% of episodes analyzed. Results suggest that as a whole, while Shark Week is likely contributing to the collective public perception of sharks as bad, even relatively small alterations to programming decisions could substantially improve the presentation of sharks and shark science and conservation issues.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000533
- Format
- Document (PDF)
- Title
- Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs.
- Creator
- Monica G. Risley, Stephanie P. Kelly, Kailiang Jia, Brock Grill, Ken Dawson- Scully
- Abstract/Description
-
The microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electroshock/electroconvulsion remains absent. Here, we have developed a quantitative behavioral method to...
Show moreThe microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electroshock/electroconvulsion remains absent. Here, we have developed a quantitative behavioral method to assess the locomotor response following electric shock in C. elegans. Electric shock impairs normal locomotion, and induces paralysis and muscle twitching; after a brief recovery period, shocked animals resume normal locomotion. We tested electric shock responses in loss-of-function mutants for unc-25, which encodes the GABA biosynthetic enzyme GAD, and unc-49, which encodes the GABAA receptor. unc-25 and unc-49 mutants have decreased inhibitory GABAergic transmission to muscles, and take significantly more time to recover normal locomotion following electric shock compared to wild-type. Importantly, increased sensitivity of unc-25 and unc-49 mutants to electric shock is rescued by treatment with antiepileptic drugs, such as retigabine. Additionally, we show that pentylenetetrazol (PTZ), a GABAA receptor antagonist and proconvulsant in mammalian and C. elegans seizure models, increases susceptibility of worms to electric shock.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000530
- Format
- Document (PDF)
- Title
- egl‑4 modulates electroconvulsive seizure duration in C. elegans.
- Creator
- Monica G. Risley, Stephanie P. Kelly, Justin Minnerly, Kailiang Jia, Ken Dawson‑Scully
- Abstract/Description
-
Increased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An unexplored, novel target for seizure therapeutics is the cGMP/protein kinase G (PKG) pathway, which targets downstream K+ channels, a mechanism similar to Retigabine, a recently FDA-approved antiepileptic drug. Our results demonstrate that...
Show moreIncreased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An unexplored, novel target for seizure therapeutics is the cGMP/protein kinase G (PKG) pathway, which targets downstream K+ channels, a mechanism similar to Retigabine, a recently FDA-approved antiepileptic drug. Our results demonstrate that increased PKG activity decreased seizure duration in C. elegans utilizing a recently developed electroconvulsive seizure assay. While the fly is a well-established seizure model, C. elegans are an ideal yet unexploited model which easily uptakes drugs and can be utilized for high-throughput screens. In this study, we show that treating the worms with either a potassium channel opener, Retigabine or published pharmaceuticals that increase PKG activity, significantly reduces seizure recovery times. Our results suggest that PKG signaling modulates downstream K+ channel conductance to control seizure recovery time in C. elegans. Hence, we provide powerful evidence, suggesting that pharmacological manipulation of the PKG signaling cascade may control seizure duration across phyla.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000532
- Format
- Document (PDF)
- Title
- The enigmatic Marmorkrebs (marbled crayfish) is the parthenogenetic form of Procambarus fallax (Hagen, 1870).
- Creator
- Peer Martin, Nathan J. Dorn, Tadashi Kawai, Craig van der Heiden, Gerhard Scholtz
- Abstract/Description
-
A mysterious parthenogenetic cambarid crayfish (the Marmorkrebs) has been spreading across the globe for the past decade. We compare this crayfish directly to two other cambarids, Procambarus fallax and P. alleni, that have been suggested to be related or even identical to the Marmorkrebs. Using external morphology and sequences of two mitochondrial genes we show clear correspondences between Marmorkrebs and P. fallax, a species found natively throughout peninsular Florida, USA. Based on...
Show moreA mysterious parthenogenetic cambarid crayfish (the Marmorkrebs) has been spreading across the globe for the past decade. We compare this crayfish directly to two other cambarids, Procambarus fallax and P. alleni, that have been suggested to be related or even identical to the Marmorkrebs. Using external morphology and sequences of two mitochondrial genes we show clear correspondences between Marmorkrebs and P. fallax, a species found natively throughout peninsular Florida, USA. Based on these congruent results we suggest that the Marmorkrebs is the parthenogenetic form of P. fallax. This finding has potential evolutionary and ecological implications at several levels. The Marmorkrebs might be a type of geographical parthenogenesis, but a natural population in the wild is so far unknown. Furthermore, challenges arise in regard to the respective species status of the Marmorkrebs. Taxonomically we suggest that the Marmorkrebs is treated as ‘parthenogenetic form’ of P. fallax. Last but not least, the identity of this animal and its ecology has an impact for considering potential spread and effects of this species across the globe.
Show less - Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000482
- Format
- Document (PDF)
- Title
- Chemopreventive Effects of Magnesium Chloride Supplementation on Hormone Independent Prostate Cancer Cells.
- Creator
- Saheed Oluwasina Oseni, Elsa Quiroz, James Kumi-Diaka
- Abstract/Description
-
Lifestyle significantly impacts the risk factors associated with prostate cancer, out of which diet appears to be the most influential. An emerging chemopreventive approach, which involves the adequate intake of dietary constituents, has shown great potential in preventing the occurrence or progression of cancer. Magnesium is known to be an essential cofactor for more than 300 enzymatic processes, and is responsible for the regulation of various cellular reactions in the body. A plethora of...
Show moreLifestyle significantly impacts the risk factors associated with prostate cancer, out of which diet appears to be the most influential. An emerging chemopreventive approach, which involves the adequate intake of dietary constituents, has shown great potential in preventing the occurrence or progression of cancer. Magnesium is known to be an essential cofactor for more than 300 enzymatic processes, and is responsible for the regulation of various cellular reactions in the body. A plethora of studies have shown evidence that changes in the intracellular levels of magnesium could contribute to cell proliferation and apoptosis in some normal and malignant cells. The aim of the study was to investigate the effects of magnesium chloride (MgCl2) in DU-145 prostate cancer cells.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000486
- Format
- Document (PDF)
- Title
- Association of SIM2 with cancer.
- Creator
- Narayanan, Ramaswamy, Florida Atlantic University
- Date Issued
- 2004-08
- PURL
- http://purl.flvc.org/fcla/dt/15822
- Format
- Document (PDF)
- Title
- Methods of detecting a colon cancer cell.
- Creator
- Narayanan, Ramaswamy, Florida Atlantic University
- Date Issued
- 2004-01
- PURL
- http://purl.flvc.org/fcla/dt/15819
- Format
- Document (PDF)
- Title
- Catalytic antioxidants and methods of use.
- Creator
- Weissbach, Herbert, Brot, Nathan, Florida Atlantic University
- Date Issued
- 2006-10
- PURL
- http://purl.flvc.org/fcla/dt/15818
- Format
- Document (PDF)
- Title
- Channel catfish virus disease vaccine and method of preparation thereof and method of immunization therewith.
- Creator
- Hartmann, James X., Noga, Edward J., Florida Atlantic University
- Date Issued
- 1980-08
- PURL
- http://purl.flvc.org/fcla/dt/15860
- Format
- Document (PDF)
- Title
- Colon carcinoma related oligonucleotides and methods of use.
- Creator
- Narayanan, Ramaswamy, Florida Atlantic University
- Date Issued
- 2004-06
- PURL
- http://purl.flvc.org/fcla/dt/15823
- Format
- Document (PDF)