Current Search: Spreading cortical depression (x)
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Title
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CORTICAL SPREADING DEPRESSION INDUCED STATE DEPENDENCY OF A HEART RATE RESPONSE.
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Creator
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GREENWOOD, PAMELA MARGARET, Florida Atlantic University
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Abstract/Description
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To investigate dissociated (state dependent) learning of a classically conditioned heart rate response, 24 rats were trained either normally or under cortical spreading depression (CSD). Testing in extinction for experimentals was carried out over two days with Ss experiencing a reversal of state (i.e., depressed or non-depressed) in the first extinction and then returned to the learning state on the second extinction. Results indicated that all groups learned in a comparable fashion....
Show moreTo investigate dissociated (state dependent) learning of a classically conditioned heart rate response, 24 rats were trained either normally or under cortical spreading depression (CSD). Testing in extinction for experimentals was carried out over two days with Ss experiencing a reversal of state (i.e., depressed or non-depressed) in the first extinction and then returned to the learning state on the second extinction. Results indicated that all groups learned in a comparable fashion. Experimental groups demonstrated no retention of the learned response on the first extinction, but extinguished normally on the second extinction when Ss were returned to the cortical state present during training. These results are consistent with an explanation of symmetrical dissociation. Control ~s which experienced the same state over all days demonstrated a predicted lack of dissociation. The theory of subcortical state specific retrieval was proposed to account for these data as well as results of studies reporting dissociation with other agents to relate dissociation phenomena to a single underlying process.
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Date Issued
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1972
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PURL
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http://purl.flvc.org/fcla/dt/13527
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Subject Headings
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Spreading cortical depression, Dissociation (Psychology), Conditioned response
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Format
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Document (PDF)
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Title
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Role of methionine sulfoxide reductase in thermal-induced spreading depression coma in Drosophila melanogaster.
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Creator
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Schey, Karin., Charles E. Schmidt College of Science, Department of Biological Sciences
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Abstract/Description
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Drosophila melanogaster encounter periods of increased temperature or decreased oxygen in its native environment. One consequence of these environmental stresses is increased production of reactive oxygen species that damage major molecules within cells. Another consequence is that flies fall into a protective coma where biological functions are minimized to conserve energy expenditures. This biological phenomenon is called spreading depression. The overarching aim of this project is to...
Show moreDrosophila melanogaster encounter periods of increased temperature or decreased oxygen in its native environment. One consequence of these environmental stresses is increased production of reactive oxygen species that damage major molecules within cells. Another consequence is that flies fall into a protective coma where biological functions are minimized to conserve energy expenditures. This biological phenomenon is called spreading depression. The overarching aim of this project is to determine if methionine sulfoxide reductases affect entrance or exit from the protective coma induced by acute thermal stress. The data revealed that complete deficiency of Msr in young flies causes a faster induction of the coma. In both young and old flies, Msr does not affect average recovery time but does affect the pattern of recovery from coma. Entrance into the coma is age dependent with young flies maintaining activity longer than before entering into the coma as compared to old flies.
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Date Issued
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2012
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PURL
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http://purl.flvc.org/FAU/3355873
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Subject Headings
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Cellular signal transduction, Proteins, Chemical modification, Spreading cortical depression, Oxidation-reduction reaction, Aging, Molecular aspects, Mutation (Biology)
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Format
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Document (PDF)
