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High-resolution vertical profiles of pelagic tunicates
Title
High-resolution vertical profiles of pelagic tunicates.
Creator
Paffenhöfer, G.-A., Stewart, T. B., Youngbluth, Marsh J., Bailey, T. G.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3355145
Subject Headings
Tunicates, Tunicata, Thaliacea, Doliolum
Format
Document (PDF)
Synthesis and testing the intermediacy of diketopiperazines in the biosynthesis of ecteinascidins
Title
Synthesis and testing the intermediacy of diketopiperazines in the biosynthesis of ecteinascidins.
Creator
Jeedigunta, Shanti, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Ecteinascidin 743 is a trace secondary metabolite isolated from the marine tunicate, Ecteinascidia turbinata. Ecteinacidin 743 a most potent antitumor agent, is currently in Phase II clinical trials in Europe and in the USA. A cell-free extract of Ecteinascidia turbinata was used to investigate the biogenetic origin of the ecteinascidins. Incubation experiments with radiolabeled diketopiperazines indicated that the diketopiperazine of tyrosine is the first committed intermediate in the...
Show moreEcteinascidin 743 is a trace secondary metabolite isolated from the marine tunicate, Ecteinascidia turbinata. Ecteinacidin 743 a most potent antitumor agent, is currently in Phase II clinical trials in Europe and in the USA. A cell-free extract of Ecteinascidia turbinata was used to investigate the biogenetic origin of the ecteinascidins. Incubation experiments with radiolabeled diketopiperazines indicated that the diketopiperazine of tyrosine is the first committed intermediate in the biosynthesis of ecteinascidins. Phenylalanine diketopiperazine was not transformed into the ecteinascidins indicating that this cyclic dipeptide is not an intermediate in the biosynthesis of ecteinascidins. The diketopiperazine of DOPA was used as a cold carrier demonstrating that the diketopiperazine of tyrosine is oxidized to DOPA diketopiperazine and then further transformed to the ecteinascidins.
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Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/15754
Subject Headings
Sea squirts, Dopa, Tunicata
Format
Document (PDF)
Heterotrophic activity on appendicularian (Tunicata: Appendicularia) houses in mesopelagic regions and their potential contribution to particle flux
Title
Heterotrophic activity on appendicularian (Tunicata: Appendicularia) houses in mesopelagic regions and their potential contribution to particle flux.
Creator
Davoll, P. J., Youngbluth, Marsh J.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3353847
Subject Headings
Tunicata, Appendicularia, Marine zooplankton, Detritus
Format
Document (PDF)
Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata
Title
Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata.
Creator
Miranda, Neil Fermino, Florida Atlantic University, Kerr, Russell G.
Abstract/Description
Ecteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have...
Show moreEcteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have also been identified. These preliminary experiments set the stage for subsequent protein isolation.
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Date Issued
1996
PURL
http://purl.flvc.org/fcla/dt/15242
Subject Headings
Tunicata, Marine pharmacology, Biological assay
Format
Document (PDF)
efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis
Title
An efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis.
Creator
Fawehinmi, Hafusat Abosede, Florida Atlantic University, Kerr, Russell G.
Abstract/Description
The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5...
Show moreThe ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.
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Date Issued
1999
PURL
http://purl.flvc.org/fcla/dt/15725
Subject Headings
Tunicata, Pyruvic acid--Synthesis
Format
Document (PDF)
Patterns of stimulated bioluminescence in two pyrosomes (Tunicata: Pyrosomatidae)
Title
Patterns of stimulated bioluminescence in two pyrosomes (Tunicata: Pyrosomatidae).
Creator
Bowlby, Mark R., Widder, Edith A., Case, J. F., Harbor Branch Oceanographic Institute
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3171565
Subject Headings
Bioluminescence, Luminescence --Research, Pyrosoma, Tunicata, Marine organisms
Format
Document (PDF)
Are filtration rates for the rough tunicate Styela plicata independent of weight or size?
Title
Are filtration rates for the rough tunicate Styela plicata independent of weight or size?.
Creator
Draughon, Lisa D., Scarpa, John, Hartmann, James X.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3352943
Subject Headings
Filtration, Tunicata, Styela, Bioremediation, Estuaries, Microalgae, Bacteria
Format
Document (PDF)
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
Title
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata.
Creator
Wright, Amy E., Forleo, D. A., Gunawardana, G. P., Gunasekera, Sarath P., Koehn, F. E., McConnell, O. J.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3332974
Subject Headings
Ascidians, Perophoridae (Tunicata), Tetrahydroisoquinolines, Alkaloids, Antineoplastic agents
Format
Document (PDF)
Additions to the inventory of eastern tropical Atlantic ascidians; arrival of cosmopolitan species
Title
Additions to the inventory of eastern tropical Atlantic ascidians; arrival of cosmopolitan species.
Creator
Monniot, Claude, Monniot, Françoise, Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3172865
Subject Headings
Sea squirts, Ascidia, Tunicata, Scuba apparatus, Biochemistry
Format
Document (PDF)