Current Search: Morphine (x)
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Title
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Adult preference for morphine can be predicted from infant loss-of-righting response.
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Creator
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Siegel, Lawrence Allen., Florida Atlantic University
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Abstract/Description
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Infant rats display differences in duration of loss-of-righting (LOR) in response to an hypnotic dose of morphine sulfate. These differences in LOR duration are predictive of the rats' preference for drinking morphine solutions as adults. Infants tested at 16 days of age were designated Short-, Medium-, or Long-sleep based upon a 2.5 mg/kg dose of morphine sulfate administered intraperitoneally. Infants displaying long durations of LOR (long-sleep) subsequently display a marked preference for...
Show moreInfant rats display differences in duration of loss-of-righting (LOR) in response to an hypnotic dose of morphine sulfate. These differences in LOR duration are predictive of the rats' preference for drinking morphine solutions as adults. Infants tested at 16 days of age were designated Short-, Medium-, or Long-sleep based upon a 2.5 mg/kg dose of morphine sulfate administered intraperitoneally. Infants displaying long durations of LOR (long-sleep) subsequently display a marked preference for morphine solutions when tested as adults. Conversely, infants that displayed little or no LOR (short-sleep) did not consume as much of the morphine solutions in subsequent testing. This effect was consistent across the animals tested and appears to be independent of the screening dose. These findings demonstrate that adult differences in preference for drinking morphine solutions can be predicted in infancy.
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Date Issued
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1988
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PURL
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http://purl.flvc.org/fcla/dt/14492
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Subject Headings
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Conditioned response, Morphine, Narcotics
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Format
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Document (PDF)
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Title
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Limited influence of Pavlovian conditioning on tolerance to the anorexic effect of morphine.
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Creator
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Benson, Henry Donald, Jr., Florida Atlantic University, Wolgin, David L.
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Abstract/Description
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Rats that developed tolerance to the anorexic effect of morphine under conditions supportive of associational tolerance were tested for Pavlovian conditioned tolerance. Initially sensitive and nonsensitive rats received chronic morphine injections of 10 and 20mg/kg respectively in the presence of an explicitly paired compound cue until tolerant to the morphine induced suppression of milk intake. In a test for compensatory responding, only nonsensitive rats increased their intake in response...
Show moreRats that developed tolerance to the anorexic effect of morphine under conditions supportive of associational tolerance were tested for Pavlovian conditioned tolerance. Initially sensitive and nonsensitive rats received chronic morphine injections of 10 and 20mg/kg respectively in the presence of an explicitly paired compound cue until tolerant to the morphine induced suppression of milk intake. In a test for compensatory responding, only nonsensitive rats increased their intake in response to a placebo injection of saline in the presence of the morphine cue. In tests of associative tolerance, morphine injections in the presence of an explicitly unpaired saline cue, or in the absence of either cue, did not produce a loss of tolerance. After the temporal pattern of morphine administration was extinguished, only nonsensitive rats showed both a loss of tolerance in the presence of the saline cue, and tolerance retention in the presence of the morphine cue.
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Date Issued
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1990
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PURL
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http://purl.flvc.org/fcla/dt/14672
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Subject Headings
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Classical conditioning, Drug tolerance, Morphine, Appetite--Effect of drugs on
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Format
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Document (PDF)