Current Search: Spectroscopic imaging (x)
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Title
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Raman and surface-enhanced raman spectroscopy of G-quadruplexes.
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Creator
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Friedman, Samantha, Terentis, Andrew C., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
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Abstract/Description
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G-quadruplexes (G4s) are nucleic acid structures formed from π-stacked planar sets of four Hoogsteen hydrogen bonded guanine bases. G4s emerged as potential therapeutic targets based on their ability to modulate gene expression and inhibit the ability of telomerase to elongate chromosomal telomeres. Raman spectroscopy, polarized Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), and other optical spectroscopic techniques were used to characterize the G4s formed by four different...
Show moreG-quadruplexes (G4s) are nucleic acid structures formed from π-stacked planar sets of four Hoogsteen hydrogen bonded guanine bases. G4s emerged as potential therapeutic targets based on their ability to modulate gene expression and inhibit the ability of telomerase to elongate chromosomal telomeres. Raman spectroscopy, polarized Raman spectroscopy, surface-enhanced Raman spectroscopy (SERS), and other optical spectroscopic techniques were used to characterize the G4s formed by four different DNA sequences: human telomeric (HT), thrombin-binding aptamer (TBA), nuclease hypersensitive element III1 region of the c- Myc gene promoter (Myc), and a single loop-isomer of Myc (MycL1).
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Date Issued
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2015
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PURL
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http://purl.flvc.org/fau/fd/FA00004370, http://purl.flvc.org/fau/fd/FA00004370
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Subject Headings
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Nucleic acids, Binding sites (Biochemistry), Biochemical genetics, Raman spectroscopy, Raman effect, Surface enhanced, Spectroscopic imaging, Spectrum analysis
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Format
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Document (PDF)
