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(1 - 7 of 7)
- Title
- Formation of transition metal-oxaziridines from molybdenum oxide(Et(2)dtc)(2)(THF)(2)iodine(2) and nitroso compounds.
- Creator
- Rodriguez-Bracero, Shirley A., Florida Atlantic University, Baird, Donald M.
- Abstract/Description
-
Mo2O3(Et2dtc)2(THF) 2I2 (1) reacts with a variety of oxygen atom donor substrates, X-O, such as pyridine-N-oxides, sulfoxides and nitrate to produce MoO2^2+ complexes and X by oxygen atom transfer. Results from kinetics studies indicate the formation of a (1)-substrate intermediate that decomposes to form the products. The lifetime of the intermediate apparently depends on the stability of the leaving group, X. Since the R-group in nitroso compounds, R-N=0, would not be stable leaving groups...
Show moreMo2O3(Et2dtc)2(THF) 2I2 (1) reacts with a variety of oxygen atom donor substrates, X-O, such as pyridine-N-oxides, sulfoxides and nitrate to produce MoO2^2+ complexes and X by oxygen atom transfer. Results from kinetics studies indicate the formation of a (1)-substrate intermediate that decomposes to form the products. The lifetime of the intermediate apparently depends on the stability of the leaving group, X. Since the R-group in nitroso compounds, R-N=0, would not be stable leaving groups the (1)-nitroso complex might be expected to be quite long lived or even stable. Indeed, reaction of (1) with nitroso compounds such as nitrosobenzene produce stable molybdenum-oxaziridines which have been identified using 1H-NMR, IR and electronic spectral data. The use of these complexes in the mediation of allylic amination reactions was studied.
Show less - Date Issued
- 1994
- PURL
- http://purl.flvc.org/fcla/dt/15107
- Subject Headings
- Nitroso compounds, Organometallic compounds
- Format
- Document (PDF)
- Title
- Synthesis and characterization of tin-containing polymers derived from amino acids.
- Creator
- Li, Fengmai, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
- Abstract/Description
-
Tin-containing polymers were synthesized by reaction of amino acids (4-aminobenzoic acid, ampicillin, glycylglycine and glycyl-D-phenylalanine) with organotin dichloride via the interfacial condensation technique. The products were characterized using Fourier Transform Infrared spectrometry, Ultraviolet spectrometry, light scattering photometry and mass spectral analysis. The biological activities of the products were tested against selected microorganisms and human cells.
- Date Issued
- 1998
- PURL
- http://purl.flvc.org/fcla/dt/15611
- Subject Headings
- Organometallic polymers, Organotin compounds
- Format
- Document (PDF)
- Title
- Synthesis and characterization of polyazo-group IVB metallocene dichloride derivatives.
- Creator
- Kloss, John Edward, Florida Atlantic University, Carraher, Charles E., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
- Abstract/Description
-
Reaction of Group IVB metallocene dichlorides with a monoaza dye yields a polymer in which the metal is bonded to a sulfonic and a hydroxyl group. The structure and bonding of the polymer was confirmed using infrared, mass spectrometry and 1H-NMR spectroscopy. Thermo and elemental analysis was used to confirm the presence of the metal. The stability of the polydye to the monomer unit was compared employing an argon laser in the visible region.
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/fcla/dt/14912
- Subject Headings
- Metallocenes, Organometallic polymers, Infrared spectroscopy, Azo compounds
- Format
- Document (PDF)
- Title
- Synthesis and characterization of ruthenium-containing polymers.
- Creator
- Zhang, Qingmao, Florida Atlantic University, Carraher, Charles E.
- Abstract/Description
-
Ruthenium-containing polymers derived from dichloro-bis(2,2-bipyridine)-ruthenium and selected dithiol or diamines have been synthesized. These polymeric products were characterized using FTIR, ultraviolet spectroscopy, light scattering photometry and mass spectral analysis. Thermal degradation studies of these products are presented.
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/fcla/dt/14952
- Subject Headings
- Ruthenium compounds, Ligands, Organometallic polymers, Mass spectrometry
- Format
- Document (PDF)
- Title
- Studies towards a catalytic asymmetric isomerization of manganese complexed alkynes to allenes using chiral bases.
- Creator
- He, Chang., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
- Abstract/Description
-
The conversion of alkynyl carbonyls to allenyl carbonyls via manganese mediated coordination followed by a base-catalyzed isomerization was carried out using a range of chiral and achiral amine bases. Chiral amidine and chiral DBU derivatives were synthesized to carry out the isomerization enantioselectively. We employed HPLC equipped with a chiral column to determine the enantiomeric excess. We also proved that the mechanism of that the manganese-coordinated alkyne/allene rearrangement...
Show moreThe conversion of alkynyl carbonyls to allenyl carbonyls via manganese mediated coordination followed by a base-catalyzed isomerization was carried out using a range of chiral and achiral amine bases. Chiral amidine and chiral DBU derivatives were synthesized to carry out the isomerization enantioselectively. We employed HPLC equipped with a chiral column to determine the enantiomeric excess. We also proved that the mechanism of that the manganese-coordinated alkyne/allene rearrangement reaction involved an intermediate cumenolate. It was also confirmed that amine base with pKa lower than that of DBU (pKa = 13.6) would not carry out the isomerization. Alkoxy base were also used in isomerization and the mechanism was also investigated.
Show less - Date Issued
- 2009
- PURL
- http://purl.flvc.org/FAU/192983
- Subject Headings
- Enzyme kinetics, Organometallic compounds, Synthesis, Asymmetric synthesis, Methathesis (Chemistry), Carbonyl compounds, Synthesis
- Format
- Document (PDF)
- Title
- Hemisynthesis and Characterization of Cyclopheophorbides.
- Creator
- Mortezaei-Rad, Mitra, Florida Atlantic University, Louda, J. William, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
- Abstract/Description
-
Cyclopheophorbides absorb light at higher wavelengths (> 670 run) as compared to their precursor pyropheophorbides ( ~ 666 run) and are strong antioxidants. Therefore they could potentially be used as photosensitizers in photodynamic therapy, although this study does not focus on the pharmacology aspect of this class of compounds. The overall goal of this study was to hemisynthesize, purify and characterize certain cyclopheophorbides from both chlorophyll a and b families. The known...
Show moreCyclopheophorbides absorb light at higher wavelengths (> 670 run) as compared to their precursor pyropheophorbides ( ~ 666 run) and are strong antioxidants. Therefore they could potentially be used as photosensitizers in photodynamic therapy, although this study does not focus on the pharmacology aspect of this class of compounds. The overall goal of this study was to hemisynthesize, purify and characterize certain cyclopheophorbides from both chlorophyll a and b families. The known hemisynthesis of 13^2,17^3-cyclopheophorbide a enol was repeated. A major success in the purification process was achieved by utilizing polystyrene divinylbenzene (PS-DVB a.k .a. PRP-1 TM) as the stationary phase in reversed phase flash chromatography. Altering (TMS)2-NNa with (TMS)2-NLi was found to increase yields. 13^2,17^3 -mesocyclopheophorbide a enol was successfully hemisynthesized as a novel compound. Methyl-3-devinyl-3-[1-hexyloxy]ethyl pyropheophorbide a (HPPH-ME), was prepared, purified and molecular characteri zation on the compound was performed. Hemisynthesis ofHPPH-CYCLO from HPPH-ME was attempted, but was unsuccessful. Zinc and copper pyropheophorbide a methyl esters were prepared with the intent of forming of zinc and copper CYCLO. Hemisynthesis of corresponding metalloCYCLO from both insertion of the metal inside the CYCLO core and cyclizations of metal derivatives of pyropheophorbide a methyl ester were unsuccessful. Chlorophyll b was successfully extracted from green algae Chiarella and purified in mg lots (100%) utilizing RP-LPLC and with a binary solvent gradient program. Pheophorbide b methyl ester and pyropheophorbide b methyl ester were made and characterized. Hemisynthesis of CYCLO-b was unsuccessful likely due to the altered reactivity of pyropheophorbide b (vs. -a) methyl ester. To reduce the reactivity, reduction of formyl group of pyropheophorbide b methyl ester with NaBH4 was performed. Still, formation of a CYCLO derivative was not achieved. Chromatographic purification, mass and NMR characterization of CYCLO, mesoCYCLO, HPPH-ME and all precursor compounds are reported. 2D NMR of most of these compounds are reported here for the first time.
Show less - Date Issued
- 2007
- PURL
- http://purl.flvc.org/fau/fd/FA00000872
- Subject Headings
- High performance liquid chromatography, Organometallic chemistry, Organic compounds--Spectra, Organophosphorus compounds
- Format
- Document (PDF)
- Title
- Initial evaluation of organotin monomers and polymers as potential anticancer agents.
- Creator
- Doucette, Randy D., Florida Atlantic University, Louda, Deborah W.
- Abstract/Description
-
A large number of metal-containing compounds show significant activity against cancer cells and incorporating a metal into a polymer offers several possible advantages. Compounds of the type R2SnCl2 (R = methyl, ethyl, propyl, butyl, t-butyl, octyl and phenyl) were tested for the ability to inhibit the growth of Balb 3T3 mouse fibroblast cells and CAOV3 human ovarian carcinoma cells. Polymers of 2-chloro-1,4-benzenediamine and the same organotin dichloride were synthesized and tested as well....
Show moreA large number of metal-containing compounds show significant activity against cancer cells and incorporating a metal into a polymer offers several possible advantages. Compounds of the type R2SnCl2 (R = methyl, ethyl, propyl, butyl, t-butyl, octyl and phenyl) were tested for the ability to inhibit the growth of Balb 3T3 mouse fibroblast cells and CAOV3 human ovarian carcinoma cells. Polymers of 2-chloro-1,4-benzenediamine and the same organotin dichloride were synthesized and tested as well. For both monomers and polymers, the pattern of growth inhibition relative to the R group was butyl > propyl = t-butyl = octyl = phenyl > ethyl > methyl. This and other aspects of the structure-activity relationship of the monomers and polymers were examined.
Show less - Date Issued
- 2006
- PURL
- http://purl.flvc.org/fcla/dt/13410
- Subject Headings
- Apoptosis--Molecular aspects, Polymeric composites, Organometallic compounds, Cancer--Molecular aspects, Antineoplastic agents--Testing, Polymers in medicine
- Format
- Document (PDF)
