Current Search: "kbrew@health.fau.edu" (x)
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Title
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Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia.
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Creator
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Ashutosh, Chao, C, Borgmann, K, Brew, Keith, Ghorpade, A
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Date Issued
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2012-06
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000129
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Format
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Citation
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Title
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Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.
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Creator
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Thiyagarajan, Nethaji, Pham, Tram T. K., Stinson, Brittany, Sundriyal, Amit, Tumbale, Percy, Lizotte-Waniewski, Michelle, Brew, Keith, Acharya, K. Ravi
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Date Issued
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2012-12-07
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000113
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Format
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Citation
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Title
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Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.
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Creator
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Nagase, Hideaki, Brew, Keith
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Abstract/Description
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Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition...
Show moreMatrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue inhibitors of metalloproteinases (TIMPs). This review highlights the structures and inhibition mechanism of TIMPs, the biological activities of TIMPs, the unique properties of TIMP-3, and the altered specificity towards MMPs achieved by mutagenesis. A potential therapeutic use of TIMP variants is discussed.
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Date Issued
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2002-04-02
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PURL
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http://purl.flvc.org/fcla/dt/3327266
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Subject Headings
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Gene Therapy --Methods, Genetic Engineering --methods, Protein Structure, Tertiary, Rheumatic Diseases --therapy, Tissue Inhibitor of Metalloproteinases, Wound Healing --physiology, Metalloproteinases --Inhibitors --Therapeutic use
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Format
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Document (PDF)
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Title
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A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons.
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Creator
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Ould-yahoui, Adlane, Tremblay, Evelyne, Sbai, Oualid, Ferhat, Lotfi, Bernard, Anne, Charrat, Eliane, Gueye, Yatma, Lim, Ngee Han, Brew, Keith, Risso, Jean-Jacques, Dive, Vincent, Khrestchatisky, Michel, Rivera, Santiago, Chédotal, Alain
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Date Issued
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2009-12-14
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000096
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Format
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Citation
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Title
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The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity.
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Creator
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Minond, Dmitriy, Lauer-Fields, Janelle L., Cudic, Mare, Overall, Christopher M., Pei, Duanqing, Brew, Keith, Visse, Robert, Nagase, Hideaki, Fields, Gregg B.
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Date Issued
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2006-12
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M606004200_1638203001
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Format
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Document (PDF)
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Title
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Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis.
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Creator
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Crabtree, Benedict, Thiyagarajan, Nethaji, Prior, Stephen H., Wilson, Peter, Iyer, Shalini, Ferns, Tyrone, Shapiro, Robert, Brew, Keith, Subramanian, Vasanta, Acharya, K. Ravi
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Date Issued
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2007-10-01
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_bi701333h_1638203835
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Format
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Document (PDF)
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Title
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Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria.
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Creator
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Van Doren, Steven R., Wei, Shuo, Gao, Guanghua, DaGue, Beverly B., Palmier, Mark O., Bahudhanapati, Harinath, Brew, Keith
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Date Issued
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2008-11
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1002_bip.21043_1638215239
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Format
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Document (PDF)
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Title
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Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors.
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Creator
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Lauer-Fields, Janelle L., Cudic, Mare, Wei, Shuo, Mari, Frank, Fields, Gregg B., Brew, Keith
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Date Issued
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2007-09
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M611612200_1638212835
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Format
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Document (PDF)
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Title
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Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
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Creator
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Lim, Ngee H., Kashiwagi, Masahide, Visse, Robert, Jones, Jonathan, Enghild, Jan J., Brew, Keith, Nagase, Hideaki
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Date Issued
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2010-10-01
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1042_BJ20100725_1638297790
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Format
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Document (PDF)
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Title
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Structures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis Products.
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Creator
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Pham, Tram T.K., Stinson, Brittany, Thiyagarajan, Nethaji, Lizotte-Waniewski, Michelle, Brew, Keith, Acharya, K. Ravi
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Date Issued
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2014-03
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M113.545384_1638284195
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Format
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Document (PDF)