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Marine natural products
Title
Marine natural products.
Creator
Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
Date Issued
1999
PURL
http://purl.flvc.org/fau/fd/FA00007503
Subject Headings
Marine natural products
Format
Document (PDF)
Virgin
Title
The Virgin.
Creator
Kaplan, Vanessa Michele., Florida Atlantic University, Payne, Johnny
Abstract/Description
The romantic and naturalistic schools of literature have long been pitted against each other by talented theorists best on divorcing freedom (romantic) from determinism (naturalistic) and using literature to promote the extreme they decide is either morally good (freedom) or effectively caused (determinism). In Negligence in the Garden, the characters are faced with deciding if they are free to determine the courses of their lives, or if their lives are set in motion by endless chains of...
Show moreThe romantic and naturalistic schools of literature have long been pitted against each other by talented theorists best on divorcing freedom (romantic) from determinism (naturalistic) and using literature to promote the extreme they decide is either morally good (freedom) or effectively caused (determinism). In Negligence in the Garden, the characters are faced with deciding if they are free to determine the courses of their lives, or if their lives are set in motion by endless chains of cause and effect. Their world is the place where romanticism meets naturalism. They discover that through acting free, they can become free, but that the importance of understanding where they might stand in relation to any string of cause and effect is also of the utmost importance in determining how to use their freedoms.
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Date Issued
2003
PURL
http://purl.flvc.org/fcla/dt/12974
Subject Headings
Romanticism, Naturalism in literature
Format
Document (PDF)
A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS
Title
A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS.
Creator
Miller-Xavier, René Kathleen, Mincer, Tracy, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Genomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it...
Show moreGenomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it analyzes disparate biomes (environmental and host microbiomes) at varying sequencing depths (shallow and deep). FCHsm was used to resolve molecular dynamics and mine trans-kingdom metagenomes for secondary metabolic biosynthetic gene clusters (BGCs) in two marine environments— Indian River Lagoon toxic harmful algal blooms (IRL HABs) and the medicinal Leiodermatium sponge holobiont. First, an in silico mock dataset was analyzed to benchmark the FCHsm workflow. Sourmash, coupled with the Genome Taxonomy Database, outcompeted the other taxonomic profilers by accurately predicting the size of the mock metagenome (450 genomes) and recalling the highest number of species (82 %) and strains (44 %). Nonpareil calculated the sequencing effort needed for 100 % coverage for all the datasets and correctly estimated the 75 Gbp of sequencing needed for almost 100 % coverage of the mock metagenomes (99.5 %). Next, the trans-kingdom metagenomes of the IRL were explored, and potential HAB biomarkers were identified.
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Date Issued
2023
PURL
http://purl.flvc.org/fau/fd/FA00014186
Subject Headings
Marine natural products, Metagenomics
Format
Document (PDF)
Antitumor activity and biochemical effects of topsentin
Title
Antitumor activity and biochemical effects of topsentin.
Creator
Burres, N. S., Barber, D. A., Gunasekera, Sarath P., Clement, J. J., Shen, L. L.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3355144
Subject Headings
Marine natural products, Antitumor agents
Format
Document (PDF)
Two steroidal alkaloids from a sponge, Corticium sp.
Title
Two steroidal alkaloids from a sponge, Corticium sp.
Creator
Jurek, J., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319071
Subject Headings
Sponges --Research, Marine natural products
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Title
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3351980
Subject Headings
Sponges, Sesterterpenes, Marine natural products
Format
Document (PDF)
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus
Title
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
Creator
Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332982
Subject Headings
Sponges, Indoles, Marine natural products
Format
Document (PDF)
8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp
Title
8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp.
Creator
Ichiba, T., Corgiat, J. M., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3318972
Subject Headings
Sponges --Research, Marine natural products
Format
Document (PDF)
New sterol ester from a deep water marine sponge, Xestospongia sp.
Title
New sterol ester from a deep water marine sponge, Xestospongia sp.
Creator
Gunasekera, Sarath P., Cranick, S., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332980
Subject Headings
Sponges, Sterols, Marine natural products
Format
Document (PDF)
Florida's Great Hurricane
Title
Florida's Great Hurricane.
Creator
Reese, Joseph Hugh
Date Issued
1926
PURL
http://purl.flvc.org/fcla/dl/fa00000038.pdf
Subject Headings
History, Hurricanes, Natural disasters
Format
E-book
Isolation and Semi-synthesis of Marine Diterpenoids
Title
Isolation and Semi-synthesis of Marine Diterpenoids.
Creator
Scesa, Paul D., West, Lyndon, Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
Abstract/Description
Natural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in...
Show moreNatural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in vitro (GI50 < 10 μM). The biomimetic semisynthesis of diterpendoids and analogues is also presented. Access to the bielschowskyane carbon skeleton by dearomatization of a furanocembranoid precursor is described. Highlights include a stereoselective alkene epoxidation, a novel kinetic furan dearomatization method, and an efficient [2+2] photochemical cycloaddition. The role of conformational steering was studied spectroscopically using VT 1H-NMR and NOESY as well as quantum chemical calculations at the DFT level of theory. We also disclose a biomimetic synthesis of providencin using a photochemical Norrish-Yang cyclization. This provided the absolute configuration by chemical correlation with the precursor bipinnatin E, the latter determined by x-ray diffraction. An unexpected, regioisomeric byproduct was observed and a possible mechanism is proposed. A biomimetic synthesis of the diterpene alkaloid aceropterine is also described, using an epoxidation-rearrangement cascade. This work led to a revised structure of aceropterine, formulated by spectroscopic methods. Finally, the isolation and structure elucidation of a novel, cyclic lipopeptide from Pseudomonas sp. is described. The compound was obtained using a unique antibiotic crowd sourcing approach and the structure determined by spectroscopic methods and advanced Marfey’s analysis.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013539
Subject Headings
Marine natural products, Diterpenoids, Biomimetics
Format
Document (PDF)
Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites
Title
Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
Creator
Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319079
Subject Headings
Sponges --Research, Marine natural products, NMR spectroscopy
Format
Document (PDF)
Five new Discodermolide analogues from the marine sponge Discodermia species
Title
Five new Discodermolide analogues from the marine sponge Discodermia species.
Creator
Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3319106
Subject Headings
Sponges --Research, Cytotoxin, Marine natural products, Polyketides
Format
Document (PDF)
Marine biotechnology: realizing the potential
Title
Marine biotechnology: realizing the potential.
Creator
Pomponi, Shirley A., Baden, Daniel G., Zohar, Y.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3338530
Subject Headings
Marine biotechnology, Marine pharmacology, Marine natural products
Format
Document (PDF)
Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol
Title
Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
Creator
Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
Date Issued
2011
PURL
http://purl.flvc.org/fau/fd/FA00007463
Subject Headings
Macrolides, Antimitotic Agents, Natural products, Tubulin
Format
Document (PDF)
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta
Title
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta.
Creator
Gunasekera, Sarath P., Gunasekera, M., McCarthy, Peter J.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332985
Subject Headings
Sponges, Lactams, Macrocyclic, Marine natural products
Format
Document (PDF)
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp
Title
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp.
Creator
Ohtani, I. I., Ichiba, T., Isobe, M., Kelly-Borges, M., Scheuer, P. J., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3319093
Subject Headings
Sponges, Sponges --Research, Marine natural products, Alkaloids
Format
Document (PDF)
A new bastadin from the sponge Psammaplysilla purpurea
Title
A new bastadin from the sponge Psammaplysilla purpurea.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318955
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products
Format
Document (PDF)
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi
Title
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi.
Creator
Koehn, F. E., Gunasekera, M., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332977
Subject Headings
Sponges, Sterols, Marine natural products, Antiviral agents
Format
Document (PDF)

Pages