Current Search:  Retinal ganglion cells (x)

View All Items

  • CSV Spreadsheet
(1 - 2 of 2)
response of rat retinal ganglion cells to axotomy: Early changes in the regulation of fast transported proteins
Title
The response of rat retinal ganglion cells to axotomy: Early changes in the regulation of fast transported proteins.
Creator
Wodarczyk, Linda, Florida Atlantic University, Perry, Gary W.
Abstract/Description
Mammals, unlike lower vertebrates, cannot normally regenerate injured central nervous system neurons. Although rat retinal ganglion cells (RGCs), following optic nerve crush, will undergo an initial period of sprouting, axon outgrowth is limited and subsequently aborted. This study examined how extensive the changes in fast transported proteins (FTPs) were during the early response to RGC damage and whether these changes were comparable to those known to occur in lower vertebrate RGCs....
Show moreMammals, unlike lower vertebrates, cannot normally regenerate injured central nervous system neurons. Although rat retinal ganglion cells (RGCs), following optic nerve crush, will undergo an initial period of sprouting, axon outgrowth is limited and subsequently aborted. This study examined how extensive the changes in fast transported proteins (FTPs) were during the early response to RGC damage and whether these changes were comparable to those known to occur in lower vertebrate RGCs. Changes in mRNA for several known proteins were also analyzed. It was found that, within 2 days, axotomized rat RGCs initiated a program of cell growth, involving the differential synthesis and transport of a broad range of FTPs. This response is very similar to that of lower vertebrates and indicates that rat RGCs are capable of initiating the metabolic responses necessary for regeneration to begin. This response, however, was not sustained beyond 5 days axotomy.
Show less
Date Issued
1994
PURL
http://purl.flvc.org/fcla/dt/15074
Subject Headings
Regeneration (Biology), Retinal ganglion cells, Rats as laboratory animals, Nerves--Growth
Format
Document (PDF)
Reciprocal regulation between taurine and glutamate response via Ca2+ - dependent pathways in retinal third-order neurons
Title
Reciprocal regulation between taurine and glutamate response via Ca2+ - dependent pathways in retinal third-order neurons.
Creator
Bulley, Simon, Shen, Wen
Date Issued
2010-08-24
PURL
http://purl.flvc.org/fcla/dt/3327274
Subject Headings
Amacrine Cells*/cytology, Amacrine Cells*/drug effects, Amacrine Cells*/metabolism, Ambystoma, Calcium/metabolism, Calcium Channels/metabolism, Cells, Cultured, Enzyme Inhibitors/metabolism, Excitatory Amino Acid Agonists/pharmacology, GABA Antagonists/pharmacology, Glutamic Acid/metabolism, Glycine Agents/pharmacology, Kainic Acid/pharmacology, Membrane Glycoproteins, Membrane Potentials, Neurotransmitter Agents, Retinal Ganglion Cells, Signal Transduction, Synaptic Transmission
Format
Document (PDF)