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Disordered caffeination: a biocultural analysis of adverse reactions to caffeine
Title
Disordered caffeination: a biocultural analysis of adverse reactions to caffeine.
Creator
Porter, Carlyn M., Cameron, Mary, Florida Atlantic University, Dorothy F. Schmidt College of Arts and Letters, Department of Anthropology
Abstract/Description
While coffee culture has long since been positively associated with intellectual and working life, the health and safety of its primary stimulant, caffeine, has recently fallen under scrutiny by the FDA. This medical anthropology thesis provides a biocultural synthesis of caffeine culture, health effects, and biological variation in adverse effects related to pharmacodynamics and pharmacokinetics. Supporting evidence for variation in responses to caffeine was found through surveying 100...
Show moreWhile coffee culture has long since been positively associated with intellectual and working life, the health and safety of its primary stimulant, caffeine, has recently fallen under scrutiny by the FDA. This medical anthropology thesis provides a biocultural synthesis of caffeine culture, health effects, and biological variation in adverse effects related to pharmacodynamics and pharmacokinetics. Supporting evidence for variation in responses to caffeine was found through surveying 100 participants, investigating caffeine consumption levels, perceptions and health beliefs, adverse effects experienced, and medical encounters. Increased rates of adverse effects were found for students, pharmaceutical and over-the-counter drug users, and for participants reporting negative or ambivalent perceptions of caffeine, intolerance, or sensitivity to caffeine. Variation in rates of adverse effects suggests biocultural interactions account not only for patterns in pharmacological data, but are also clinically significant in constructing risk of caffeine intoxication.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004319, http://purl.flvc.org/fau/fd/FA00004319
Subject Headings
Adenosine triphosphate -- Physiological effect, Caffeine -- Health aspects, Caffeine -- Physiological effect, Medical anthropology, Physiology, Pathological
Format
Document (PDF)
Peroxiredoxin 3 and Methionine sulfoxide reductase A are Essential for Lens Cell Viability by Preserving Lens Cell Mitochondrial Function through Repair of Cytochrome c
Title
Peroxiredoxin 3 and Methionine sulfoxide reductase A are Essential for Lens Cell Viability by Preserving Lens Cell Mitochondrial Function through Repair of Cytochrome c.
Creator
Lee, Wanda, Florida Atlantic University, Kantorow, Marc, Charles E. Schmidt College of Science, Department of Biomedical Science
Abstract/Description
The central premise of this dissertation is that mitochondrial antioxidant enzymes are essential to lens cell viability by preserving lens cell mitochondria and protecting and/or repairing lens cell proteins, and two mitochondrial-specific antioxidant enzymes, Peroxiredoxin 3 (PRDX3) and Methionine sulfoxide reductase A (MsrA), are explored. In this dissertation, we will examine the expression ofPRDX3 in the human lens, its colocalization to the lens cell mitochondria, its ability to be...
Show moreThe central premise of this dissertation is that mitochondrial antioxidant enzymes are essential to lens cell viability by preserving lens cell mitochondria and protecting and/or repairing lens cell proteins, and two mitochondrial-specific antioxidant enzymes, Peroxiredoxin 3 (PRDX3) and Methionine sulfoxide reductase A (MsrA), are explored. In this dissertation, we will examine the expression ofPRDX3 in the human lens, its colocalization to the lens cell mitochondria, its ability to be induced by H20 2-oxidative stress, and speculate how PRDX3 function/sf could affect the lens. We will also examine the reduced levels of MsrA by targeted gene silencing and its effect on reactive oxygen species production and mitochondrial membrane potential in human lens cells to determine its role in mitochondrial function in the lens. Lastly, we will examine the ability of MsrA to repair and restore function to a critical mitochondrial protein, Cytochrome c. The collective evidence strongly indicates that the loss of mitochondrial-specific enzymes, such as PRDX3 and MsrA, are responsible for increased reactive oxygen species levels, decreased mitochondrial membrane potential, protein aggregation and lens cell death, and further indicates that mitochondrial repair, protective, and reducing systems play key roles in the progression of age-related cataract and other agerelated diseases.
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Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FA00000868
Subject Headings
Genetic regulation, Proteins--Chemical modification, Cellular signal transduction, Eye--Physiology, Mitochondrial pathology
Format
Document (PDF)
High summer
Title
High summer.
Creator
Hasler Martinez, Michelle., Dorothy F. Schmidt College of Arts and Letters, Department of English
Abstract/Description
High Summer is a manuscript-length compilation of narrative science essays that trace the relationship the narrator has with her father. These essays focus on the ongoing presence of drugs, their historical basis, and their pharmacological effects on the body.
Date Issued
2012
PURL
http://purl.flvc.org/FAU/3358552
Subject Headings
Fathers and daughters, Parent and child, Symbolism in literature, Psychology, Pathological, Substance abuse, Physiological aspects, Narration (Rhetoric), Creative nonfiction
Format
Document (PDF)