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Effects of target neuron loss on olfactory sensory neurons in adult mice
Title
Effects of target neuron loss on olfactory sensory neurons in adult mice.
Creator
Ardiles, Yona., Florida Atlantic University, Guthrie, Kathleen M.
Abstract/Description
Olfactory sensory neurons (OSN) expressing the same odor receptor (OR) project their axons to topographically fixed glomeruli in the olfactory bulb (OB). This topographic map results from axon guidance mechanisms determined by ORs, glia and molecular guidance cues. The present study examined the organization of mature OSNs expressing the P2 OR in adult mice after ablation of bulb neurons with N-methyl-D-aspartate (NMDA). Rapid neuronal degeneration was followed by progressive laminar...
Show moreOlfactory sensory neurons (OSN) expressing the same odor receptor (OR) project their axons to topographically fixed glomeruli in the olfactory bulb (OB). This topographic map results from axon guidance mechanisms determined by ORs, glia and molecular guidance cues. The present study examined the organization of mature OSNs expressing the P2 OR in adult mice after ablation of bulb neurons with N-methyl-D-aspartate (NMDA). Rapid neuronal degeneration was followed by progressive laminar disorganization of the OB and glomerular shrinkage. P2 axon targeting and convergence was maintained within degenerating glomeruli for up to 2 weeks. After that time, fewer P2 axons were observed in the lesioned OB with fewer P2 neurons in the olfactory epithelium (OE). By 3 weeks, the mature OSN population was reduced and the immature population was increased. These results suggest that bulbar synaptic contacts do not maintain sensory axon convergence in the adult, but regulate neuronal survival in the OE.
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Date Issued
2004
PURL
http://purl.flvc.org/fcla/dt/13166
Subject Headings
Sensory neurons--Testing, Senses and sensation, Neurotransmitter receptors, Mice as laboratory animals, Smell--Research--Methodology
Format
Document (PDF)
Over-Expression of BDNF Does Not Rescue Sensory Deprivation-Induced Death of Adult-Born Olfactory Granule Cells
Title
Over-Expression of BDNF Does Not Rescue Sensory Deprivation-Induced Death of Adult-Born Olfactory Granule Cells.
Creator
Berger, Rachel A., Guthrie, Kathleen M., Florida Atlantic University, Charles E. Schmidt College of Medicine, Department of Biomedical Science
Abstract/Description
It is of interest to understand how new neurons incorporate themselves into the existing circuitry of certain neuronal populations. One such population of neurons is that which are born in the subventricular zone (SVZ) and migrate to the olfactory bulb where they differentiate into granule cells. Another area of interest is the role of brain-derived neurotrophic factor (BDNF) on the survival and overall health of these neurons. This study aimed to test whether or not BDNF is a survival factor...
Show moreIt is of interest to understand how new neurons incorporate themselves into the existing circuitry of certain neuronal populations. One such population of neurons is that which are born in the subventricular zone (SVZ) and migrate to the olfactory bulb where they differentiate into granule cells. Another area of interest is the role of brain-derived neurotrophic factor (BDNF) on the survival and overall health of these neurons. This study aimed to test whether or not BDNF is a survival factor for adult-born granule cells. Here were utilized a transgenic mouse model over-expressing BDNF under the α- calcium/calmodulin-dependent protein kinase II (CAMKIIα) promoter, and tested its effect on olfactory granule cells under sensory deprived conditions. Results from this experiment indicated that there was no significant difference in cell death or cell survival when comparing transgenic and wild type animals. We concluded that BDNF is not a survival factor for adult-born granule cells.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004722, http://purl.flvc.org/fau/fd/FA00004722
Subject Headings
Cellular control mechanisms, Mice as laboratory animals, Nervous system -- Diseases -- Gene therapy, Neural circuitry, Neuroplasticity, Neurotransmitter receptors, Sensory deprivation, Sensory neurons -- Testing
Format
Document (PDF)