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Noncoding RNAs as novel pancreatic cancer targets
Title
Noncoding RNAs as novel pancreatic cancer targets.
Creator
Makler, Amy, Narayanan, Ramaswamy, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description
Pancreatic cancer is an abhorrent malignancy with limited diagnostics and response to drug therapy. It is believed that noncoding RNAs (ncRNAs) will further the understanding behind the mechanisms of pancreatic cancer development and progression, providing a novel approach for drug development and biomarker discovery. Therefore, a database of pancreatic cancer ncRNAs was established using bioinformatics and text mining approaches. These ncRNAs were characterized for RNA expression, copy...
Show morePancreatic cancer is an abhorrent malignancy with limited diagnostics and response to drug therapy. It is believed that noncoding RNAs (ncRNAs) will further the understanding behind the mechanisms of pancreatic cancer development and progression, providing a novel approach for drug development and biomarker discovery. Therefore, a database of pancreatic cancer ncRNAs was established using bioinformatics and text mining approaches. These ncRNAs were characterized for RNA expression, copy number variation, disease association, single nucleotide polymorphisms, secretome analysis, and identification of protein targets. Exosomal proteins and ncRNA identified through this study provide the basis for noninvasive diagnostic potential. Additionally, a secreted microRNA, MIR3620, emerged from this study as a potential prognostic and diagnostic biomarker for pancreatic cancer. By analyzing MIR3620 and its protein targets, a mechanism of regulation for these genes in contributing to the progression and development of pancreatic cancer was established.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00013086
Subject Headings
Pancreas--Cancer., Non-coding RNA., Pancreas--Cancer--Pathogenesis., Biomarkers.
Format
Document (PDF)
Early effects of Lasonolide A on pancreatic cancer cells
Title
Early effects of Lasonolide A on pancreatic cancer cells.
Creator
Isbrucker, Richard A., Guzman, Esther A., Pitts, Tara P., Wright, Amy E.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007053
Subject Headings
Macrolides, Sponges, Marine natural products, Pancreatic Neoplasms, Pancreas--Cancer
Format
Document (PDF)
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
Title
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
Creator
Guzman, Esther A., Johnson, J. D., Linley, P. A., Wright, Amy E., Gunasekera, Sarath P.
Date Issued
2010
PURL
http://purl.flvc.org/FCLA/DT/3318907
Subject Headings
Pancreas--Cancer, Apoptosis, Sponges--Research, Marine natural products, Drug Discovery
Format
Document (PDF)
Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines
Title
Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
Creator
Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
Date Issued
2009
PURL
http://purl.flvc.org/fau/fd/FA00007114
Subject Headings
Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
Format
Document (PDF)