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Assimilation of fenthion in coastal water
Title
Assimilation of fenthion in coastal water.
Creator
Wang, Tsen C., Tucker, John W., Jr., Harbor Branch Oceanographic Institute
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3352206
Subject Headings
Fenthion, Water, Toxins, Coasts
Format
Document (PDF)
Evaluation of a sodium hydroxymethanesulfonate product for reducing total ammonia nitrogen in a small-scale rotifer batch culture system
Title
Evaluation of a sodium hydroxymethanesulfonate product for reducing total ammonia nitrogen in a small-scale rotifer batch culture system.
Creator
Riche, Marty A., Pfeiffer, Timothy J., Garcia, J.
Date Issued
2006
PURL
http://purl.flvc.org/FCLA/DT/3343843
Subject Headings
Metabolites, Rotifera, Toxins
Format
Document (PDF)
Impacts of algal toxins on marine mammals
Title
Impacts of algal toxins on marine mammals.
Creator
Van Dolah, F. M., Doucette, G. J., Gulland, F. M. D., Rowles, T. L., Bossart, Gregory D., Harbor Branch Oceanographic Institute
Date Issued
2003
PURL
http://purl.flvc.org/fcla/dt/3352937
Subject Headings
Algal toxins, Marine mammals, Neurotoxins
Format
Document (PDF)
Dercitin, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp.
Title
Dercitin, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp.
Creator
Gunawardana, G. P., Kohmoto, S., Gunasekera, Sarath P., McConnell, O. J., Koehn, F. E., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332948
Subject Headings
Sponges, Alkaloids, Acridine, Marine toxins
Format
Document (PDF)
Isolation of Latrunculin A, 6,7-Epoxylatrunculin A, Fijianolide A, and Euryfuran from a new genus of the family Thorectidae
Title
Isolation of Latrunculin A, 6,7-Epoxylatrunculin A, Fijianolide A, and Euryfuran from a new genus of the family Thorectidae.
Creator
Gulavita, N. K., Gunasekera, Sarath P., Pomponi, Shirley A.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3332996
Subject Headings
Sponges, Marine toxins, Marine metabolites
Format
Document (PDF)
Abamectin: ant toxin or antifeedant?
Title
Abamectin: ant toxin or antifeedant?.
Creator
Kissner, William, Kaul, Christopher, McGuire, Megan, Pick, David, Dragojlovic, Veljko
Date Issued
2012-04-06
PURL
http://purl.flvc.org/fcla/dt/3348829
Subject Headings
Abamectin, Toxin, Antifeedant, Chemistry techniques, Pest control
Format
Document (PDF)
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Title
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Creator
Sakemi, S., Ichiba, T., Kohmoto, S., Saucy, G., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332945
Subject Headings
Sponges, Bioactive compounds, Marine metabolites, Marine Toxins
Format
Document (PDF)
Conclusions and perspectives for the future
Title
Conclusions and perspectives for the future.
Creator
O'Shea, T. J., Bossart, Gregory D., Fournier, M., Vos, Joseph G., Harbor Branch Oceanographic Institute
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3352939
Subject Headings
Marine mammals, Toxicology--Research, Marine toxins
Format
Document (PDF)
A mammalian cell agar-diffusion assay for the detection of toxic compounds
Title
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Creator
Burres, N. S., Hunter, J. E., Wright, Amy E.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332955
Subject Headings
Antineoplastic agents, Toxins, Chromatographic analysis, Thin layer chromatography
Format
Document (PDF)
Crystalline rotenone as a selective fish toxin
Title
Crystalline rotenone as a selective fish toxin.
Creator
Gilmore, R. G., Hastings, P. A., Kulczycki, G. R., Jennison, Brian L., Harbor Branch Oceanographic Institute
Date Issued
1981
PURL
http://purl.flvc.org/FCLA/DT/3183158
Subject Headings
Rotenone, Rotenone --Toxicology, Toxins, Rotenone--Physiological effect
Format
Document (PDF)
Manatees and brevetoxicosis
Title
Manatees and brevetoxicosis.
Creator
Bossart, Gregory D., Baden, Daniel G., Ewing, Ruth Y., Wright, S. D., Harbor Branch Oceanographic Institute
Date Issued
2002
PURL
http://purl.flvc.org/fau/fd/FA00007319
Subject Headings
Manatees, Marine mammals--Mortality, Dinoflagellate blooms, Marine toxins
Format
Document (PDF)
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol
Title
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
Creator
Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, Ross E., Gunasekera, Sarath P., Rosenkranz, H. S., Day, B. W., Harbor Branch Oceanographic Institute
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3319092
Subject Headings
Marine natural products, Antimitotic agents, Taxol, Cytotoxin, Marine toxins
Format
Document (PDF)
Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide
Title
Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide.
Creator
Burres, N. S., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/fau/fd/FA00007377
Subject Headings
Marine natural products, Pyrans, Marine Toxins, Antineoplastic agents
Format
Document (PDF)
Immunoassay test strip for Microcystin-LR detection
Title
Immunoassay test strip for Microcystin-LR detection.
Creator
Xu, Jiesi., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Microcystin-LR (MCLR) is hepatotoxic to animals and humans with disruption of liver structure causing cytoskeletal damage, necrosis and pooling of blood in the liver, leading to large increase in liver weight. It is also a strong liver tumor promoter and protein phosphatase inhibitor. Microcysin-LR binds protein phosphatases 1 and 2A, and influences regulation of cellular protein phosphorylation. In the present study, a colloidal gold based immunoassay test strip was developed for Microcystin...
Show moreMicrocystin-LR (MCLR) is hepatotoxic to animals and humans with disruption of liver structure causing cytoskeletal damage, necrosis and pooling of blood in the liver, leading to large increase in liver weight. It is also a strong liver tumor promoter and protein phosphatase inhibitor. Microcysin-LR binds protein phosphatases 1 and 2A, and influences regulation of cellular protein phosphorylation. In the present study, a colloidal gold based immunoassay test strip was developed for Microcystin-LR detection. The detection limit was found to be 1 ng/mL. 5 nm colloidal gold test strips exhibits more efficient for detection, compared with 20 nm colloidal gold test strips. The interaction between Microcystin-LR antibody (immunoglobulin G) and colloidal gold nanoparticles was investigated by various analytical methods, including Ultraviolet/Visible (UV/VIS), Fourier Transform Infrared (FTIR) and Fluorescence spectroscopy as well as transmission electron microscopy (TEM).
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Date Issued
2010
PURL
http://purl.flvc.org/FAU/2683532
Subject Headings
Immunoassay, Biosensors, Environmental chemistry, Cyanobacterial toxins, Drinking water, Microbiology
Format
Document (PDF)
Clinicopathologic features ofsuspected brevetoxicosis in double-crested cormorants (Phalacrocorax auritis) along the Florida Gulfcoast
Title
Clinicopathologic features ofsuspected brevetoxicosis in double-crested cormorants (Phalacrocorax auritis) along the Florida Gulfcoast.
Creator
Kreuder, C., Mazet, J. A. K., Bossart, Gregory D., Carpenter, T. E., Holyoak, M., Elie, M. S., Wright, S. D., Harbor Branch Oceanographic Institute
Date Issued
2002
PURL
http://purl.flvc.org/fau/fd/FA00007241
Subject Headings
Gulf Coast (Fla.), Double-crested cormorant, Phalacrocorax auritus, Neurotoxins, brevetoxin, Marine toxins
Format
Document (PDF)
Cytotoxic cembranoids from the gorgonian Pseudopterogorgia bipinnata
Title
Cytotoxic cembranoids from the gorgonian Pseudopterogorgia bipinnata.
Creator
Wright, Amy E., Burres, N. S., Schulte, G. K.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3353845
Subject Headings
Gorgonacea, Cytotoxins, Antineoplastic agents, Marine toxins, X-ray crystallography, Spectrum analysis, Chemical structure
Format
Document (PDF)
Red tide and marine mammal mortalities
Title
Red tide and marine mammal mortalities.
Creator
Flewelling, L. J., Naar, Jerome, Abbott, J. P., Baden, Daniel G., Barros, N. B., Bossart, Gregory D., Bottein, M-Y. D., Hammond, Daniel G., Haubold, E. M., Heil, Cynthia A., Henry, M. S., Jacocks, H. M., Leighfield, T. A., Pierce, Richard H., Pitchford, T. D., Rommel, Sentiel A., Scott, P. S., Steidinger, K. A., Truby, E. W., Van Dolah, F. M., Landsberg, J. H., Harbor Branch Oceanographic Institute
Date Issued
2005
PURL
http://purl.flvc.org/FCLA/DT/3183799
Subject Headings
Marine toxins, Dinoflagellate blooms, Red tide, Marine mammals--Mortality--United States
Format
Document (PDF)
Brevetoxin Metabolism and Physiology - A Freshwater Model of Morbidity in Endangered Sea Turtles
Title
Brevetoxin Metabolism and Physiology - A Freshwater Model of Morbidity in Endangered Sea Turtles.
Creator
Cocilova, Courtney Christine, Milton, Sarah L., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
The dinoflagellate Karenia brevis is one organism responsible for harmful algal blooms (HABs) that severely impact marine life. K. brevis produces a suite of neurotoxins referred to as brevetoxins (PbTx) which bind to voltage-gated sodium channels (VGSCs) in excitable tissues, affecting cellular permeability leading to a suite of symptoms and potentially cell death. Brevetoxicosis is difficult to treat in sea turtles as the physiological impacts have not been investigated and the magnitude...
Show moreThe dinoflagellate Karenia brevis is one organism responsible for harmful algal blooms (HABs) that severely impact marine life. K. brevis produces a suite of neurotoxins referred to as brevetoxins (PbTx) which bind to voltage-gated sodium channels (VGSCs) in excitable tissues, affecting cellular permeability leading to a suite of symptoms and potentially cell death. Brevetoxicosis is difficult to treat in sea turtles as the physiological impacts have not been investigated and the magnitude and duration of brevetoxin exposure are generally unknown. Due to their threatened and endangered status, experimental exposures cannot be performed to determine the fate of brevetoxin in sea turtle tissues, making it difficult to design appropriate treatments. The freshwater turtle, Trachemys scripta, was utilized as a model for brevetoxin exposure in turtles. Turtles were exposed to intratracheal instillation (10.53μg/kg) or oral dosing (33.48μg/kg) of PbTx-3 3x weekly over a period of 2-4 weeks. Tissues and fluids were collected for ELISA to determine PbTx-3 uptake and distribution, routes of excretion and rates of clearance (1h-1wk post-exposure). Tissues were also preserved for histopathology. Primary turtle neuronal cell cultures were exposed to PbTx-3 in the presence and absence of various agonists and antagonists to determine brevetoxin’s mode of action. PbTx-3 was widely distributed in all tissues and fluids following both intratracheal and oral exposures, but was largely cleared from the system within 24 hours; PbTx-3 moved into the bile and feces over 48h post exposure indicating that this is the main route of excretion. While exposed animals showed clear behavioral symptoms of toxicity including muscle twitching, swimming in circles, and ataxia, there was no evident tissue pathology. Despite the evident behavioral effects, turtle neurons are surprisingly resistant to PbTx-3, with an EC50 significantly higher than is seen in mammalian neurons. While PbTx-3 exposure resulted in significant Ca2+ influx, various antagonists prevented Ca2+ influx when added with PbTx-3 confirming the mechanism of action through VGSCs. Upregulation of Hsp72 in the turtle brain could be enhancing cell survival. Based on results, intralipid treatment post PbTx-3 exposure rapidly decreases symptoms and proves to be a suitable treatment for toxin exposure.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00004812
Subject Headings
Sea turtles--Mortality., Sea turtles--Physiology., Marine toxins., Neurotoxic agents--Analysis.
Format
Document (PDF)
EXPOSURE TO ALGAL BIOTOXINS: EXPLORING HEALTH EFFECTS IN GREEN SEA TURTLES (CHELONIA MYDAS)
Title
EXPOSURE TO ALGAL BIOTOXINS: EXPLORING HEALTH EFFECTS IN GREEN SEA TURTLES (CHELONIA MYDAS).
Creator
Brown, Hunter, Page, Annie, Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
Abstract/Description
In the inter-coastal waters of Florida, green sea turtles (Chelonia mydas) are regularly exposed to regional blooms of harmful algae which produce biotoxins. A retrospective analysis was conducted on stranded green sea turtles along the Indian River Lagoon, FL, USA. Stranding, necropsy, and histopathology reports were analyzed for 40 juvenile turtles. Liver (N=40) and kidney (N=36) tissues were analyzed for a suite of 14 harmful algal bloom (HAB)-associated biotoxins. Thirty-four (85%)...
Show moreIn the inter-coastal waters of Florida, green sea turtles (Chelonia mydas) are regularly exposed to regional blooms of harmful algae which produce biotoxins. A retrospective analysis was conducted on stranded green sea turtles along the Indian River Lagoon, FL, USA. Stranding, necropsy, and histopathology reports were analyzed for 40 juvenile turtles. Liver (N=40) and kidney (N=36) tissues were analyzed for a suite of 14 harmful algal bloom (HAB)-associated biotoxins. Thirty-four (85%) turtles tested positive for at least one biotoxin, including 21(53%) liver and 22(61%) kidney tissues. Statistically significant relationships were identified between the presence of common histopathological abnormalities and biotoxins of: melanomacrophage/hyperplasia and brevetoxin-3 (P=0.03) in liver tissues, and renal fibrosis and nodularin (P = 0.04) and lymphocytosis and neosaxitoxin (P=0.03) in kidney tissues. These data demonstrate that wild turtles are commonly exposed to HAB-associated biotoxins with potential chronic health effects that contribute to strandings in the Indian River Lagoon.
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Date Issued
2023
PURL
http://purl.flvc.org/fau/fd/FA00014363
Subject Headings
Chelonia mydas, Green sea turtles, Algal toxins, Indian River (Fla. : Lagoon)
Format
Document (PDF)