Current Search: Naturalization (x)
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Pages
- Title
- Marine natural products.
- Creator
- Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/fau/fd/FA00007503
- Subject Headings
- Marine natural products
- Format
- Document (PDF)
- Title
- The Virgin.
- Creator
- Kaplan, Vanessa Michele., Florida Atlantic University, Payne, Johnny
- Abstract/Description
-
The romantic and naturalistic schools of literature have long been pitted against each other by talented theorists best on divorcing freedom (romantic) from determinism (naturalistic) and using literature to promote the extreme they decide is either morally good (freedom) or effectively caused (determinism). In Negligence in the Garden, the characters are faced with deciding if they are free to determine the courses of their lives, or if their lives are set in motion by endless chains of...
Show moreThe romantic and naturalistic schools of literature have long been pitted against each other by talented theorists best on divorcing freedom (romantic) from determinism (naturalistic) and using literature to promote the extreme they decide is either morally good (freedom) or effectively caused (determinism). In Negligence in the Garden, the characters are faced with deciding if they are free to determine the courses of their lives, or if their lives are set in motion by endless chains of cause and effect. Their world is the place where romanticism meets naturalism. They discover that through acting free, they can become free, but that the importance of understanding where they might stand in relation to any string of cause and effect is also of the utmost importance in determining how to use their freedoms.
Show less - Date Issued
- 2003
- PURL
- http://purl.flvc.org/fcla/dt/12974
- Subject Headings
- Romanticism, Naturalism in literature
- Format
- Document (PDF)
- Title
- A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS.
- Creator
- Miller-Xavier, René Kathleen, Mincer, Tracy, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
- Abstract/Description
-
Genomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it...
Show moreGenomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it analyzes disparate biomes (environmental and host microbiomes) at varying sequencing depths (shallow and deep). FCHsm was used to resolve molecular dynamics and mine trans-kingdom metagenomes for secondary metabolic biosynthetic gene clusters (BGCs) in two marine environments— Indian River Lagoon toxic harmful algal blooms (IRL HABs) and the medicinal Leiodermatium sponge holobiont. First, an in silico mock dataset was analyzed to benchmark the FCHsm workflow. Sourmash, coupled with the Genome Taxonomy Database, outcompeted the other taxonomic profilers by accurately predicting the size of the mock metagenome (450 genomes) and recalling the highest number of species (82 %) and strains (44 %). Nonpareil calculated the sequencing effort needed for 100 % coverage for all the datasets and correctly estimated the 75 Gbp of sequencing needed for almost 100 % coverage of the mock metagenomes (99.5 %). Next, the trans-kingdom metagenomes of the IRL were explored, and potential HAB biomarkers were identified.
Show less - Date Issued
- 2023
- PURL
- http://purl.flvc.org/fau/fd/FA00014186
- Subject Headings
- Marine natural products, Metagenomics
- Format
- Document (PDF)
- Title
- Antitumor activity and biochemical effects of topsentin.
- Creator
- Burres, N. S., Barber, D. A., Gunasekera, Sarath P., Clement, J. J., Shen, L. L.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3355144
- Subject Headings
- Marine natural products, Antitumor agents
- Format
- Document (PDF)
- Title
- Two steroidal alkaloids from a sponge, Corticium sp.
- Creator
- Jurek, J., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3319071
- Subject Headings
- Sponges --Research, Marine natural products
- Format
- Document (PDF)
- Title
- Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
- Creator
- Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/3333011
- Subject Headings
- Sponges, Macrolides, Marine natural products
- Format
- Document (PDF)
- Title
- A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
- Creator
- Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
- Date Issued
- 2003
- PURL
- http://purl.flvc.org/FCLA/DT/3351980
- Subject Headings
- Sponges, Sesterterpenes, Marine natural products
- Format
- Document (PDF)
- Title
- A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
- Creator
- Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332982
- Subject Headings
- Sponges, Indoles, Marine natural products
- Format
- Document (PDF)
- Title
- 8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp.
- Creator
- Ichiba, T., Corgiat, J. M., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3318972
- Subject Headings
- Sponges --Research, Marine natural products
- Format
- Document (PDF)
- Title
- New sterol ester from a deep water marine sponge, Xestospongia sp.
- Creator
- Gunasekera, Sarath P., Cranick, S., Pomponi, Shirley A.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332980
- Subject Headings
- Sponges, Sterols, Marine natural products
- Format
- Document (PDF)
- Title
- Florida's Great Hurricane.
- Creator
- Reese, Joseph Hugh
- Date Issued
- 1926
- PURL
- http://purl.flvc.org/fcla/dl/fa00000038.pdf
- Subject Headings
- History, Hurricanes, Natural disasters
- Format
- E-book
- Title
- Isolation and Semi-synthesis of Marine Diterpenoids.
- Creator
- Scesa, Paul D., West, Lyndon, Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
- Abstract/Description
-
Natural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in...
Show moreNatural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in vitro (GI50 < 10 μM). The biomimetic semisynthesis of diterpendoids and analogues is also presented. Access to the bielschowskyane carbon skeleton by dearomatization of a furanocembranoid precursor is described. Highlights include a stereoselective alkene epoxidation, a novel kinetic furan dearomatization method, and an efficient [2+2] photochemical cycloaddition. The role of conformational steering was studied spectroscopically using VT 1H-NMR and NOESY as well as quantum chemical calculations at the DFT level of theory. We also disclose a biomimetic synthesis of providencin using a photochemical Norrish-Yang cyclization. This provided the absolute configuration by chemical correlation with the precursor bipinnatin E, the latter determined by x-ray diffraction. An unexpected, regioisomeric byproduct was observed and a possible mechanism is proposed. A biomimetic synthesis of the diterpene alkaloid aceropterine is also described, using an epoxidation-rearrangement cascade. This work led to a revised structure of aceropterine, formulated by spectroscopic methods. Finally, the isolation and structure elucidation of a novel, cyclic lipopeptide from Pseudomonas sp. is described. The compound was obtained using a unique antibiotic crowd sourcing approach and the structure determined by spectroscopic methods and advanced Marfey’s analysis.
Show less - Date Issued
- 2020
- PURL
- http://purl.flvc.org/fau/fd/FA00013539
- Subject Headings
- Marine natural products, Diterpenoids, Biomimetics
- Format
- Document (PDF)
- Title
- Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
- Creator
- Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3319079
- Subject Headings
- Sponges --Research, Marine natural products, NMR spectroscopy
- Format
- Document (PDF)
- Title
- Five new Discodermolide analogues from the marine sponge Discodermia species.
- Creator
- Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/3319106
- Subject Headings
- Sponges --Research, Cytotoxin, Marine natural products, Polyketides
- Format
- Document (PDF)
- Title
- Marine biotechnology: realizing the potential.
- Creator
- Pomponi, Shirley A., Baden, Daniel G., Zohar, Y.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/FCLA/DT/3338530
- Subject Headings
- Marine biotechnology, Marine pharmacology, Marine natural products
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
- Creator
- Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007463
- Subject Headings
- Macrolides, Antimitotic Agents, Natural products, Tubulin
- Format
- Document (PDF)
- Title
- Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta.
- Creator
- Gunasekera, Sarath P., Gunasekera, M., McCarthy, Peter J.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332985
- Subject Headings
- Sponges, Lactams, Macrocyclic, Marine natural products
- Format
- Document (PDF)
- Title
- Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp.
- Creator
- Ohtani, I. I., Ichiba, T., Isobe, M., Kelly-Borges, M., Scheuer, P. J., Harbor Branch Oceanographic Institute
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3319093
- Subject Headings
- Sponges, Sponges --Research, Marine natural products, Alkaloids
- Format
- Document (PDF)
- Title
- A new bastadin from the sponge Psammaplysilla purpurea.
- Creator
- Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1993
- PURL
- http://purl.flvc.org/FCLA/DT/3318955
- Subject Headings
- Sponges --Research, Marine metabolites, Marine natural products
- Format
- Document (PDF)
- Title
- New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi.
- Creator
- Koehn, F. E., Gunasekera, M., Cross, S. S., Harbor Branch Oceanographic Institute
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/FCLA/DT/3332977
- Subject Headings
- Sponges, Sterols, Marine natural products, Antiviral agents
- Format
- Document (PDF)