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ADDRESSING HIGHLY IMBALANCED BIG DATA CHALLENGES FOR MEDICARE FRAUD DETECTION
Title
ADDRESSING HIGHLY IMBALANCED BIG DATA CHALLENGES FOR MEDICARE FRAUD DETECTION.
Creator
Johnson, Justin M., Khoshgoftaar, Taghi M., Florida Atlantic University, Department of Computer and Electrical Engineering and Computer Science, College of Engineering and Computer Science
Abstract/Description
Access to affordable healthcare is a nationwide concern that impacts most of the United States population. Medicare is a federal government healthcare program that aims to provide affordable health insurance to the elderly population and individuals with select disabilities. Unfortunately, there is a significant amount of fraud, waste, and abuse within the Medicare system that inevitably raises premiums and costs taxpayers billions of dollars each year. Dedicated task forces investigate the...
Show moreAccess to affordable healthcare is a nationwide concern that impacts most of the United States population. Medicare is a federal government healthcare program that aims to provide affordable health insurance to the elderly population and individuals with select disabilities. Unfortunately, there is a significant amount of fraud, waste, and abuse within the Medicare system that inevitably raises premiums and costs taxpayers billions of dollars each year. Dedicated task forces investigate the most severe fraudulent cases, but with millions of healthcare providers and more than 60 million active Medicare beneficiaries, manual fraud detection efforts are not able to make widespread, meaningful impact. Through the proliferation of electronic health records and continuous breakthroughs in data mining and machine learning, there is a great opportunity to develop and leverage advanced machine learning systems for automating healthcare fraud detection. This dissertation identifies key challenges associated with predictive modeling for large-scale Medicare fraud detection and presents innovative solutions to address these challenges in order to provide state-of-the-art results on multiple real-world Medicare fraud data sets. Our methodology for curating nine distinct Medicare fraud classification data sets is presented with comprehensive details describing data accumulation, data pre-processing, data aggregation techniques, data enrichment strategies, and improved fraud labeling. Data-level and algorithm-level methods for treating severe class imbalance, including a flexible output thresholding method and a cost-sensitive framework, are evaluated using deep neural network and ensemble learners. Novel encoding techniques and representation learning methods for high-dimensional categorical features are proposed to create expressive representations of provider attributes and billing procedure codes.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FA00014057
Subject Headings
Medicare fraud, Big data, Machine learning
Format
Document (PDF)
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficien
Title
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficien.
Creator
Tomoyuki Sasaki, Shanshan Lian, Jie Qi, Peter E. Bayliss, Christopher E. Carr, Jennifer L. Johnson, Sujay Guha, Patrick Kobler, Sergio D. Catz, Matthew Gill, Kailiang Jia, Daniel J. Klionsky
Abstract/Description
Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptoms, but little is known about the mechanisms leading to the pathogenesis in vivo. Beclin 1 and p53 are two pivotal tumor suppressors that are critically involved in the autophagic process and its...
Show moreSpinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptoms, but little is known about the mechanisms leading to the pathogenesis in vivo. Beclin 1 and p53 are two pivotal tumor suppressors that are critically involved in the autophagic process and its regulation. Using zebrafish as a genetic model, we show that Beclin 1 suppression ameliorates Spns1 lossmediated senescence as well as autophagic impairment, whereas unexpectedly p53 deficit exacerbates both of these characteristics. We demonstrate that ‘basal p53’ activity plays a certain protective role(s) against the Spns1 defect-induced senescence via suppressing autophagy, lysosomal biogenesis, and subsequent autolysosomal formation and maturation, and that p53 loss can counteract the effect of Beclin 1 suppression to rescue the Spns1 defect. By contrast, in response to DNA damage, ‘activated p53’ showed an apparent enhancement of the Spns1-deficient phenotype, by inducing both autophagy and apoptosis. Moreover, we found that a chemical and genetic blockage of lysosomal acidification and biogenesis mediated by the vacuolar-type H+-ATPase, as well as of subsequent autophagosome-lysosome fusion, prevents the appearance of the hallmarks caused by the Spns1 deficiency, irrespective of the basal p53 state. Thus, these results provide evidence that Spns1 operates during autophagy and senescence differentially with Beclin 1 and p53.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FAUIR000526
Format
Document (PDF)
New records and range extensions of deepwater algae from east Flower Garden Bank, northwestern Gulf of Mexico
Title
New records and range extensions of deepwater algae from east Flower Garden Bank, northwestern Gulf of Mexico.
Creator
Eiseman, N. J., Blair, Stephen M., Harbor Branch Oceanographic Institute
Date Issued
1982
PURL
http://purl.flvc.org/fau/fd/FA00007070
Subject Headings
Mexico, Gulf of, Flower Garden Banks National Marine Sanctuary (Tex.), Algae, Species
Format
Document (PDF)
Life-history evidence for sibling species in Axiothella rubrocincta (Polychaeta: Maldanidae)
Title
Life-history evidence for sibling species in Axiothella rubrocincta (Polychaeta: Maldanidae).
Creator
Wilson, W. Herbert, Jr., Harbor Branch Oceanographic Institute
Date Issued
1983
PURL
http://purl.flvc.org/FCLA/DT/3176722
Subject Headings
Polychaeta, Maldanidae, Polychaetes
Format
Document (PDF)
Ophioderma devaneyi and Ophioderma ensiferum, new brittlestar species from the western Atlantic (Echinodermata: Ophiuroidea)
Title
Ophioderma devaneyi and Ophioderma ensiferum, new brittlestar species from the western Atlantic (Echinodermata: Ophiuroidea).
Creator
Hendler, Gordon, Miller, John E., Harbor Branch Oceanographic Institute
Date Issued
1984
PURL
http://purl.flvc.org/FCLA/DT/3321214
Subject Headings
Echinodermata, Ophiuroidea, Brittle-stars
Format
Document (PDF)
Swimming seacucumbers (Echinodermata: Holothuroidea): a survey, with analysis of swimming behavior in fourbathyal species
Title
Swimming seacucumbers (Echinodermata: Holothuroidea): a survey, with analysis of swimming behavior in fourbathyal species.
Creator
Miller, John E., Pawson, David L., Harbor Branch Oceanographic Institute
Date Issued
1990
PURL
http://purl.flvc.org/fau/fd/FA00007097
Subject Headings
Sea cucumbers, Echinodermata, Holothuroidea, Sea cucumbers--Behavior, Swimming
Format
Document (PDF)
Systematics andecology of the sea-urchin genus Centrostephanus (Echinodermata: Echinoidea) from the Atlantic andeastern Pacific Oceans
Title
Systematics andecology of the sea-urchin genus Centrostephanus (Echinodermata: Echinoidea) from the Atlantic andeastern Pacific Oceans.
Creator
Pawson, David L., Miller, John E., Harbor Branch Oceanographic Institute
Date Issued
1983
PURL
http://purl.flvc.org/fau/fd/FA00007096
Subject Headings
Atlantic Ocean, Echinodermata, Echinoidea, Sea urchins--Ecology, Centrostephanus, Sea urchins--Pacific Ocean
Format
Document (PDF)
The correlation of downwelling irradiance and staggered vertical migration patterns of zooplankton in Wilkinson Basin, Gulf of Maine
Title
The correlation of downwelling irradiance and staggered vertical migration patterns of zooplankton in Wilkinson Basin, Gulf of Maine.
Creator
Frank, Tamara M., Widder, Edith A., Harbor Branch Oceanographic Institute
Date Issued
1997
PURL
http://purl.flvc.org/FCLA/DT/3355151
Subject Headings
Zooplankton--Migration, Vertical distribution (Aqauatic biology)
Format
Document (PDF)
On the spatial distribution and nearest neighbor distance between particles in the water column determined from in situ holographic measurements
Title
On the spatial distribution and nearest neighbor distance between particles in the water column determined from in situ holographic measurements.
Creator
Malkiel, E., Abras, J. N., Widder, Edith A., Katz, J., Harbor Branch Oceanographic Institute
Date Issued
2005
PURL
http://purl.flvc.org/FCLA/DT/3177162
Subject Headings
Zooplankton, Holography, Plankton sampling, Plankton--Measurement
Format
Document (PDF)
In situ observations on three species of largefinned deep-sea squids
Title
In situ observations on three species of largefinned deep-sea squids.
Creator
Vecchione, M., Roper, C. F. E., Widder, Edith A., Frank, Tamara M., Harbor Branch Oceanographic Institute
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3171653
Subject Headings
Squids, Giant squids, Oceanography --Observations, Oceanographic submersibles, Marine biology
Format
Document (PDF)
A new species of coronate scyphomedusa from the Bahamas, Atorella octogonos
Title
A new species of coronate scyphomedusa from the Bahamas, Atorella octogonos.
Creator
Mills, Claudia E., Larson, R. J., Youngbluth, Marsh J.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3171641
Subject Headings
Gonads, Jellyfishes, Scyphozoa, Polyps, Oceanographic submersibles
Format
Document (PDF)
Periclimenes ingressicolumbi, new species, a pontoniine shrimp associated with deep-water echinoids off San Salvador Island in the Bahamas, and a comparison with Periclimenes milleri
Title
Periclimenes ingressicolumbi, new species, a pontoniine shrimp associated with deep-water echinoids off San Salvador Island in the Bahamas, and a comparison with Periclimenes milleri.
Creator
Berggren, M., Svane, Ib, Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3336705
Subject Headings
Periclimenes, Echinoidea, Morphology, Shrimps
Format
Document (PDF)
Heterotrophic activity on appendicularian (Tunicata: Appendicularia) houses in mesopelagic regions and their potential contribution to particle flux
Title
Heterotrophic activity on appendicularian (Tunicata: Appendicularia) houses in mesopelagic regions and their potential contribution to particle flux.
Creator
Davoll, P. J., Youngbluth, Marsh J.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3353847
Subject Headings
Tunicata, Appendicularia, Marine zooplankton, Detritus
Format
Document (PDF)
The significance of macroscopic aggregates (marine snow) as sites for heterotrophic bacterial production in the mesopelagic zone of the subtropical Atlantic
Title
The significance of macroscopic aggregates (marine snow) as sites for heterotrophic bacterial production in the mesopelagic zone of the subtropical Atlantic.
Creator
Alldredge, A. L., Youngbluth, Marsh J.
Date Issued
1985
PURL
http://purl.flvc.org/FCLA/DT/3353759
Subject Headings
Detritus, Heterotrophic bacteria, Protozoa, Benthos, Atlantic Ocean
Format
Document (PDF)
Chemical composition and oxygen consumption rates of ctenophore Bolinopsis infundibulum from the Gulf of Maine
Title
Chemical composition and oxygen consumption rates of ctenophore Bolinopsis infundibulum from the Gulf of Maine.
Creator
Bailey, T. G., Youngbluth, Marsh J., Owen, G. P.
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3355149
Subject Headings
Ctenophora, Ctenophora--Atlantic Coast, Marine zooplankton
Format
Document (PDF)
Chemical composition, metabolic rates and feeding behavior of the midwater ctenophore Bathocyroe fosteri
Title
Chemical composition, metabolic rates and feeding behavior of the midwater ctenophore Bathocyroe fosteri.
Creator
Youngbluth, Marsh J., Kremer, P., Bailey, T. G., Jacoby, C. A.
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3333092
Subject Headings
Ctenophora, Feeding Behavior, Biochemistry, Metabolism--Measurement
Format
Document (PDF)
Aggregations of myctophid fishes with other pelagic fauna
Title
Aggregations of myctophid fishes with other pelagic fauna.
Creator
Auster, P. J., Griswold, C. A., Youngbluth, Marsh J., Bailey, T. G.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333202
Subject Headings
Myctophidae, Submersibles, Predator and prey, Fishes--Behavior
Format
Document (PDF)
A purpose-built ROV for submersible rescue
Title
A purpose-built ROV for submersible rescue.
Creator
Clark, A. M., Neely, J. W., White, Dan G., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/fau/fd/FA00007451
Subject Headings
Submersibles, Oceanographic submersibles, Submarine rescue vehicles, Harbor Branch Oceanographic Institution
Format
Document (PDF)
Lipogramma Robinsi, a new basslet from the tropical western Atlantic, with descriptive and distributional notes on L. Flavescens and L. Anabantoides (Perciformes: Grammatidae)
Title
Lipogramma Robinsi, a new basslet from the tropical western Atlantic, with descriptive and distributional notes on L. Flavescens and L. Anabantoides (Perciformes: Grammatidae).
Creator
Gilmore, R. G., Harbor Branch Oceanographic Institute
Date Issued
1997
PURL
http://purl.flvc.org/FCLA/DT/3340507
Subject Headings
Perciformes, Perciformes--Classification
Format
Document (PDF)
Western Atlantic midwater hydrozoan and scyphozoan medusae: in situ studies using manned submersibles
Title
Western Atlantic midwater hydrozoan and scyphozoan medusae: in situ studies using manned submersibles.
Creator
Larson, R. J., Mills, C. E., Harbison, G. R., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3333168
Subject Headings
Medusae, Hydrozoa, Scyphozoa, Vertical distribution (Aquatic biology), North Atlantic Ocean
Format
Document (PDF)

Pages