Current Search: Serotonin (x)
-
-
Title
-
Effects of Serotonin Modulation on Methionine Sulfoxide Reductase Deficient Drosophila melanogaster.
-
Creator
-
Hamadeh, Ali, Binninger, David, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
-
Abstract/Description
-
Methionine sulfoxide reductase (MSR) is an important antioxidant to help mitigate oxidative stress that contributes to age-associated neurodegenerative diseases, such as Alzheimer’s Disease and Parkinson’s Disease. In MSR deficient Drosophila melanogaster (fruit flies), larvae show a developmental delay like that seen when wild-type larvae are reared on nutrient deficit culture medium. These investigators further showed that serotonin levels were depressed in these nutrient deficient larvae....
Show moreMethionine sulfoxide reductase (MSR) is an important antioxidant to help mitigate oxidative stress that contributes to age-associated neurodegenerative diseases, such as Alzheimer’s Disease and Parkinson’s Disease. In MSR deficient Drosophila melanogaster (fruit flies), larvae show a developmental delay like that seen when wild-type larvae are reared on nutrient deficit culture medium. These investigators further showed that serotonin levels were depressed in these nutrient deficient larvae. The overarching aim of this study was to better understand the role of serotonin in MSR regulated physiology. Supplementing food with serotonin partially rescued the slower mouth hook movements (MHM) observed in the MSR-deficient flies. However, supplementation with serotonin altering drugs that cross the blood brain barrier (5-hydroxytryptophan, fluoxetine, or paravi chlorophenylalanine) did not rescue MHM and caused impairments to the growth of larvae during development. This study indicates that serotonin regulates feeding behavior partially through the regulation of MSR production but acts independently to regulate development.
Show less
-
Date Issued
-
2021
-
PURL
-
http://purl.flvc.org/fau/fd/FA00013761
-
Subject Headings
-
Drosophila melanogaster, Methionine sulfoxide reductase, Serotonin
-
Format
-
Document (PDF)
-
-
Title
-
Roles of serotonin 2A receptor in a serotonin syndrome.
-
Creator
-
Zhang, Gongliang, Charles E. Schmidt College of Medicine, Department of Biomedical Science
-
Abstract/Description
-
Serotonin (5-HT) is a neurotransmitter in the central nervous system. Decrease in the brain 5-HT level could induce depression, showing a state of low mood, aversion to motion and feeling of worthlessness. About 12 million adults in the United States have depression. Antidepressants, such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors, can alleviate the depressive mood by increasing the brain's 5-HT activity, however they can also induce a potentially life...
Show moreSerotonin (5-HT) is a neurotransmitter in the central nervous system. Decrease in the brain 5-HT level could induce depression, showing a state of low mood, aversion to motion and feeling of worthlessness. About 12 million adults in the United States have depression. Antidepressants, such as monoamine oxidase inhibitors and selective serotonin reuptake inhibitors, can alleviate the depressive mood by increasing the brain's 5-HT activity, however they can also induce a potentially life-threatening side effect, namely 5-HT syndrome. This syndrome is manifested by neuromuscular hyperactivities, mental disorders and autonomic dysfunctions. Clinical studies have demonstrated that 5-HT2A receptor antagonists could effectively block severe symptoms of patients with the 5-HT syndrome. To understand the underlying mechanisms, in this study we examined the activity of the 5-HT2A receptor in rats with the 5-HT syndrome evoked by a combined injection of clorgyline, a monoamine oxidase inhibitor , and paroxetine, a selective 5-HT reuptake inhibitor. The major findings from my study were that: (1) Chronic clorgyline treatment significantly exacerbated 5-HT2A receptor-mediated symptoms of the 5-HT syndrome animals; (2) The 5-HT2A receptor-mediated symptoms were also aggravated when the 5-HT syndrome animals were housed in warm (32 ÀC) ambient temperature; (3) Blocking 5-HT2A receptors in the medial prefrontal cortex alleviated the 5-HT syndrome through a circuit between raphe serotonergic neurons and medial prefrontal cortex glutamatergic neurons. Taken together, my data demonstrate that the activity of 5-HT2A receptors may be enhanced by chronic antidepressant treatment and warm environmental temperature., The sensitized 5-HT2A receptor in the medial prefrontal cortex may exacerbate the syndrome through a positive-feedback circuit between medial prefrontal cortex and raphe nuclei, which would result in excessive 5-HT in the brain. This study casts a new light on the underlying mechanisms of the 5-HT syndrome.
Show less
-
Date Issued
-
2010
-
PURL
-
http://purl.flvc.org/FAU/2100576
-
Subject Headings
-
Serotonin uptake inhibitors, Therapeutic use, Serotonin uptake inhibitors, Physiological effect, Serotonin, Receptors, Physiological effect, Central nervous system, Physiology, Neurotransmitter receptors, Serotoninergic mechanisms
-
Format
-
Document (PDF)
-
-
Title
-
Hippocampal neurogenesis in the SERT ALA56 mouse model to autism.
-
Creator
-
Di Mase, Julieta Maria, Guthrie, Kathleen, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
-
Abstract/Description
-
The causes of autism spectrum disorder (ASD) are not all known, but it is suspected that the serotonin transporter (SERT) plays an important role for some subjects with ASD. Mutations in the SLC6A4 gene, that encodes SERT, including the Ala56 mutation (Gly56Ala), have been found in some autism patients. This mutation makes the transporter more active and reduces the probability of serotonergic neurotransmission in the brain, which is linked to behavioral changes that are associated with core...
Show moreThe causes of autism spectrum disorder (ASD) are not all known, but it is suspected that the serotonin transporter (SERT) plays an important role for some subjects with ASD. Mutations in the SLC6A4 gene, that encodes SERT, including the Ala56 mutation (Gly56Ala), have been found in some autism patients. This mutation makes the transporter more active and reduces the probability of serotonergic neurotransmission in the brain, which is linked to behavioral changes that are associated with core domain deficits of ASD 1. Depression also has been linked to decreases in the availability of serotonin (5-hydroxytryptamine; 5-HT) in the central nervous system (CNS), and is associated with reduced hippocampal neurogenesis. Selective serotonin reuptake inhibitors (SSRIs), drugs used to block SERTs, are used to treat depression and/or anxiety by inhibiting SERT to increase synaptic 5-HT levels.
Show less
-
Date Issued
-
2019
-
PURL
-
http://purl.flvc.org/fau/fd/FA00013297
-
Subject Headings
-
Autism Spectrum Disorder, Hippocampus, Neurogenesis, Serotonin Plasma Membrane Transport Proteins
-
Format
-
Document (PDF)
-
-
Title
-
Effect of MDMA abuse on axonal transportation of serotonergic nervous system in the rat brain.
-
Creator
-
Adams, Herbert D., Ma, Zhiyuan, Tao, Rui
-
Date Issued
-
2012-04-06
-
PURL
-
http://purl.flvc.org/fcla/dt/3348609
-
Subject Headings
-
N-Methyl-3,4-methylenedioxyamphetamine, Ecstasy, Receptors, Serotonin - drug effects, Serotonergic nervous system, Substance-related disorders, Methamphetamine --adverse effects, Serotonin --pharmacokinetics
-
Format
-
Document (PDF)
-
-
Title
-
The effect of ambient temperature on serotonin syndrome.
-
Creator
-
Krishnamoorthy, Swapna., Charles E. Schmidt College of Medicine
-
Abstract/Description
-
Serotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and...
Show moreSerotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and prefrontal cortex (PFC), in particular, are sensitive to changes in ambient temperature (Tamb). The toxic increase of 5-HT is postulated to occur due to the temperature-dependent activation of these receptors that promotes a positive feedback mechanism. Our results suggest that changes in Tamb can either exacerbate or alleviate the symptom and that this is mediated by the 5-HT2A receptors. Understanding the mechanism involved in elevating Tcor is imperative in treating and preventing the disorder.
Show less
-
Date Issued
-
2008
-
PURL
-
http://purl.flvc.org/FAU/186297
-
Subject Headings
-
Serotoninergic mechanisms, Central nervous system, Physiology, Body temperature, Regulation, Neurotransmitter receptors, Serotonin, Physiological effect
-
Format
-
Document (PDF)