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synthesis of a new polymeric ligand poly[5-(1,3-bis-(2'-pyridylimino)isoindolyloxy)ethylene] (PBPIIIOE)
Title
The synthesis of a new polymeric ligand poly[5-(1,3-bis-(2'-pyridylimino)isoindolyloxy)ethylene] (PBPIIIOE).
Creator
Jiang, Yi, Florida Atlantic University, Carraher, Charles E., Baird, Donald M., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
A new polymeric ligand, poly[5-(1,3-bis-(2'-pyridylimino) isoindolyloxy)ethylene], was synthesized. At same time, 1,3-bis-(2 '-pyridylimino)-5-hexadecanyloxyisoindoline was also synthesized. These two products were characterized with fourier transform infrared spectrometry, ultraviolet spectrometry, mass spectral analysis and elemental analysis. Their complexes of Cu+2 were prepared.
Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/12663
Subject Headings
Ligands, Organometallic polymers
Format
Document (PDF)
Synthesis and characterization of tin-containing polymers derived from amino acids
Title
Synthesis and characterization of tin-containing polymers derived from amino acids.
Creator
Li, Fengmai, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Tin-containing polymers were synthesized by reaction of amino acids (4-aminobenzoic acid, ampicillin, glycylglycine and glycyl-D-phenylalanine) with organotin dichloride via the interfacial condensation technique. The products were characterized using Fourier Transform Infrared spectrometry, Ultraviolet spectrometry, light scattering photometry and mass spectral analysis. The biological activities of the products were tested against selected microorganisms and human cells.
Date Issued
1998
PURL
http://purl.flvc.org/fcla/dt/15611
Subject Headings
Organometallic polymers, Organotin compounds
Format
Document (PDF)
I. The synthesis of organotin-modified poly(vinyl alcohol) for the inhibition of Candida albicans. II. The synthesis and structural characterization of titanocene-containing polyethers based on ethylene glycols
Title
I. The synthesis of organotin-modified poly(vinyl alcohol) for the inhibition of Candida albicans. II. The synthesis and structural characterization of titanocene-containing polyethers based on ethylene glycols.
Creator
Reckleben, Lisa., Florida Atlantic University, Carraher, Charles E.
Abstract/Description
Organotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the...
Show moreOrganotin-modified poly(vinyl alcohol) products and titanocene-containing polyethers were synthesized via the interfacial polymerization technique. The structures were determined using infrared and mass spectroscopy. Further characterization involved elemental analysis, thermal analysis, and solubility studies. For the organotin products, the biological activities towards selected microorganisms were determined. The products exhibited selective inhibition of Candida Albicans, the microorganism most responsible for yeast infections in man. The titanocene-containing polyethers exhibited flexibility when derived from longer chained polyethylene glycols, but were inflexible when shorter chained polyethylene glycols were used.
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Date Issued
1991
PURL
http://purl.flvc.org/fcla/dt/14752
Subject Headings
Candida albicans, Organometallic polymers, Polymerization, Polyethylene glycol
Format
Document (PDF)
Nuclear magnetic resonance spectroscopic studies of metallocene (IVB) squarate polymers and other metallocene (IVB)-containing polymers
Title
Nuclear magnetic resonance spectroscopic studies of metallocene (IVB) squarate polymers and other metallocene (IVB)-containing polymers.
Creator
Li, Alicia Qing, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Group IVB metallocene polymers and oligomers undergo a pi-sigma rearrangement of the cyclopentadienyl moieties in DMSO based on NMR data. The sigma-Cp rings are stereochemically rigid at room temperature.
Date Issued
1991
PURL
http://purl.flvc.org/fcla/dt/14681
Subject Headings
Organometallic polymers, Metallocenes, Nuclear magnetic resonance
Format
Document (PDF)
Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives
Title
Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives.
Creator
Kloss, John Edward, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Reaction of Group IVB metallocene dichlorides with a monoaza dye yields a polymer in which the metal is bonded to a sulfonic and a hydroxyl group. The structure and bonding of the polymer was confirmed using infrared, mass spectrometry and 1H-NMR spectroscopy. Thermo and elemental analysis was used to confirm the presence of the metal. The stability of the polydye to the monomer unit was compared employing an argon laser in the visible region.
Date Issued
1993
PURL
http://purl.flvc.org/fcla/dt/14912
Subject Headings
Metallocenes, Organometallic polymers, Infrared spectroscopy, Azo compounds
Format
Document (PDF)
Synthesis and characterization of ruthenium-containing polymers
Title
Synthesis and characterization of ruthenium-containing polymers.
Creator
Zhang, Qingmao, Florida Atlantic University, Carraher, Charles E.
Abstract/Description
Ruthenium-containing polymers derived from dichloro-bis(2,2-bipyridine)-ruthenium and selected dithiol or diamines have been synthesized. These polymeric products were characterized using FTIR, ultraviolet spectroscopy, light scattering photometry and mass spectral analysis. Thermal degradation studies of these products are presented.
Date Issued
1993
PURL
http://purl.flvc.org/fcla/dt/14952
Subject Headings
Ruthenium compounds, Ligands, Organometallic polymers, Mass spectrometry
Format
Document (PDF)
Synthesis, structural characterization and biological studies of organotin polyethers (Sn-O)
Title
Synthesis, structural characterization and biological studies of organotin polyethers (Sn-O).
Creator
Barot, Girish Vallabhbhai., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Cancer is the second leading cause of death in the western world. In order to treat various types of cancer, platinum-based drugs are most widely employed as metal-containing chemotherapeutic agents. However, their clinical usage is hindered by toxic side effects, and by the emergence of drug resistance. Our focus was to replace platinum with less toxic metal like tin which can give better alternatives for cancer treatment. The major aim of our study was to synthesize novel organotin...
Show moreCancer is the second leading cause of death in the western world. In order to treat various types of cancer, platinum-based drugs are most widely employed as metal-containing chemotherapeutic agents. However, their clinical usage is hindered by toxic side effects, and by the emergence of drug resistance. Our focus was to replace platinum with less toxic metal like tin which can give better alternatives for cancer treatment. The major aim of our study was to synthesize novel organotin polyethers (Sn-O) which can be used to combat cancer. Preliminary results from our laboratory using organotin polyethers, that were synthesized by varying the structure of diols showed growth inhibition in Balb-3T3 cells. This study directly led us to hypothesize the two structural windows, first by changing the distance between diol and second, by presence of unsaturation in diols, the biological activity of organotin polyethers (Sn-O) can be enhanced significantly. Different series of polymeric compounds were synthesized based upon these two structural windows and the formation of products was validated using standard techniques like infrared spectroscopy (IR), light scattering photometer, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and nuclear magnetic resonance (NMR). The synthesized polymers arrested the growth of cancer cell lines including bone, prostate, colon, breast, pancreas and lung cancer derived cell lines in vitro. In number of instances where chemotherapeutic index values of two and greater were found that these polymers are significantly more active against cancer cells than non-cancerous cells in culture., These results support the starting premise that the polymers may exhibit cancer cell selectivity. In general, it was found that the presence of unsaturation increased the probability that the polyether would inhibit the growth of various cancer cell lines. Further, in some cases, polyethers with short distances between the oxygen atoms showed a superior ability to inhibit the growth of various cancer cell lines in comparison to those with longer distances between the oxygen atoms. These results provide a framework for the discovery of novel cancer therapeutics.
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Date Issued
2009
PURL
http://purl.flvc.org/FAU/186672
Subject Headings
Organometallic polymers, Cancer, Molecular aspects, Apoptosis, Molecular aspects, Antineoplastic agents, Testing, Polymers in medicine
Format
Document (PDF)
Initial evaluation of organotin monomers and polymers as potential anticancer agents
Title
Initial evaluation of organotin monomers and polymers as potential anticancer agents.
Creator
Doucette, Randy D., Florida Atlantic University, Louda, Deborah W.
Abstract/Description
A large number of metal-containing compounds show significant activity against cancer cells and incorporating a metal into a polymer offers several possible advantages. Compounds of the type R2SnCl2 (R = methyl, ethyl, propyl, butyl, t-butyl, octyl and phenyl) were tested for the ability to inhibit the growth of Balb 3T3 mouse fibroblast cells and CAOV3 human ovarian carcinoma cells. Polymers of 2-chloro-1,4-benzenediamine and the same organotin dichloride were synthesized and tested as well....
Show moreA large number of metal-containing compounds show significant activity against cancer cells and incorporating a metal into a polymer offers several possible advantages. Compounds of the type R2SnCl2 (R = methyl, ethyl, propyl, butyl, t-butyl, octyl and phenyl) were tested for the ability to inhibit the growth of Balb 3T3 mouse fibroblast cells and CAOV3 human ovarian carcinoma cells. Polymers of 2-chloro-1,4-benzenediamine and the same organotin dichloride were synthesized and tested as well. For both monomers and polymers, the pattern of growth inhibition relative to the R group was butyl > propyl = t-butyl = octyl = phenyl > ethyl > methyl. This and other aspects of the structure-activity relationship of the monomers and polymers were examined.
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Date Issued
2006
PURL
http://purl.flvc.org/fcla/dt/13410
Subject Headings
Apoptosis--Molecular aspects, Polymeric composites, Organometallic compounds, Cancer--Molecular aspects, Antineoplastic agents--Testing, Polymers in medicine
Format
Document (PDF)