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Investigation of Structure-Property Relationship of a High Temperature Polyimide Reinforced with Nanoparticles
Title
Investigation of Structure-Property Relationship of a High Temperature Polyimide Reinforced with Nanoparticles.
Creator
Rowbottom, Colin, Mahfuz, Hassan, Florida Atlantic University, College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering
Abstract/Description
Nano-reinforced polymeric systems have demonstrated a great deal of interest within academia and industry, due to the intrinsic properties of the graphene nanofillers, having excellent mechanical, thermal and electrical properties. The reinforcement of multiwall carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) were introduced into a low cost, non-carcinogenic, high temperature PMR type polyimide resin. The effects of the interfacial interaction and dispersion quality resulted in...
Show moreNano-reinforced polymeric systems have demonstrated a great deal of interest within academia and industry, due to the intrinsic properties of the graphene nanofillers, having excellent mechanical, thermal and electrical properties. The reinforcement of multiwall carbon nanotubes (MWCNTs) and graphene nanoplatelets (GNPs) were introduced into a low cost, non-carcinogenic, high temperature PMR type polyimide resin. The effects of the interfacial interaction and dispersion quality resulted in improvement in the glass transition temperature (Tg), elastic modulus and thermal stability by, 31°C, 63% and 16°C, respectively. In fine, this study presents a simple but effective high temperature polyimide (HTPI) nanocomposites manufacturing procedure and established that nanoparticle reinforcement can be used to improve both thermal and mechanical properties.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00013035
Subject Headings
Polyimides, Nanoparticles, Carbon nanotubes, Graphene
Format
Document (PDF)
Development of MnO2 Hollow Nanoparticles for Drug Delivery
Title
Development of MnO2 Hollow Nanoparticles for Drug Delivery.
Creator
Greene, Allison, Kang, Yunqing, Florida Atlantic University, Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science
Abstract/Description
This thesis reports the development of a novel drug delivery system consisting of hollow nanoparticles, formed from manganese dioxide (δ-MnO2) sheets, that are coated with polydopamine and folic acid to selectively target cancer cells. The biodegradability and colloidal stability of the uncoated hollow nanoparticles were investigated in comparison to solid MnO2 nanoparticles and graphene oxide sheets. The MnO2 hollow nanoparticles degraded at a faster rate and seem to have a higher surface...
Show moreThis thesis reports the development of a novel drug delivery system consisting of hollow nanoparticles, formed from manganese dioxide (δ-MnO2) sheets, that are coated with polydopamine and folic acid to selectively target cancer cells. The biodegradability and colloidal stability of the uncoated hollow nanoparticles were investigated in comparison to solid MnO2 nanoparticles and graphene oxide sheets. The MnO2 hollow nanoparticles degraded at a faster rate and seem to have a higher surface area and better colloidal dispersion than solid MnO2 nanoparticles. Xanthan gum was proven to improve colloidal dispersion of these hollow nanoparticles and were used for further cell studies. In this study, cancer and healthy cells were treated with coated hollow nanoparticles, and results indicate that this novel hollow nanoparticle may preferentially target and kill cancer cells. Particle aggregation has shown to be toxic to cells. Further studies with this novel drug delivery system may lead to a groundbreaking solution to targeted cancer therapy.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013513
Subject Headings
Drug Delivery Systems, Nanoparticles, Manganese dioxide, Xanthan gum, Cancer cells
Format
Document (PDF)
Enhancement of spike and stab resistance of flexible armor using nanoparticles and a cross-linking fixative
Title
Enhancement of spike and stab resistance of flexible armor using nanoparticles and a cross-linking fixative.
Creator
Lambert, Vincent., College of Engineering and Computer Science, Department of Ocean and Mechanical Engineering
Abstract/Description
A novel approach has been introduced in making flexible armor composites. Armor composites are usually made by reinforcing Kevlar fabric into the mixture of a polymer and nanoscale particles. The current procedure deviates from the traditional shear thickening fluid (STF) route and instead uses silane (amino-propyl-trimethoxy silane) as the base polymer. In addition, a cross-linking fixative such as Glutaraldehyde (Gluta) is added to the polymer to create bridges between distant pairs of...
Show moreA novel approach has been introduced in making flexible armor composites. Armor composites are usually made by reinforcing Kevlar fabric into the mixture of a polymer and nanoscale particles. The current procedure deviates from the traditional shear thickening fluid (STF) route and instead uses silane (amino-propyl-trimethoxy silane) as the base polymer. In addition, a cross-linking fixative such as Glutaraldehyde (Gluta) is added to the polymer to create bridges between distant pairs of amine groups present in Kevlar and silated nanoparticles. Water, silane, nanoparticles and Gluta are mixed using a homogenizer and an ultra-sonochemical technique. Subsequently, the admixture is impregnated with Kevlar - bypassing the heating and evaporating processes involved with STF. The resulting composites have shown remarkable improvement in spike resistance; at least one order higher than that of STF/Kevlar composites. The source of improvement has been traced to the formation of secondary amine C-N stretch due to the presence of Gluta.
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Date Issued
2009
PURL
http://purl.flvc.org/FAU/186769
Subject Headings
Armor, Design and construction, Composite materials, Testing, Nanoparticles, Testing, Viscoelasticity
Format
Document (PDF)
SELF-ASSEMBLING OF NEUTRAL AND CHARGED NANOPARTICLES INTO CORE-SHELL NANOHYBRIDS THROUGH HETEROAGGREGATION WITH SIZE CONTROL
Title
SELF-ASSEMBLING OF NEUTRAL AND CHARGED NANOPARTICLES INTO CORE-SHELL NANOHYBRIDS THROUGH HETEROAGGREGATION WITH SIZE CONTROL.
Creator
Hussain, Kazi Albab, Yi, Peng, Florida Atlantic University, College of Engineering and Computer Science, Department of Civil, Environmental and Geomatics Engineering
Abstract/Description
Core-shell nanohybrids have wide applications in pollutant degradation. In this study, core-shell nanohybrid was formed through heteroaggregation between neutral nanoparticles (i.e., hematite nanoparticles or HemNPs) and charged nanoparticles (i.e., carboxylated polystyrene nanoparticles or PSNPs). In the dispersant solution of 1 mM NaCl at pH 6.3, HemNPs were neutral and underwent favorable homoaggregation, whereas PSNPs were negatively charged and underwent no homoaggregation. When the two...
Show moreCore-shell nanohybrids have wide applications in pollutant degradation. In this study, core-shell nanohybrid was formed through heteroaggregation between neutral nanoparticles (i.e., hematite nanoparticles or HemNPs) and charged nanoparticles (i.e., carboxylated polystyrene nanoparticles or PSNPs). In the dispersant solution of 1 mM NaCl at pH 6.3, HemNPs were neutral and underwent favorable homoaggregation, whereas PSNPs were negatively charged and underwent no homoaggregation. When the two types of particles were mixed, homoaggregation of HemNPs and heteroaggregation between HemNPs and PSNPs took place simultaneously, forming HemNPs-PSNPs heteroaggregates. The transmission electron microscopy images of heteroaggregates show that HemNPs and PSNPs formed core-shell structure in which HemNPs were the cores and PSNPs were the shells. The size of the core-shell nanohybrids can be controlled by varying the concentration ratio of HemNPs to PSNPs. The increase of the size of charged nanoparticles resulted in larger nanohybrids. This new method has lower energy footprint than existing ones.
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Date Issued
2019
PURL
http://purl.flvc.org/fau/fd/FA00013317
Subject Headings
Nanoparticles, Core-shell structures, Nanohybrids, Aggregation (Chemistry)
Format
Document (PDF)
Overcoming Multidrug Resistance in Prostate Cancer Cells Using Nanoparticle Delivery of a Two-Drug Combination
Title
Overcoming Multidrug Resistance in Prostate Cancer Cells Using Nanoparticle Delivery of a Two-Drug Combination.
Creator
Toluleke, O. Famuyiwa, Kumi-Diaka, James, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Prostate cancer (PCa) is the second most diagnosed cancer in men. The resistance of prostate cancer to chemotherapy has been linked to the ATP Binding Cassette (ABC)-Mediated Multidrug Resistance (MDR). This study investigated the combination of 3-Bromopyruvate (3-BPA) and the anti-inflammatory molecule SC-514 in reducing MDR in prostate cancer. The compounds were incorporated into a PLGA nanoparticles to increase delivery to target cells. To investigate the effectiveness of SC-514 and/3-BPA,...
Show moreProstate cancer (PCa) is the second most diagnosed cancer in men. The resistance of prostate cancer to chemotherapy has been linked to the ATP Binding Cassette (ABC)-Mediated Multidrug Resistance (MDR). This study investigated the combination of 3-Bromopyruvate (3-BPA) and the anti-inflammatory molecule SC-514 in reducing MDR in prostate cancer. The compounds were incorporated into a PLGA nanoparticles to increase delivery to target cells. To investigate the effectiveness of SC-514 and/3-BPA, cytoxicity assays including trypan blue dye exclusion, MTT tetrazolium reduction, NBT, LDH release poly caspase detection, cell titer glow assay, and ELISA were utilized. Both immunofluorescence and multidrug resistance efflux assays were utilized to estimate the number of drug resistant cells. SC-514 was encapsulated in PLGA nanoparticles via single-emulsion method. SC-514 nanoparticles were analyzed utilizing Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Liquid chromatography–mass spectrometry (LC–MS) was used to measure the amount of SC- 514 released from the nanoparticle. Alternative SC-514 drug release quantification methods such as colony forming assay, wound healing assay, and transwell and migration assay were explored.
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Date Issued
2021
PURL
http://purl.flvc.org/fau/fd/FA00013677
Subject Headings
Prostate--Cancer, Nanoparticles, Drug Delivery Systems, Multidrug resistance
Format
Document (PDF)
SUPPORTED ERYTHROCYTE MEMBRANES ON PIEZOELECTRIC SENSORS FOR STUDYING THE INTERACTIONS BETWEEN NANOPARTICLES AND SURFACES OF RED BLOOD CELLS
Title
SUPPORTED ERYTHROCYTE MEMBRANES ON PIEZOELECTRIC SENSORS FOR STUDYING THE INTERACTIONS BETWEEN NANOPARTICLES AND SURFACES OF RED BLOOD CELLS.
Creator
Islam, Tanaz, Yi, Peng, Florida Atlantic University, Department of Civil, Environmental and Geomatics Engineering, College of Engineering and Computer Science
Abstract/Description
The Supported red blood cell membrane (SRBCm) was developed on a piezoelectric sensor to study the attachment of nanoparticles to erythrocyte surfaces. A well-dispersed colloidal suspension of fragments of RBCm was prepared from whole blood, and characterized thoroughly using cryogenic transmission electron microscopy, dynamic light scattering, and zeta potential analysis. To develop SRBCm, RBCm fragments were immobilized onthe sensor in a quartz crystal microbalance with dissipation...
Show moreThe Supported red blood cell membrane (SRBCm) was developed on a piezoelectric sensor to study the attachment of nanoparticles to erythrocyte surfaces. A well-dispersed colloidal suspension of fragments of RBCm was prepared from whole blood, and characterized thoroughly using cryogenic transmission electron microscopy, dynamic light scattering, and zeta potential analysis. To develop SRBCm, RBCm fragments were immobilized onthe sensor in a quartz crystal microbalance with dissipation monitoring system. A complete monolayer of flattened fragments of RBCm was formed on the positively charged surface of the piezoelectric sensor in 1 mM NaCl and 0.2 mM NaHCO3 at pH 7.1. The surface morphology of SRBCm was characterized via atomic force microscopy. The even distribution of surface proteins expressed on erythrocytes was found on SRBCm through indirect immunofluorescence microscopy. The attachment efficiencies of model nanoparticles, e.g. hematite nanoparticles and carboxylated polystyrene nanoparticles, on the SRBCm were quantified using a classic methodology. KEYWORDS: Supported erythrocyte membrane, piezoelectric sensor, phospholipid bilayers, nanoparticles
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Date Issued
2019
PURL
http://purl.flvc.org/fau/fd/FA00013383
Subject Headings
Erythrocyte Membrane, Piezoelectric polymer biosensors, Nanoparticles, Phospholipid bilayers, Bilayer lipid membranes
Format
Document (PDF)