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Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Title
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Creator
Paterson, Ian, Naylor, G. J., Wright, Amy E.
Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FA00007062
Subject Headings
Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
Format
Document (PDF)
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
Title
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
Creator
Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
Date Issued
2010
PURL
http://purl.flvc.org/fau/fd/FA00007065
Subject Headings
Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
Format
Document (PDF)
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Title
The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
Creator
Kowalski, R. J., Giannakakou, P., Gunasekera, Sarath P., Longley, Ross E., Day, B. W., Hamel, E., Harbor Branch Oceanographic Institute
Date Issued
1997
PURL
http://purl.flvc.org/fau/fd/FA00007052
Subject Headings
Marine natural products, Cytotoxins, Tubulin Modulators, Paclitaxel, Lactones, Sponges
Format
Document (PDF)
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Title
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Creator
Paterson, Ian, Britton, R., Delgado, Oscar, Wright, Amy E.
Date Issued
2004
PURL
http://purl.flvc.org/fau/fd/FA00007061
Subject Headings
Macrolides, Sponges, Tubulin Modulators, Stereochemistry, Microtubules, Polyketides, Antimitotic Agents
Format
Document (PDF)