Current Search: Prostate--Cancer--Treatment (x)
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Title
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Inhibition of the Growth and Spread of Human Prostate Cancer.
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Creator
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Yi, Zoey, Hartmann, James, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
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Abstract/Description
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Prostate cancer, the most frequent non-skin cancer, is the second leading cause of cancer-related deaths in males within the United States. Men diagnosed with metastatic prostate cancer have a 5-year survival rate of approximately 30%. Goals of this study were to produce a combination of compounds that are effective against the disease with minimal side effects on normal cells, especially those of the immune system. This study showed KBU2046 in combination with calcitriol, limit proliferation...
Show moreProstate cancer, the most frequent non-skin cancer, is the second leading cause of cancer-related deaths in males within the United States. Men diagnosed with metastatic prostate cancer have a 5-year survival rate of approximately 30%. Goals of this study were to produce a combination of compounds that are effective against the disease with minimal side effects on normal cells, especially those of the immune system. This study showed KBU2046 in combination with calcitriol, limit proliferation, inhibit migration, and are cytotoxic in a testosterone dependent human prostate cancer cell line. Organic compounds, ellagic acid and curcumin were tested alone and in combination with either calcitriol or KBU2046. No combinations were as effective as KBU2046 and calcitriol in inhibiting migration and proliferation of LNCaP cells. The findings of this study support further investigation into therapeutic use of a combination of KBU2046 and calcitriol in prevention and remission of human prostate cancer.
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Date Issued
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2023
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PURL
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http://purl.flvc.org/fau/fd/FA00014242
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Subject Headings
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Prostate--Cancer, Prostate--Cancer--Treatment--Research, Prostate--Cancer--Prevention, Calcitriol
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Format
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Document (PDF)
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Title
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Anticancer activity of two dietary phytochemicals: Genistein and beta-lapachone.
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Creator
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Merchant, Kendra T., Florida Atlantic University, Kumi-Diaka, James
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Abstract/Description
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Phytochemicals are biologically active secondary plant metabolites that have been shown to exhibit anti-cancer activity. The dietary phytochemicals genistein isoflavone and beta-lapachone, were investigated to determine their effect on the growth of human prostate adenocarcinoma cells in vitro. The cells were exposed to varying concentrations of both phytochemicals in single and combination treatments for specified time periods and their effect was determined using post-treatment cell...
Show morePhytochemicals are biologically active secondary plant metabolites that have been shown to exhibit anti-cancer activity. The dietary phytochemicals genistein isoflavone and beta-lapachone, were investigated to determine their effect on the growth of human prostate adenocarcinoma cells in vitro. The cells were exposed to varying concentrations of both phytochemicals in single and combination treatments for specified time periods and their effect was determined using post-treatment cell viability, treatment-induced apoptosis and cell signaling assays. The overall results revealed that both phytochemicals inhibited cell growth and proliferation and induced apoptosis in a dose-dependent manner for both single and combination treatments. However, combination treatments were not significantly more effective than single treatment with either drug. Both phytochemicals could therefore offer therapeutic efficacy in human prostate adenocarcinoma.
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Date Issued
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2005
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PURL
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http://purl.flvc.org/fcla/dt/13250
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Subject Headings
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Phytochemicals--Physiological effect, Prostate--Cancer--Molecular aspects, Apoptosis--Molecular aspects, Prostate--Cancer--Treatment
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Format
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Document (PDF)
