Current Search: chamoun (x)
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Scholar's name
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Tony Chamoun
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Department
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Department of Anthropology
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Status
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Current
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Email
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tchamoun@fau.edu
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Format
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Institutional Scholar
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Title
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Molecular characterization of a subset of KRAB-ZFPs.
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Creator
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Chamoun, Alain., Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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There are approximately 20,000 genes in the human genome. Around 2% of these genes code for transcriptional repressors known as KRAB-ZFPs. It is already known that Zinc-Finger Proteins contain two main functional domains at either end of the polypeptide. In today's database, you will find a KRAB (Kruppell-associated Box) domain at one end and a tandem array of Zinc-finger repeats at the other end. The carboxyl terminal tandem Zinc-finger repeats function as sequence-specific DNA-binding...
Show moreThere are approximately 20,000 genes in the human genome. Around 2% of these genes code for transcriptional repressors known as KRAB-ZFPs. It is already known that Zinc-Finger Proteins contain two main functional domains at either end of the polypeptide. In today's database, you will find a KRAB (Kruppell-associated Box) domain at one end and a tandem array of Zinc-finger repeats at the other end. The carboxyl terminal tandem Zinc-finger repeats function as sequence-specific DNA-binding domains. The amino terminal KRAB domain serves as a repressor domain, which will recruit a co-repressor termed KAP-1 (KRAB Associated Protein-1). Located in between these two domains is a region of uncharacterized DNA referred to as the "Linker Region". This thesis will explore the DNA-binding domains of 6 known KRAB-ZFPs, as well as utilize the linker regions to derive an evolutionary history for this superfamily.
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Date Issued
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2010
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PURL
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http://purl.flvc.org/FAU/2684313
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Subject Headings
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Zinc-finger proteins, Synthesis, Metalloproteins, Synthesis, Genetic transcription, Regulation, Gene expression
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Format
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Document (PDF)
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Title
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A paleopathological survey of ancient Peruvian crania housed at the Peabody museum of archaeology and ethnology at Harvard University, Cambridge, Massachusetts: a special emphasis on scurvy.
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Creator
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Chamoun, Tony J., Broadfield, Douglas C., Florida Atlantic University, Dorothy F. Schmidt College of Arts and Letters, Department of Anthropology
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Abstract/Description
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This thesis is a paleopathological survey of ancient Peruvian crania housed at the Peabody Museum of Archaeology and Ethnology at Harvard University, Cambridge, Massachusetts. Chapter one discusses the significance of this research, work prior to this thesis’s formulation, and defines paleopathological and bioarchaeological terms relevant to this thesis. Chapter two presents this thesis’s materials and methods. Of the 196 Peruvian crania in this study sample, 11 case studies are presented....
Show moreThis thesis is a paleopathological survey of ancient Peruvian crania housed at the Peabody Museum of Archaeology and Ethnology at Harvard University, Cambridge, Massachusetts. Chapter one discusses the significance of this research, work prior to this thesis’s formulation, and defines paleopathological and bioarchaeological terms relevant to this thesis. Chapter two presents this thesis’s materials and methods. Of the 196 Peruvian crania in this study sample, 11 case studies are presented. Chapter three reports a case of probable scurvy and likely anemia comorbidity. This case study is accompanied by a critical analysis and review of the literature surrounding scurvy, a detailed macroscopic examination, and a rigorous differential diagnosis process. Chapter four offers cases representing pseudopathology, hematopoietic disease, infectious disease, joint disease, neoplastic disease, trauma, and trauma-induced disease. Chapter five presents a summary of this thesis.
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Date Issued
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2014
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PURL
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http://purl.flvc.org/fau/fd/FA00004273, http://purl.flvc.org/fau/fd/FA00004273
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Subject Headings
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Human remains (Archaeology) -- Peru, Human skeleton -- Abnormalities -- Peru, Paleopathology, Peabody Museum of Archaeology and Ethnology
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Format
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Document (PDF)
