Current Search: Taurine--Physiological effect (x)
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Title
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Taurine inhibits glutamate-induced excitotoxicity through a calpain dependent pathway.
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Creator
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Leon, Rebecca, Prentice, Howard, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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Taurine, an endogenous ammo acid and neuromodulator, has been found to be neuroprotective against numerous forms of neurotoxicity including glutamate-induced excitotoxicity. Previously we have shown that taurine inhibits glutamate-induced calcium influx through VGCCs and NMDA receptors. Although the neuroprotective effects of taurine against excitotoxicity have been attributed to its intracellular Ca2+ regulatory functions, the complete mechanism underling taurine neuroprotection has remained...
Show moreTaurine, an endogenous ammo acid and neuromodulator, has been found to be neuroprotective against numerous forms of neurotoxicity including glutamate-induced excitotoxicity. Previously we have shown that taurine inhibits glutamate-induced calcium influx through VGCCs and NMDA receptors. Although the neuroprotective effects of taurine against excitotoxicity have been attributed to its intracellular Ca2+ regulatory functions, the complete mechanism underling taurine neuroprotection has remained unclear. Using primary rat cortical neuronal cell cultures, we have determined key cytosolic components to the mechanism of taurine neuroprotection. In this study we have found that taurine inhibits excitotoxicity by suppressing glutamate-induced elevations in [Ca2+]i, preventing calpain activation, and inhibiting reductions in Bel- 2:Bax ratios and consequently activation of the intrinsic pathway.
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Date Issued
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2008
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PURL
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http://purl.flvc.org/fau/fd/FA00000788
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Subject Headings
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Cellular signal transduction, Taurine--Physiological effect, Proteolytic enzymes--Research
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Format
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Document (PDF)
