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Title: Window in the Sea.
Creator: Jerry D. Stachiw
Abstract/Description: The Edwin A. Link lectures are made possible by grants from the Link Foundation in honor of its founder Edwin A. Link, engineer, inventor, and explorer. They are administered by the Smithsonian Institution and designed to enrich the literature on the history of aerospace and oceanography, and to contribute to "the increase and diffusion of knowledge among men." As a further tribute to the inventive genius of Mr. Link, it is appropriate that this, the seventh of the Link Lecture Series, be...
Show moreThe Edwin A. Link lectures are made possible by grants from the Link Foundation in honor of its founder Edwin A. Link, engineer, inventor, and explorer. They are administered by the Smithsonian Institution and designed to enrich the literature on the history of aerospace and oceanography, and to contribute to "the increase and diffusion of knowledge among men." As a further tribute to the inventive genius of Mr. Link, it is appropriate that this, the seventh of the Link Lecture Series, be devoted to his development of the newest and most practical underwater work vehicle. The Johnson-Sea-Link submersible has just been commissioned and promises a great advancement in the area of marine research. For this achievement, also, we give immeasurable credit to J. Seward Johnson, whose financial contributions have helped in its construction, and will continue to help in its research operations.
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Date Issued: 1971
PURL: http://purl.flvc.org/fau/fd/FAUIR000512
Format: Document (PDF)

Title: Preliminary cruise report: Submersible and scuba collections in the coastal waters of Honduras, the Bay Islands: Biomedical and biodiversity research of the benthic communities with emphasis on the porifera, algae and gorgonacea.
Creator: Reed, John K., Pomponi, Shirley A., Hanisak, M. Dennis, Wright, Amy E., Janda, Kathleen E., Pitts, Tara P., Willoughby, Robin, Killday, K. B., Robertson, Lynn, Lopez, Jose V., Kelly-Borges, Klaus, Overdorf, Laura S., Monaghan, Pat
Date Issued: 1997-12-15
PURL: http://purl.flvc.org/fcla/dt/3359259
Subject Headings: Honduras, Biomedical Research, Biodiversity--Research
Format: Document (PDF)

Title: A system for dynamic stress analysis of a launch & recovery crane at sea with some preliminary results.
Creator: Stewart, Ken
Date Issued: 1981
PURL: http://purl.flvc.org/fcla/dt/3358773
Subject Headings: Submersibles, Submersibles--Design and construction, Submersibles--Technological innovations
Format: Document (PDF)

Title: Governor Farris Bryant Addresses the Attendees, 1964.
Creator: Wilkerson, John [Photographer]
Date Issued: 1964
PURL: http://purl.flvc.org/fau/2700118
Subject Headings: Florida Atlantic University -- History, Florida Atlantic University -- Students
Format: Image (JPEG2000)

Title: All I Need.
Creator: Mighdoll Hoffmaster, Diana [Choreographer], Cold Play; Radiohead [Music], Dorothy F. Schmidt College of Arts and Letters, Brooks, Clarence [Artistic director], Department of Theatre and Dance
Abstract/Description: The Dances We Dance Performance Showcase is a capstone experience for students enrolled in all levels of the Department of Theatre and Dance performance course offerings.
Date Issued: 2010
PURL: http://purl.flvc.org/fau/fd/FAdwd10need
Subject Headings: Dance performance
Format: Set of related objects

Title: Land of Snow.
Creator: Brooks, Clarence[Choreographer], Peter I. Tchaikovsky [Music], Dorothy F. Schmidt College of Arts and Letters, Department of Theatre and Dance
Abstract/Description: The Dances We Dance Performance Showcase is a capstone experience for students enrolled in all levels of the Department of Theatre and Dance performance course offerings.
Date Issued: 2011
PURL: http://purl.flvc.org/fau/fd/FAdwd2011land
Subject Headings: Dance performance
Format: Set of related objects

Title: FAU Symphony Band and Wind Ensemble - February 2008.
Creator: Murray, Sean (Conductor), Prescott, Kyle (Conductor), FAU Department of Music
Date Issued: 2008-02
PURL: http://purl.flvc.org/fau/fd/FADT222055
Subject Headings: Wind ensembles, Band music
Format: Set of related objects

Title: Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
Creator: Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
Date Issued: 2009
PURL: http://purl.flvc.org/fau/fd/FA00007114
Subject Headings: Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
Format: Document (PDF)

Title: Maternal Health Status Correlates with Nest Success of Leatherback Sea Turtles (Dermochelys coriacea) from Florida.
Creator: Perrault, Justin R., Miller, Debra L., Eads, Erica, Johnson, Chris, Merrill, Anita, Thompson, Larry J., Wyneken, Jeanette, Reina, Richard
Abstract/Description: Of the seven sea turtle species, the critically endangered leatherback sea turtle (Dermochelys coriacea) exhibits the lowest and most variable nest success (i.e., hatching success and emergence success) for reasons that remain largely unknown. In an attempt to identify or rule out causes of low reproductive success in this species, we established the largest sample size (n = 60–70 for most values) of baseline blood parameters (protein electrophoresis, hematology, plasma biochemistry) for this...
Show moreOf the seven sea turtle species, the critically endangered leatherback sea turtle (Dermochelys coriacea) exhibits the lowest and most variable nest success (i.e., hatching success and emergence success) for reasons that remain largely unknown. In an attempt to identify or rule out causes of low reproductive success in this species, we established the largest sample size (n = 60–70 for most values) of baseline blood parameters (protein electrophoresis, hematology, plasma biochemistry) for this species to date. Hematologic, protein electrophoretic and biochemical values are important tools that can provide information regarding the physiological condition of an individual and population health as a whole. It has been proposed that the health of nesting individuals affects their reproductive output. In order to establish correlations with low reproductive success in leatherback sea turtles from Florida, we compared maternal health indices to hatching success and emergence success of their nests. As expected, hatching success (median = 57.4%) and emergence success (median = 49.1%) in Floridian leatherbacks were low during the study period (2007–2008 nesting seasons), a trend common in most nesting leatherback populations (average global hatching success =~50%). One protein electrophoretic value (gamma globulin protein) and one hematologic value (red blood cell count) significantly correlated with hatching success and emergence success. Several maternal biochemical parameters correlated with hatching success and/or emergence success including alkaline phosphatase activity, blood urea nitrogen, calcium, calcium:phosphorus ratio, carbon dioxide, cholesterol, creatinine, and phosphorus. Our results suggest that in leatherbacks, physiological parameters correlate with hatching success and emergence success of their nests. We conclude that long-term and comparative studies are needed to determine if certain individuals produce nests with lower hatching success and emergence success than others, and if those individuals with evidence of chronic suboptimal health have lower reproductive success.
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Date Issued: 2012-02-16
PURL: http://purl.flvc.org/fau/fd/FAUIR000084
Format: Citation

Title: Concurrent Enrollment and Academic Performance of Community College English Language Learners.
Creator: Johnson, Stephen R., Floyd, Deborah L., Bogotch, Ira, Florida Atlantic University, College of Education, Department of Educational Leadership and Research Methodology
Abstract/Description: Community colleges provide open access and affordable options for higher education to a growing population of adult English Language Learners (ELLs) in the United States. Language minority groups, particularly native Spanish speakers, are currently the fastest growing demographic in the nation. Community college English as a Second Language (ESL) courses constitute a vital support for these students by providing adult ELL students with foundational college literacy skills. With the growing...
Show moreCommunity colleges provide open access and affordable options for higher education to a growing population of adult English Language Learners (ELLs) in the United States. Language minority groups, particularly native Spanish speakers, are currently the fastest growing demographic in the nation. Community college English as a Second Language (ESL) courses constitute a vital support for these students by providing adult ELL students with foundational college literacy skills. With the growing demand for college graduates in today's workforce, language minority students, like their native English-speaking (NES) counterparts, need to leave college with vendible work credentials. Community colleges need practical and affordable ways to improve learning and degree completion rates of their English language learners. College ESL programs face two key challenges in realizing this goal: (1) providing quality language preparation for college-bound E LLs, and (2) developing efficient ways to deliver curricula to a student population that has limited financial resources and time. This was a single institution case study that investigated two ESL curriculum models at a large urban community college. The study compared the academic performance and persistence of ELL students who studied in a sheltered ESL curriculum to ELL students who studied in a concurrent enrollment ESL curriculum that combined college-level courses with advanced ESL study. The researcher analyzed student data from college archives: transcript data, admission data, and course performance results. Data from three student groups were salient to the study -- students in concurrent enrollment courses (partially-mainstreamed ESL students), students in traditional ESL courses (not mainstreamed), and native English speakers in freshmen-level general education courses. The study described the relationship between the two types of ESL curriculum and the academic performance and persistence of ELL students in each program. Findings showed that advanced ELL students were able to successfully complete select college courses as they finished their ESL program. Results indicated that early access to college courses motivated students to persist. This study can help ESL practitioners and administrators in higher education determine if a concurrent enrollment curriculum model is a viable alternative for intermediate and advanced level ELL students.
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Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00004509, http://purl.flvc.org/fau/fd/FA00004509
Subject Headings: Academic achievement, Community colleges -- Administration -- Evaluation, Community colleges -- Curricula, English language -- Study and teaching -- Foreign speakers -- Education (Higher), Second language acquisition
Format: Document (PDF)

Title: ACUTE RESPONSE OF NEUROPROTECTIVE ASSOCIATED BIOMARKERS TO VARIOUS COMPOUND RESISTANCE EXERCISES IN WELL-TRAINED MEN.
Creator: Johnson, Trevor K., Zourdos, Michael C., Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description: This study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p0.05)....
Show moreThis study examined if multi-joint resistance exercises could elicit expression of biomarkers associated with neuroprotection. Thirteen well-trained males performed 4 sets to failure at 80% of a one-repetition maximum (1RM) on the back squat, bench press, and deadlift. The biomarkers measured immediately pre- and post-exercise were brain derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), cathepsin B (CatB), and interleukin 6 (IL-6). There was a main time effect (p<0.01) for BDNF with significant increases in the deadlift (p=0.01) and bench press (p=0.01) conditions, but not the squat (p=0.21). There was a main time effect (p<0.01) for IL-6 with a significant increase in the squat (p<0.01). There was no significant increase in CatB or IGF-1 (p>0.05). Additionally, there was no significant relationship between BDNF and IL-6 response.
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Date Issued: 2019
PURL: http://purl.flvc.org/fau/fd/FA00013322
Subject Headings: Biomarkers, Neuroprotection, Resistance Training, Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Cathepsin B, Interleukin-6, Men.
Format: Document (PDF)

Title: Absence.
Creator: Johnson, Sarah, McConnell, Brian E., Florida Atlantic University, Dorothy F. Schmidt College of Arts and Letters, Department of Visual Arts and Art History
Abstract/Description: Absence is the thesis exhibition resulting from the culmination of my three years in the graduate program. In this documentation, I outline historical and contextual influences that shape my ceramic practice. I specify that my work is centered on my life and describe how my work has evolved since I first started in the program. In the process I have gathered source material and have explored key points in the theory and history of Minimalism. As I developed the work, I was able to discuss how...
Show moreAbsence is the thesis exhibition resulting from the culmination of my three years in the graduate program. In this documentation, I outline historical and contextual influences that shape my ceramic practice. I specify that my work is centered on my life and describe how my work has evolved since I first started in the program. In the process I have gathered source material and have explored key points in the theory and history of Minimalism. As I developed the work, I was able to discuss how my work applied to these sources, and where it differed. I ended with introspective installation work that paralleled the themes I was working with at the start of my graduate experience that shows my evolution from being a child continually bounced around from one family member to another, to being the confidant of my mother and holding her darkest secrets, to feeling alone and unloved, to finally beginning to heal and accept who I am.
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Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00004383, http://purl.flvc.org/fau/fd/FA00004383
Subject Headings: Artists -- Conduct of life, Bee culture, Ceramics -- Exhibitions, Emotional intelligence, Minimalism (Literature), Self actualization (Psychology), Stress (Psychology)
Format: Document (PDF)

Title: ANTENNULAR CHEMOSENSITIVITY TO FEEDING STIMULI IN THE SPINY LOBSTER PANULIRUS ARGUS.
Creator: JOHNSON, BRUCE RAYMOND, Florida Atlantic University, Ache, Barry W., Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description: Antennular chemoreceptors of P. argus were surveyed electro-physiologically to determine their relative sensitivity to low molecular weight components of the shrimp, Penaeus duorarum. An ultrafiltrate (less than 1,000 molecular weight) of shrimp extract did not differ significantly in stimulus value from the total extract itself. A mixture of the 19 amino acids present in the ultrafiltrate was slightly less stimulatory than the total extract. Taurine alone approximated the stimulus value of...
Show moreAntennular chemoreceptors of P. argus were surveyed electro-physiologically to determine their relative sensitivity to low molecular weight components of the shrimp, Penaeus duorarum. An ultrafiltrate (less than 1,000 molecular weight) of shrimp extract did not differ significantly in stimulus value from the total extract itself. A mixture of the 19 amino acids present in the ultrafiltrate was slightly less stimulatory than the total extract. Taurine alone approximated the stimulus value of the amino acid mixture at its component concentration. Taurine was also the most stimulatory of the 19 amino acids when compared at the homogeneous 10^-3 M concentration. Taurine is the major individual stimulant of shrimp extract but a contribution is also made from other non-amino acid low molecular weight compounds.
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Date Issued: 1976
PURL: http://purl.flvc.org/fcla/dt/13805
Subject Headings: Caribbean spiny lobster, Spiny lobsters, Chemoreceptors
Format: Document (PDF)

Title: PERFORMATIVE ACTIVISM AND POLITICS: A REPRESENTATIONAL ANALYSIS OF THE 2020 RESURGENCE OF THE BLACK LIVES MATTER MOVEMENT.
Creator: McCalla-Johnson, Alexa G., Robé, Christopher, Florida Atlantic University, School of Communication and Multimedia Studies, Dorothy F. Schmidt College of Arts and Letters
Abstract/Description: This study seeks to analyze the performative activism and political performance that took place during the Black Lives Matter protests between May and November of the year 2020. Various points of view perceive such acts as merely reductive or otherwise worthy of disdain, however, this study seeks to analyze these acts to identify different components within each performance. The primary focus is to further understand the advantages and disadvantages of performative activism and political...
Show moreThis study seeks to analyze the performative activism and political performance that took place during the Black Lives Matter protests between May and November of the year 2020. Various points of view perceive such acts as merely reductive or otherwise worthy of disdain, however, this study seeks to analyze these acts to identify different components within each performance. The primary focus is to further understand the advantages and disadvantages of performative activism and political performance. This research concentrates on examining the significant social and political impacts of these performances and their symbolic nature. This study also evaluates how discourse related to marginalized communities enters the public sphere and influences it. This study will include the analysis of performance via social media platforms, such as Instagram and Twitter during the 2020 resurgence of Black Lives Matter, including performances carried out by political leaders along the 2020 U.S. presidential campaign trail.
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Date Issued: 2021
PURL: http://purl.flvc.org/fau/fd/FA00013804
Subject Headings: Performative (Philosophy), Black lives matter movement--2020
Format: Document (PDF)

Title: Alternatives for Third World small farm development.
Creator: Johnson, Victoria., Florida Atlantic University, Lee, David R., Charles E. Schmidt College of Science, Department of Geosciences
Abstract/Description: Conventional agricultural development models have sought to improve Third World agricultural productivity by replacing traditional subsistence systems with sophisticated high-external-input farming methods. This approach has not solved the food problem of Third World nations because small farmers have been unable to participate in the modernization process and because modern methods are not environmentally sustainable. Alternative low-external-input agriculture provides greater opportunities...
Show moreConventional agricultural development models have sought to improve Third World agricultural productivity by replacing traditional subsistence systems with sophisticated high-external-input farming methods. This approach has not solved the food problem of Third World nations because small farmers have been unable to participate in the modernization process and because modern methods are not environmentally sustainable. Alternative low-external-input agriculture provides greater opportunities for small farmer participation, offers more benefits to small farmers, and is environmentally sustainable over a longer period of time than conventional agriculture. Comparative analysis of conventional and alternative projects indicates that the alternative model is more successful in effecting agricultural development and is more likely to improve Third World food security.
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Date Issued: 1988
PURL: http://purl.flvc.org/fcla/dt/14479
Subject Headings: Farms, Small--Developing countries
Format: Document (PDF)

Title: Carbohydrate Recognition of Bi-pyridine Bridged Peptide Receptor.
Creator: Johnson, Claudia A., Cudic, Predrag, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: A novel carbohydrate receptor based on the structure of the antibiotic polymxin B was synthesized. The receptor was a cyclic heptapeptide. which was bridged using 2, 2'-bi pyridine-5,5"- dicarboxylic acid. The association constants of the receptor and a variety of sugars were determined using UV /Vis and fluorescence spectroscopy and observed log K0 values are in the range from 3 .8 to 4.1 for the pentoses, logKa 3.3 to 3.8 for the hexoxes and 0 to 2.9 logKa values from 0-2.9 for...
Show moreA novel carbohydrate receptor based on the structure of the antibiotic polymxin B was synthesized. The receptor was a cyclic heptapeptide. which was bridged using 2, 2'-bi pyridine-5,5"- dicarboxylic acid. The association constants of the receptor and a variety of sugars were determined using UV /Vis and fluorescence spectroscopy and observed log K0 values are in the range from 3 .8 to 4.1 for the pentoses, logKa 3.3 to 3.8 for the hexoxes and 0 to 2.9 logKa values from 0-2.9 for disaccharides and logKa of2.6 to 3.11 for the charged sugars. We demonstrated that polymixin based receptors are capable of binding various monosaccharide substrates in aqueous media, displaying structure selectivity with respect to monosaccharide ring size.
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Date Issued: 2007
PURL: http://purl.flvc.org/fau/fd/FA00000776
Subject Headings: Protein engineering, Neuropeptides--Receptors, Chemistry, Organic, Cellular recognition
Format: Document (PDF)

Title: CULTURE CHRONOLOGY OF THE WESTERN GEORGIA PIEDMONT.
Creator: JOHNSON, KENNETH WYNNE., Florida Atlantic University, Sears, William H., Dorothy F. Schmidt College of Arts and Letters, Department of Anthropology
Abstract/Description: Surface collections from 244 prehistoric sites on the Fortson and O'Hara Transmission Lines in the western Georgia Piedmont were analyzed. An attempt to define the Old Quartz Industry led to a review of Middle Archaic Morrow Mountain in the Southeastern United States. The Old Quartz Industry was not an integral cultural unit, but an industry involving utilization of locally available lithic resources. The industry was not limited to any one culture or culture period, but reached a peak in the...
Show moreSurface collections from 244 prehistoric sites on the Fortson and O'Hara Transmission Lines in the western Georgia Piedmont were analyzed. An attempt to define the Old Quartz Industry led to a review of Middle Archaic Morrow Mountain in the Southeastern United States. The Old Quartz Industry was not an integral cultural unit, but an industry involving utilization of locally available lithic resources. The industry was not limited to any one culture or culture period, but reached a peak in the Middle Archaic period. Percentages of local versus exotic materials are highest for the Middle Archaic period in western Georgia. Sites of this period are also more abundant than those of other periods. The data suggests decreasing inter-regional mobility in the Middle Archaic period in the Southern Piedmont. Hypotheses for further testing included attainment of primary forest efficiency or increasing dependance on horticulture in the Middle Archaic period, leading up to the establishment of settled villages.
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Date Issued: 1980
PURL: http://purl.flvc.org/fcla/dt/14018
Subject Headings: Piedmonts (Geology)--Georgia
Format: Document (PDF)

Title: Object Oriented Classification of Australian Pine (Casuarina equisetifolia), an Invasive Exotic Species in South Florida.
Creator: Johnson, Brian A., Xie, Zhixiao, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Geosciences
Abstract/Description: Invasive exotic plant species cause a number of problems in native south Florida ecosystems, and a great deal of effort is being put into controlling the populations ofthese species. Control efforts require updated information on the locations of exotic species. This information can be obtained from high resolution remotely sensed data such as digital orthoimagery and LIDAR. Extraction of information from these data sources is often problematic using traditional pixel-based image processing...
Show moreInvasive exotic plant species cause a number of problems in native south Florida ecosystems, and a great deal of effort is being put into controlling the populations ofthese species. Control efforts require updated information on the locations of exotic species. This information can be obtained from high resolution remotely sensed data such as digital orthoimagery and LIDAR. Extraction of information from these data sources is often problematic using traditional pixel-based image processing techniques. An object oriented method of image analysis, however, has been shown to be better suited to this task. One invasive exotic species that has become widespread in south Florida is Casuarina equisetifolia, also known as Australian pine. This study develops a semiautomated procedure for detecting Australian pine over a large, diverse area with high resolution remotely sensed data using the object oriented method of analysis.
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Date Issued: 2007
PURL: http://purl.flvc.org/fau/fd/FA00000775
Subject Headings: Ecology--Remote sensing, Aerial photogrammetry
Format: Document (PDF)

Title: Photodegradation of bromacil and terbacil by ultraviolet radiation.
Creator: Johnson, Hannah Kalyani, Florida Atlantic University, Parkanyi, Cyril, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: The photodegradation of bromacil (5-bromo-3-sec-butyl-6-methyluracil) and terbacil (5-chloro-3-tert-butyl-6-methyluracil) by ultraviolet radiation has been investigated. Irradiation of aerated aqueous solutions of the title compounds (25 ppm), led to fast degradation of both. The reactions were found to follow first order kinetics with rate constants 5.77x10^-1 hr^-1 in the case of bromacil and 8.45x10^-2 hr^-1 in the case of terbacil. Degradation in ethanol and cyclohexane was also studied,...
Show moreThe photodegradation of bromacil (5-bromo-3-sec-butyl-6-methyluracil) and terbacil (5-chloro-3-tert-butyl-6-methyluracil) by ultraviolet radiation has been investigated. Irradiation of aerated aqueous solutions of the title compounds (25 ppm), led to fast degradation of both. The reactions were found to follow first order kinetics with rate constants 5.77x10^-1 hr^-1 in the case of bromacil and 8.45x10^-2 hr^-1 in the case of terbacil. Degradation in ethanol and cyclohexane was also studied, but the solutions were not analyzed for photoproducts. The photoreaction mixture of both the herbicides in water showed four peaks on GC, indicating four photoproducts. Loss of halogens from the heterocyclic ring has been observed as shown by the presence of Br- in the case of bromacil and Cl- in the case of terbacil in the photoreaction solution. 6-Methyluracil which was isolated from the aqueous fraction of the photoreaction mixture was the common photoproduct from both bromacil and terbacil. From the organic fractions 3-sec-butyl-5-acetyl-5-hydroxyhydantoin was identified in the case of bromacil and 3-tert-butyl-5-acetyl-5-hydroxyhydantoin in the case of terbacil. The other two photoproducts were left unidentified.
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Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14929
Subject Headings: Ultraviolet radiation, Photochemistry--Deterioration, Herbicides, Uracil
Format: Document (PDF)

Title: Therapeutic Options for the Treatment of Breast Cancer: Using Cytoreg and Genistein Isoflavone.
Creator: Johnson, Michelle M., Kumi-Diaka, James, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description: In spite the heavy investments in therapeutic research breast cancer still impacts the lives of women globally. The projected incidence of new cases in USA for 2008 is 67,770, with estimated 40,480 deaths. In this study, we investigated the therapeutic efficacy of Cytoreg®-genistein combination treatment on MCF-7 human breast cancer cells. MCF-7 cells were treated with genistein and Cytoreg® single and combination treatments for 24- 48hr; and the chemosensitivity assessed using bioassays:...
Show moreIn spite the heavy investments in therapeutic research breast cancer still impacts the lives of women globally. The projected incidence of new cases in USA for 2008 is 67,770, with estimated 40,480 deaths. In this study, we investigated the therapeutic efficacy of Cytoreg®-genistein combination treatment on MCF-7 human breast cancer cells. MCF-7 cells were treated with genistein and Cytoreg® single and combination treatments for 24- 48hr; and the chemosensitivity assessed using bioassays: Trypan Blue and MTT for cell viability; Ethidium bromide/Rhodamine 123 to assess apoptosis induction; F AM PolyCaspase binding assay for mechanism of action. The overall data indicated dose- and timedependent cell death in the MCF-cells and that apoptosis was the major means of treatmentinduced growth inhibition. There was evidence of Cytoreg®-induced autophagy in the cells. The overall findings indicated that genistein-Cytoreg® combination was more efficacious than either genistein or Cytoreg® alone. Cytoreg® enhanced the phytosensitivity of MCF-7 cells to genistein isoflavone.
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Date Issued: 2008
PURL: http://purl.flvc.org/fau/fd/FA00000777
Subject Headings: Breast--Cancer--Treatment, Phytochemicals--Physiological effect, Apoptosis--Molecular aspects, Phytoestrogens--Health aspects, Outcome assessment (Medical care)
Format: Document (PDF)

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