View All Items

Title: Synthesis and characterization of poly(magnesium acrylate) and poly(zirconyl acrylate) towards formation of magnesia partially stabilized zirconia ceramics.
Creator: Xu, Xinhua, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Poly(magnesium acrylate) and poly(zirconyl acrylate) have been formed by chelating the magnesium ion and the zirconyl ion onto poly(acrylic acid). The PAA is usually neutralized by addition of sodium hydroxide before the synthesis process. The structures and characterisitics of these polymers are studied by various analytical methods such as thermal analysis, elemental analysis, infrared spectroscopy, and mass spectroscopy. The formation of these polymers is verified and their structures are...
Show morePoly(magnesium acrylate) and poly(zirconyl acrylate) have been formed by chelating the magnesium ion and the zirconyl ion onto poly(acrylic acid). The PAA is usually neutralized by addition of sodium hydroxide before the synthesis process. The structures and characterisitics of these polymers are studied by various analytical methods such as thermal analysis, elemental analysis, infrared spectroscopy, and mass spectroscopy. The formation of these polymers is verified and their structures are determined. In addition, a preliminary attempt was carried out to make an advanced structural ceramic from a mixture of poly(magnesium acrylate) and poly(zirconyl acrylate).
Show less
Date Issued: 1997
PURL: http://purl.flvc.org/fcla/dt/15367
Subject Headings: Polymers, Ceramics
Format: Document (PDF)

Title: Low velocity impact and compression after impact characterization of woven carbon/vinylester at dry and water saturated conditions.
Creator: Dale, Michael, Acha, Betiana A., Carlson, Lief, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3164519
Subject Headings: Polymers, Polymeric composites, Accelerometers
Format: Document (PDF)

Title: Crystallographic studies of lanthanide coordination polymers based on 3,4-furandicarboxylate.
Creator: Karram, Joseph P., Kent, Charles A., Chan, Benny C., De Lill, Daniel T.
Date Issued: 2013-04-05
PURL: http://purl.flvc.org/fcla/dt/3361101
Subject Headings: Lanthanides, Crystallography, Coordination polymers
Format: Document (PDF)

Title: New materials based on metal complexes of bis(arylimino)isoindoline.
Creator: Rosenberg, Jay Merlin., Florida Atlantic University, Baird, Donald M.
Abstract/Description: Molecular architecture has been used to develop new materials with our knowledge of Bis(arylimino)isoindoline (BAII). Ni(BAII)2,\ Ni(NBAII)2 and Cu(NBAII)(OAc) complexes were prepared and studied using their Crystal packing diagrams and data in order to evaluate $\pi$-overlapping. It is believed that $\pi$-overlapping will occur in complexes with mono BAII substituted complexes and not di-substituted. The first steps have been made in the development of a polymeric BAII complex with the...
Show moreMolecular architecture has been used to develop new materials with our knowledge of Bis(arylimino)isoindoline (BAII). Ni(BAII)2,\ Ni(NBAII)2 and Cu(NBAII)(OAc) complexes were prepared and studied using their Crystal packing diagrams and data in order to evaluate $\pi$-overlapping. It is believed that $\pi$-overlapping will occur in complexes with mono BAII substituted complexes and not di-substituted. The first steps have been made in the development of a polymeric BAII complex with the production of an oligomeric BAII (GBAII). The GBAII complex was analysis using a molecular device approach with the use of NMR instrumentation.
Show less
Date Issued: 1998
PURL: http://purl.flvc.org/fcla/dt/15553
Subject Headings: Polymers, Materials, Chemistry, Ligands
Format: Document (PDF)

Title: Synthesis and structural characterization of vanadocene containing polymers.
Creator: Randolph, Ernest B., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: The synthesis of polymers which contain vanadocene in the polymer backbone is accomplished by interfacial condensation reactions with the appropriate diols, diacids, and diamines. Structural characterization is accomplished by using FTIR and HREI-MS spectroscopic methods. Weight average molecular weights were determined using light scattering photometry for products which are soluble. Molecular weights for the products vary from 3500 to 15,000 Daltons. The structural characterization results...
Show moreThe synthesis of polymers which contain vanadocene in the polymer backbone is accomplished by interfacial condensation reactions with the appropriate diols, diacids, and diamines. Structural characterization is accomplished by using FTIR and HREI-MS spectroscopic methods. Weight average molecular weights were determined using light scattering photometry for products which are soluble. Molecular weights for the products vary from 3500 to 15,000 Daltons. The structural characterization results are consistent with the proposed structures.
Show less
Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15299
Subject Headings: Polymers, Polymerization, Vanadium
Format: Document (PDF)

Title: The synthesis of a new polymeric ligand poly[5-(1,3-bis-(2'-pyridylimino)isoindolyloxy)ethylene] (PBPIIIOE).
Creator: Jiang, Yi, Florida Atlantic University, Carraher, Charles E., Baird, Donald M., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: A new polymeric ligand, poly[5-(1,3-bis-(2'-pyridylimino) isoindolyloxy)ethylene], was synthesized. At same time, 1,3-bis-(2 '-pyridylimino)-5-hexadecanyloxyisoindoline was also synthesized. These two products were characterized with fourier transform infrared spectrometry, ultraviolet spectrometry, mass spectral analysis and elemental analysis. Their complexes of Cu+2 were prepared.
Date Issued: 2000
PURL: http://purl.flvc.org/fcla/dt/12663
Subject Headings: Ligands, Organometallic polymers
Format: Document (PDF)

Title: Synthesis and characterization of tin-containing polymers derived from amino acids.
Creator: Li, Fengmai, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: Tin-containing polymers were synthesized by reaction of amino acids (4-aminobenzoic acid, ampicillin, glycylglycine and glycyl-D-phenylalanine) with organotin dichloride via the interfacial condensation technique. The products were characterized using Fourier Transform Infrared spectrometry, Ultraviolet spectrometry, light scattering photometry and mass spectral analysis. The biological activities of the products were tested against selected microorganisms and human cells.
Date Issued: 1998
PURL: http://purl.flvc.org/fcla/dt/15611
Subject Headings: Organometallic polymers, Organotin compounds
Format: Document (PDF)

Title: Determination and evaluation of electrical properties of metal-containing condensation polymers.
Creator: Battin, Amitabh J., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: Doped electrically conductive polymers are one of the critical materials that have allowed the current technological revolution. Essentially all of today's applications of doped conductive polymers involve vinyl-related polymers. While the application of conductive polymers is rapidly increasing, there is need for additional materials with different electrical behaviors. The current focus is on studying condensation polymers that contain a metal atom and the possibility of undergoing entire...
Show moreDoped electrically conductive polymers are one of the critical materials that have allowed the current technological revolution. Essentially all of today's applications of doped conductive polymers involve vinyl-related polymers. While the application of conductive polymers is rapidly increasing, there is need for additional materials with different electrical behaviors. The current focus is on studying condensation polymers that contain a metal atom and the possibility of undergoing entire chain delocalization of electrons. The different series of organometallic condensation polymers were synthesized by employing interfacial polycondensation technique and characterization of these products were carried out using standard techniques like light scattering photometer, fourier transform infrared spectroscopy (FTIR), matrix assisted laser desorption ionization time of flight mass spectroscopy (MALDI TOF MS) and nuclear magnetic resonance spectroscopy (NMR). The electrical measurements were carried out employing Genrad 1650-B impedance spectroscopy. Prior studies conducted in this area have led to the pathway of looking at two aspects; first, surveying 60 metal-containing polymers that can undergo entire chain delocalization studying the effect of different substituents on their electrical properties and secondly, doping selected candidates employing iodine. The products derived from 2-nitro-1,4-phenylenediamine and N-methyl-1,4- pheneylenediamines with titanocene dichloride exhibited about 10 3 to 10 5 fold magnitude increases in the electrical conductivity on doping with iodine, moving it near conductive region. This increase is dependent on the concentration of the iodine and is cyclic. The results support the starting premise that selected metal-containing condensation polymers can be doped to increase their electrical conductivity., Further investigation is warranted to see if metal-containing condensation polymers can be important materials in the electronic industry. This research sets the stage for studying not only metal-containing polymeric materials but also to investigate the ability to increase the conductivity of other condensation polymers such as nylons and polyesters through doping.
Show less
Date Issued: 2009
PURL: http://purl.flvc.org/FAU/216415
Subject Headings: Polycondensation, Condensation products (Chemistry), Polymers and polymerization, Polymers, Electric properties
Format: Document (PDF)

Title: DEVELOPMENT OF AN ELASTIC POLYMER-BASED DRUG DELIVERY SYSTEM FOR TISSUE REGENERATION.
Creator: Firoozi, Negar, Kang, Yunqing, Florida Atlantic University, College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering
Abstract/Description: In spite of the vast research on polymer-based tissue regeneration, extensive studies to develop an elastic and cell-promoting polymer biomaterial are still ongoing. However, using a renewable resource and a simple, environment-friendly synthesis route to synthesize an elastic polymer has not been successfully achieved yet. The objective of this work was to develop an elastic polymer for tissue engineering and drug delivery applications by using non-toxic, inexpensive and renewable monomers....
Show moreIn spite of the vast research on polymer-based tissue regeneration, extensive studies to develop an elastic and cell-promoting polymer biomaterial are still ongoing. However, using a renewable resource and a simple, environment-friendly synthesis route to synthesize an elastic polymer has not been successfully achieved yet. The objective of this work was to develop an elastic polymer for tissue engineering and drug delivery applications by using non-toxic, inexpensive and renewable monomers. A new nature-derived renewable material, xylitol, was used to synthesize an elastic polymer with the presence of a crosslinking agent, dodecanedioic acid. Here a simple melt condensation polymerization method was used to synthesize the poly(xylitoldodecanedioic acid)(PXDDA). The physicochemical and biological properties of the new PXDDA polymer were characterized. Fourier transform infrared (FTIR) confirmed the formation of ester bonding in the polymer structure, and thermal analysis demonstrated that the polymer was completely amorphous. The polymer shows high elasticity. Increasing the molar ratio of dodecanedioic acid resulted in higher hydrophobicity and lower glass transition temperature. Further, the polymer degradation and in vitro dye release studies revealed that the degradation and dye release from the polymer became slower when the amount of dodecanedioic acid in the composite increased.
Show less
Date Issued: 2019
PURL: http://purl.flvc.org/fau/fd/FA00013306
Subject Headings: Drug Delivery Systems, Polymers, Tissue Engineering, Xylitol
Format: Document (PDF)

Title: Adhesive Joint Analyses Using Ansys CZM Modeling of a Prefabricated Hybrid Concrete-GFRP-CFRP Unit.
Creator: Kabaluk, Maksim, Arockiasamy, Madasamy, Florida Atlantic University, College of Engineering and Computer Science, Department of Civil, Environmental and Geomatics Engineering
Abstract/Description: The present study reviews applications of FRP materials joined by structural adhesives in civil engineering. FE analysis with mix-mode cohesive zone material model (CZM) was used to analyze stresses induced in two structural adhesives joining dissimilar materials (concrete GFRP-CFRP) of the hybrid-composite unit. The predicted failure loads, displacements and deformation by the 3-D non-linear FE analysis in the present study are in good agreement with the experimental results of the hybrid...
Show moreThe present study reviews applications of FRP materials joined by structural adhesives in civil engineering. FE analysis with mix-mode cohesive zone material model (CZM) was used to analyze stresses induced in two structural adhesives joining dissimilar materials (concrete GFRP-CFRP) of the hybrid-composite unit. The predicted failure loads, displacements and deformation by the 3-D non-linear FE analysis in the present study are in good agreement with the experimental results of the hybrid-composite unit reported by Deskovic et al. (1995). The contact analysis revealed a complex 3-D state of stress in the bondlines of both structural adhesives. It is concluded that higher joint strength is expected when a ductile adhesive is used.
Show less
Date Issued: 2019
PURL: http://purl.flvc.org/fau/fd/FA00013222
Subject Headings: Adhesive joints, Fiber reinforced polymers, Composites, Concrete
Format: Document (PDF)

Title: Modeling and Experimental Study of Evaporation and Diffusion of Water Droplets on Foam Substrates.
Creator: Tian, Yining, Du, Sarah E., Florida Atlantic University, College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering
Abstract/Description: The objective of this thesis is to develop a new experimental method to characterize the diffusion of water in polymer resins, based on the evolution in the volume of water droplets as a function of time. A finite element model is established to model the mass transport of water droplet through evaporation and diffusion processes. Diffusivity of water into polymer resins is then extracted by matching the volume variation of the simulated water droplet to the experimental results. Capability...
Show moreThe objective of this thesis is to develop a new experimental method to characterize the diffusion of water in polymer resins, based on the evolution in the volume of water droplets as a function of time. A finite element model is established to model the mass transport of water droplet through evaporation and diffusion processes. Diffusivity of water into polymer resins is then extracted by matching the volume variation of the simulated water droplet to the experimental results. Capability of this method is demonstrated by determining the diffusivity of water into void-free epoxy and epoxy samples with voids. Diffusion coefficient value obtained from this method agrees with data from conventional water immersion method. The significantly small scale of the water droplet (less than 10 microliter) allows rapid characterization of diffusivity in hours instead of months as typically required by the conventional immersion method. The method developed here provides a useful tool for rapid and effective characterization of diffusivity of water in polymer substrates and can be extended to other substances as well.
Show less
Date Issued: 2019
PURL: http://purl.flvc.org/fau/fd/FA00013270
Subject Headings: Polymers, Resins, Diffusion, Water, Evaporation--Experiments
Format: Document (PDF)

Title: Cytokinetic effects of platinum (II) polyamines on three different cell lines using flow cytometry.
Creator: Fitch, Claire E., Florida Atlantic University, Hartmann, James X., Louda, Deborah W.
Abstract/Description: The association between cytotoxicity and cell cycle perturbation caused by cisplatin and two platinum (II) polyamines, containing a methotrexate or a 2-chloro-p-phenylenediamine component, was investigated in human ovarian carcinoma cells (CAOV3), murine Balb 3T3 fibroblasts and Chinese ovarian hamster cells by flow cytometric DNA/protein, DNA/RNA and DNA degradation assays. Continuous in vitro drug exposure caused a time- and dose-dependent suppression of growth. Flow cytometric analysis...
Show moreThe association between cytotoxicity and cell cycle perturbation caused by cisplatin and two platinum (II) polyamines, containing a methotrexate or a 2-chloro-p-phenylenediamine component, was investigated in human ovarian carcinoma cells (CAOV3), murine Balb 3T3 fibroblasts and Chinese ovarian hamster cells by flow cytometric DNA/protein, DNA/RNA and DNA degradation assays. Continuous in vitro drug exposure caused a time- and dose-dependent suppression of growth. Flow cytometric analysis revealed a multiplicity of cytokinetic perturbations, the most important of which was Go/G1 depletion and S phase arrest. The latter correlated with inhibition of DNA synthesis and subsequent inhibition of RNA and protein synthesis. Prolonged S phase arrest concomitant with DNA degradation, followed by RNA and protein degradation, resulted in cell death via apoptosis. The platinum polymers appear to be effective in vitro chemotherapeutic agents. The study of cytokinetic perturbations is useful in determining the relative potency of antitumor drugs and in monitoring drug effectiveness during treatment.
Show less
Date Issued: 1999
PURL: http://purl.flvc.org/fcla/dt/15626
Subject Headings: Cisplatin, Cell lines, Flow cytometry, Polymers
Format: Document (PDF)

Title: I. The synthesis of organotin-modified poly(vinyl alcohol) for the inhibition of Candida albicans. II. The synthesis and structural characterization of titanocene-containing polyethers based on ethylene glycols.
Creator: Reckleben, Lisa., Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Organotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the...
Show moreOrganotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the microorganism most responsible for yeast infections in man. The titanocene-containing polyethers exhibited flexibility when derived from longer chained polyethylene glycols, but were inflexible when shorter chained polyethylene glycols were used.
Show less
Date Issued: 1991
PURL: http://purl.flvc.org/fcla/dt/14752
Subject Headings: Candida albicans, Organometallic polymers, Polymerization, Polyethylene glycol
Format: Document (PDF)

Title: Nuclear magnetic resonance spectroscopic studies of metallocene (IVB) squarate polymers and other metallocene (IVB)-containing polymers.
Creator: Li, Alicia Qing, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: Group IVB metallocene polymers and oligomers undergo a pi-sigma rearrangement of the cyclopentadienyl moieties in DMSO based on NMR data. The sigma-Cp rings are stereochemically rigid at room temperature.
Date Issued: 1991
PURL: http://purl.flvc.org/fcla/dt/14681
Subject Headings: Organometallic polymers, Metallocenes, Nuclear magnetic resonance
Format: Document (PDF)

Title: Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives.
Creator: Kloss, John Edward, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: Reaction of Group IVB metallocene dichlorides with a monoaza dye yields a polymer in which the metal is bonded to a sulfonic and a hydroxyl group. The structure and bonding of the polymer was confirmed using infrared, mass spectrometry and 1H-NMR spectroscopy. Thermo and elemental analysis was used to confirm the presence of the metal. The stability of the polydye to the monomer unit was compared employing an argon laser in the visible region.
Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14912
Subject Headings: Metallocenes, Organometallic polymers, Infrared spectroscopy, Azo compounds
Format: Document (PDF)

Title: Synthesis and characterization of ruthenium-containing polymers.
Creator: Zhang, Qingmao, Florida Atlantic University, Carraher, Charles E.
Abstract/Description: Ruthenium-containing polymers derived from dichloro-bis(2,2-bipyridine)-ruthenium and selected dithiol or diamines have been synthesized. These polymeric products were characterized using FTIR, ultraviolet spectroscopy, light scattering photometry and mass spectral analysis. Thermal degradation studies of these products are presented.
Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14952
Subject Headings: Ruthenium compounds, Ligands, Organometallic polymers, Mass spectrometry
Format: Document (PDF)

Title: NANOPARTICLE-INDUCED CATALYTIC CARBON CAPTURE: A MICROFLUIDICS APPROACH.
Creator: Donjuan, Joshua, Kim, Myeongsub, Florida Atlantic University, Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science
Abstract/Description: Due to technological advancement, energy consumption and demand have been increasing significantly, primarily satisfied by fossil fuel consumption. This reliance on fossil fuels results in substantial greenhouse gas emissions, with CO₂ being the most prominent contributor to global warming. To mitigate this issue and prevent CO₂ emissions, Carbon Capture, Utilization, and Storage (CCUS) technologies are employed. Among these, the amine scrubbing method is widely used due to its high CO2...
Show moreDue to technological advancement, energy consumption and demand have been increasing significantly, primarily satisfied by fossil fuel consumption. This reliance on fossil fuels results in substantial greenhouse gas emissions, with CO₂ being the most prominent contributor to global warming. To mitigate this issue and prevent CO₂ emissions, Carbon Capture, Utilization, and Storage (CCUS) technologies are employed. Among these, the amine scrubbing method is widely used due to its high CO2 capture efficiency and regenerative ability. However, this method has drawbacks, including high toxicity, corrosion, and substantial freshwater consumption. To develop an environmentally sustainable carbon capture solution, researchers are exploring alternatives such as the use of seawater and enhanced CO2 capture with catalysts. In this study, we analyze the catalytic performance of nickel nanoparticles (NiNPs) in seawater with carboxymethyl cellulose (CMC) polymers. Using flow-focusing geometry-based microfluidic channels, we investigated CO₂ dissolution at various concentrations of nanoparticles and CMC polymers. The objective is to optimize the concentration of nanoparticles and CMC polymers for effective CO₂ dissolution. We utilized NiNPs with diameters of 100 nm and 300 nm in CMC concentrations of 100 ml/L, 200 ml/L, and 300 ml/L. Additionally, NiNP concentrations ranging from 6 mg/L to 150 mg/L were tested for CO₂ dissolution in seawater. The results indicated that a concentration of 10 mg/L NiNPs in 100 mg/L CMC provided a CO₂ dissolution of 57%, the highest for this specific CMC concentration. At CMC concentrations of 200 ml/L and 300 ml/L, NiNP concentrations of 70 mg/L and 90 mg/L achieved CO₂ dissolution rates of 58.8% and 67.2%, respectively.
Show less
Date Issued: 2024
PURL: http://purl.flvc.org/fau/fd/FA00014483
Subject Headings: Carbon sequestration, Global warming, Polymer chemistry, Nanoparticles
Format: Document (PDF)

Title: Effects of Repeated Wet-Dry Cycles on Compressive Strength of Fly-Ash Based Recycled Aggregate Geopolymer Concrete (RAGC).
Creator: Mendelson, Monica, Sobhan, Khaled, Florida Atlantic University, College of Engineering and Computer Science, Department of Civil, Environmental and Geomatics Engineering
Abstract/Description: Geopolymer concrete (GC) is a sustainable construction material and a great alternative to regular concrete. GC is a zero-cement material made from a combination of aluminate, silicate and an activator to produce a binder-like substance. This investigation focused on the effects of wet and dry cycles on the strength and durability of fly ash-based recycled aggregate geopolymer concrete (RAGC). The wet-dry cycles were performed approximately according to ASTM D559 standards. RAGC specimens...
Show moreGeopolymer concrete (GC) is a sustainable construction material and a great alternative to regular concrete. GC is a zero-cement material made from a combination of aluminate, silicate and an activator to produce a binder-like substance. This investigation focused on the effects of wet and dry cycles on the strength and durability of fly ash-based recycled aggregate geopolymer concrete (RAGC). The wet-dry cycles were performed approximately according to ASTM D559 standards. RAGC specimens with nearly 70% recycled materials (recycled aggregate and fly ash) achieved a compressive strength of approximately 3600 psi, after 7 days of heat curing at 60ºC. Although the recycled aggregate is prone to high water absorption, the compressive strength decreased by only 4% after exposure to 21 wet-dry cycles, compared to control specimens that were not exposed to the same conditions. Accordingly, the RAGC material developed in this study can be considered as a promising environmentally friendly alternative to cement-based regular concrete.
Show less
Date Issued: 2018
PURL: http://purl.flvc.org/fau/fd/FA00013016
Subject Headings: Polymer-impregnated concrete, Recycled materials, Fly ash, Polymers--Compression testing
Format: Document (PDF)

Title: Synthesis, structural characterization and biological studies of organotin polyethers (Sn-O).
Creator: Barot, Girish Vallabhbhai., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: Cancer is the second leading cause of death in the western world. In order to treat various types of cancer, platinum-based drugs are most widely employed as metal-containing chemotherapeutic agents. However, their clinical usage is hindered by toxic side effects, and by the emergence of drug resistance. Our focus was to replace platinum with less toxic metal like tin which can give better alternatives for cancer treatment. The major aim of our study was to synthesize novel organotin...
Show moreCancer is the second leading cause of death in the western world. In order to treat various types of cancer, platinum-based drugs are most widely employed as metal-containing chemotherapeutic agents. However, their clinical usage is hindered by toxic side effects, and by the emergence of drug resistance. Our focus was to replace platinum with less toxic metal like tin which can give better alternatives for cancer treatment. The major aim of our study was to synthesize novel organotin polyethers (Sn-O) which can be used to combat cancer. Preliminary results from our laboratory using organotin polyethers, that were synthesized by varying the structure of diols showed growth inhibition in Balb-3T3 cells. This study directly led us to hypothesize the two structural windows, first by changing the distance between diol and second, by presence of unsaturation in diols, the biological activity of organotin polyethers (Sn-O) can be enhanced significantly. Different series of polymeric compounds were synthesized based upon these two structural windows and the formation of products was validated using standard techniques like infrared spectroscopy (IR), light scattering photometer, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and nuclear magnetic resonance (NMR). The synthesized polymers arrested the growth of cancer cell lines including bone, prostate, colon, breast, pancreas and lung cancer derived cell lines in vitro. In number of instances where chemotherapeutic index values of two and greater were found that these polymers are significantly more active against cancer cells than non-cancerous cells in culture., These results support the starting premise that the polymers may exhibit cancer cell selectivity. In general, it was found that the presence of unsaturation increased the probability that the polyether would inhibit the growth of various cancer cell lines. Further, in some cases, polyethers with short distances between the oxygen atoms showed a superior ability to inhibit the growth of various cancer cell lines in comparison to those with longer distances between the oxygen atoms. These results provide a framework for the discovery of novel cancer therapeutics.
Show less
Date Issued: 2009
PURL: http://purl.flvc.org/FAU/186672
Subject Headings: Organometallic polymers, Cancer, Molecular aspects, Apoptosis, Molecular aspects, Antineoplastic agents, Testing, Polymers in medicine
Format: Document (PDF)

Title: The effects of POSS surface treatment on the interlaminar property of marine composites.
Creator: Powell, Felicia M., Granata, Richard D., Hosur, Mahesh, Mahfuz, Hassan, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3164682
Subject Headings: Composite materials --Delamination, Fibrous composites, Polymers --Effect of radiation on
Format: Document (PDF)

FAU Theses and Dissertations (36)	+ -
FAU Graduate Student Research (2)	+ -
FAU Undergraduate Student Research (1)	+ -

Polymers (13)	+ -
Organometallic polymers (7)	+ -
Polymers in medicine (4)	+ -
Composite materials (3)	+ -
Ligands (3)	+ -

Polymeric composites (3)	+ -
Polymerization (3)	+ -
Concrete (2)	+ -
Deterioration (2)	+ -
Electric properties (2)	+ -
Fibrous composites (2)	+ -
Graphite fibers (2)	+ -
Mechanical properties (2)	+ -
Metallocenes (2)	+ -
Nanoparticles (2)	+ -
Nanostructured materials (2)	+ -
Polymer composites (2)	+ -
Polymers and polymerization (2)	+ -
Polymers--Deterioration (2)	+ -
Reinforced concrete construction (2)	+ -
Ruthenium compounds (2)	+ -
Testing (2)	+ -
Water (2)	+ -
3-D printing (1)	+ -
Accelerometers (1)	+ -
Adhesive joints (1)	+ -
Antineoplastic agents (1)	+ -
Antineoplastic agents--Testing (1)	+ -
Apoptosis (1)	+ -
Apoptosis--Molecular aspects (1)	+ -

Electronic Thesis or Dissertation (36)	+ -
abstract (2)	+ -
poster (1)	+ -

Florida Atlantic University (25)	+ -
College of Engineering and Computer Science (19)	+ -
Department of Ocean and Mechanical Engineering (13)	+ -
Carraher, Charles E. (10)	+ -
Charles E. Schmidt College of Science (7)	+ -

Search In

Pages

Pages

Sort Results By:

Narrow results by:

Collection

Topical Subject

Genre

Type of Resource

Language

Creator

Format

Owner